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Hepatitis A virus infection and hepatitis A vaccination in human immunodeficiency virus-positive patients: A review

World Journal of Gastroenterology 2017年第20期23卷 3589-3606页

作者： Kuan-Yin Lin Guan-Jhou Chen yu-Lin lee Yi-Chia Huang Aristine Cheng Hsin-yun Sun Sui-yuan Chang Chun-Eng Liu Chien-ching Hung Department of Medicine National Taiwan University Hospital Jin-Shan Branch Department of Internal Medicine National Taiwan University Hospital Department of Internal Medicine Changhua Christian Hospital National Taiwan University College of Medicine Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of Medicine Department of Laboratory Medicine National Taiwan University Hospital and National Taiwan University College of Medicine Department of Parasitology National Taiwan University College of Medicine Department of Medical Research China Medical University Hospital China Medical University

Hepatitis A virus(HAV)is one of the most common infectious etiologies of acute hepatitis *** virus is known to be transmitted fecal-orally,resulting in symptoms ranging from asymptomatic infection to fulminant *** can also be transmitted through oral-anal *** from regions of low endemicity for HAV infection often remain susceptible in their ***,clustered HAV infections or outbreaks of acute hepatitis A among men who have sex with men and injecting drug users have been reported in countries of low endemicity for HAV *** duration of HAV viremia and stool shedding of HAV may be longer in human immunodeficiency virus(HIV)-positive individuals compared to HIV-negative individuals with acute hepatitis *** guidelines recommend HAV vaccination for individuals with increased risks of exposure to HAV(such as from injecting drug use,oral-anal sex,travel to or residence in endemic areas,frequent clotting factor or blood transfusions)or with increased risks of fulminant disease(such as those with chronic hepatitis).The seroconversion rates following the recommended standard adult dosing schedule(2doses of HAVRIX 1440 U or VAQTA 50 U administered6-12 mo apart)are lower among HIV-positive individuals compared to HIV-negative *** the response rates may be augmented by adding a booster dose at week 4 sandwiched between the first dose and the 6-mo dose,the need of booster vaccination remain less clear among HIV-positive individuals who have lost anti-HAV antibodies.

关键词： Epidemiology Viral hepatitis Acute hepatitis Fecal-oral transmission Oral-anal sex Men who have sex with men Injecting drug use Immunosuppression Immunization

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T4 cervical esophageal cancer cured with modern chemoradiotherapy: A case report

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World Journal of Clinical Cases 2020年第10期8卷 1950-1957页

作者： Chia ching lee Chong Ming Yeo Wee Khoon Ng Akash Verma Jeremy CS Tey Department of Radiation Oncology National University Cancer InstituteNational University HospitalTan Tock Seng HospitalSingapore 119228Singapore Department of Medical Oncology Tan Tock Seng HospitalSingapore 308433Singapore Department of Gastroenterology and Hepatology Tan Tock Seng HospitalSingapore 308433Singapore Department of Respiratory and Critical Care Medicine Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND T4 esophageal cancer portends a poor prognosis,particularly when it is complicated by a tracheoesophageal fistula(TEF)either resulting from disease or occurring as a complication of *** with TEF that occurs during treatment are commonly treated with palliative intent because fistula-associated treatment complications such as aspiration pneumonia and mediastinitis are associated with high morbidity and *** date,there is no clear evidence on the optimal treatment of T4 esophageal cancer,particularly when a TEF formation *** SUMMARY A 67-year-old gentleman who presented with dysphagia and weight *** and imaging revealed a T4N1M0 cervical esophageal squamous cell *** received image-guided intensity-modulated radiation therapy,with concurrent weekly carboplatin(area under curve 2 mg/mL per minute)and paclitaxel(50 mg/m2 of body surface area).One week after treatment initiation(16.2 Gy thus far),he developed cough on swallowing.A TEF was detected on image-guided radiation therapy using cone-beam computed tomography during the treatment course,for which a tracheal stent was *** discussing the risks and morbidity of continuing treatment,he resumed chemoradiotherapy with an additional radiation dose of 45 Gy in 25 *** months after completion of chemoradiotherapy,he developed an esophageal stricture that required esophageal stenting and *** patient remains cancer-free at two year on *** response of esophageal cancer was evident on post-treatment endoscopy and computed tomography imaging,with successful closure of *** This case highlights that successful curative treatment for esophageal cancer complicated by a TEF is possible using novel chemotherapeutic regimens and modern radiation technologies.

关键词： Esophageal cancer Chemoradiotherapy Fistula Stenting T4 Case report

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Mimetic Preparation of Analogues of Territrem B, A Potent Acetylcholinesterase Inhibitor

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Chinese Chemical Letters 2000年第12期11卷 1045-1048页

作者： yu ZHAO yuan Ling KU Shoei Sheng lee Laboratory of Phytochemistry Kunming Institute of BotanyChinese Academy of SciencesKunming 650204 School of Pharmacy College of MedicineNational Taiwan UniversityTaipei 10018

A mimetic synthesis of a potent acetylcholinesterase inhibitor, Territrem B, was carried out from the naturally occurring jujubosides. The anti-AChE activity of the product, which possesses the 2-en-1-one pharmacophore and the aromatic ring, was measured. The aromatic ring moiety seemed to be less influencing when comparing with the 2-en-1-one moiety.

关键词： acetylcholinesterase inhibitor territrem B analogues jujubosides

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Preparation of AChE Inhibitors From Jujubogenin

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Chinese Chemical Letters 2000年第8期11卷 671-674页

作者： yu ZHAO yuan Ling KU Shoei Sheng lee Laboratory of Phytochemistry Kunnming Institute of BotanyChinese Academy of SciencesKunming 650204 School of Pharmacy College of MedicineNational Taiwan UniversityTaipei 10018

A dammarane derivative dihydrojujubogenin-2-en-1-one, which possesses a skeleton and pharmacophore partially similar to those of Territrem B, a potent AChE inhibitor, was synthesized via three different paths. The ant... 详细信息

关键词： Alzheimer disease (AD) acetylcholinesterase AChE inhibitor pharmaceutical chemistry jujubogenin Territrem B analogues

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Differential DNA methylation analysis of SUMF2,ADAMTS5,and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

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World Journal of Gastroenterology 2022年第8期28卷 825-839页

作者： Jing-Quan Su Pin-yu Lai Pei-Hsuan Hu Je-Ming Hu Pi-Kai Chang Chao-Yang Chen Jia-Jheng Wu yu-Jyun Lin Chien-An Sun Tsan Yang Chih-Hsiung Hsu Hua-ching Lin yu-ching Chou School of Medicine National Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Department of surgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Health Business Administration Meiho UniversityPingtung County 912TaiwanChina Division of Colorectal Surgery Department of SurgeryCheng-Hsin General HospitalTaipei 112TaiwanChina

BACKGROUND Patients with colorectal cancer(CRC)undergo surgery,as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node–metastasis(TNM)cancer staging ***,treatment responses and prognostic outcomes of patients within the same stage vary *** potential use of novel biomarkers can improve prognostication and shared decision making before implementation into certain *** To investigate whether SUMF2,ADAMTS5,and PXDN methylation status could be associated with CRC *** We conducted a Taiwan region cohort study involving 208 patients with CRC recruited from TriService General Hospital and applied the candidate gene approach to identify three genes involved in oncogenesis pathways.A methylation-specific polymerase chain reaction(MS-PCR)and Epi TYPER DNA methylation analysis were employed to detect methylation status and to quantify the methylation level of candidate genes in tumor tissue and adjacent normal tissue from *** evaluated SUMF2,ADAMTS5,and PXDN methylation as predictors of prognosis,including recurrence-free survival(RFS),progression-free survival(PFS),and overall survival(OS),using a Cox regression model and Kaplan–Meier *** We revealed various outcomes related to methylation and *** shorter PFS and OS were associated with the CpG_3+CpG_7 hypermethylation of SUMF2 from tumor tissue compared with CpG_3+CpG_7 hypomethylation[hazard ratio(HR)=2.24,95%confidence interval(CI)=1.03-4.85 for PFS,HR=2.56 and 95%CI=1.08-6.04 for OS].By contrast,a significantly longer RFS was associated with CpG_2 and CpG_13 hypermethylation of ADAMTS5 from normal tissue compared with CpG_2 and CpG_13 hypomethylation[HR(95%CI)=0.15(0.03-0.71)for CpG_2 and 0.20(0.04-0.97)for CpG_13].The relationship between the methylation status of PXDN and the prognosis of CRC did not reach statistical *** Our study found that CpG_3+CpG_7 hypermethylation o

关键词： DNA methylation Biomarkers Tumor tissue Adjacent normal tissue Prognosis prediction Colorectal cancer

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Coexistence of urinary tuberculosis and urothelial carcinoma:A case report

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World Journal of Clinical Cases 2023年第16期11卷 3921-3928页

作者： yu-Chi Tsai Chiao-ching Li Bing-Tau Chen Chien-Yao Wang Division of Infectious Diseases Department of Internal MedicineKaohsiung Armed Forces General HospitalKaohsiung 802301Taiwan Division of Infectious Diseases and Tropical Medicine Department of Internal MedicineTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan Division of Urology Department of SurgeryPingtung branchKaohsiung Armed Forces General HospitalPingtung 900048Taiwan Division of Urology Department of SurgeryKaohsiung Armed Forces General HospitalKaohsiung 802301Taiwan Division of Urology Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan Division of Urology Department of SurgeryKaohsiung Veterans General HospitalKaohsiung Veterans General HospitalKaohsiung 813414Taiwan

BACKGROUND Taiwan has a high prevalence of tuberculosis and urothelial ***,the simultaneous occurrence of both disorders in one patient is *** and urothelial carcinoma share some common risk factors and could demonstrate overlapping clinical *** SUMMARY Herein,we report the case of a patient who presented with fever,persistent hematuria,and *** computed tomography scans revealed a bilateral upper lobes cavitary lesion with *** hydronephrosis of the right kidney and renal stones and cysts in the left kidney were *** microbiological testing was negative;however,a polymerase chain reaction assay of the urine confirmed a urinary tuberculosis *** patient was started on an anti-tuberculosis *** performed to resolve obstructive nephropathy revealed the incidental finding of a left middle-third ureteral *** after biopsy and transurethral resection of the bladder tumor indicated urothelial *** patient underwent laparoscopic nephroureterectomy,with bladder cuff excision for the right kidney and ureter,and holmium laser ablation of the ureteral lesion to preserve the left kidney and *** has remained stable after the *** Although establishing a causal relationship between tuberculosis and cancer is difficult,medical personnel should consider their correlation.

关键词： Urinary tuberculosis Urothelial carcinoma Fever Hematuria Taiwan Case report

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Tunable multiband terahertz metamaterials using a reconfigurable electric split-ring resonator array

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Light(Science & Applications) 2014年第1期3卷 211-218页

作者： Fusheng Ma yu-Sheng Lin Xinhai Zhang Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117576Singapore Institute of Materials Research and Engineering A*STARSingapore 117602Singapore

We demonstrate micromachined reconfigurable metamaterials working at multiple frequencies simultaneously in the terahertz *** proposed metamaterial structures can be structurally reconfigured by employing flexible microelectromechanical system-based cantilevers in the resonators,which are designed to deform out of plane under an external *** proposed metamaterial structures provide not only multiband resonance frequency operation but also polarization-dependent *** kinds of metamaterials are investigated as electric split-ring resonator(eSRR)arrays with different positions of the *** moving the position of the split away from the resonator’s center,the eSRR exhibits anisotropy,with the dipole resonance splitting into two *** dipole–dipole coupling strength can be continuously adjusted,which enables the electromagnetic response to be tailored by adjusting the direct current(DC)voltage between the released cantilevers and the silicon *** observed tunability of the eSRRs is found to be dependent on the polarization of the incident terahertz *** polarization-dependent tunability is demonstrated by both experimental measurements and electromagnetic simulations.

关键词： MEMS reconfigurable metamaterials split-ring resonator terahertz tunability

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H■rmander's Multipliers for the Weighted Herz-type Hardy Spaces

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Acta Mathematica Sinica,English Series 2006年第5期22卷 1509-1518页

作者： Ming Yi lee Chin Cheng LIN yu Tien LIN Institute of Mathematics Academia Sinica Taipei 115 China ( Taiwan) Department of Mathematics National Central University Chung-Li 320 China (Taiwan)

In this article, we apply the molecular characterization of the weighted Hardy space developed by the first two authors to show the boundedness of Hormander multiplier on the weighted Herz-type Hardy spaces HK^α,p 2... 详细信息

关键词： Ap weights Herz-type Hardy spaces Hormander's multipliers Weighted Hardy spaces

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Acid Blue 25 adsorption on base treated Shorea dasyphylla sawdust:Kinetic,isotherm,thermodynamic and spectroscopic analysis

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Journal of Environmental Sciences 2012年第2期24卷 261-268页

作者： Megat Ahmad Kamal Megat Hanafiah Wan Saime Wan Ngah Shahira Hilwani Zolkafly lee ching Teong Zafri Azran Abdul Majid Department of Chemistry Faculty of Applied SciencesUniversiti Teknologi MARA School of Chemical Sciences Universiti Sains Malaysia Kulliyyah of Allied Health Sciences International Islamic University Malaysia

The potential of base treated Shorea dasyphylla（BTSD） sawdust for Acid Blue 25（AB 25） adsorption was investigated in a batch adsorption *** physiochemical parameters such as pH,stirring rate,dosage,concentration,contact time and temperature were *** adsorbent was characterized with Fourier transform infrared spectrophotometer,scanning electron microscope and Brunauer,Emmett and Teller *** optimum conditions for AB 25 adsorption were pH 2,stirring rate 500 r/min,adsorbent dosage 0.10 g and contact time 60 *** pseudo second-order model showed the best conformity to the kinetic *** equilibrium adsorption of AB 25 was described by Freundlich and Langmuir,with the latter found to agree well with the isotherm *** maximum monolayer adsorption capacity of BTSD was 24.39 mg/g at 300 K,estimated from the Langmuir *** parameters such as Gibbs free energy,enthalpy and entropy were *** was found that AB 25 adsorption was spontaneous and exothermic.

关键词： Acid Blue 25 adsorption Shorea dasyphylla sawdust spectroscopy thermodynamic

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Efficacy and safety of transnasal butorphanol for pain relief after anal surgery

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World Journal of Gastroenterology 2009年第38期15卷 4829-4832页

作者： Chen-Ming Mai Liang-Tsai Wan yu-ching Chou Hsiang-yu Yang Chang-Chieh Wu Shu-Wen Jao Cheng-Wen Hsiao Department of Surgery Huailien Armed Forces General Hospital Huailien 97144 Taiwan China Division of Colorectal Surgery Department of Surgery Tri-Service General Hospital National Defense University Taipei 11490 Taiwan China School of Public Health National Defense Medical Center Taipei 11490 Taiwan China

AIM:To compare the analgesic properties and efficacy of transnasal butorphanol with intramuscular meperidine after anal ***: Sixty patients who underwent fistulectomy were enrolled in the study from January 2006 to December 2007. They were randomly divided into transnasal butorphanol (n=30) or intramuscular meperidine (n=30) treatment groups. Assessment of postoperative pain was made using a visual analogue scale (VAS). The VAS score was recorded 6 h after the completion of surgery, before receiving the first dose of analgesic, 60 min after analgesia and the next morning. Any adverse clinical effects such as somnolence, dizziness, nausea or vomiting were recorded. Satisfaction with narcotic efficacy, desire to use the particular analgesic in the future and any complaints were recorded by patients using questionnaires before being ***: Forty-two men and eighteen women were included in the study. There were no significant differences in VAS scores between the groups within 24 h. Length of hospital stay and the incidence of adverse effects between the groups were similar. In addition, most patients were satisfied with butorphanol nasal spray and wished to receive this analgesic in the future, if ***: Butorphanol nasal spray is effective for the relief of pain after fistulectomy. However, it offered patients more convenient usage and would be suitable for outpatients.

关键词： Butorphanol Fistulectomy Meperidine Opioid

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