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Continuously Injection with Diluted Heparin Solution via Catheter for Implantation of Totally Implantable Access Ports (TIAP)

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Surgical Science 2012年第7期3卷 371-372页

作者： Chien-Hua Lin Jing-Jim Ou yueh-Tsung Lee Hurng-Sheng Wu Department of Surgery Chang-Bing Show Chwan Memorial Hospital Changhua Chinese Taipei

Background: Totally implantable access ports (TIAP) could be done in two methods: puncture of subclavian vein and cephalic vein cutdown. Cephalic vein cutdown method has fewer complications but has higher failure rates. We present a method to decrease the failure rates. Methods: We use the continuously injection with diluted heparin solution via catheter while introducing the TIAP catheter into the cephalic vein. Results: From January 2005 to January 2009, 20 patients were performed. This method was successfully applied in 11 patients with no complications. The other 9 patients was unsuccessfully and further underwent guidewire assisted. Conclusions: Continuously injection with diluted heparin solution via catheter while inserting TIAP catheter into the cephalic vein is safe and simple. It could be used for difficulties of insertion of TIAP and increased the successful rates of cephalic vein cut-down method.

关键词： Totally Implantable Access Ports (TIAP) Arrhythmia Port-A

Endoscopic Management of Leaks Following Laparoscopic Sleeve Gastrectomy: The Experience of IRCAD Taiwan

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Surgical Science 2020年第11期11卷 347-353页

作者： Chien-Hua Lin Jing-Jim Ou yueh-Tsung Lee Hurng-Sheng Wu Sheng-Lei Yan Department of Surgery IRCAD Taiwan Chinese Taipei Department of Surgery Tri-Service General Hospital Chinese Taipei Division of Gastroenterology Department of Internal Medicine Chang-Bing Show Chwan Memorial Hospital Chinese Taipei

Background: To present the experience of management of leaks following laparoscopic sleeve gastrectomy for morbid obesity in Show-Chwan memorial Hospital. Patients and Methods: Laparoscopic sleeve gastrectomy is considered one of the surgical options for morbid obesity. It is effective, with an average loss of 50% of excessive weight after 2 years of follow-up. The first laparoscopic sleeve gastrectomy was performed in January 2010 at Show-Chwan Memorial Hospital. Between January 2010 and October 2016, 300 patients underwent laparoscopic sleeve gastrectomy for morbid obesity. There were 218 women and 82 men with a mean age of 35.4 years. Preoperative mean body weight was 90.7 kg and mean body mass index (BMI) was 37.3 kg/m2. Results: Mean operative time was 85 minutes. Mean hospital stay was 3.5 days. There were no deaths. There were 5 complications (1.67%): leakage of gastroesophageal junction. One patient was conservative treatment. Two patients were successfully treated by self-expandable metallic stents and the other two patients were treated with esophageal stent also, but failed and further treated with fibrin (Histoacryl) injection to the leak site to try to seal the fistula. In six months follow-up, mean BMI decreased from 37.3 to 29.2 kg/m2, and mean excess weight loss reached 42.8%. Conclusions: Laparoscopic sleeve gastrectomy is a beneficial operation in terms of excessive weight loss, with acceptably complications. The leaks were located in gastroesophageal junction mostly, and could be resolved with esophageal stent. For the patients failed in esophageal stents, we try Histoacryl injection to improve it.

关键词： Bariatric Surgery Leaks Stent Histoacryl

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波浪与内外壁透空双层透水结构相互作用

哈尔滨工程大学学报 2016年第11期37卷 1473-1478页

作者：岳景云何翊钧庄世璇台湾海洋大学河海工程学系中国台湾基隆20224

本文探讨波浪入射内、外壁皆透空双层透水沉箱的无因次波力、总力及沉箱内、外圈四周相对爬升的问题,并在线性波浪理论下,采用复合边界元素法(composite BEM)做数值解析。为了验证本文数值模式正确性,与SBFEM方法所计算外壁透空双圆筒... 详细信息

本文探讨波浪入射内、外壁皆透空双层透水沉箱的无因次波力、总力及沉箱内、外圈四周相对爬升的问题,并在线性波浪理论下,采用复合边界元素法(composite BEM)做数值解析。为了验证本文数值模式正确性,与SBFEM方法所计算外壁透空双圆筒内、外圆柱相对爬升及无因次波力的结果进行比较及验证,获得精度高、正确且合理结果。数值计算结果显示:采用双层透水沉箱与传统单层外壁透空内筒不透水的波力比较,大部分也都有降低现象。波浪作用于内、外壁皆透空双层透水沉箱内、外筒无因次波力及总力值皆会随透水参数的增加而降低。

关键词：相对爬升无因次波力透水影响参数复合边界元素法波浪

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SPT5 affects the rate of mRNA degradation and physically interacts with CCR4 but does not control mRNA deadenylation

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American Journal of Molecular Biology 2012年第1期2卷 11-20页

作者： Yajun Cui yueh-Chin Chiang Palaniswamy Viswanathan Darren J. Lee Clyde L. Denis Department of Molecular Cellular and Biomedical Sciences University of New Hampshire Durham UK

The CCR4-NOT complex has been shown to have multiple roles in mRNA metabolism, including that of transcriptional elongation, mRNA transport, and nuclear exosome function, but the primary function of CCR4 and CAF1 is in the deadenylation and degradation of cytoplasmic mRNA. As previous genetic analysis supported an interaction between SPT5, known to be involved in transcriptional elongation, and that of CCR4, the physical association of SPT5 with CCR4 was examined. A two-hybrid screen utilizing the deadenylase domain of CCR4 as a bait identified SPT5 as a potential interacting protein. SPT5 at its physiological concentration was shown to immunoprecipitate CCR4 and CAF1, and in vitro purified SPT5 specifically could bind to CAF1 and the deadenylase domain of CCR4. We additionally demonstrated that mutations in SPT5 or an spt4 deletion slowed the rate of mRNA degradation, a phenotype associated with defects in the CCR4 mRNA deadenylase complex. Yet, unlike ccr4 and caf1 deletions, spt5 and spt4 defects displayed little effect on the rate of deadenylation. They also did not affect decapping or 5' - 3' degradation of mRNA. These results suggest that the interactions between SPT5/SPT4 and the CCR4-NOT complex are probably the consequences of effects involving nuclear events and do not involve the primary role of CCR4 in mRNA deadenylation and turnover.

关键词： mRNA Degradation CCR4-NOT Complex SPT5/SPT4 Deadenylation

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加州大学洛杉矶分校商学院如何具有战略远见

董事会 2008年第5期 98-99页

作者： yueh Fei Ho

必须养成经常进行战略思考的习惯，锻炼自己的战略思维能力。战略的制定是一个人平时的思考过程在逻辑上的拓展，它体现着一种生活态度。

关键词：加州大学商学院洛杉矶分校远见思维能力生活态度

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Aryl hydrocarbon receptor signaling promotes ORMDL3- dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase

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Cellular & Molecular Immunology 2019年第10期16卷 783-790页

作者： Hsueh-Chun Wang Tzu-Hsuan Wong Li-Ting Wang Hsiang-Han Su Hsiu-yueh Yu Ai-Hsuan Wu Yu-Chun Lin Hua-Ling Chen Jau-Ling Suen Shih-Hsien Hsu Li-Chen Chen Yufeng Zhou Shau-Ku Huang Department of Medical Research China Medical University HospitalChina Medical University40402 TaichungTaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Division of Allergy Asthma and RheumatologyDepartment of PediatricsChang Gung Memorial HospitalTaoyuanTaiwanChina National Institute of Environmental Health Sciences National Health Research InstitutesMiaoliTaiwanChina Research Center of Environmental Medicine Kaohsiung Medical UniversityKaohsiungTaiwanChina Center for Research Resources and Development Kaohsiung Medical UniversityKaohsiungTaiwanChina Community Medicine Research Center Chang Gung Memorial Hospital at KeelungKeelungTaiwanChina Department of Pediatrics Xiamen Chang Gung HospitalXiamenChina Johns Hopkins University School of Medicine BaltimoreMDUSA Key Laboratory of Neonatal Disease Children’s Hospital and Institute of Biomedical SciencesMinistry of HealthFudan University201102 ShanghaiChina Lou-Hu Hospital Shen-Zhen UniversityShen-ZhenChina

Aryl hydrocarbon receptor(AhR),a cellular chemical sensor,controls cellular homeostasis,and sphingosine-1-phosphate(S1P),a bioactive intermediate of sphingolipid metabolism,is believed to have a role in immunity and inflammation,but their potential crosstalk is currently *** aimed to determine whether there is a functional linkage between AhR signaling and sphingolipid *** showed that AhR ligands,including an environmental polycyclic aromatic hydrocarbon(PAH),induced S1P generation,and inhibited S1P lyase(S1PL)activity in resting cells,antigen/IgE-activated mast cells,and mouse lungs exposed to the AhR ligand alone or in combination with antigen *** reduction of S1PL activity was due to AhR-mediated oxidation of S1PL at residue 317,which was reversible by the addition of an antioxidant or in cells with knockdown of the ORMDL3 gene encoding an ER transmembrane protein,whereas C317A S1PL mutant-transfected cells were resistant to the AhR-mediated ***,analysis of AhR ligand-treated cells showed a time-dependent increase of the ORMDL3–S1PL complex,which was confirmed by FRET *** change increased the S1P levels,which in turn,induced mast cell degranulation via S1PR2 *** addition,elevated levels of plasma S1P were found in children with asthma compared to non-asthmatic *** results suggest a new regulatory pathway whereby the AhR–ligand axis induces ORMDL3-dependent S1P generation by inhibiting S1PL,which may contribute to the expression of allergic diseases.

关键词： Aryl hydrocarbon receptor ORMDL sphingolipid biosynthesis regulator 3 Sphingosine-1-phosphate Sphingosine-1-phosphate lyase

Gradient defects mediate negative thermal quenching in phosphors

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Advanced Photonics 2023年第2期5卷 34-45页

作者： Mingxue Deng Xingzhong Cao Yangmin Tang Zhenzhen Zhou Lijia Liu Xiaofeng Liu Peng Zhang Lo-yueh Chang Hao Ruan Xinjun Guo Jiacheng Wang Qian Liu Chinese Academy of Sciences Shanghai Institute of CeramicsState Key Laboratory of High Performance Ceramics and Superfine MicrostructureShanghaiChina University of Chinese Academy of Sciences Center of Materials Science and Optoelectronics EngineeringBeijingChina Chinese Academy of Sciences Institute of High Energy PhysicsBeijingChina Western University Department of ChemistryLondonOntarioCanada Zhejiang University School of Materials Science and EngineeringHangzhouChina Taiwan Synchrotron Radiation Centre HsinchuChina Chinese Academy of Sciences Shanghai Institute of Optics and Fine MechanicsLaboratory of Micro-Nano Optoelectronic Materials and DevicesShanghaiChina North China University of Science and Technology College of Materials Science and EngineeringHebei Provincial Key Laboratory of Inorganic Nonmetallic MaterialsTangshanChina Taizhou University School of Materials Science and EngineeringTaizhouChina

Luminescent materials often suffer from thermal quenching(TQ),limiting the continuation of their applications under high temperatures up to 473 *** formation of defect levels could suppress TQ,but rational synthesis and deep understanding of multiple defects-regulated luminescent materials working in such a wide temperature range still remain ***,we prepare a negative thermal quenching(NTQ)phosphor LiTaO_(3)∶Tb^(3+)by introducing gradient defects V_(Ta)^(5−),Tb_(Li)^(2+),and(V_(Ta)Tb_(Li))^(3−)as identified by advanced experimental and theoretical *** photoluminescence significantly becomes intense with rising temperatures and then slowly increases at 373 to 473 *** mechanism studies reveal that gradient defects with varied trapping depths could act as energy buffer layers to effectively capture the *** thermal disturbance,the stored carriers could successively migrate to the activators in consecutive and wide temperature zones,compensating for TQ to enhance luminescence *** study initiates the synthesis of multi-defect NTQ phosphors for temperature-dependent applications.

关键词： gradient defects negative thermal quenching energy buffer layers temperature-dependent information encryption

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SYNTHESIS OF THE PEPTIDE FRAGMENTS OF THE B-CHAIN OF INSULIN Ⅷ.SYNTHESIS OF TWO OCTAPEPTIDE DERIVATIVES OF THE SEQUENCE B9-16

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Science in China,Ser.A 1964年第9期 1435-1445页

作者：葛麟俊龚岳亭汪克臻钮经义 Institute of Biochemistry Academia Sinica Shanghai

Carbobenzoxyseryl-Nim-benzylhistidylleucylvalyl-γ-methylglumylalanylleucyltyrosine1)(B9-16a)and its ethylester(B9-16),two derivatives of an octapeptide fragment of the B-chain of insulin,have been synthesizedby condensing carbobenzoxyseryl-Nim-benzylhistidylleucine azide with valyl-γ-methylglutamylalanylleucyltyrosineand carbobenzoxyseryl-Nim-benzylhistidine azide with leucylvalyl-γ-methylglutamylalanylleucyltyrosine ethyl es-ter(B11-16b)***-γ-methylglutamic acid(B12-13a),prepared by coupling p-nitro-phenyl carbobenzoxyvalinate with γ-methylglutamic acid,was condensed through its P-nitrophenyl ester withalanylleucyltyrosine to give the protected pentapeptide(B12-16a).The protected hexapeptide ester(B11-16)was prepared,through the carbodiimide route,by condensing ethyl alanylleucyltyrosinate with carbobenzoxy-leucylvalyl-γ-methylglutamic acid(B11-13a),which,in turn,was obtained by coupling valyl-γ-methylglutamicacid with P-nitrophenyl *** free pentapeptide and the hexapeptide ester (B11-16b)were obtained respectively from B12-16a,a and B11-16,by catalytic hydrogenolysis;whereas,the protected di-and tripeptide esters(B9-10 and B9-11),from which the corresponding hydrazides were obtained,were pre-pared,through the carbodiimide or the azide route,by condensing carbobenzoxyserine with benzyl Nim-ben-zylhistidinate and methyl Nim-benzylhistidylleucinate respectively.

关键词： OCH SYNTHESIS OF TWO OCTAPEPTIDE DERIVATIVES OF THE SEQUENCE B SYNTHESIS OF THE PEPTIDE FRAGMENTS OF THE B-CHAIN OF INSULIN

α- Carbonyl Radical Cyclization for the Total Synthesis of Natural Products

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α- Carbonyl Radical Cyclization for the Total Synthesis of ...