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Profiling of seminal antioxidant indices and sperm quality in Plasmodium bergheiinduced malarial mice treated with Phyllanthus amarus

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Asian pacific Journal of Reproduction 2022年第2期11卷 84-92页

作者： Williams Oshiegbu chinwendu obogheneophruhe elu Innocent Onyesom Department of Biochemistry Delta State UniversityAbrakaNigeria Department of Medical Biochemistry Delta State UniversityAbrakaNigeria

Objective:To evaluate the antiplasmodial activity of Phyllanthus(P.)amarus crude ethanol leaf extract and its effects on semen quality in male BALB/c ***:A total of 36 adult mice were divided into six groups,with 6 mice *** groups were infected with Plasmodium(P.)berghei,and one group was left *** the five infected groups,one group was left untreated,three groups were treated with varying doses(100,250 and 400 mg/kg)of *** crude ethanol leaf extract orally for 4 days,and another group was treated with standard drug,artemether and lumefantrine(Lonart®DS).Antiplasmodial activity,seminal quality,some biochemical indices(neutral毩-glucosidase,fructose,and citric acid)in seminal plasma and seminal antioxidant markers(catalase,glutathione peroxidase,reduced glutathione,malondialdehyde,total antioxidant capacity,and acid phosphates)were *** mice were euthanized 3 days post treatment and semen was collected from the caudal epididymis and processed for analysis using documented methods and ***:Malarial infection led to oxidative stress,causing a significant decline in seminal quality(P<0.05).However,treatment with *** crude ethanol leaf extract alleviated oxidative stress and significantly improved seminal *** improvement was dose-dependent and compared well with the standard drug,artemether and lumefantrine(Lonart®DS)***:The ethanol leaf extracts of *** alleviate male reproductive capacity during malaria infection in murine model by enhancing antioxidant activities.

关键词： Malaria Sperm quality Phyllanthus amarus Seminal oxidative stress Seminal antioxidant markers Antioxidants Ethanol extracts Antimalarials

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