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World Journal of Gastroenterology 2005年第30期11卷 4764-4765页

作者： Ming-Jen Chen ching-chung lin Wen-Hsiung Chang Fei-Shih Yang Division of Gastroenterology Department of Radiation

Biloma is an encapsulated bile collection outside the biliary tree due to a bile leak. It is occasionally found following traumatic liver injury or iatrogenic injury to the biliary tract, induced either during an endoscopic or surgical procedure. It is a rare complication of transcatheter arterial embolization (TAE). Although biloma can be shrunk by appropriate aspiration or drainage in majority of cases,we report a case of intrahepatic biloma following repeated TAE for hepatocellular carcinoma (HCC) and complicated by infection and intrahepatic stones. This particular constellation of problems has not been reported before and the intrahepatic stones need to be removed by percutaneous procedure.

关键词： Biloma Biliary tract Transcatheter Arterial embolization

Clinical predictors of severe gallbladder complications in acute acalculous cholecystitis

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World Journal of Gastroenterology 2003年第12期9卷 2821-2823页

作者： Ay-Jiun Wang Tsang-En Wang ching-chung lin Shee-Chan lin Shou-Chuan Shih Division of GastrOenterology Department of Internal MedicineMackay Memorial HospitalTaipeiTaiwanChina

AIM: To evaluate the relationship between clinical information (including age, laboratory data, and sonographic findings) and severe complications, such as gangrene,perforation, or abscess, in patients with acute acalculous cholecystitis (AAC).METHODS: The medical records of patients hospitalized from January1997 to December 2002 with a diagnosis of acute cholecystitis were retrospectively reviewed to find those with AAC, confirmed at operation or by histologic examination. Data collected included age, sex, white blood cell count, AST, total bilirubin, alkaline phosphatase,bacteriology, mortality, and sonographic findings. The sonographic findings were recorded on a 3-point scale with 1 point each for gallbladder distention, gallbladder wall thickness ＞3.5 mm, and sludge. The patients were divided into 2 groups based on the presence (group A) or absence (group B) of severe gallbladder complications, defined as perforation, gangrene, or ***: There were 52 cases of AAC, accounting for 3.7% of all cases of acute cholecystitis. Males *** patients were diagnosed by ultrasonography (48 of 52) or computed tomography (17 of 52). Severe gallbladder complications were present in 27 patients (52 %, group A) and absent in 25(group B).Six patients died with a mortality of 12 %.Four of the 6 who died were in group *** in group A were significantly older than those in group A were significantly older than those in group B (mean 60.88 y vs. 54.12 y, P=0.04) and had a significantly higher white blood cell count (mean 15 885.19 vs. 9 948.40,P=0.0005). All the 6 patients who died had normal white blood cell counts with an elevated percentage of band *** most commonly cultured bacteria in both blood and bile were E. Coli and Klebsiella pneurnoniae. The cumulative sonographic points did not reliably distinguish between groups A and B, even though group A tended to have more ***: Older patients with a high white cell count are more li

关键词：急性胆囊炎并发症临床特点早期诊断急腹症

Outcome of simple use of mechanical lithotripsy of difficult common bile duct stones

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World Journal of Gastroenterology 2005年第4期11卷 593-596页

作者： Wen-Hsiung Chang Cheng-Hsin Chu Tsang-En Wang Ming-Jen Chen ching-chung lin Division of Gastroenterology Department of Internal Medicine Mackay Memorial HospitalMackay MedicineNursing and Management college TaipeiTaiwan

AIM: The usual bile duct stone may be removed by means of Dormia basket or balloon catheter, and results are quite good. However, the degree of difficulty is increased when stones are larger. Studies on the subject reported many cases where mechanical lithotripsy is combined with a second technique, e.g. electrohydraulic lithotripsy (EHL), where stones are crushed using baby-mother scope electric shock. The extracorporeal shock-wave lithotripsy (ESWL) or laser lithotripsy also yields an excellent success rate of greater than 90%. However, the equipment for these techniques are very expensive; hence we opted for the simple mechanical lithotripsy and evaluated its performance. METHODS: During the period from August 1996 to December 2002, Mackay Memorial Hospital treated 304 patients suffering from difficult bile duct stones (stone>1.5 cm or stones that could not be removed by the ordinary Dormia basket or balloon catheter). These patients underwent endoscopic papillotomy (EPT) procedure, and stones were removed by means of the Olympus BML-4Q lithotripsy. A follow-up was conducted on the post-treatment conditions and complications of the patients. RESULTS: Out of the 304 patients, bile duct stones were successfully removed from 272 patients, a success rate of about 90%. The procedure failed in 32 patients, for whom surgery was needed. Out of the 272 successfully treated patients, 8 developed cholangitis, 21 developed pancreatitis, and 10 patients had delayed bleeding, and no patient died. Among these 272 successful removal cases, successful bile duct stone removal was achieved after the first lithotripsy in 211 patients, whereas 61 patients underwent multiple sessions of lithotripsy. As for the 61 patients that underwent multiple sessions of mechanical lithotripsy, 6 (9.8%) had post-procedure cholangitis, 12 (19.6%) had pancreatitis, and 9 patients (14.7%) had delayed bleeding. Compared with the 211 patients undergoing a single session of mechanical lithotripsy, 3 (1.4

关键词： Common bile duct stones Mechanical lithotripsy

Acute transient hepatocellular injury in cholelithiasis and cholecystitis without evidence of choledocholithiasis

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World Journal of Gastroenterology 2009年第30期15卷 3788-3792页

作者： Chen-Wang Chang Wen-Hsiung Chang ching-chung lin Cheng-Hsin Chu Tsang-En Wang Shou-Chuan Shih Wen-Hsiung Chang Ching-Chung Lin Cheng-Hsin Chu Tsang-En Wang Division of Gastroenterology Department of Intemal Medicine Mackay Memorial Hospital Mackay Medicine Nursing and Management College Taipei 10449 Taiwan China Division of Gastroenterology Department of Internal Medicine Health Evaluation Center Mackay Memorial Hospital Mackay Medicine Nursing and Management College Taipei 10449 Taiwan China

AIM： To investigate acute transient hepatocellular injury in patients with cholelithiasis and cholecystitis but no evidence of choledocholithiasis.METHODS： The medical records of patients with cholelithiasis who underwent cholecystectomy between July 2003 and June 2007 were retrospectively reviewed. Imaging studies to detect common bile duct （CBD） stones were performed in 186 patients, who constituted the study population. Biochemical liver tests before and after surgery, and with the presence or absence of CBD stones were analyzed.RESULTS： In 96 patients with cholelithiasis and cholecystitis without evidence of CBD stones, 49 （51.0%） had an alanine aminotransferase level elevated to 2-3 times the upper limit of normal, and 40 （41.2%） had an elevated aspartate aminotransferase level. Similar manifestations of hepatocellular injury were, as would be expected, even more obvious in the 90 patients with CBD stones. These markers of hepatocellular injury resolved almost completely within 2 wk to 1 mo after cholecystectomy. Compared to 59 patients with histologically less severe cholecystitisin the group undergoing urgent surgery （total 74 patients）, the 15 patients with a gangrenous gallbladder had a higher mean level of total bilirubin （2.14 ± 1.27 mg/dL vs 2.66 ± 2.97 mg/dL, P 〈 0.001） and white cell count （9480 ± 4681/μL vs 12840 ± 5273/μL, P = 0.018）.CONCLUSION： Acute hepatocellular injury in cholelithiasis and cholecystitis without choledocholithiasis is mild and transient. Hyperbilirubinemia and leukocytosis may predict severe inflammatory changes in the gallbladder.

关键词： Acute transient hepatitis Cholelithiasis Cholecystitis Hyperbilirubinemia Leukocytosis

Training gastroenterology fellows to perform gastric polypectomy using a novel ex vivo model

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World Journal of Gastroenterology 2011年第41期17卷 4619-4624页

作者： Ming-Jen Chen ching-chung lin Chia-Yuan Liu Chih-Jen Chen Chen-Wang Chang ching-Wei Chang Chien-Wei Lee Shou-Chuan Shih Horng-Yuan Wang Division of Gastroenterology Department of Internal MedicineMackay Memorial Hospital Mackay Medicine Nursing and Management College Clinical Skills Training Center Department of Medical EducationMackay Memorial Hospital Mackay Medical College

AIM:To evaluate the effect of hands-on training of gastroenterology fellows in gastric polypectomy using an ex vivo ***:Eight gastroenterology fellows at Mackay Memorial Hospital,Taipei were evaluated in gastricpolypectomy techniques using a pig stomach with artificial polyps created by a rubber band ligation *** performance of four second year(year-2)fellows who had undergone one year of clinical training was compared with that of four f irst year(year-1)fellows both before and after a 4-h workshop using the ex vivo *** workshop allowed for hands-on train-ing in the removal of multiple artif icial polyps and the placement of hemoclips at the excision *** included observation of technical skills,procedure time,and the fellows' conf idence ***:One week after the workshop,the year-1 fellows were re-evaluated and had significantly im-proved mean performance scores(from 17.9 ± 1.8 to 22.5 ± 0.7),conf idence scale(from 4.5 ± 1.0 to 7.8 ± 0.5)and procedure time(from 615.0 ± 57.4 s to 357.5 ± 85.0 s)compared with their baseline *** 4 h of training using the ex vivo simulator,the skills of the year-1 fellows were statistically similar to those of the year-2 ***:Use of this ex vivo simulator significantly improved the endoscopic gastric polypectomy skills of gastroenterology fellows who had not had previous clinical training in gastric polypectomy.

关键词： Ex vivo Animal tissue model Hands-on training Pig stomach Polypectomy

Etoposide sensitizes CT26 colorectal adenocarcinoma to radiation therapy in BALB/c mice

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World Journal of Gastroenterology 2005年第31期11卷 4895-4898页

作者： Chia-Yuan Liu Hui-Fen Liao Tsang-En Wang Shee-Chan lin Shou-Chuan Shih Wen-Hsuing Chang Yuh-Cheng Yang ching-chung lin Yu-Jen Chen Division of Gastroenterology Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Medical Research Mackay Memorial HospitalTaipei Taiwan China Department of Molecular Biology and Biochemistry National Chiayi University Chiayi 300 Taiwan China Nursingand Management College Taipei Taiwan China Department of Radiation Oncology Mackay Memorial Hospital Taipei Taiwan China

AIM： To investigate the combined effect of etoposide and radiation on CT26 colorectal adenocarcinoma implanted into BALB/c mice. METHODS： We evaluated the radiosensitizing effect of etoposide on CT26 colorectal adenocarcinoma in a syngeneic animal model. BALB/c mice were subcutaneously implanted with CT26 cells and divided into four groups： Gonlyol （intra-peritoneal saline×2） group, etoposide （5 mg/kg intra-peritoneally×2） group, radiation therapy （RT 5 Gy×2 fractions） group, and combination therapy with etoposide （5 mg/kg intra-peritoneally 1 h before radiation） group. RESULTS： Tumor growth was significantly inhibited by RT and combination therapy. The effect of combination therapy was better than that of RT. No significant changes were noted in body weight, plasma alanine aminotransferase, or creatinine in any group. The leukocyte count significantly but transiently decreased in the RT and combination therapy groups, but not in the etoposide and control groups. There was no skin change or hair loss in the RT and combination therapy groups. CONCLUSION： Etoposide can sensitize CT26 colorectal adenocarcinoma in BALB/c mice to RT without significant toxicity.

关键词： Etoposide (VP-16) Colorectal adenocarcinoma CT26 BALB/c mice Radiosensitization

Benign esophageal lesions: Endoscopic and pathologic features

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World Journal of Gastroenterology 2015年第4期21卷 1091-1098页

作者： Shu-Jung Tsai ching-chung lin Chen-Wang Chang Chien-Yuan Hung Tze-Yu Shieh Horng-Yuan Wang Shou-Chuan Shih Ming-Jen Chen Division of Gastroenterology Department of Internal MedicineMackay Memorial Hospital Department of Nursing Nursing and Management Mackay Junior College of Medicine Mackay Medical College

Benign esophageal lesions have a wide spectrum of clinical and pathologic features. Understanding the endoscopic and pathologic features of esophageal lesions is essential for their detection, differential diagnosis, and management. The purpose of this review is to provide updated features that may help physicians to appropriately manage these esophageal lesions. The endoscopic features of 2997 patients are reviewed. In epithelial lesions, the frequency of occurrence was in the following order: glycogenic acanthosis, heterotopic gastric mucosa, squamous papilloma, hyperplastic polyp, ectopic sebaceous gland and xanthoma. In subepithelial lesions, the order was as follows: hemangioma, leiomyoma, dysphagia aortica and granular cell tumor. Most benign esophageal lesions can be diagnosed according to their endoscopic appearance and findings on routine biopsy, and submucosal lesions, by endoscopic resection. Management is generally based upon the confidence of diagnosis and whether the lesion causes symptoms. We suggest endoscopic resection of all granular cell tumors and squamous papillomas because, while rare, these lesions have malignant potential. Dysphagia aortica should be considered in the differential diagnosis of dysphagia in the elderly.

关键词： Benign tumor Esophagus Epithelial lesions Subepith

Channel pruning on frequency response

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Science China(Information Sciences) 2025年第1期68卷 159-170页

作者： Hang lin Yifan PENG lin BIE Chenggang YAN Xibin ZHAO Yue GAO School of Software Tsinghua University School of Automation Hangzhou Dianzi University

Network pruning has a significant role in reducing network parameters and accelerating the inference time of the network. Some existing methods prune the network based on the frequency of the data, and finally obtain a sub-network with high accuracy. However, according to our experimental analysis, different frequencies of information in the data contribute differently to the accuracy of the model, and using this information directly for pruning without making a selection will lead to incorrect results. We believe that pruning should retain the convolutional kernels in the network that process important information, while those kernels that process unimportant information should be removed. In this paper, we first investigate the meaning of each frequency band information in the spectrum and their contribution to the prediction accuracy of the network,and according to these results, we propose a new pruning method based on frequency response(PFR). Our PFR finds and removes the convolutional kernels in the network that specialize in processing unimportant information, resulting in a compact neural network model. PFR obtains significant experimental results on different datasets, for example, a 56.0% raduction of float points operations(FLOPs) on Res Net-50 and only 0.37% of Top-1 accuracy degradation on the Image Net dataset.

关键词： deep learning model compression filter pruning channel pruning frequency response

Fine-tuning the spatial allocation of phytohormones for smart canopy, smart breeding, and smart agriculture

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Science China Life Sciences 2025年第1期68卷 309-310页

作者： Tao Zhou lin Li National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University HuBei HongShan Laboratory

The dual challenges of global climate change and population growth have increased demand for higher crop yields per unit area. The innovative technology of smart agriculture aims to synergize breeding, cultivation, and production through the application of biological and informatics technologies. Historically, the “Green Revolution” introduced semidwarf varieties of certain key crops by utilizing mutations affecting gibberellin pathways, which significantly increased planting densities and yields.

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High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming Wu lin He lin-Sen Ye Xiao-Feng Yang Jia-Jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness