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An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome

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chinese Journal of Natural Medicines 2024年第3期22卷 249-264页

作者： ZHOU Jiangtao WANG Jun WANG Jiajing LI Deyun HOU Jing LI Jiankuan BAI Yun’e GAO Jianping School of Pharmaceutical Science Shanxi Medical UniversityJinzhong 030600China

Inulin-type fructan CP-A,a predominant polysaccharide in Codonopsis pilosula,demonstrates regulatory effects on immune activity and *** efficacy of CP-A in treating ulcerative colitis(UC)is,however,not *** study employed an in vitro lipopolysaccharide(LPS)-induced colonic epithelial cell model(NCM460)and an in vivo dextran sulfate sodium(DSS)-induced colitis mouse model to explore CP-A’s protective effects against experimental colitis and its underlying *** monitored the clinical symptoms in mice using various parameters:body weight,disease activity index(DAI),colon length,spleen weight,and histopathological ***,molecular markers were assessed through enzyme-linked immunosorbent assay(eLISA),quantitative real-time polymerase chain reaction(qRT-PCR),immunofluorescence(IF),immunohistochemistry(IHC),and Western blotting *** showed that CP-A significantly reduced reactive oxygen species(ROS),tumor necrosis factor-alpha(TNF-α),and interleukins(IL-6,IL-1β,IL-18)in LPS-induced cells while increasing IL-4 and IL-10 levels and enhancing the expression of Claudin-1,ZO-1,and occludin proteins in NCM460 ***,in vivo findings revealed that CPA administration markedly improved DAI,reduced colon shortening,and decreased the production of myeloperoxidase(MPO),malondialdehyde(MDA),ROS,IL-1β,IL-18,and NOD-like receptor protein 3(NLRP3)inflammasome-associated genes/proteins in UC ***-A treatment also elevated glutathione(GSH)and superoxide dismutase(SOD)levels,stimulated autophagy(LC3B,P62,Beclin-1,and ATG5),and reinforced Claudin-1 and ZO-1 expression,thereby aiding in intestinal epithelial barrier repair in colitis ***,the inhibition of autophagy via chloroquine(CQ)diminished CP-A’s protective impact against colitis in *** findings elucidate that CP-A’s therapeutic effect on experimental colitis possibly involves mitigating intestinal inflammation through autophagymediated N

关键词： Inulin-type fructan CP-A Codonopsis pilosula Ulcerative colitis NLRP3 inflammasome Autophagy

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Analysis of cancer-specific survival in patients with metastatic colorectal cancer: A evidence-based medicine study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1791-1802页

作者： Yin-Jie Zhou Zhi-e Tan Wei-Da Zhuang Xin-Hua Xu Department of Oncology The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Department of Nuclear Medicine The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Department of Athe and Intestinal Surgery Cancer Hospital of The Chinese Academy of Medical SciencesBeijing 100021China

BACKGROUND Metastatic colorectal cancer(mCRC)is a common malignancy whose treatment has been a clinical ***-specific survival(CSS)plays a crucial role in assessing patient prognosis and treatment ***,there is still li-mited research on the factors affecting CSS in mCRC patients and their *** To predict CSS,we developed a new nomogram model and risk grading system to classify risk levels in patients with *** Data were extracted from the United States Surveillance,epidemiology,and end Results database from 2018 to *** eligible patients were randomly divided into a training cohort and a validation *** Cox proportional hazards model was used to investigate the independent risk factors for CSS.A new nomogram model was developed to predict CSS and was evaluated through internal and external *** A multivariate Cox proportional risk model was used to identify independent risk factors for ***,new CSS columns were developed based on these *** consistency index(C-index)of the histogram was 0.718(95%CI:0.712-0.725),and that of the validation cohort was 0.722(95%CI:0.711-0.732),indicating good discrimination ability and better performance than tumor-node-metastasis staging(C-index:0.712-0.732).For the training set,0.533,95%CI:0.525-0.540;for the verification set,0.524,95%CI:*** calibration map and clinical decision curve showed good agreement and good potential clinical *** risk grading system divided all patients into three groups,and the Kaplan-Meier curve showed good stratification and differentiation of CSS between different *** median CSS times in the low-risk,medium-risk,and high-risk groups were 36 months(95%CI:34.987-37.013),18 months(95%CI:17.273-18.727),and 5 months(95%CI:4.503-5.497),*** Our study developed a new nomogram model to predict CSS in patients with synchronous *** addition,the risk-grading system helps to accurately ass

关键词： Colorectal tumor Surveillance epidemiology and end results database Nomogram analysis Survival prognosis Retrospective study

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Guidelines for the application of artificial intelligence in the diagnosis of anterior segment diseases(2023)

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International Journal of Ophthalmology(english edition) 2023年第9期16卷 1373-1385页

作者： Yi Shao Ying Jie Zu-Guo Liu expert Workgroup of Guidelines for the application of artificial intelligence in the diagnosis of anterior segment diseases(2023) Ophthalmic Imaging and Intelligent Medicine Branch of chinese Medicine education Association Ophthalmology Committee of International Association of Translational Medicine chinese Ophthalmic Imaging study Groups Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang UniversityNanchang 330006Jiangxi ProvinceChina Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China eye Institute of Xiamen University Xiamen 361102Fujian ProvinceChina 不详

The landscape of ophthalmology has obser ved monumental shifts with the advent of artificial intelligence(AI)*** article is devoted to elaborating on the nuanced application of AI in the diagnostic realm of anterior segment eye diseases,an area ripe with potential yet complex in its imaging ***,AI’s entrenchment in ophthalmology was predominantly rooted in the posterior ***,the evolution of machine learning paradigms,particularly with the advent of deep learning methodologies,has reframed the *** combined with the exponential surge in available electronic image data pertaining to the anterior segment,AI’s role in diagnosing corneal,conjunctival,lens,and eyelid pathologies has been solidified and has emerged from the realm of theoretical to *** light of this transformative potential,collaborations between the Ophthalmic Imaging and Intelligent Medicine Subcommittee of the China Medical education Association and the Ophthalmology Committee of the International Translational Medicine Association have been *** eminent bodies mobilized a consortium of experts to dissect and assimilate advancements from both national and international *** mandate was not limited to AI’s application in anterior segment pathologies like the cornea,conjunctiva,lens,and eyelids,but also ventured into deciphering the existing impediments and envisioning future *** iterative deliberations,the consensus synthesized herein serves as a touchstone,assisting ophthalmologists in optimally integrating AI into their diagnostic decisions and bolstering clinical *** this guideline,we aspire to offer a comprehensive framework,ensuring that clinical decisions are not merely informed but transformed by *** building upon existing literature yet maintaining the highest standards of originality,this document stands as a testament to both innovation and academic integrity,in line with the e

关键词： artificial intelligence corneal disease lens disease conjunctive disease eyelid disease guideline

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Thermal conductivity of iron under the earth’s inner core pressure

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chinese Physics B 2024年第10期33卷 343-348页

作者： Cui-e Hu Mu-Xin Jiao Xue-Nan Yang Zhao-Yi Zeng Jun Chen College of Physics and electronic engineering Chongqing Normal UniversityChongqing 400047China Laboratory of Computational Physics Institute of Applied Physics and Computational MathematicsBeijing 100088China Center for Applied Physics and Technology Peking UniversityBeijing 100071China

The thermal conductivity ofε-iron at high pressure and high temperature is a key parameter to constrain the dynamics and thermal evolution of the earth’s *** this work,we use first-principles calculations to study the Hugoniot sound velocity and the thermal transport properties ofε-*** total thermal conductivity considering lattice vibration is 200 W/mK at the earth’s inner core *** suppressed anharmonic interactions can significantly enhance the lattice thermal conductivity under high pressure,and the contribution of the lattice thermal conductivity should not be ignored under the earth’s core conditions.

关键词： thermal conductivity first-principles high pressure and high temperature

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Generation of macroscopic entanglement in ensemble systems based on silicon vacancy centers

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chinese Physics B 2024年第9期33卷 308-315页

作者： Jian-Zhuang Wu Ying Xi Bo-Ya Li Lian-e Lu Yong-Hong Ma School of Science Inner Mongolia University of Science and TechnologyBaotou 014010China

entanglement in macroscopic systems,as a fundamental quantum resource,has been utilized to propel the advancement of quantum technology and probe the boundary between the quantum and classical *** study focuses on a unique hybrid quantum system comprising of an ensemble of silicon vacancy(SiV)centers coupled to phononic waveguides in diamond via strain *** employing two sets of time-dependent,non-overlapping driving fields,we investigate the generation process and dynamic properties of macroscopic quantum entanglement,providing fresh insights into the behavior of such hybrid quantum ***,it paves the way for new possibilities in utilizing quantum entanglement as an information carrier in quantum information processing and quantum communication.

关键词： quantum entanglement silicon vacancy centers diamond waveguide

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Stream-vorticity NS equation ADI Scheme to Investigate Properties of Impulsively Started Translatory Flows Around the Rotational Circular Cylinder without Wall Vorticity Conditions

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Communications in Nonlinear Science and Numerical Simulation 1998年第4期3卷 221-232页

作者： Caimao LUO and Xuequan e (Institute of Mechanics, chinese Academy of Sciences, Beijing 100080, China)e-mail: lcm@*** exq@*** Institute of Mechanics Chinese Academy of Sciences Beijing 100080 China

The properties of flow around a circular cylinder impulsively started into translatory and rotatory motion with rotational parameter a less than or equal to 8.0 and Reynolds number Re=100 and 200 are investigated in the present paper. The vorticity and stream function N-S equations are adopted here, with a 2nd-order spatial and temporal accuracy ADI (alternating direction implicit) scheme. Moreover the wall vorticityobtain through the principle of conservation of the total computational domain vorticityis determined by domain vorticity and stream function, therefore, through the wall vorticity iteration, the wall vorticity condition is not fixed during the time step. And the present model results indicate: (1) when α >4.0, vortex street suppression is obvious for the computational period (t e Re numbers here studied; (2) the higher the a number for the same Reynolds number, the slower the upper main vortex proceeds; (3) the maximum instantaneous transverse coefficient exceeds the limitation 4π.

关键词： wake vortex shedding mode rotation and translation ADI wall vorticitycondition.

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A Method of Obtaining the Pitch Angle of Spiral Arms and the Inclination of Galactic Discs

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chinese Journal of Astronomy and Astrophysics 2001年第5期1卷 395-405页

作者： Jun Ma (National Astronomical Observatories, chinese Academy of Sciences, Beijing 100012) e-mail:majun@*** National Astronomical Observatories Chinese Academy of Sciences Beijing 100012

We investigate the mathematical form, the symmetry of spiral structure and the projected images of galactic discs. The measured pitch angles of spiral arms and inclination angles of galactic discs for 60 spiral galaxies are presented. The global spiral structure is emphasized in the study. It is found that, except for small-scale distortions, the spiral arms of those galaxies that were classified as AC 12 in the arm classification system of elmegreen & elmegreen, can be represented by the logarithmic spiral form.

关键词： galaxies: spiral galaxies - galaxies: spiral arm disc: inclination

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Detection of anti-HAV and anti-HeV IgM in patients with sporadic acute hepatitis in Beijing between 1995-2000

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Hepatobiliary & Pancreatic Diseases International 2002年第1期1卷 83-86页

作者： Jian Lu Hong-Lan Zhao Qing-Ling Meng Sheng-Dong Liao Yuan Wang Yong-Zhen Jiang From the Laboratory of hepatitis, Institute of Virology, chinese Academy of Preventive Medicine, Beijing 100052, China Laboratory of hepatitis Institute of Virology Chinese Academy Preventive Medicine Beijing 100052 China

Objective: To investigate the age range, liver functiondamage and prognosis of patients with sporadic acutehepatitis A and e in ***: enzyme immunoassay (eIA) was used todetect anti-HAV and anti-HeV immunoglobulin M(IgM). Serum samples were collected from the pa-tients with sporadic acute viral hepatitis in Beijingfrom January 1995 to June ***: The total positive rate for anti-HAV and an-ti-HeV IgM was 55.2% (112)in 203 patients with a-cute hepatitis, of whom 22.2% (45 patients) and33.0% (67) were positive for anti-HAV and anti-HeV respectively. The duration of anti-HeV IgMwas 45-60 days and that of anti-HAV IgM was atleast 2-3 months. The patients with acute hepatitis Aand hepatitis e all experienced jaundice and a risingof liver enzyme, but did not develop chronic hepatitisor ***: Acute hepatitis A as well as acute hepatitise plays an important role in sporadic entericallytransmitted hepatitis in Beijing.

关键词： hepatitis A hepatitis e antibody IgM

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Structural color of metallic glass through picosecond laser

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chinese Physics B 2024年第10期33卷 120-128页

作者： Yue’e Zhang Xing Tong Yuqiang Yan Shuo Cao Hai-Bo Ke Wei-Hua Wang College of Physics Liaoning UniversityShenyang 110036China Songshan Lake Materials Laboratory Dongguan 523808China Institute of Physics Chinese Academy of SciencesBeijing 100190China

The alteration in surface color of metallic glasses(MGs)holds great significance in the context of microstructuredesign and commercial *** is essential to accurately describe the structures that are formed during the laser and colorseparation processes in order to develop practical laser coloring *** to the high oxidation sensitivity of Labasedmetallic glass,it can broaden the color range but make it more *** coloring by laser processing on thesurface of La-based metallic glass can be conducted after thermoplastic *** is particularly important to clarify therole of structure and composition in the surface coloring *** aim is to study the relationship between amorphoussurface structural color,surface geometry,and oxide formation by laser processing in metallic *** findings revealedthat the periodic structure primarily determines the surface color at laser energy densities below 1.0 J/mm^(2).In contrast,thesurface color predominantly depends on the proportion of oxides that are formed when energy densities exceed 1.0 J/mm^(2).Consequently,this study provides a novel concept for the fundamental investigation of laser coloring and establishes a newavenue for practical application.

关键词： metallic glass picosecond laser periodic structure oxides

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Functional mitral regurgitation combined with increased early diastolic transmitral velocity to early mitral annulus diastolic velocity ratio is associated with a poor prognosis in patients with shock

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chinese Medical Journal 2021年第19期134卷 2299-2305页

作者： Ran Zhou Tongjuan Zou Wanhong Yin Xiaoting Wang Yan Kang chinese Critical Ultrasound study Group(CCUSG) Department of Critical Care Medicine West China Hospital/West China School of MedicineSichuan UniversityChengduSichuan 610041China Department of Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100730China 不详

Background:Functional mitral regurgitation(FMR)is common in critically ill patients and may cause left atrial(LA)pressure *** study aims to explore the prognostic impact of synergistic LA pressure elevation and FMR in patients with ***:We retrospectively screened 130 consecutive patients of 175 patients with shock from April 2016 to June *** incidence and impact of FMR and early diastolic transmitral velocity to early mitral annulus diastolic velocity ratio(e/e’)≥4 within 6 h of shock on the prognosis of patients were ***,the synergistic effect of FMR and e/e’were assessed by combination,grouping,and trend ***:Forty-four patients(33.8%)had FMR,and 15 patients(11.5%)had e/e’elevation.A multivariate analysis revealed FMR and e/e’as independent correlated factors for 28-day mortality(P=0.043 and 0.028,respectively).The Kaplan-Meier survival analysis revealed a significant difference in survival between patients with and without FMR(χ2=7.672,P=0.006)and between the e/e’≥14 and e/e’enty-eight-day mortality was significantly different among the four groups(χ2=30.141,Pe risk of 28-day mortality was significantly higher in group 4(e/e’≥14 with FMR)compared with groups 1(e/e’e/e’espectively).Conclusions:Patients with shock can be identified by the presence of *** and e/e’are independent risk factors for a poor prognosis in these patients,and prognosis is worst when FMR and e/e’≥14 are *** may be possible to improve prognosis by reducing LA pressure and e/e’.Trial Registration:***,NCT03082326.

关键词： Shock Ultrasound Functional mitral regurgitation e/e’ Prognosis

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