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Autophagy in neuroinflammation after traumatic brain injury

Neural Regeneration Research 2024年第5期19卷 951-952页

作者： chinmoy sarkar Marta M.Lipinski Shock Trauma and Anesthesiology Research(STAR)CenterDepartment of AnesthesiologyUniversity of Maryland School of MedicineBaltimoreMDUSA Department of Anatomy and Neurobiology University of Maryland School of MedicineBaltimoreMDUSA

Traumatic brain injury(TBI)is an acquired injury of the brain caused by the impact of external forces on the brain(Maas et al.,2008).It is a major cause of death and disability among people of all ages(Maas et al.,2008).The primary mechanical injury to the brain initiates a cascade of secondary biochemical events that lead to acute and chronic neurodegeneration and activation of inflammatory pathways(Maas et al.,2008).Both brain-resident microglia and blood-derived myeloid cells-macrophages and monocytes that infiltrate the brain due to injury-induced blood-brain barrier damage,contribute to the inflammatory responses after TBI(Morganti et al.,2015).

关键词： damage death after

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N-acetyl-L-leucine: a promising treatment option for traumatic brain injury

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Neural Regeneration Research 2022年第9期17卷 1957-1958页

Traumatic brain injury(TBI)is a mechanical injury to the brain,which can be sustained due to falls,accidents,contact sports or in combat situation.It is a serious health problem-affecting people of all ages worldwide.As per the recent epidemiological study,more than 55 million people suffer from TBI annually(GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators,2019),and its prevalence has increased by almost 8.4%between 1990 and 2016(GBD 2016 Traumatic Brain Injury and Spinal Cord Injury Collaborators,2019).Depending on severity,TBI can lead to premature death and disability.

关键词： sustained Traumatic injury

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建成环境与健康的关联来自香港大学高密度健康城市研究中心的探索性研究

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时代建筑 2017年第5期60卷 29-33页

作者：肖扬 [印度]钦莫伊·萨卡尔 [英]克里斯·韦伯斯特无同济大学建筑与城市规划学院高密度人居环境生态与节能教育部重点实验室 Healthy High Density Cities Lab UKUrbanLab 香港大学建筑学院

中国城市化的快速发展在推动城市经济高速增长的同时,改变了城市建成环境的特征,也给城市居民带来了诸多健康问题,例如肥胖、心理压力、心血管疾病。当下建成环境研究的重点是建立健康导向的空间设计研究。对此,文章力图为缓解中国城市... 详细信息

中国城市化的快速发展在推动城市经济高速增长的同时,改变了城市建成环境的特征,也给城市居民带来了诸多健康问题,例如肥胖、心理压力、心血管疾病。当下建成环境研究的重点是建立健康导向的空间设计研究。对此,文章力图为缓解中国城市居民的健康问题和推进健康城市建成环境规划设计提供研究框架和路径。文章主要包括三个内容:概述建成环境空间对于健康的影响机制体系;介绍健康城市中的新技术和多源城市数据运用;展示香港大学高密度健康城市研究中心、在三个建成环境微观尺度方面的成果。

关键词：城市化建成环境健康机制影响

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Experimental assessment of arsenic toxicity in garole sheep in India

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Emerging Contaminants 2016年第3期2卷 128-134页

作者： chinmoy Maji Samar sarkar Suman Biswas Pabitra Hriday Patra Bakul Kumar Datta Samiran Bandyopadhyay Tapas Kumar Biswas Chandrakanta Jana Tapan Kumar Mandal Department of Veterinary Medicine Ethics&JurisprudenceFaculty of Veterinary and Animal SciencesWest Bengal University of Animal and Fishery SciencesKolkataWest BengalIndia Department of Veterinary Pharmacology and Toxicology Faculty of Veterinary and Animal SciencesWest Bengal University of Animal and Fishery SciencesKolkataWest BengalIndia Indian Veterinary Research Institute Eastern Regional StationKolkataWest BengalIndia Indian Veterinary Research Institute Regional Station MukteswarMukteshwarUttarakhandIndia

Arsenic,a dangerous bio-accumulative poison,is a grave threat affecting a large number of people as well as animals throughout theWorld,particularly in Bangladesh and West Bengal,India.It is also a matter of concern as continuously entering into food chain through biotic and abiotic products.The present study was conducted to evaluate the experimental effect of arsenic toxicosis on Garole sheep of West Bengal.One group was subjected to oral arsenic exposure@6.6 mg Kg1 over 133 days when rests considered as negative control.Periodical arsenic estimation in wool,urine and feces along with hemato-biochemical alteration were checked thoroughly.It was evident from the study that long term arsenic exposure exerted a significant(p<0.01)alteration compared to normal animal which were further supported by clinical abnormalities.Exposed animals showed histological changes throughout major internal organs like coagulative necrosis of liver,tubular nephritis of kidney and acanthosis of skin etc.The bioaccumulative and excretion pattern of arsenic inside body were also well understood by the arsenic estimation study of wool,urine and feces which may be helpful for discussion regarding arsenic entry into food chain via animals.

关键词： Arsenic Garole sheep Excretion Bioaccumulation Liver Kidney

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