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An in vitro efficacy validation of mangrove associates

Journal of Coastal Life Medicine 2014年第7期 560-565页

作者： Aseer Manilal Behailu Merdekios Jimna Kambivelikkakath Velappan Jose Paul Veliyath Paul Akbar Idhayadhulla chinnaswamy muthukumar Mulugeta Melkie College of Medicine and Health Sciences Arba Minch UniversityArba MinchEthiopia Department of Biotechnology Presentation College of Applied SciencesPuthenvelikkara 683594EranakulamIndia School of Chemical Engineering Yeungnam UniversityGyeongsan 712-749South Korea Department of Botany and Microbiology College of ScienceKing Saud UniversityRiyadh 11451Kingdom of Saudi Arabia

Objective:To investigate the in vitro antimicrobial potential of mangrove associates against a battery of human and shrimp pathogenic bacteria and to elucidate its antimicrobial ***:In the present study,12 species of mangrove associates collected from the Kollam(southwest coast of India)vicinity were extracted in different organic solvents of increasing *** resultant extracts obtained from the respective species were examined for the antimicrobial activity against a panel of shrimp and human pathogens by agar diffusion ***:Of the 12 species evaluated,three species of mangrove associates[Calophyllum inophyllum(***),Cerbera odollam and Dalbergia candenatensis]were found to be *** broadest and highest rank of activity was observed in the crude extract of *** the pathogens tested,shrimp pathogenic Vibrios were the most sensitive organisms while human pathogens were found to be a bit *** the present study,ethyl acetate was found to be the best solvent for extracting antimicrobial *** bioactive principles present in the crude extract of *** were chemically elucidated by gas chromatography-mass *** gas chromatography-mass spectrometer studies revealed the presence of two principal compounds such as 1-Dimethyl(phenyl)silyloxyhexadecane(24.73%)and β-d-Mannofuranoside,O-geranyl(50%)which might play functional role in the chemical defense against microbial ***:Based on the overall findings,it could be inferred that the mangrove associate *** is a promising candidate for the development of plant-based human and veterinary grade antibiotics in future.

关键词： Mangrove associates Antimicrobial Crude extract Bioactives

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