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第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Lin Kao Chang chio chung ching Chang ching Ping Chi Mei Medical Center Department of Neurology Chi Mei Medical Center Department of Neurosurgery Chi Mei Medical Center Department of Medical Research Chi Mei Medical Center

The build-up of amyloid-β（Aβ） peptides in the brain has been linked to Alzheimer's disease pathogenesis and may represent a key target for *** radix（the root of Astragalus mongholicus Bunge or *** Bunge） is used mainly as a tonic agent in traditional Chinese ***（AST）,the major component of Astragali radix,can reduce the infarction volume after *** attempted to ascertain whether AST acts through the MAPK and PI3 K/AKT pathway to protect against b-amyloid pathways in cortical *** cortical neurons were cultured and exposed to 2 mM Ab in the absence or presence of AST（50-400 mg/ml）.In cultured cortical neurons,hyperphosphorylation of Tau,mitochondrial membrane potential,synaptotoxicity,apoptosis and activation of caspase-3 determined after Ab *** Ab-treated rats displayed severe memory impairments in passive avoidance test and both markedly tau hyperphosphorylation and increased numbers of degenerative neurons in the cerebral *** these effects were prevented or substantially attenuated by AST *** of cultured cortical neurons with AST attenuated the Ab-induced cytotoxicity,apoptosis,synaptotoxicity,and mitochondrial *** beneficial effect of AST in reducing Ab-induced cytotoxicity,apoptosis,and mitochondrial dysfunction in cortical cells can be blocked by inhibition of phosphoinositide 3-kinase（PI3 K）-dependent protein kinase B（PKB,as known as AKT） activation by *** addition,inhibition of extracellular protein kinase（ERK） with U0126 shares with the AST the same beneficial effects in reducing Ab-induced *** prevents Ab-induced Alzheimer's disease conditions by a mechanism involving the control of both the MAPK（or ERK）and the PI3 K/AKT pathways in injured cortical neurons.

关键词： Astragalosides protect against beta-amyloid-induced neurotoxicity in primary cortical neurons

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The effects of memantine on glutamic receptor associated nitrosative stress in a traumatic brain injury rat model

The effects of memantine on glutamic receptor associated nit...

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第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Wang Chechuan Wee Hsiao-Yue Hu Chiao-Ya chio chung-ching Kuo Jinn-Rung Chi-Mei Medical Center Center for General Education Southern Taiwan University of Science and Technology Department of Neurosurgery LiouyingChi-Mei Medical Center Medical Research Chi-Mei Medical Center Departments of Biotechnology Southern Taiwan University of Science and Technology

Background:The main aim of this study is to elucidate whether the neuroprotective effect of memantine,a non-competitive NMDA receptor 2 B(NR2 B) antagonist,affect neuronal nitrosative stress,apoptosis,and NR2 B expression and ultimately improve functional *** and methods:Immediately after the onset of fluid percussion TBI,anesthetized male Sprague-Dawley rats were divided into sham,TBI,and TBI+Memantine *** rats were treated

关键词： The effects of memantine on glutamic receptor associated nitrosative stress in a traumatic brain injury rat model

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Selective brain cooling attenuates intestine and brain injury in a rat model of hemorrhagic shock

Selective brain cooling attenuates intestine and brain injur...

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第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Wang Che-Chuan Hsu Chien-Chin chio chung-ching Lin Hung-Jung Lin Kao-Chang Department of Neurosurgery Chi Mei Medical Center Department of Emergency Medicine Chi Mei Medical Center Department of Neurology Chi Mei Medical Center

Hemorrhagic shock(HGS) is the leading cause of mortality in trauma *** loss and subsequent systemic hypotension are major causes of secondary insult to the brain following *** aimed to analyze the therapeutic effects of retrograde hypothermic retrograde jugular vein flush(HRJVF) after HGS and resuscitation in a rat *** rats were randomized into four groups as follows:sham operation group,HGS group,HGS with HRJVF 36℃ saline group,and HGS

关键词： Selective brain cooling attenuates intestine and brain injury in a rat model of hemorrhagic shock

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Estrogen Receptor-α is Involved in Tamoxifen Neuroprotective Effects in a Traumatic Brain Injury Male Rat Model

Estrogen Receptor-α is Involved in Tamoxifen Neuroprotectiv...

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第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Wang Chechuan Lim Sher-Wei Nyam Tee-Tau Hu Cho-Ya chio chung-ching Kuo Jinn-Rung Departments of Neurosurgery Chi-Mei Medical Center Medical Research Chi-Mei Medical Center General education Southern Taiwan University of Science and Technology Departments of Neurosurgery Chia-Li Chi-Mei Medical Center Department of Biotechnology Southern Taiwan University of Science and Technology

Purpose:The aim of the present study is to determine the neuroprotective mechanisms of tamoxifen(TMX) during traumatic brain injury(TBI),especially the effects on estrogen receptor-α(ERα)expression,as well as neuroi... 详细信息

关键词： tamoxifen is Involved in Tamoxifen Neuroprotective Effects in a Traumatic Brain Injury Male Rat Model Estrogen Receptor

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New Optimization Method, the Algorithms of Changes, for Heat Exchanger Design

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Chinese Journal of Mechanical Engineering 2012年第1期25卷 55-62页

作者： TAM Houkuan TAM Lapmou TAM Sikchung chio Chouhei GHAJAR Afshin J Department of Electromechanical Engineering Faculty of Science and TechnologyUniversity of Macao Department of Mathematics Faculty of Science and TechnologyUniversity of Macao School of Mechanical and Aerospace Engineering Oklahoma State University

Heat exchangers are widely used in the process engineering such as the chemical industries, the petroleum industries, and the HVAC applications etc. An optimally designed heat exchanger cannot only help the optimization of the equipment size but also the reduction of the power consumption. In this paper, a new optimization approach called algorithms of changes (AOC) is proposed for design and optimization of the shell-tube heat exchanger. This new optimization technique is developed based on the concept of the book of changes (I ching) which is one of the oldest Chinese classic texts. In AOC, the hexagram operations in I ching are generalized to binary string case and an iterative process, which imitates the I ching inference, is defined. Before applying the AOC to the heat exchanger design problem, the new optimization method is examined by the benchmark optimization problems such as the global optimization test functions and the travelling salesman problem (TSP). Based on the TSP results, the AOC is shown to be superior to the genetic algorithms (GA). The AOC is then used in the optimal design of heat exchanger. The shell inside diameter, tube outside diameter, and baffles spacing are treated as the design (or optimized) variables. The cost of the heat exchanger is arranged as the objective function. For the heat exchanger design problem, the results show that the AOC is comparable to the GA method. Both methods can find the optimal solution in a short period of time.

关键词： optimization genetic algorithms (GA) travelling salesman problem (TSP) heat exchanger design algorithms of changes (AOC)

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年齡對脈衝射頻治療神經根性疼痛療效的影響

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镜湖医学 2024年第1期24卷 14-16,84页

作者：黃鍇亮吳朝興錢曉暉澳門鏡湖醫院麻醉科中国

目的觀察年齡對腰脊神經根射頻療效的影響。方法回顧性分析本院2020年1月~2022年12月期間,採用脊神經脈衝射頻治療的68例下肢神經根性疼痛患者的臨床資料,年齡介於42歲~92歲(中位數69.5歲),按年齡中位數分為年輕組與年老組,兩組各34例,... 详细信息

目的觀察年齡對腰脊神經根射頻療效的影響。方法回顧性分析本院2020年1月~2022年12月期間,採用脊神經脈衝射頻治療的68例下肢神經根性疼痛患者的臨床資料,年齡介於42歲~92歲(中位數69.5歲),按年齡中位數分為年輕組與年老組,兩組各34例,分析兩組患者術前、術後1週、術後1個月、術後2個月、術後3個月的視覺模擬評分(VAS)及改良MacNab療效評定標準評價術後3個月療效優良率。結果兩組患者術後各時間點的VAS評分均較術前降低,差異有統計學意義(P0.05);術後1週療效相當,VAS評分差異無統計學意義(P>0.05);術後1個月、術後2個月、術後3個月年老組VAS評分低於年輕組,差異有統計學意義(P<0.05);術後3個月MacNab評定療效優良率年老組為85.2%,顯著高於年輕組的50%(P<0.05)。結論腰脊神經脈衝射頻可有效治療下肢神經根性疼痛,尤其是高齡患者療效確切,持續時間較長,可顯著減輕疼痛、改善生活質量、減少手術風險,具有臨床應用價值。

关键词：年齡神經根性疼痛脈衝射頻

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Ambient vibration testing and updating of the finite element model of a simply supported beam bridge

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Frontiers of Structural and Civil Engineering 2011年第3期5卷 344-354页

作者： Ivan Gomez ARAUJO Esperanza MALDONADO Gustavo chio CHO School of Civil Engineering Research Group INMEIndustrial University of SantanderSantanderColombia

An ambient vibration test on a concrete bridge constructed in 1971 and calibration of its finite element model are *** bridge is characterized by a system of post-tensioned and simply supported *** dynamic characteristics of the bridge,*** frequencies,mode shapes and damping ratios were computed from the ambient vibration tests by using the Eigensystem Realization Algorithm(ERA).Then,these characteristics were used to update the finite element model of the bridge by formulating an optimization problem and then using Genetic Algorithms(GA)to solve *** the results of the ambient vibration test of this type of bridge,it is concluded that two-dimensional mode shapes exist:in the longitudinal and transverse;and these experimentally obtained dynamic characteristics were also achieved in the analytical model through *** application of GAs as optimization techniques showed great versatility to optimize any number and type of variables in the model.

关键词： modal analysis parameter identification ambient vibration test Eigensystem Realization Algorithm(ERA)method finite element method

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心脏缺血之低温疗法:小分子质量蛋白质表现正常化（英文）

心脏缺血之低温疗法:小分子质量蛋白质表现正常化（英文）

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第七届海峡两岸心血管科学研讨会

作者：邱仲庆 chung-ching chio Chi Mei Medical Center

＜正＞Although clinical application of mild hypothermia（32℃）for patients with brain injury and cardiac arrest has been carried out with promising results,the molecular mechanisms underlying the protective effects of mild hypothermia are not fully *** deal with the question,we first examined the effects of mild hypothermia on H9C2 rat ventricular myoblasts underwent apoptosis in conditions of simulated ischemia,represented by serum withdrawal plus hypoxia.H9C2 cell apoptosis is evidenced by an increased apoptotic cells with Annexin-V positive and propidium iodide negative by flow cytometry,DNA fragmentation,and activation of caspase *** this model of simulated ischemia,cardiomyoblasts apoptosis was associated with a down-regulation of small molecular weight proteins including heat shock protein（HSP）20,HSP27,andαβ-crystallin and a reduction of cell *** hypothermia significantly reduced the simulated ischemia-induced apoptosis,down-regulation of small molecular weight proteins, and reduction of cell ***,our findings have further shown that mild hypothermia causes amelioration of hypotension by enhancing stroke volume,heart beat,and total peripheral resistance in the rat during heatstroke. A comparative analysis using two-dimensional in-gel electrophoresis of cardiac protein patterns is performed in rat controls,untreated heatstroke rats,and mild hypothermia-treated heatstroke *** the onset of heatstroke, animals display hypotension and down-regulation of cardiac small molecular weight proteins,which can be reversed by mild *** data indicate that mild hypothermia may act via normalization of small molecular weight protein expressionand cardiac function to exert its therapeutic effect in ischemic hearts.

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Synergistic realization of high efficiency solar desalination and carbon dioxide reduction

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Nano Research 2023年第7期16卷 10530-10536页

作者： Xiaoying Song Pei Wang Yi Huang Xiaoqiang Zhu U-Fat chio Fang Wang Guanyu Wang Wei Wang Bin Liu School of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China Chongqing Institute of Green and Intelligent Technology Chinese Academy of ScienceChongqing 400714China School of Electronic Science and Engineering Nanjing UniversityNanjing 210093China

Methods of seawater desalination and carbon dioxide(CO_(2))reduction using clean and renewable energy have attracted much attention withing the reducing fresh water and growing CO_(2)***,we propose a synergistic method for solardriven desalination and CO_(2)reduction at the surface of sea using a three-dimensional titanium oxide-gold semiconductor/metal(TiO_(2)-Au NW/NPs(NW:nanowire,NP:nanoparticle))photothermal conversion membrane that can efficiently harvest a broad solar spectrum(200 to 2500 nm,94%)to undertake the conversion of light-to-heat and *** TiO_(2)-Au NW/NPs membrane demonstrated a high solar vapor conversion efficiency of~90%,CO_(2)reduction yields of 0.066μmol·cm^(-2)CH_(4)and 0.015μmol·cm^(-2)CO within 5 *** addition,the membrane efficiently evaporated seawater with different salt concentrations to produce drinking water which meet World Health Organization(WHO)and US Environmental Protection Agency(EPA)*** work provides an integrated solution for solar desalination and CO_(2)reduction at the surface of sea to reduce the harm to marine life caused by ocean acidification while producing pure water.

关键词： solar desalination CO_(2)reduction titanium oxide nanowires gold nanoparticles

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Advances in nanomaterials for brain microscopy

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Nano Research 2018年第10期11卷 5144-5172页

作者： Jackson T. Del Bonis-O'Donnell Linda chio Gabriel F. Dorlhiac lan R. McFarlane Markita P. Landry Department of Chemical and Biomolecular Engineering University of California Berkeley CA 94720 USA Biophysics Graduate Group University of California Berkeley CA 94720 USA Innovative Genomics Institute (IGI) Berkeley CA 94720 USA California Institute for Quantitative Biosciences QB3 University of California Berkeley CA 94720 USA Chan-Zuckerberg Biohub San Francisco CA 94158 USA

Microscopic imaging of the brain continues to reveal details of its structure, connectivity, and function. To further improve our understanding of the emergent properties and functions of neural circuits, we need to directly visualize the relationship between brain structure, neuron activity, and neurochemistry. Advances in the chemical and optical properties of nanomaterials, and developments in deep-tissue microscopy, may help to overcome the current challenges of in-vivo brain imaging, particularly when imaging the brain through optically-dense brain tissue, skull, and scalp. Developments in nanomaterials may enable the implementation of tunable chemical functionality for neurochemical targeting and sensing, and fluorescence stability for long-term imaging. In this review, we summarize the current methods used for brain microscopy and describe the diverse classes of nanomaterials recently offered as contrast agents and functional probes for microscopic optical imaging of the brain.

关键词： nanomaterials neuroscience imaging microscopy

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