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白虎加人参汤治疗肥胖症合并2型糖尿病的潜在活性成分及作用机制分析

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中国实验方剂学杂志 2024年第13期30卷 1-10页

作者：谭丹妮向琴俞赟丰喻嵘湖南中医药大学中医学院长沙410208

目的:通过网络药理学结合体内实验验证,探讨白虎加人参汤治疗肥胖症合并2型糖尿病(T2DM)的潜在活性成分和作用靶点。方法:利用超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法(UPLC-Q-Exactive Orbitrap MS)分析鉴定白虎加人参汤物质... 详细信息

目的:通过网络药理学结合体内实验验证,探讨白虎加人参汤治疗肥胖症合并2型糖尿病(T2DM)的潜在活性成分和作用靶点。方法:利用超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法(UPLC-Q-Exactive Orbitrap MS)分析鉴定白虎加人参汤物质基础。在ChEMBL、疗效药靶数据库(TTD)、YaTCM、DisGeNET和中药免疫肿瘤学(TCMIO)等数据库中查询活性成分作用的潜在靶点,并将这些靶点与疾病靶点取交集确定共同靶点。将共同靶点导入STRING数据库构建蛋白质-蛋白质相互作用(PPI)网络,通过cytoHubba插件确定hub基因,利用分子对接验证hub基因与白虎加人参汤中生物活性成分的结合能。同时,将共同靶点导入DAVID平台进行基因本体(GO)功能注释及京都基因和基因组百科全书(KEGG)通路富集分析。通过动物实验验证预测结果,将18只8周龄雄性骨骼肌胰岛素样生长因子-1受体功能缺失(MKR)小鼠高脂饮食饲养12周,制备肥胖症合并T2DM小鼠模型。随机将小鼠均分为模型组、二甲双胍组(0.2 g·kg^(-1))、白虎加人参汤组(以生药计27 g·kg^(-1)),另设6只同龄雄性FVB小鼠作为正常组,各组小鼠给予相应药物灌胃,正常组及模型组灌胃等量蒸馏水,1次/d,连续6周。给药结束后,检测各组小鼠的体质量、lee's指数、空腹血糖(FBG)、口服糖耐量试验(OGTT),观察附睾白色脂肪组织病理形态,并采用实时荧光定量聚合酶链式反应(Real-time PCR)检测附睾白色脂肪组织中hub基因mRNA的表达水平。结果:共鉴定出白虎加人参汤200种化合物,其中64种生物活性成分反向匹配到384个靶点,与肥胖症合并T2DM相关的靶点共308个。hub基因包括丝裂原活化蛋白激酶1(MAPK1)、信号转导与转录激活因子3(STAT3)、MAPK3、白细胞介素(IL)-2、Janus酪氨酸蛋白激酶1(JAK1)、核转录因子-κB p65(RELA)、雌激素受体1(ESR1)、转录因子AP-1(JUN)、MAPK14和淋巴细胞特异性蛋白酪氨酸激酶(LCK)。GO功能注释结果显示,主要富集于细胞内的胞质、胞膜和胞核等成分,且与肽丝氨酸磷酸化、蛋白质磷酸化、炎症反应等重要生物过程密切相关。在KEGG富集分析中,代谢途径、脂质与动脉粥样硬化、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)和MAPK等信号通路被明显富集。分子对接结果显示,hub基因与白虎加人参汤中的槲皮素、异甘草素、桑黄素等10种生物活性成分具有稳定的结合关系。动物实验结果显示,白虎加人参汤能够显著降低肥胖症合并T2DM小鼠的体质量、lee's指数和FBG水平(P<0.01),并能够改善附睾白色脂肪组织的病理变化,下调附睾白色脂肪组织中hub基因的mRNA表达(P<0.01)。结论:该研究通过网络药理学及动物实验验证确定了白虎加人参汤中槲皮素、异甘草素、桑黄素等10种潜在活性成分,可能通过调节代谢途径、脂质与动脉粥样硬化、PI3K/Akt和MAPK等信号通路治疗肥胖症合并T2DM,为其机制与临床研究提供了重要的线索和理论基础。

关键词：白虎加人参汤 2型糖尿病肥胖胰岛素抵抗网络药理学超高效液相色谱-四极杆/静电场轨道阱高分辨质谱法(UPLC-Q-Exactive Orbitrap MS) hub基因

Micromachining soda-lime glass by femtosecond laser pulses

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Frontiers of physics 2015年第4期10卷 51-54页

作者： Wei Jia Jian yu Lu Chai ching-yue Wang Ultrafast Laser Laboratory School of Precision Instruments and Opto-Electronics Engineering Tianjin University and Key Laboratory of Opto-Electronic Information Technical Science EMC Tianjin 300072 China School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

The physical process of forming a modified region in soda-lime glass was investigated using 1 kHz intense femtosecond laser pulses from a Ti： sapphire laser at 775 nm. Through the modifications in- duced by the femtosecond laser radiation using selective chemical etching techniques, we fabricated reproducible and defined microstructures and further studied their morphologies and etching prop- erties. Moreover, a possible physical mechanism for the femtosecond laser modification in soda-lime glass was proposed.

关键词： ultrafast processes glass laser ablation

Effects of soy components on blood and liver lipids in rats fed high-cholesterol diets

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World Journal of Gastroenterology 2005年第35期11卷 5549-5552页

作者： ching-Yi Lin Cheng-yu Tsai Shyh-Hsiang Lin Graduate Institute of Nutrition and Health Sciences Taipei Medical University (110) 250 Wu-Hsing Street Taipei Taiwan China

AIM: To assess the effects of soy protein, isoflavone, and saponin on liver and blood lipid in rats that consumed high-cholesterol ***: High-cholesterol diets (1%) with or without soy material were fed to 6-wk-old male Sprague-Dawley rats for 8 wk. Blood lipids, liver lipids, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) levels were measured. The in vitro bile acid-binding ability of soy materials was ***: The results of in vitro studies showed that soy protein isolate had a significantly higher bile acid-binding ability (8.4±0.8%) than soy saponin (3.1±0.7%) and isoflavone (1.3±0.4%, P＜0.05). On the other hand, at the end of the experimental period, rats that consumed soy protein diets had lower GOT and GPT levels than rats that consumed casein under high-cholesterol *** that consumed soy protein also had lower total cholesterol (TC) levels in the liver than those that consumed casein under high-cholesterol diets. Rats that consumed the soy protein diet containing both saponin and isoflavone had lower hepatic TC level than those that consumed the soy protein diet without isoflavone *** effect of different types of proteins on triglyceride was not ***: Consumption of soy provided benefits to control lipid levels under high-cholesterol dieting conditions in this rat model of hypercholesterolemia. The major component that reduced hepatic TC was not saponin, but possibly isoflavone.

关键词： Soy Isoflavone Saponin Triglyceride Cholesterol

Enhance of TiO_2 dopants incorporated reduced graphene oxide via RF magnetron sputtering for efficient dye-sensitised solar cells

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Rare Metals 2018年第11期37卷 919-928页

作者： Foo Wah Low Chin Wei Lai Kian Mun lee Joon ching Juan Nanotechnology and Catalysis Research Centre Institute Postgraduate Studies University of Malaya

In particular, the dye-sensitised solar cells(DSSCs) have a high potential in the rational energy conversion efficiency to secure our sustainable energy *** the present study, advanced radio frequency(RF) magnetron sputtering technique was applied to incorporate titanium dioxide(TiO) dopants into reduced graphene oxide(rGO) nanosheet for improving the power conversion efficiency(PCE) of DSSCs device. An optimum TiOcontent incorporated onto rGO nanosheet plays an important role in improving the PCE of DSSCs by minimising the recombination losses of photo-induced charge *** on the results obtained, 40-s sputtering duration for incorporating TiOdopants onto rGO nanosheet exhibits a maximum PCE of 8.78% than that of pure rGO film(0.68%). In fact, the presence of optimum content of TiOdopants within rGO nanosheet could act as mediators for efficient separation photo-induced charge carriers. However, the excessive of sputtering duration(e.g. 60 s) of TiOdopants onto rGO nanosheet results higher charge recombination and lowers the PCE of DSSCs(5.39%).

关键词： Dye-sensitised solar cell RF magnetron sputtering Titanium dioxide Reduced graphene oxide

Surface-modified barium titanate by MEEAA for high-energy storage application of polymer composites

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High Voltage 2016年第4期1卷 175-180页

作者： Yanbin Shen Suibin Luo Shuhui yu Rong Sun ching-Ping Wong Center for Advanced Materials Research Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhenPeople’s Republic of China Department of Nano Science and Technology Institute Nano Science and Technology InstituteUniversity of Science and Technology of ChinaSuzhouPeople’s Republic of China Faculty of Engineering The Chinese University of Hong KongHong KongPeople’s Republic of China

In this study,2-[2-(2-methoxyethoxy)ethoxy]acetic acid(MEEAA)was used to modify the surface of barium titanate nanoparticles(BT NPs)to enhance the compatibility and dispersion of the BT ceramic fillers in polymer matrix.A uniform coating layer with a thickness about 2 nm was formed on the surface of BT after *** poly(vinylidene fluoride)-hexafluoropropene[P(VDF-HFP)]composites filled with MEEAA-modified BT NPs achieved higher permittivity(∼13 at 3.0 vol%filler)and discharged energy density than that of the untreated BT filled *** maximum discharge energy density of 7.8 J/cm^(3)was obtained in the nanocomposites with 3 vol%MEEAA-modified BT NPs at electric field of 425 kV/mm,which is 77%higher than that of 4.4 J/cm^(3)of pure P(VDF-HFP)film at electric field of 420 kV/mm.

关键词： composites barium modified

Micromechanical analysis of the behavior of stiffclay

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Acta Mechanica Sinica 2011年第6期27卷 1013-1022页

作者： Zhen-yu Yin ching S. Chang Pierre-Yves Hicher Jian-Hua Wang Department of Civil Engineering Shanghai Jiao Tong University 200240 Shanghai China Department of Civil and Environmental Engineering University of Massachusetts Amherst MA 01002 USA Research Institute in Civil and Mechanical Engineering UMR CNRS 6183 Ecole Centrale de Nantes BP 92101 44321 Nantes France

Cementations formed in geological timescale are observed in various stiff clays.A micromechanical stress strain model is developed for modeling the effect of cementation on the deformation behavior of stiff *** proposed approach considers explicitly cementations at intercluster contacts,which is different from conventional *** concept of inter-cluster bonding is introduced to account for an additional cohesion in shear sliding and a higher yield stress in normal compression.A damage law for inter-cluster bonding is proposed at cluster contacts for the debonding process during mechanical *** model is used to simulate numerous stress-path tests on Vallericca stiff *** applicability of the present model is evaluated through comparisons between the predicted and the measured *** order to explain the stress-induced anisotropy arising from externally applied load,the evolution of local stresses and local strains at inter-cluster planes are discussed.

关键词： Stiff clay Destructuration Micromechanics Plasticity Induced anisotropy

The design of China Reconfigurable ANalog-digital backEnd for FAST

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Research in Astronomy and Astrophysics 2020年第5期20卷 155-164页

作者： Xin-Xin Zhang Ran Duan Xin-Ying yu Di Li Ning-yu Tang Tao-Chung ching National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Guizhou University Guiyang 550025China

The Five-hundred-meter Aperture Spherical radio Telescope(FAST)was launched on 2016 September *** early 2017,we began to use the FAST wideband receiver,which was designed,constructed and installed on the FAST in Guizhou,*** front end of the receiver is composed an uncooled Quad Ridge Flared Horn feed(QRFH)with the frequency range of 270 to 1620 MHz,and a cryostat operating at 10 *** have cooperated with the Institute of Automation of the Chinese Academy of Sciences to develop the China Reconfigurable ANalog-digital backEnd(CRANE).The system covers the 3 GHz operating band of *** hardware part of the backend includes an Analog Front-end Board,a wideband high precision Analog Digital Converter,and a FAST Digital *** circuit boards,field programmable gate arrays,and control computers form a set of hardware,software,and firmware platforms to achieve flexible bandwidth requirements through parameter *** is also suitable for the versatility of different astronomical observations,and can meet specific *** paper briefly introduces the hardware and software of CRANE,as well as some observations of the system.

关键词： radio astronomy instrumentation methods and techniques instrumentation:miscellaneous

The fabrication and application of Ni-DNA nanowire-based nanoelectronic devices

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Nano Research 2019年第6期12卷 1293-1300页

作者： Pang-Chia Chang Chia-yu Chang Wen-Bin Jian Chiun-Jye yuan yu-Chang Chen Chia-ching Chang Department of Electrophysics "National Chiao Tung University"Hsinchu 30010TaiwanChina Department of Biological Science and Technology "National Chiao Tung University"Hsinchu 30068TaiwanChina Center for Intelligent Drug Systems and Smart Bio-devices(IDS^2B) "National Chiao Tung University"Hsinchu 30068TaiwanChina Institute of Physics "Academia Sinica"Taipei 11529TaiwanChina

DNA is a self-assembled,double stranded natural molecule that can chelate and align nickel ions between its base *** fabrication of a DNA-guided nickel ion chain (Ni-DNA) device was successful,as indicated by the conducting currents exhibiting a Ni ion redox reaction-driven negative differential resistance effect,a property unique to mem-elements (1).The redox state of nickel ions in the Ni-DNA device is programmable by applying an external bias with different polarities and writing times (2).The multiple states of Ni-DNA-based memristive and memcapacitive systems were characterized (3).As such,the development of Ni-DNA nanowire device-based circuits in the near future is proposed.

关键词： DNA-guided nickel ion chain (Ni-DNA) negative differential resistance (NDR) memristive systemmem capacitive system nanowire

Real non-Hermitian energy spectra without any symmetry

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Chinese Physics B 2022年第7期31卷 1-7页

作者： Boxue Zhang Qingya Li Xiao Zhang ching Hua lee School of Physics Sun Yat-sen UniversityGuangzhou 510275China Department of Physics National University of SingaporeSingapore 117542Singapore

Non-Hermitian models with real eigenenergies are highly desirable for their ***,most of the currently known ones are constrained by symmetries such as PT-symmetry,which is incompatible with realizing some of the most exotic non-Hermitian *** this work,we investigate how the non-Hermitian skin effect provides an alternative route towards enforcing real spectra and system *** showcase,for different classes of energy dispersions,various ansatz models that possess large parameter space regions with real spectra,despite not having any obvious *** minimal local models can be quickly implemented in non-reciprocal experimental setups such as electrical circuits with operational amplifiers.

关键词： non-Hermitian physics real energy spectra non-Hermitian skin effect