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A comprehensive overview on the role of phytocompounds in human immunodeficiency virus treatment

Journal of Integrative Medicine 2023年第4期21卷 332-353页

作者： Chinmayee Priyadarsani Mandhata chita ranjan sahoo Rabindra Nath Padhy Central Research Laboratory Institute of Medical Sciences and SUM HospitalSiksha O Anusandhan Deemed to be UniversityBhubaneswarOdisha 751003India

Acquired immune deficiency syndrome(AIDS)is a worldwide epidemic caused by human immunodeficiency virus(HIV)*** medicines for eliminating the viral reservoir and eradicating the virus are urgently *** to locate relatively safe and non-toxic medications from natural resources are ongoing ***-product-based antiviral candidates have been exploited to a limited ***,antiviral research is inadequate to counteract for the resistant ***-derived bioactive compounds hold promise as powerful pharmacophore scaffolds,which have shown anti-HIV *** review focuses on a consideration of the virus,various possible HIV-controlling methods and the recent progress in alternative natural compounds with anti-HIV activity,with a particular emphasis on recent results from natural sources of anti-HIV agents.

关键词： HIV Latent reservoir Antiretroviral agents Plant extracts Phytochemicals Antiretroviral therapy Highly active Gene therapy

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Role of hormone receptors and HER2 as prospective molecular markers for breast cancer:An update

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Genes & Diseases 2022年第3期9卷 648-658页

作者： Swati Sucharita Mohanty chita ranjan sahoo Rabindra Nath Padhy Cytogenetics Laboratory P.G.Department of ZoologyUtkal UniversityBhubaneswarOdisha 751004India Central Research Laboratory Institute of Medical Sciences&SUM HospitalSiksha'O’Anusandhan Deemed to be UniversityBhubaneswarOdisha 751003India

This review provides an updated account on the current methods,principles and mechanism of action of therapies for the detection of molecular markers of therapeutic importance in the prognosis of breast cancer progression and recurrence,which includes estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor2(HER2).Indeed,hormone-receptors namely,ER,PR,proto-oncogene HER2 are the basic molecular markers that are recognized and established prognostic factors and predictors of response,for therapeutic *** markers can be detected by using immunohistochemistry(IHC)and fluorescence in situ hybridization(FISH),which are established,faster and cost effective detection *** molecular markers along with clinicopathological prognostic parameters give the best prediction of the prognosis of cancer recurrence and ***,hormone receptors and HER2 as molecular markers are of prime therapeutic importance and have the capability to take part in future drug development techniques.

关键词： Breast cancer Molecular diagnostic Molecular markers Predictive markers Prognostic

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Impact of Cumulative Exposure to Circulating Ovarian Sex Hormones on Increasing the Risk of Hormone Receptor-Positive Breast Cancer

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Journal of Bio-X Research 2024年第1期7卷 36-43页

作者： Swati Sucharita Mohanty Sumit Subhadarshi Mohanty Soumya Surath Panda chita ranjan sahoo Prafulla Kumar Mohanty Rabindra Nath Padhy Siksha O Anusandhan University Institute of Medical Sciences and SUM Hospital BhubaneswarOdishaIndia Regional Medical Research Centre Bhubaneswar BhubaneswarOdishaIndia Khallikote Unitary University BrahmapurOdishaIndia

There were 2.3 million new cases of breast cancer registered in 2020,establishing it as the world’s leading *** regular exposure of breast cells to circulating ovarian sex hormones may contribute to cancer growth at all stages.A literature review was performed by downloading research articles from PubMed Central,with keywords such as breast cancer,hormone exposure in breast cancer,estrogen/progesterone exposure in breast cancer,and breast cancer risk *** breast cancer is a hormone-related disease,several factors that influence hormonal conditions or are indicators of alterations in hormonal conditions have been linked with the risk for breast ***,an elevated risk for breast cancer has been related to reproductive history and exogenous estrogen exposure because they may amplify lifetime estrogen *** these factors address the total cumulative exposure to circulating ovarian sex hormones that a female is vulnerable to in her lifetime.A healthy lifestyle,a more extended breastfeeding period,and regular physical activity may help lower one’s *** review summarizes the factors that increase the risk of estrogen/progesterone(hormone receptor)receptor-positive breast cancer due to overall cumulative estrogen exposure,with an understanding of estrogen biosynthesis mechanisms and estrogen receptor signaling.

关键词： alterations elevated exposure

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A Heuristic Algorithm for Core Selection in Multicast Routing

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Journal of Computer Science & Technology 2011年第6期26卷 954-961页

作者： Manas ranjan Kabat Manoj Kumar Patel chita ranjan Tripathy Department of Computer Science and Engineering Veer Surendra Sai University of Technology

With the development of network multimedia technology, more and more real-time multimedia applications need to transmit information using multicast. The basis of multicast data transmission is to construct a multicast tree. The main problem concerning the construction of a shared multicast tree is selection of a root of the shared tree or the core point. In this paper, we propose a heuristic algorithm for core selection in multicast routing. The proposed algorithm selects core point by considering both delay and inter-destination delay variation. The simulation results show that the proposed algorithm performs better than the existing algorithms in terms of delay variation subject to the end-to-end delay bound. The mathematical time complexity and the execution time of the proposed algorithm are comparable to those of the existing algorithms.

关键词： QoS routing multicast routing delay-variation end-to-end delay

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