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Acta Mathematicae Applicatae Sinica 2011年第4期27卷 561-568页

作者： Kuo-Shou chiu Manuel PINTO Departamento de Matemótica Facultad de Ciencias BósicasUniversidad Metropolitana de Ciencias de la EducacinJ.P.Alessandri 774SantiagoChile Departamento de Matemóticas Facultad de CienciasUniversidad de ChileCasilla 653SantiagoChile

A variation of parameters formula and Gronwall type integral inequality are proved for a differential equation involving general piecewise alternately advanced and retarded argument.

关键词： variation of parameters formula Gronwall integral inequality alternately advanced and retarded argument

Expression and prognostic role of molecular markers in 99 KIT-positive gastric stromal tumors in Taiwan Residents

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World Journal of Gastroenterology 2006年第4期12卷 595-602页

作者： Tsung-Hui Hu Seng-Kee Chuah Jui-wei Lin Yi-Chun chiu Chi-Sin Changchien Chih-Chi Wang Yaw-Sen Chen Li-Na Yi King-Wah chiu Chuan-Mo Lee Division of Gastroenterology Department of Internal MedicineChanggung Memorial Hospital Kaohsiung Taiwan China Department of Pathology Chang Gung Memorial Hospital Kaohsiung Taiwan China Department of Surgery Chang Gung Memorial Hospital Kaohsiung Taiwan China

AIM： TO elucidate the prognostic role and relationship of three molecular markers such as tumor suppressor gene p53, proliferating cell nuclear antigen （PCNA） and Ki-67 in gastric stromal tumor. METHODS： A total of 108 surgically resected gastric smooth muscle tumor specimens were collected from January 1987 to December 1999. Immunohistochemical studies were performed on the paraffin sections of 99 of 108 CDl17-positive tumors with antibodies of p53, PCNA, and Ki-67. Immunoreactivity of three molecular markers was recorded by labeling index （LI, %） and was analyzed for clinicopathologic and survival correlation. RESULTS： Of the 99 cases, immunostaining revealed that 52 patients （52.5%） had p53, and 37 patients （37.3%） had Ki-67 immunoreactivity （defined as 〉10% of LI）. All patients （100%） had PCNA immunoreactivity ranging from 12% to 93% of LI, divided into high or low by median. Statistics revealed that LI of three markers positively correlate to each other （P〈0.01） and to microscopic tumor mitotic counts （P〈0.001）. By combination, patients with ≥2 markers （positive or high） in tumors had early tumor recurrence （P〈0.001） and unfavorable outcome （P〈0.001）. Univariate analysis indicated that patients with tumor size 〉5 cm （P=0.003）, tumor mitosis 〉5/50 HPF （P〈0.001）, p53 immunoreactivity （P=0.001）, Ki-67 immunoreactivity （P=0.026）, high PCNA LI （P=0.015） and male gender （P=0.036） were six predictors for early disease recurrence. Subsequent multivariate analysis revealed that mitotic counts, tumor size, and p53 immunoreactivity were three independent prognostic factors for both disease free and overall survival of patients. By combination of three independent prognostic factors for grouping, we found higher tumor recurrence rate （P〈0.001） and shorter survival （P〈0.001） existed in groups with increasing factors. CONCLUSION： We first provide the prognostic value and linkage of three molecular markers in GISTs. The combination of three factors （p53, tumor size, and t

关键词： Gastrointestinal stromal tumor GIST p53 PCNA Ki-67 Prognosis

Application of double-balloon enteroscopy in jejunal diverticular bleeding

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World Journal of Gastroenterology 2010年第44期16卷 5616-5620页

作者： Tsung-Hsing Chen Cheng-Tang chiu wei-Pin Lin Ming-Yao Su Chen-Ming Hsu Pang-Chi Chen Department of Gastroenterology and Hepatology Linkou Chang Gung Memorial Hospital Chang Gung University College of MedicineTaoyuan 333TaiwanChina

AIM:To evaluate the efficacy of endoscopic diagnosis and therapy for jejunal diverticular ***:From January 2004 to September 2009,154 patients underwent double-balloon enteroscopy (DBE) for obscure gastrointestinal *** consecutive patients with jejunal diverticula (5 males and 5 females) at the age of 68.7 ± 2.1 years (range 1995 years) at Chang Gung Memorial Hospital,Academic Tertiary Referral Center,were enrolled in this ***:Of the 10 patients,5 had melena,2 had hematochezia,2 had both melena and hematochezia,1 had anemia and *** revealed ulcers with stigmata of recent hemorrhage in 6 patients treated by injection of epinephrine diluted at 1:10 000,Dieulafoylike lesions in 4 patients treated by deploying hemoclips on the vessels,colonic diverticula in 2 patients,and duodenal diverticula in 3 patients,*** the 2patients who underwent surgical intervention,1 had a large diverticulum and was referred by the surgeon for DBE,1 received endoscopic therapy but failed due to massive *** patient had a second DBE for recurrent hemorrhage 7 mo later,which was successfully treated with a repeat *** mean follow-up time of patients was 14.7 ± 7.8 ***:DBE is a safe and effective treatment modality for jejunal diverticular bleeding.

关键词： Double-balloon enteroscopy Jejunal diverticular bleeding Obscure gastrointestinal bleeding

The effect of variable viscosity on the flow and heat transfer of a viscous Agwater and Cu-water nanofluids

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Journal of Hydrodynamics 2013年第1期25卷 1-9页

作者： VAJRAVELU Kuppalapalle PRASAD Kerehalli Vinayaka NG chiu-On Department of Mathematics University of Central Florida Department of Mathematics VSK University Department of Mechanical Engineering The University of Hong Kong

A numerical study is carried out to study the effects of the temperature dependent viscosity on the flow and heat transfer of a nanofluid over a flat surface in the presence of viscous dissipation. The governing nonlinear partial differential equations are transformed into nonlinear ordinary differential equations, and are solved numerically by the Keller-box method. The numerical results indicate that the effect of nanoparticle volume fraction is to increase the heat transfer and hence enhance the thermal boundary layer thickness. This is true even in the presence of variable viscosity and the viscous dissipation. Furthermore, the results obtained for heat transfer characteristics with nanoparticles reveal many interesting behaviors that warrant further study on the effects of the ＂nano-solid-particles＂.

关键词： nanofluid particles variable viscosity boundary layers viscous dissipation Keller-box method

Estimation of Water Particle Velocities by Empirical Transfer Function

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China Ocean Engineering 1997年第4期12卷 393-410页

作者： chiu, YF Kuo, YY Inst Harbor & Marine Technol Wuchi Coastal Engn Div Taichung Taiwan Natl Chiao Tung Univ Dept Civil Engn Hsinchu Taiwan

In previous and this studies it appears that the linear and nonlinear wave theory-can not accurately and easily predict the water particle velocities: Therefore, different from the theoretical considerations, in this study we have attempted to determine the transfer function empirically. Laboratory experiments were performed under various wave conditions. The empirical formulas of the transfer function of the wave height, angular frequency and water particle velocity were obtained on the basis of these test data by dimensional analysis and regression analysis. In intermediate and deep water depth conditions, the transfer function was only a function of a nondimensional parameter which is composed of the angular frequency, the depth of the velocity gauge under the still water level, water depth and the acceleration of gravity. Finally, the empirical formulas were compared with experimental data and observational data form present and Cavaleri's (1978) studies. The empirical formulas were found to be in sufficient correltion with these data.

关键词： water particle velocity empirical transfer function

Three New Cucurbitacins from Hemsleya lijiangensis

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Chinese Chemical Letters 2003年第4期14卷 389-392页

作者： Ming Hua chiu Juan GAO State Key Laboratory of Phytochemistry and Plant Resource in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650204

Three new cucurbitacins were isolated from the BuOH extract of the rhizomes of Hemsleya lijiangensis. Their structures were elucidated as 23, 24 -dihydro cucurbitacin F-16, 25-diacetate(1), 23, 24-dihydro cucurbitacin F-16, 25-diacetate-2-O-β-D glucopyranoside (2), 23, 24-dihydro-cucurbitacin F-16-acetate(3), respectively; by spectral analyses.

关键词： Hemsleya lijiangensis Cucurbitaceae Hemslecins D, E, F.

Game-Theory Analysis for High Satisfaction Matchingon Strategic Decision

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学术界 2017年第7期 257-261页

作者： chiu ChiaHao Taiwan University

In any group,the project’s members want to create the highest value for the common goal,and how to choose project’s members could be a *** study investigated the cooperating with education *** of the players’strategic choices and relative outcomes was *** researchers would organize a simple tree model and sort to payoff *** results revealed that the strategy of each player is different *** were two strategies for selecting a member-'Choosing Good Friendship player'and'Choosing Good Ability player'.Furthermore,this study also analyzed the influencing factors and stable matching possibility among the factors.

关键词：博弈理论匹配满意度决策教育机构支付矩阵研究人员影响因素

Cholecystoenteric fistula in a patient with advanced gallbladder cancer: A case report and review of literature

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World Journal of Clinical Cases 2023年第36期11卷 8519-8526页

作者： Chun-Yu Wang Sung-Hua chiu wei-Chou Chang Meng-Hsing Ho Ping-Ying Chang Department of General Medicine Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Radiology Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of General Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Hematology/Oncology Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan

BACKGROUND Cholecystoenteric fistula(CEF)involves the formation of a spontaneous ano-malous tract between the gallbladder and the adjacent gastrointestinal *** gallbladder inflammation can lead to tissue necrosis,perforation,and *** most prevalent cause of CEF is chronic cholelithiasis,which rarely results from *** the symptoms and laboratory findings associated with CEF are nonspecific,the condition is often misdiagnosed,pre-senting a challenge to the surgeon when detected ***,a preoperative diagnosis of CEF is *** present the case of a 57-year-old male with advanced gallbladder cancer(GBC)who arrived at the emergency room with persistent vomiting,abdominal pain,and *** abdominopelvic computed tomography scan revealed a contracted gallbladder with bubbles in the fundus connected to the second por-tion of the duodenum and transverse *** suspected that GBC had invaded the adjacent gastrointestinal tract through a cholecystoduodenal fistula(CDF)or a cholecystocolonic fistula(CCF).He underwent multiple examinations,including esophagogastroduodenoscopy,an upper gastrointestinal series,colo-noscopy,and magnetic resonance cholangiopancreatography;the results of these tests con-firmed a diagnosis of synchronous CDF and *** patient underwent a Roux-en-Y gastrojejunostomy and loop ileostomy to address the severe adhesions that were previously observed to cover the second portion of the duodenum and hepatic flexure of the *** symptoms improved with supportive treatment while *** initiated oral targeted therapy with lenvatinib for further anticancer *** The combination of imaging and surgery can enhance preoperative diagnosis and alleviate symptoms in patients with GBC complicated by CEF.

关键词： Cholecystoenteric fistula Biliary enteric fistula Cholecystoduodenal fistula Cholecystocolonic fistula Gallbladder neoplasms Case report

From Hai Yao, Yang Yao to Xi Yao: Sinification of Material Medical from the West

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Chinese Medicine and Culture 2023年第4期6卷 319-329页

作者： Patrick chiu Hong Kong Society for the History of Pharmacy Hong Kong 999077China International Center for Drug Control Policy Studies Shanghai UniversityShanghai 200444China

In ancient China, Daoist philosophers developed the concepts of qi(energy), Wu Xing(five elements), and yin(feminine, dark, negative) and yang(masculine, bright, positive) opposite forces between 200 and 600 BCE. Based on these philosophies, Zhen Jiu(acupuncture), Ben Cao(materia medica), and the practice of Qi Gong(energy optimization movements) evolved as the three interrelated therapeutic regimens of Chinese medicine(Note 1). Since the time of Zhang Qian, who discovered China's western regions in the 1st century BCE, Hai Yao(the exotic elements of materia medica from the maritime Silk Road countries), had been transmitted from the ancient land and maritime routes of the Silk Road to China in the past two millennia(Note 2). Since the late 17th century, the English East India Company, later called the British East India Company, introduced Yang Yao(opium) to the Manchu Qing Empire to balance a growing trade deficit for tea export from China to the British Empire. After the First Opium War ended in 1842, enterprising expatriate chemists and druggists in the treaty ports imported Xi Yao(modern medicines from the Western world) for sale to the merchant navy and the local market. From the second half of the 19th century onwards, both Hai Yao and Xi Yao have become a fully integrated part of modern China's armamentarium for the Chinese medicine and Western hospitals and retail pharmacy sectors. This paper articulates the journey of adoption of exotic elements of materia medica from the ancient land and sea routes of the Silk Road, including the western regions and the rest of the world in the past two millennia. Opium traders, ship surgeons, medical and pharmaceutical missionaries, enterprising traders, and policymakers together transformed Ben Cao into Xi Yao during the late Manchu Qing dynasty and the early Nationalist Era.

关键词： Hai Yao Materia Medica Opium Cures Xi Yao Yang Yao

Review of Computational Approaches to Optimization Problems in Inhomogeneous Rods and Plates

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Communications on Applied Mathematics and Computation 2024年第1期6卷 236-256页

作者： weitao Chen chiu-Yen Kao Department of Mathematics University of California at Riverside900 University AveRiversideCA92521USA Department of Mathematical Sciences Claremont McKenna College850 Columbia AveClaremontCA91711USA

In this paper,we review computational approaches to optimization problems of inhomogeneous rods and *** consider both the optimization of eigenvalues and the localization of *** problems are motivated by physical problems including the determination of the extremum of the fundamental vibration frequency and the localization of the vibration *** demonstrate how an iterative rearrangement approach and a gradient descent approach with projection can successfully solve these optimization problems under different boundary conditions with different densities given.

关键词： Inhomogeneous rods and plates Bi-Laplacian Optimization of eigenvalues Localization of eigenfunctions Rearrangement