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褪黑激素对严重烧伤大鼠迟发型超敏反应的影响

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中国临床康复 2006年第32期10卷 89-91页

作者：韩晓华温冠清青岛大学医学院生理学教研室山东省青岛市266021 香港理工大学护理学院

目的:观察褪黑激素对30%Ⅲ度烧伤大鼠迟发型超敏反应的影响,估计它在严重烧伤中的免疫调节作用。方法:实验于2005-07/12在青岛大学医学院完成。24只SD大鼠数字表法随机分为对照组、烧伤组及褪黑激素组,每组8只。烧伤组及褪黑激素组麻醉... 详细信息

目的:观察褪黑激素对30%Ⅲ度烧伤大鼠迟发型超敏反应的影响,估计它在严重烧伤中的免疫调节作用。方法:实验于2005-07/12在青岛大学医学院完成。24只SD大鼠数字表法随机分为对照组、烧伤组及褪黑激素组,每组8只。烧伤组及褪黑激素组麻醉状态下将动物背部皮肤置于沸水中15s制备烧伤模型,对照组大鼠背部皮肤置于37℃水中15s。对照组和烧伤组伤后立即腹腔注射溶剂(体积分数为0.01的乙醇生理盐水),而褪黑激素组注射剂量为10mg/kg的褪黑激素,烧伤当天下午4点补充注射一次药物或溶剂,此后按同法每天注射一次至伤后第7天。末次注射后立即将5g/L二硝基氟苯溶液100μL涂抹于大鼠腹部,次日同法强化一次,以诱导迟发型超敏反应。致敏后第5天,测定大鼠右耳肿胀百分率(对照组定义为100%)代表迟发型超敏反应强度。此外,还测定烧伤前后外周血白细胞计数,估计动物的一般免疫反应状态。结果:24只大鼠全部进入结果分析。①右耳肿胀百分率:烧伤组大鼠显著低于对照组[(41.2±8.2)%,(100±7.6)%,P<0.001],褪黑激素组高于烧伤组[(73.0±10.1)%,P<0.01],但仍低于对照组水平(P<0.05)。②外周血白细胞计数:烧伤组及褪黑激素组大鼠在烧伤后12h内均明显升高(P<0.05),伤后72h和120h,两实验组白细胞再次出现升高(P<0.05),褪黑激素组白细胞数值在这两个时间点均明显低于烧伤组水平(P<0.05,0.01)。结论:褪黑激素治疗能明显改善烧伤大鼠严重受抑的迟发型超敏反应,提示它在烧伤中可能具有免疫调节作用。

关键词：褪黑激素烧伤超敏反应,迟发型大鼠

A New Disaccharide from the Fern Macrothelypteris digophlebia

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Chinese Chemical Letters 2000年第12期11卷 1063-1064页

作者： Ming hua QIU Jin Ming GAO Hu Qi LIU Jian Xi FU Kunming Institute of Botany The Chinese Academy of SciencesKunming 650204 Northwest Sci.&Tech.University of Agriculture and Forestry YanglingShaanxi 712100

A new disaccharide, digobiose 1, was isolated from the rhizomes of Macrothelypteris digophlebia (Bak.) ching var. elegans (koidz.). Its structure which is very similar with that of sucrose was identified as alpha -D-g... 详细信息

关键词： Macrothelypteris digophlebia Disaccharide digobiose.

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运动如何使人长寿

中国食品学报 2012年第8期12卷 1-10页

作者：郭家骅陈昱青台北体院运动科学研究所台北11153

以往研究一致表明,经常运动的人未来的死亡风险(relative risk in mortality)明显下降,规律运动确实可延长人类寿命,并且这个长寿效果与运动挑战的量成正比。很有趣的是,运动造成能量储存减少,肌肉损伤与氧化伤害指数提高,且与运动强度... 详细信息

以往研究一致表明,经常运动的人未来的死亡风险(relative risk in mortality)明显下降,规律运动确实可延长人类寿命,并且这个长寿效果与运动挑战的量成正比。很有趣的是,运动造成能量储存减少,肌肉损伤与氧化伤害指数提高,且与运动强度和伤害指数成正比。为何造成短暂伤害可使人长寿?主要的原因是运动使得人体对细胞除旧布新(cell renewal)。这个结果使组织年轻化,强化身体承受挑战的能力。从另外的角度来看,人体是多细胞生物,能有效联合众多细胞分工合作,应付外在挑战后迅速恢复,仰赖细胞彼此间有效的讯息沟通。老化使细胞间的沟通灵敏度下降,各组织资源分配不均(例如肥胖、癌症、肌少症),为降低人体众多细胞合作共生的负面因素,使人体生存能力下降。运动使肌肉组织持续获得合理的养分分配。缺乏运动者,除了肌肉细胞汰旧换新速度慢外,资源分配给肌肉的量减少,转向脂肪组织与肝脏储存的比例增加,肥胖的脂肪细胞进一步透过内分泌讯息(adipokines)降低肌肉细胞对胰岛素的敏感度,抑制肌肉细胞对葡萄糖的吸收储存能力。肌肉是全身最主要的醣类储存库,养分储存能力退化,除了造成体能下降外,未被吸收的葡萄糖滞留在血液中逐渐形成高血糖而使全身各处蛋白质被糖化增加(protein glycation),被糖化的蛋白因结构改变将遭受免疫细胞辨识为不正常的蛋白,进而释放出大量自由基攻击消灭。因此,高血糖将造成持续性氧化伤害,使全身蛋白进一步氧化,全身蛋白结构进一步改变,造成恶性循环,低度的慢性发炎(Low grade chronic inflammation)或自体免疫攻击(Autoimmune attack),最后发展成糖尿病、高血压、心脏病、中风、癌症等发炎相关疾病。流行病学研究发现生命期血糖上升速度愈快的人,寿命愈短。因此,通过运动使身体年轻化,提高肌肉细胞对胰岛素的敏感度来维持正常的葡萄糖的吸收能力,进而避免高血糖的发生。如此,既可保持好身材、避免肥胖、保持好体能,又可延长寿命。

关键词：运动肌肉肥胖发炎胰岛素

Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage

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World Journal of Gastroenterology 2013年第5期19卷 673-681页

作者： Peter G Arthur Xian-Wa Niu Wen-hua huang Bastiaan DeBoer ching Tat Lai Enrico Rossi John Joseph Gary P Jeffrey School of Biomedical Biomolecular and Chemical Sciencesthe University of Western AustraliaCrawleyWA 6009Australia School of Medicine and Pharmacology the University of Western AustraliaCrawleyWA 6009Australia Gastroenterology/Hepatology Sir Charles Gairdner HospitalNedlandsWA 6009Australia WA Liver and Kidney Transplantation Services QEII Medical CentreHospital AvenueNedlandsWA 6009Australia Division of Anatomical Pathology PathWestQEII Medical CentreHospital AvenueNedlandsWA 6009Australia Department of Biochemistry Path-WestQEII Medical CentreHospital AvenueNedlandsWA6009Australia

AIM:To evaluate whether desferrioxamine decreases ischemia and perfusion injury aggravated by cold storage(CS)in a rat liver perfusion model. METHODS:Isolated rat livers were kept in CS in University of Wisconsin Solution for 20 h at 4℃,then exposed to 25 min of warm ischemia(WI)at 37℃ followed by 2 h of warm perfusion(WP)at 37℃with oxygenated(95%oxygen and 5%carbon dioxide) Krebs-Henseleit ***(DFO),an iron chelator,was added at different stages of storage,ischemia and perfusion:in CS only,in WI only,in WP only, in WI and perfusion,or in all *** samples were collected after CS and after *** samples and bile were collected every 30 min(0,0.5,1,1.5 and 2 h)during liver *** injury was assessed by the determination of lactate dehydrogenase(LDH) and aspartate aminotransferase(AST)in the effluent and perfusate *** iron was analysed in the perfusate *** WP,the liver was collected for the determination of liver swelling(wet to dry ratio) and liver morphological examination(hematoxylin and eosin staining). RESULTS:Increased CS time caused increased liver dysfunction during *** 2 h of WP,liver injury was indicated by increased release of AST(0.5 h CS:9.4± 2.2 U/g liver vs 20 h CS:45.9±10.8 U/g liver,P<0.05) and LDH(0.5 h CS:59±14 U/g liver vs 20 h CS:297 ±71 U/g liver,P<0.05).There was an associated increase in iron release into the perfusate(0.5 h CS:0.11 ±0.03μmoL/g liver vs 20 h CS:0.58±0.10μmoL/g liver,P<0.05)and reduction in bile flow(0.5 h CS: 194±12μL/g vs 20 h CS:71±8μL/g liver,P<0.05). When DFO was added during WI and WP following 20 h of CS,release of iron into the perfusate was de- creased(DFO absent 0.58±0.10μmoL/g liver vs DFO present 0.31±0.06μmoL/g liver,P<0.05),and liver function substantially improved with decreased release of AST(DFO absent 45.9±10.8 U/g liver vs DFO present 8.1±0.9 U/g liver,P<0.05)and LDH(DFO absent 297±71 U/g liver vs DFO present 56±7 U/g liver,P<0.05),and inc

关键词： Iron chelation Ischemia and perfusion injury Liver Organ preservation Rat

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矩形三合板的稳定问题

物理学报 1955年第3期 239-258页

作者：杜庆华清华大学

一.引言矩形三合板的稳定问题为高速飞机结构设针中经常遇到的实验问题,本文根据[1]所得的一般方程配合边界条件以求解。文中处理在一个方向受有均匀分布载荷、四边简支的矩形板及两边简支两边自由的矩形板,在形变初起的情况下若仅求... 详细信息

一.引言矩形三合板的稳定问题为高速飞机结构设针中经常遇到的实验问题,本文根据[1]所得的一般方程配合边界条件以求解。文中处理在一个方向受有均匀分布载荷、四边简支的矩形板及两边简支两边自由的矩形板,在形变初起的情况下若仅求临界载荷以供设计用则方程可以考虑作为線性,因之可以藉双三角函

关键词：翘曲合板弹性欧拉力学性能型式牛波

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三合板的一般弹性理论

物理学报 1954年第4期 395-411页

作者：杜庆华清华大学

一.引言本文所指之三合板是一种轻质板材,在航空工业上近年来有广泛的应用。板由三层材料构成:外层为二硬薄钣(金属薄钣),夹心为较轻软之材料(如泡状醋酸赛璐珞、软木、或蜂巢状金属材料)。前者称为表钣,后者称为夹心,表钣与夹心胶合... 详细信息

一.引言本文所指之三合板是一种轻质板材,在航空工业上近年来有广泛的应用。板由三层材料构成:外层为二硬薄钣(金属薄钣),夹心为较轻软之材料(如泡状醋酸赛璐珞、软木、或蜂巢状金属材料)。前者称为表钣,后者称为夹心,表钣与夹心胶合成一综合板。三合板之形变与应力之计算在十多年来曾引起力学家与工

关键词：方程合板弹性力弹簧力外力等向性三式限制所得弹性支撑代入

Action Recognition Using Multi-Scale Temporal Shift Module and Temporal Feature Difference Extraction Based on 2D CNN

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Journal of Software Engineering and Applications 2021年第5期14卷 172-188页

作者： Kun-Hsuan Wu ching-Te Chiu Department of Computer Science National Tsing Hua University Taiwan

Convolutional neural networks, which have achieved outstanding performance in image recognition, have been extensively applied to action recognition. The mainstream approaches to video understanding can be categorized into two-dimensional and three-dimensional convolutional neural networks. Although three-dimensional convolutional filters can learn the temporal correlation between different frames by extracting the features of multiple frames simultaneously, it results in an explosive number of parameters and calculation cost. Methods based on two-dimensional convolutional neural networks use fewer parameters;they often incorporate optical flow to compensate for their inability to learn temporal relationships. However, calculating the corresponding optical flow results in additional calculation cost;further, it necessitates the use of another model to learn the features of optical flow. We proposed an action recognition framework based on the two-dimensional convolutional neural network;therefore, it was necessary to resolve the lack of temporal relationships. To expand the temporal receptive field, we proposed a multi-scale temporal shift module, which was then combined with a temporal feature difference extraction module to extract the difference between the features of different frames. Finally, the model was compressed to make it more compact. We evaluated our method on two major action recognition benchmarks: the HMDB51 and UCF-101 datasets. Before compression, the proposed method achieved an accuracy of 72.83% on the HMDB51 dataset and 96.25% on the UCF-101 dataset. Following compression, the accuracy was still impressive, at 95.57% and 72.19% on each dataset. The final model was more compact than most related works.

关键词： Action Recognition Convolutional Neural Network 2D CNN Temporal Relationship

中文阅读中主题与语意信息在句子加工中的作用

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心理学报 2000年第1期32卷 7-12页

作者：周静仪陈少芳宋华香港中文大学心理系

采用移动窗口技术，初步探讨了主题、语意信息在句子早期加工中的作用。结果发现：（１）在中文阅读中，当主题信息比较弱时，对句子的早期加工没有作用；当主题信息比较强时，对句子的早期加工有作用。（２）句子语意信息的加工是即时的。

关键词：移动窗口中文阅读句子加工主题信息语音信息

Resource Efficient Hardware Implementation for Real-Time Traffic Sign Recognition

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Journal of Transportation Technologies 2018年第3期8卷 209-231页

作者： huai-Mao Weng ching-Te Chiu Department of Electrical Engineering National Tsing-Hua University Taiwan

Traffic sign recognition (TSR, or Road Sign Recognition, RSR) is one of the Advanced Driver Assistance System (ADAS) devices in modern cars. To concern the most important issues, which are real-time and resource efficiency, we propose a high efficiency hardware implementation for TSR. We divide the TSR procedure into two stages, detection and recognition. In the detection stage, under the assumption that most German traffic signs have red or blue colors with circle, triangle or rectangle shapes, we use Normalized RGB color transform and Single-Pass Connected Component Labeling (CCL) to find the potential traffic signs efficiently. For Single-Pass CCL, our contribution is to eliminate the “merge-stack” operations by recording connected relations of region in the scan phase and updating the labels in the iterating phase. In the recognition stage, the Histogram of Oriented Gradient (HOG) is used to generate the descriptor of the signs, and we classify the signs with Support Vector Machine (SVM). In the HOG module, we analyze the required minimum bits under different recognition rate. The proposed method achieves 96.61% detection rate and 90.85% recognition rate while testing with the GTSDB dataset. Our hardware implementation reduces the storage of CCL and simplifies the HOG computation. Main CCL storage size is reduced by 20% comparing to the most advanced design under typical condition. By using TSMC 90 nm technology, the proposed design operates at 105 MHz clock rate and processes in 135 fps with the image size of 1360 × 800. The chip size is about 1 mm2 and the power consumption is close to 8 mW. Therefore, this work is resource efficient and achieves real-time requirement.

关键词： Traffic Sign Recognition Advanced Driver Assistance System Real-Time Processing Color Segmentation Connected Component Analysis Histo-gram of Oriented Gradient Support Vector Machine German Traffic Sign Detection Benchmark CMOS ASIC VLSI