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Association of USP26 haplotypes in men in Taiwan, China with severe spermatogenic defect

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Asian Journal of Andrology 2008年第6期10卷 896-904页

作者： I-Wen Lee Long-ching Kuan Chien-Hung Lin Hsien-An Pan Chao-Chin hsu yung-Chieh Tsai Pao-Lin Kuo Yen-Ni Teng Department of Obstetrics ＆ Gynecology National Cheng Kung University College of Medicine Tainan 701 Taiwan China Department of Obstetrics and Gynecology Kuo General Hospital Tainan 700 Taiwan China Institute of Basic Sciences National Cheng Kung University College of Medicine Tainan 701 Taiwan China Department of Obstetrics and Gynecology China Medical University Taichung 404 Taiwan China Department of Obstetrics and Gynecology Chi-Mei Medical Center Tainan 710 Taiwan China Department of Biotechnology Chia Nan University of Pharmacy and Science Tainan 717 Taiwan China

Aim： To complete comprehensive haplotype analysis of USP26 for both fertile and infertile men. Methods： Two hundred infertile men with severe oligospermia or non-obstructive azoospermia were subjected to sequence analysis for the entire coding sequences of the USP26 gene. Two hundred men with proven fertility were genotyped by primer extension methods. Allele/genotype frequencies, linkage disequilibrium （LD） characteristics and haplotypes of fertile men were compared with infertile men. Results： The allele frequencies of five single nucleotide polymor- phisms （370-37 linsACA, 494T〉C, 576G〉A, ss6202791C〉T, 1737G〉A） were significantly higher in infertile patients than control subjects. The major haplotypes in infertile men were TACCGA （28% of the population）, TGCCGA （15%）, TACCAA （8%）, TGCCAA （6%）, TATCAA （5%） and CATCAA （5%）. The major haplotypes for the control subjects were TACCGA （58% of the population）, CACCGA （7%）, CATCGA （6%） and TGCCGA （5%）. Haplotypes TGCCGA, TATCAA, CATCAA, CATCGC, TACCAA and TGCCAA were over-transmitted in patients with spermato- genic defect, whereas haplotypes TACCGA, CACCGA, and CATCGA were under-transmitted in these patients. Conclusion： Some USP26 alleles and haplotypes are associated with spermatogenic defect in the Han nationality in Taiwan, China.

关键词： single nucleotide polymorphism USP26 gene spermatogenic defect linkage disequilibrium

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香港地区中学文凭考试等级预测研究

中国考试 2024年第2期 33-39,101页

作者：许嘉凌萧伟乐席小明香港考试及评核局中国香港999077

为研究香港地区中学文凭考试(简称文凭试)等级预测结果,以过往文凭试结果作为依据,通过标准化程序,对2020—2023年共计146180名考生根据其校内评核成绩进行文凭试等级预测;并采用问卷调查法,基于各参与学校组织架构、教师的工作经验、... 详细信息

为研究香港地区中学文凭考试(简称文凭试)等级预测结果,以过往文凭试结果作为依据,通过标准化程序,对2020—2023年共计146180名考生根据其校内评核成绩进行文凭试等级预测;并采用问卷调查法,基于各参与学校组织架构、教师的工作经验、公开考试阅卷经验及专业发展活动等,运用多层线性模型探讨学校属性与校内评核的关系。结果显示:中文、英文、数学、通识教育4门核心科目等级预测结果具有较高的准确度,其中英文预测结果最佳,其余3科预测结果类似;选修科目则因每年选考人数少导致文凭试成绩变化大,进而影响预测结果;多层线性模型分析显示,不同学校属性对于不同科目的校内评核具有不同的预测效果。

关键词：香港地区中学文凭考试等级预测校内评核标准参照测验

MULTIPLE POSITIVE SOLUTIONS FOR QUASILINEAR ELLIPTIC PROBLEMS INVOLVING CONCAVE-CONVEX NONLINEARITIES AND MULTIPLE HARDY-TYPE TERMS

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Acta Mathematica Scientia 2013年第5期33卷 1314-1328页

作者： Tsing-San hsu Center for General Education Chang Gung University

In this paper, we deal with the existence and multiplicity of positive solutions for the quasilinear elliptic problem -△pu-∑i=1^kμi｜u｜^p-2/｜x-ai｜p^u=｜u｜^p^＊-2u＋λ｜u｜^q-2u,x∈Ω,where Ω belong to R^N（N ≥ 3） is a smooth bounded domain such that the different points ai∈Ω,i= 1,2,...,k,0≤μi〈μ^-=（N-p/p）^p,λ〉0,1≤q〈p,and p^＊=p^N/*** results depend crucially cn the parameters λ,q and μi for i=1,2,...,k.

关键词： multiple positive solutions concave-convex nonlinearities multiple Hardy- type terms

Quark confinement, new cosmic expansion and general Yang-Mills symmetry

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Chinese Physics C 2017年第1期41卷 115-122页

作者： Jong-Ping hsu Department of Physics University of Massachusetts Dartmouth North Dartmouth MA 02747-2300 USA

We discuss a unified model of quark confinement and new cosmic expansion with linear potentials based on a general（SU3）color×（U1）baryon symmetry. The phase functions in the usual gauge transformations are generalized to new ‘action integrals＇. The general Yang-Mills transformations have group properties and reduce to usual gauge transformations in special cases. Both quarks and ‘gauge bosons＇ are permanently confined by linear potentials. In this unified model of particle-cosmology, physics in the largest cosmos and that in the smallest quark system appear to both be dictated by the general Yang-Mills symmetry and characterized by a universal length. The basic force between two baryons is independent of distance. However, the cosmic repulsive force exerted on a baryonic supernova by a uniform sphere of galaxies is proportional to the distance from the center of the sphere. The new general YangMills field may give a field-theoretic explanation of the accelerated cosmic expansion. The prediction could be tested experimentally by measuring the frequency shifts of supernovae at different distances.

关键词： general Yang-Mills symmetry particle-cosmology confining quark potentials accelerated expansion

Catalytic activity correlation of Ni(Ⅱ),Co(Ⅱ) and Pd(Ⅱ) complexes to metal atom net charge

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Science China Chemistry 2009年第1期52卷 48-55页

作者： hsu Shaw Ling Department of Polymer Science and Engineering University of Massachusetts Amherst

The metal atom net charge correlation(MANCC) method was developed in prediction of catalyst activity of asymmetric late-transition metal complexes,2-quinoxalinyl-6-iminopyridine Ni(Ⅱ),2-imino-1,10-phenanthroline Co(Ⅱ) and 2-methoxycarbonyl-6-iminopyridine Pd(Ⅱ) complexes,from the net charge of the metal atom for ethylene *** force field was modified according to the X-ray diffraction *** found that the asymmetric structure of the complexes resulted in a charge differ-ence between two halogen atoms coordinated to the metal *** order to remove such contribution we introduced the effective charge Qeff,which was obtained by the charge equilibration(QEq) *** results verified the successful introduction of Qeff and showed that the catalytic activities of different complexes are related to central metal atom effective charge.

关键词： asymmetric catalyst effective charge force field MANCC QEq

A model of unified quantum chromodynamics and Yang-Mills gravity

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Chinese Physics C 2012年第5期36卷 403-409页

作者： hsu Jong-Ping Department of Physics University of Massachusetts Dartmouth North Dartmouth

Based on a generalized Yang-Mills framework, gravitational and strong interactions can be unified in analogy with the unification in the electroweak theory. By gauging T （4） × [SU （3）] color in flat space-time, we have a unified model of chromo-gravity with a new tensor gauge field, which couples universally to all gluons, quarks and anti-quarks. The space-time translational gauge symmetry assures that all wave equations of quarks and gluons reduce to a Hamilton-Jacobi equation with the same ‘effective Riemann metric tensors’ in the geometric-optics （or classical） limit. The emergence of ef f ective metric tensors in the classical limit is essential for the unified model to agree with experiments. The unified model suggests that all gravitational, strong and electroweak interactions appear to be dictated by gauge symmetries in the generalized Yang-Mills framework.

关键词： unified model chromodynamics and gravity generalized Yang-Mills framework effective Riemann metric tensor

Ion Probe Study of Silicate Inclusions from Colomera (ⅡE) Iron Meteorite: the Rare Earth Element Perspective

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Acta Geologica Sinica(English Edition) 2004年第5期78卷 1060-1074页

作者： hsu Weibiao CA 91125 California Institute of Technology China Division of Geological & Planetary Sciences Chinese Academy of Sciences Laboratory for Astrochemistry and Planetary Sciences Purple Mountain Observatory Nanjing 210008 Pasadena USA

Coupled with a petrographical study, I carried out an ion probe study of rare earth element microdistributions in mineral phases of silicate inclusions from the Colomera ⅡE iron meteorite. Most mineral grains have homogeneous REEs, but show considerable inter-grain variations by a factor of 2 to 100. The whole rock REE abundances for Colomera, estimated by combining REE data with modal abundances, are relatively LREE-enriched with REEs of -10’CI, which suggest that Colomera silicates were highly differentiated and might represent a low degree partial melt (-10%) of a chondritic source. REE geochemistry of Colomera silicate inclusions points to an origin that involves differentiation, dynamic mixing, remelting, reduction, recrystallization, and subsequent rapid cooling near the surface of a planetary body.

关键词： ion probe rare earth elements Colomera silicate inclusions ⅡE iron meteorites

Improving bagging performance through multi-algorithm ensembles

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Frontiers of Computer Science 2012年第5期6卷 498-512页

作者： Kuo-Wei hsu Jaideep SRIVASTAVA Department of Computer Science Chengchi University Taipei 11605 China Department of Computer Science and Engineering University of Minnesota Minneapolis MN 55455 USA

Working as an ensemble method that establishes a committee of classifiers first and then aggregates their out- comes through majority voting, bagging has attracted consid- erable research interest and been applied in various applica- tion domains. It has demonstrated several advantages, but in its present form, bagging has been found to be less accurate than some other ensemble methods. To unlock its power and expand its user base, we propose an approach that improves bagging through the use of multi-algorithm ensembles. In a multi-algorithm ensemble, multiple classification algorithms are employed. Starting from a study of the nature of diver- sity, we show that compared to using different training sets alone, using heterogeneous algorithms together with different training sets increases diversity in ensembles, and hence we provide a fundamental explanation for research utilizing het- erogeneous algorithms. In addition, we partially address the problem of the relationship between diversity and accuracy by providing a non-linear function that describes the relation- ship between diversity and correlation. Furthermore, after re- alizing that the bootstrap procedure is the exclusive source of diversity in bagging, we use heterogeneity as another source of diversity and propose an approach utilizing heterogeneous algorithms in bagging. For evaluation, we consider several benchmark data sets from various application domains. The results indicate that, in terms of Fl-measure, our approach outperforms most of the other state-of-the-art ensemble meth- ods considered in experiments and, in terms of mean margin, our approach is superior to all the others considered in experiments.

关键词： bagging classification diversity ensemble

Small-bowel perforation caused by fish bone

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World Journal of Gastroenterology 2005年第12期11卷 1884-1885页

作者： Sheng-Der hsu Division of General Surgery

A diagnosis of small-bowel perforation, caused by a sharp or pointed foreign body, is rarely made preoperatively because the clinical symptoms are usually nonspecific and can mimic other surgical conditions, such as appendicitis and diverticulitis. We report the case of a 62-year-old woman who experienced severe pain in the right iliac fossa and fever for about five days before arrival at our hospital. The presumptive diagnosis was acute purulent appendicitis and an emergency appendectomy was planned. Swelling and erythema were noted in a segment of the small bowel in the lower right abdomen. A tiny pointed object was found penetrating the inflamed portion of the bowel, which proved to be a sharp fish bone (gray snapper). The bone was removed, followed by segmental resection of the terminal ileum and ascending colon. The postoperative course was uneventful.

关键词： Small-bowel perforation Fish bone