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Short- and long-term outcomes of surgical treatment in patients with intestinal Behcet’s disease

World Journal of Gastrointestinal Surgery 2024年第2期16卷 429-437页

作者： Min Young Park Yong Sik Yoon Jae Ha Park Jong Lyul lee Chang Sik yu Division of Colon and Rectal Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722South Korea Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Behcet’s disease(BD),a chronic vasculitic disorder affecting multiple organs,is characterized by recurrent oral and genital ulcers,arthritis,vasculitis,and intes-tinal *** intestinal involvement of BD is common in East Asia,the efficacy and long-term outcomes of surgical treatment of intestinal BD still remain to be *** To evaluate the postoperative clinical course of intestinal BD and determine factors associated with its *** Data from patients who underwent surgical treatment for intestinal BD between January 2010 and August 2021 were retrospectively ***’demo-graphics,clinical features,postoperative course,complications,and follow-up data were *** We analyzed 39 surgeries in 31 *** mean patient age was 45.1 years,and the mean interval between the diagnosis of intestinal BD and surgical treatment was 4.9 years(range 1.0-8.0 years).The most common indication for surgery was medical intractability(n=16,41.0%),followed by fistula or abscess(n=11,28.2%).Laparoscopic approaches were used in 19 patients(48.7%),and 5 patients(12.8%)underwent emergency *** most common surgical procedure was ileocecal resection(n=18,46.2%),followed by right colectomy(n=11,28.2%).A diverting stoma was created in only one patient(2.6%).During a mean follow-up period of 45(range 8-72)months,eight cases(20.5%)of recurrence in five patients required *** interval between operations was 12.1 months(range 6.3-17.8 mo).Four patients(10.3%)experienced recurrence within 1 year postoperatively,and all eight recurrences occurred within 2 years of the initial *** reoperation rates at 1 and 3 years were 10.3%and 20.5%,respectively.A redo ileocolic anastomosis was performed in all recurrent *** multivariate Cox regression analysis,emergency surgery[hazard ratio(HR)9.357,95%confidence interval(CI):1.608-54.453,P=0.013]and elevated C-reactive protein(CRP)levels(HR 1.154,95%CI:1.002–1.328,

关键词： Behcet syndrome Intestinal General surgery Recurrence Risk factors

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CD200Rhigghh neutrophils with dysfunctional autophagy establish systemic immunosuppression by increasing regulatory T cells

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Cellular & Molecular Immunology 2024年第4期21卷 349-361页

作者： Ye Seon Kim yu Sun Jeong Geon Ho Bae Ji Hyeon Kang Mingyu lee Brian A.Zabel Yoe-Sik Bae Department of Biological Sciences Sungkyunkwan UniversitySuwon16419Republic of Korea Department of Health Science and Technology SAIHSTSungkyunkwan UniversitySeoul06351Republic of Korea Palo Alto Veterans Institute for Research Veterans Affairs HospitalPalo AltoCA94304USA

Distinct neutrophil populations arise during certain pathological *** generation of dysfunctional neutrophils during sepsis and their contribution to septicemia-related systemic immune suppression remain *** this study,using an experimental sepsis model that features immunosuppression,we identified a novel population of pathogenic CD200R^(high) neutrophils that are generated during the initial stages of sepsis and contribute to systemic immune suppression by enhancing regulatory T(T_(reg))*** to their CD200R^(low)counterparts,sepsis-generated CD200Rhigh neutrophils exhibit impaired autophagy and dysfunction,with reduced chemotactic migration,superoxide anion production,and TNF-α*** soluble CD200 blocks autophagy and neutrophil maturation in the bone marrow during experimental sepsis,and recombinant CD200 treatment in vitro can induce neutrophil dysfunction similar to that observed in CD200R^(high) *** administration of anα-CD200R antibody effectively reversed neutrophil dysfunction by enhancing autophagy and protecting against a secondary infection challenge,leading to increased *** analysis revealed that CD200R^(high) neutrophils expressed high levels of Igf1,which elicits the generation of Treg cells,while the administration of anα-CD200R antibody inhibited Treg cell generation in a secondary infection *** together,our findings revealed a novel CD200R^(high) neutrophil population that mediates the pathogenesis of sepsis-induced systemic immunosuppression by generating Treg cells.

关键词： Sepsis Neutrophils CD200R Autophagy IGF-1 Regulatory T cells

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Tuning Structural and Electronic Configuration of FeN_(4) via External S for Enhanced Oxygen Reduction Reaction

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Energy & Environmental Materials 2024年第2期7卷 93-101页

作者： Shidong Li Lixue Xia Jiantao Li Zhuo Chen Wei Zhang Jiexin Zhu Ruohan yu Fang Liu Sungsik lee Yan Zhao Liang Zhou Liqiang Mai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528200China Chemical Sciences and Engineering Division Argonne National Laboratory9700 South Cass AvenueLemontIL 60439USA NRC(Nanostructure Research Centre) Wuhan University of TechnologyWuhan 430070China X-ray Science Division Advanced Photon SourcesArgonne National Laboratory9700 South CassAvenueLemontIL 60439USA State Key Laboratory of Silicate Materials for Architectures International School of Materials Science and EngineeringWuhan University of TechnologyWuhan 430070China The Institute of Technological Sciences Wuhan UniversityWuhan 430072China Hubei Longzhong Laboratory Xiangyang 441000China

The Fe-N-C material represents an attractive oxygen reduction reaction electrocatalyst,and the FeN_(4)moiety has been identified as a very competitive catalytic active *** tuning of the coordination structure of FeN_(4)has an essential impact on the catalytic ***,we construct a sulfur-modified Fe-N-C catalyst with controllable local coordination environment,where the Fe is coordinated with four in-plane N and an axial external *** external S atom affects not only the electron distribution but also the spin state of Fe in the FeN_(4)active *** appearance of higher valence states and spin states for Fe demonstrates the increase in unpaired *** the above characteristics,the adsorption and desorption of the reactants at FeN_(4)active sites are optimized,thus promoting the oxygen reduction reaction *** work explores the key point in electronic configuration and coordination environment tuning of FeN_(4)through S doping and provides new insight into the construction of M-N-C-based oxygen reduction reaction catalysts.

关键词： coordination structure electronic configuration FeN_(4)moiety oxygen reduction reaction sulfur doping

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Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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Nano-Micro Letters 2024年第12期16卷 468-514页

作者： Jung Hwan Park Srinivas Pattipaka Geon-Tae Hwang Minok Park yu Mi Woo Young Bin Kim Han Eol lee Chang Kyu Jeong Tiandong Zhang yuho Min Kwi-Il Park Keon Jae lee Jungho Ryu Department of Mechanical Engineering(Department of Aeronautics Mechanical and Electronic Convergence Engineering)Kumoh National Institute of Technology61Daehak-RoGumiGyeongbuk 39177Republic of Korea Department of Materials Science and Engineering Pukyong National University45Yongso-RoNam-GuBusan 48513Republic of Korea Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology(KAIST)291 Daehak-RoYuseong-GuDaejeon 34141Republic of Korea Division of Advanced Materials Engineering Jeonbuk National UniversityJeonju 54896JeonbukRepublic of Korea School of Electrical and Electronic Engineering Harbin University of Science and TechnologyHarbin 150080People’s Republic of China Key Laboratory of Engineering Dielectrics and Its Application Ministry of EducationHarbin University of Science and TechnologyHarbin 150080People’s Republic of China Department of Materials Science and Metallurgical Engineering Kyungpook National University80 Daehak-RoBuk-GuDaegu 41566Republic of Korea School of Materials Science and Engineering Yeungnam UniversityDaehak-RoGyeongsan-Si 38541Gyeongsangbuk-doRepublic of Korea

This review provides a comprehensive overview of the progress in light-material interactions(LMIs),focusing on lasers and flash lights for energy conversion and storage *** discuss intricate LMI parameters such as light sources,interaction time,and fluence to elucidate their importance in material *** addition,this study covers various light-induced photothermal and photochemical processes ranging from melting,crystallization,and ablation to doping and synthesis,which are essential for developing energy materials and ***,we present extensive energy conversion and storage applications demonstrated by LMI technologies,including energy harvesters,sensors,capacitors,and *** the several challenges associated with LMIs,such as complex mechanisms,and high-degrees of freedom,we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

关键词： Light Light-material interaction Nanomaterials Energy conversion and storage devices

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Blastomas of the digestive system in adults:A review

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1030-1042页

作者： yu Liu Tony El Jabbour Jonathan Somma yukihiro Nakanishi Saverio Ligato Hwajeong lee Zhi-Yan Fu Department of Pathology LSU Health Sciences Center School of MedicineNew OrleansLA 70112United States Department of Pathology Hartford HealthCareHartfordCT 06102United States Department of Pathology Moffitt Cancer CenterTampaFL 33612United States Department of Pathology and Laboratory Medicine Albany Medical CenterAlbanyNY 12208United States

Blastomas,characterized by a mixture of mesenchymal,epithelial,and undifferentiated blastematous components,are rare malignant neoplasms originating from precursor blast *** review focuses on digestive system blastomas in adult patients,including gastroblastoma,hepatoblastoma,and *** is a biphasic,epitheliomesenchymal tumor,with only sixteen cases reported to *** addition to the characteristic histology,metastasisassociated lung adenocarcinoma transcript 1-glioma-associated oncogene homolog 1 gene fusion is typical,although recently novel ewing sarcoma breakpoint region 1-c-terminal binding protein 1 and patched 1-glioma-associated oncogene homolog 2 fusions have been *** is exceptionally rare in adults and can show a variety of histologic patterns which may cause diagnostic ***,primarily a pediatric tumor,displays acinar differentiation and squamoid nests with other lines of differentiation also present,especially *** approaches for these blastomas include a combination of imaging modalities,histopathological examination,and molecular *** treatment generally involves surgical resection,which may be supplemented by chemotherapy or radiotherapy in some *** vary with gastroblastoma generally showing favorable outcomes post-surgery whereas hepatoblastoma and pancreatoblastoma often have poorer outcomes,particularly in the setting of *** review highlights the complexity of diagnosing and managing these rare adult blastomas as well as the need for ongoing research to better understand their pathogenesis and improve treatment strategies.

关键词： Adult blastomas Gastroblastoma Hepatoblastoma Pancreatoblastoma Digestive system

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Surface Patterning of Metal Zinc Electrode with an In‑Region Zincophilic Interface for High‑Rate and Long‑Cycle‑Life Zinc Metal Anode

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Nano-Micro Letters 2024年第6期16卷 192-209页

作者： Tian Wang Qiao Xi Kai Yao yuhang Liu Hao Fu Venkata Siva Kavarthapu Jun Kyu lee Shaocong Tang Dina Fattakhova‑Rohlfing Wei Ai Jae Su yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin‑siGyeonggi‑do 17104Republic of Korea Frontiers Science Center for Flexible Electronics(FSCFE)and Shaanxi Institute of Flexible Electronics(SIFE) Northwestern Polytechnical University(NPU)127 West Youyi RoadXi’an 710072People’s Republic of China Institute of Energy and Climate Research:Materials Synthesis and Processing(IEK‑1) Forschungszentrum Julich GmbH52425 JulichGermany School of Chemical Engineering Sungkyunkwan University2066 Seobu‑RoJangan‑GuSuwon‑siGyeonggi‑doRepublic of Korea

The undesirable dendrite growth induced by non-planar zinc(Zn)deposition and low Coulombic efficiency resulting from severe side reactions have been long-standing challenges for metallic Zn anodes and substantially impede the practical application of rechargeable aqueous Zn metal batteries(ZMBs).Herein,we present a strategy for achieving a high-rate and long-cycle-life Zn metal anode by patterning Zn foil surfaces and endowing a Zn-Indium(Zn-In)interface in the *** accumulation of electrons in the microchannel and the zincophilicity of the Zn-In interface promote preferential heteroepitaxial Zn deposition in the microchannel region and enhance the tolerance of the electrode at high current ***,electron aggregation accelerates the dissolution of non-(002)plane Zn atoms on the array surface,thereby directing the subsequent homoepitaxial Zn deposition on the array ***,the planar dendrite-free Zn deposition and long-term cycling stability are achieved(5,050 h at 10.0 mA cm^(−2) and 27,000 cycles at 20.0 mA cm^(−2)).Furthermore,a Zn/I_(2) full cell assembled by pairing with such an anode can maintain good stability for 3,500 cycles at 5.0 C,demonstrating the application potential of the as-prepared ZnIn anode for high-performance aqueous ZMBs.

关键词： Zn metal anode Surface patterning Directional Zn deposition Aqueous Zn-I_(2)batteries

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Heterogeneous Cu_(x)O Nano‑Skeletons from Waste Electronics for Enhanced Glucose Detection

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Nano-Micro Letters 2024年第11期16卷 554-568页

作者： Yexin Pan Ruohan yu Yalong Jiang Haosong Zhong Qiaoyaxiao yuan Connie Kong Wai lee Rongliang Yang Siyu Chen Yi Chen Wing Yan Poon Mitch Guijun Li Center on Smart Manufacturing Division of Integrative Systems and DesignThe Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SAR 999077People’s Republic of China The Sanya Science and Education Innovation Park of Wuhan University of Technology Sanya 572000People’s Republic of China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200People’s Republic of China

Electronic waste(e-waste)and diabetes are global challenges to modern ***,solving these two challenges together has been challenging until ***,we propose a laser-induced transfer method to fabricate portable glucose sensors by recycling copper from *** bring up a laser-induced full-automatic fabrication method for synthesizing continuous heterogeneous Cu_(x)O(h-Cu_(x)O)nano-skeletons electrode for glucose sensing,offering rapid(<1 min),clean,air-compatible,and continuous fabrication,applicable to a wide range of Cu-containing *** this approach,h-Cu_(x)O nanoskeletons,with an inner core predominantly composed of Cu_(2)O with lower oxygen content,juxtaposed with an outer layer rich in amorphous Cu_(x)O(a-Cu_(x)O)with higher oxygen content,are derived from discarded printed circuit *** employed in glucose detection,the h-Cu_(x)O nano-skeletons undergo a structural evolution process,transitioning into rigid Cu_(2)O@CuO nano-skeletons prompted by electrochemical *** transformation yields exceptional glucose-sensing performance(sensitivity:9.893 mA mM^(-1) cm^(-2);detection limit:0.34μM),outperforming most previously reported glucose *** functional theory analysis elucidates that the heterogeneous structure facilitates gluconolactone *** glucose detection device has also been downsized to optimize its scalability and portability for convenient integration into people’s everyday lives.

关键词： Copper oxide Electron 3D tomography E-waste Glucose detection Electrochemical activation

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New anti-mesenteric delta-shaped stapled anastomosis: Technical report with short-term postoperative outcomes in patients with Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2592-2601页

作者： Jong Lyul lee Yong Sik Yoon Hyun Gu lee Young Il Kim Min Hyun Kim Chan Wook Kim In Ja Park Seok-Byung Lim Chang Sik yu Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Surgery Gangdong Kyung Hee University HospitalSeoul 05278South Korea

BACKGROUND Medical treatment for Crohn’s disease(CD)has continuously improved,which has led to a decrease in surgical recurrence *** these advancements,25%of patients will undergo repeat intestinal *** of CD com-monly occurs on the mesentery side of the anastomosis *** To compare the new anti-mesenteric side-to-side delta-shaped stapled anasto-mosis(DSA)with the conventional stapled functional end-to-end anastomosis(CSA).METHODS This retrospective study included CD patients who underwent ileo-ileal or ileo-colic anastomosis between January 2020 and December *** DSA technique employed a stapler to maintain the concept of anti-mesentery side-to-side ana-stomosis by performing a 90°vertical closure of the open window compared with the CSA *** the corner where the open window is closed,the DSA avoids forming a pouch and creates an anastomosis resembling a delta shape within the intestinal *** compared demographics,preoperative condition,operative findings,and operative outcomes for the two *** The study included 175 patients,including 92 in the DSA group and 83 in the CSA *** two groups were similar in baseline characteristics,preoperative medical treatment,and operative findings except for the Montreal classification *** 30-days postoperative complication rate was signi-ficantly lower in the DSA group compared with the CSA group(16.3%vs 32.5%,P=0.009).Ileus incidence was significantly lower in the DSA group than in the CSA group(4.3%vs 14.5%,P=0.033),and the hospital stay was shorter in the DSA group than in the CSA group(5.67±1.53 days vs 7.39±3.68 days,P=0.001).CONCLUSION The DSA technique was feasible and showed comparable postoperative outcomes with lower short-term complic-ations compared with the CSA *** studies on CD recurrence and long-term complications are warranted.

关键词： Crohn’s disease Surgery Anastomosis Complication Recurrence

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Surface-functionalized hole-selective monolayer for high efficiency single-junction wide-bandgap and monolithic tandem perovskite solar cells

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Journal of Energy Chemistry 2024年第1期88卷 317-326,I0008页

作者： Devthade Vidyasagar Yeonghun yun Jae yu Cho Hyemin lee Kyung Won Kim Yong Tae Kim Sung Woong Yang Jina Jung Won Chang Choi Seonu Kim Rajendra Kumar Gunasekaran Seok Beom Kang Kwang Heo Dong Hoe Kim Jaeyeong Heo Sangwook lee School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Materials Science and Engineering and Optoelectronics Convergence Research CenterChonnam National UniversityGwangju 61186Republic of Korea Department of Materials Science and Engineering Korea UniversitySeoul 02841Republic of Korea Department of Nanotechnology and Advanced Materials Engineering Sejong UniversitySeoul 05006Republic of Korea

Carbazole moiety-based 2PACz([2-(9H-carbazol-9-yl)ethyl]phosphonic acid)self-assembled monolayers(SAMs)are excellent hole-selective contact(HSC)materials with abilities to excel the charge-transferdynamics of perovskite solar cells(PSCs).Herein,we report a facile but powerful method to functionalize the surface of 2PACz-SAM,by which reproducible,highly stable,high-efficiency wide-bandgap PSCs can be *** 2PACz surface treatment with various donor number solvents improves assembly of 2PACz-SAM and leave residual surface-bound solvent molecules on 2PACz-SAM,which increases perovskite grain size,retards halide segregation,and accelerates hole *** surface functionalization achieves a high power conversion efficiency(PCE)of 17.62%for a single-junction wide-bandgap(~1.77 e V)*** also demonstrate a monolithic all-perovskite tandem solar cell using surfaceengineered HSC,showing high PCE of 24.66%with large open-circuit voltage of 2.008 V and high fillfactor of 81.45%.Our results suggest this simple approach can further improve the tandem device,when coupled with a high-performance narrow-bandgap sub-cell.

关键词： Perovskite solar cells 2PACz Monolithic tandem solar cells Wide bandgap

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Ocular image-based deep learning for predicting refractive error:A systematic review

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Advances in Ophthalmology Practice and Research 2024年第3期4卷 164-172页

作者： Samantha Min Er Yew Yibing Chen Jocelyn Hui Lin Goh David Ziyou Chen Marcus Chun Jin Tan ching-yu Cheng Victor Teck Chang Koh Yih Chung Tham Department of Ophthalmology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Centre for Innovation and Precision Eye Health Yong Loo Lin School of MedicineNational University of SingaporeSingapore School of Chemistry Chemical Engineeringand BiotechnologyNanyang Technological UniversitySingapore Singapore Eye Research Institute Singapore National Eye CentreSingapore Department of Ophthalmology National University HospitalSingapore Ophthalmology and Visual Sciences(Eye ACP) Duke-NUS Medical SchoolSingapore

ackground:Uncorrected refractive error is a major cause of vision impairment worldwide and its increasing prevalent necessitates effective screening and management ***,deep learning,a subset of Artificial Intelligence,has significantly advanced ophthalmological diagnostics by automating tasks that required extensive clinical *** recent studies have investigated the use of deep learning models for refractive power detection through various imaging techniques,a comprehensive systematic review on this topic is has yet be *** review aims to summarise and evaluate the performance of ocular image-based deep learning models in predicting refractive *** text:We search on three databases(PubMed,Scopus,Web of Science)up till June 2023,focusing on deep learning applications in detecting refractive error from ocular *** included studies that had reported refractive error outcomes,regardless of publication *** systematically extracted and evaluated the continuous outcomes(sphere,SE,cylinder)and categorical outcomes(myopia),ground truth measurements,ocular imaging modalities,deep learning models,and performance metrics,adhering to PRISMA *** studies were identified and categorised into three groups:retinal photo-based(n=5),OCT-based(n=1),and external ocular photo-based(n=3).For high myopia prediction,retinal photo-based models achieved AUC between 0.91 and 0.98,sensitivity levels between 85.10%and 97.80%,and specificity levels between 76.40%and 94.50%.For continuous prediction,retinal photo-based models reported MAE ranging from 0.31D to 2.19D,and R^(2) between 0.05 and *** OCT-based model achieved an AUC of 0.79–0.81,sensitivity of 82.30%and 87.20%and specificity of 61.70%–68.90%.For external ocular photo-based models,the AUC ranged from 0.91 to 0.99,sensitivity of 81.13%–84.00%and specificity of 74.00%–86.42%,MAE ranges from 0.07D to 0.18D and accuracy ranges from 81.60%to 96.70%.The reported papers colle

关键词： Deep Learning Artificial Intelligence Refractive Error Retinal images Optical Coherence Tomography Photorefraction Ocular images Prediction

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