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Animal models of hepatitis e infection: Advances and challenges

Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 171-180页

作者： Ze Xiang Xiang-Lin He Chuan-Wu Zhu Jia-Jia Yang Lan Huang Chun Jiang Jian Wu chinese consortium for the study of hepatitis e(CCSHe) Zhejiang University School of Medicine Hangzhou 310030China Department of Infectious Diseases The Fifth People’s Hospital of SuzhouSuzhou 215007China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China 不详

hepatitis e virus(HeV)is one of the leading causes of acute viral hepatitis *** most of HeV infections are asymptomatic,some patients will develop the symptoms,especially pregnant women,the elderly,and patients with preexisting liver diseases,who often experience anorexia,nausea,vom-iting,malaise,abdominal pain,and *** infection may become chronic in immunosuppressed *** addition,HeV infection can also cause several extrahepatic *** exists in a wide range of hosts in nature and can be transmitted across ***,animals susceptible to HeV can be used as *** establishment of animal models is of great significance for studying HeV transmission,clinical symptoms,extrahepatic manifestations,and therapeutic strategies,which will help us understand the pathogenesis,prevention,and treatment of hepatitis *** review summarized the animal models of HeV,including pigs,monkeys,rabbits,mice,rats,and other *** each animal species,we provided a concise summary of the HeV genotypes that they can be infected with,the cross-species transmission pathways,as well as their role in studying extrahepatic manifestations,prevention,and treatment of HeV *** advantages and disadvantages of these animal models were also *** review offers new perspectives to enhance the current understanding of the research landscape surrounding HeV animal models.

关键词： hepatitis e virus Animal models Pathogenesis Prevention Treatment

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中国戊型病毒性肝炎院内筛查管理流程专家共识(2023年版)

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中华检验医学杂志 2023年第6期46卷 558-565页

作者：中国戊型肝炎研究协助组(CCSHe) 中国医师协会感染科医师分会国家感染性疾病临床医学研究中心李兰娟中国戊型肝炎研究协助组(CCSHe) 中国医师协会感染科医师分会国家感染性疾病临床医学研究中心国家感染性疾病临床医学研究中心

戊型病毒性肝炎(简称戊型肝炎)是由戊型肝炎病毒(HeV)引起的一种急慢性传染病。全球每年约发生2000万例HeV感染,其中约有330万例戊型肝炎,7万例与HeV感染相关的死亡病例。过去10年,我们对戊型肝炎的认识发生了巨大变化,我国仍有大部分He... 详细信息

戊型病毒性肝炎(简称戊型肝炎)是由戊型肝炎病毒(HeV)引起的一种急慢性传染病。全球每年约发生2000万例HeV感染,其中约有330万例戊型肝炎,7万例与HeV感染相关的死亡病例。过去10年,我们对戊型肝炎的认识发生了巨大变化,我国仍有大部分HeV感染者,尤其是重症及慢性戊型肝炎患者被漏诊或误诊。根据世界卫生组织提出的到2030年消除病毒性肝炎这一公共卫生危害的目标,并基于医疗机构是目前我国诊断和治疗HeV的主要场所这一事实,中国戊型肝炎研究协助组(CCSHe)、中国医师协会感染科医师分会和国家感染性疾病临床医学研究中心共同制订了该共识,希望促进医疗机构管理、疾病预防控制、临床、检验、感染控制的多学科、多部门联合,有效筛查和诊断HeV感染人群;帮助戊型肝炎患者及时会诊和转诊,优化患者随访及复诊管理流程,提供正确的治疗方法。同时加强非感染、非肝病专科医师对戊型肝炎的认知,以便在日常医疗活动中及时发现HeV感染者。

关键词：戊型肝炎流程筛查诊断治疗专家共识

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中国戊型病毒性肝炎院内筛查管理流程专家共识(2023年版)

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中华临床感染病杂志 2023年第2期16卷 99-107页

作者：中国戊型肝炎研究协助组(CCSHe) 中国医师协会感染科医师分会国家感染性疾病临床医学研究中心李兰娟不详浙江大学医学院附属第一医院传染病重症诊治全国重点实验室杭州310003

戊型病毒性肝炎(简称戊型肝炎)是由戊型肝炎病毒(HeV)引起的一种急慢性传染病。全球每年约发生2000万例HeV感染,其中约有330万例戊型肝炎,7万例与HeV感染相关的死亡病例。过去10年,我们对戊型肝炎的认识发生了巨大变化,我国仍有大部分HeV感染者,尤其是重症及慢性戊型肝炎患者被漏诊或误诊。根据世界卫生组织提出的到2030年消除病毒性肝炎这一公共卫生危害的目标,并基于医疗机构是目前我国诊断和治疗HeV感染的主要场所这一事实,中国戊型肝炎研究协助组(CCSHe)、中国医师协会感染科医师分会和国家感染性疾病临床医学研究中心共同制订了该共识,希望促进医疗机构管理、疾病预防控制、临床、检验、感染控制的多学科、多部门联合,有效筛查和诊断HeV感染人群;帮助戊型肝炎患者及时会诊和转诊,优化患者随访及复诊管理流程,提供正确的治疗方法。同时加强非感染、非肝病专科医师对戊型肝炎的认知,以便在日常医疗活动中及时发现HeV感染者。

关键词：戊型肝炎流程筛查诊断治疗专家共识

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中国戊型病毒性肝炎院内筛查管理流程专家共识(2023年版)

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临床肝胆病杂志 2023年第4期39卷 785-794页

作者：中国戊型肝炎研究协助组(CCSHe) 中国医师协会感染科医师分会国家感染性疾病临床医学研究中心李兰娟 chinese consortium for the study of hepatitis e(CCSHe) Chinese Physician Association for Infectious Disease National Clinical Research Center for Infectious Diseases China

戊型病毒性肝炎(简称戊型肝炎)是由戊型肝炎病毒(HeV)引起的一种急慢性传染病。全球每年约发生2000万例HeV感染,其中约有330万例戊型肝炎,7万例与HeV感染相关的死亡病例。过去10年我们对戊型肝炎的认识发生了巨大变化,我国仍有大部分He... 详细信息

戊型病毒性肝炎(简称戊型肝炎)是由戊型肝炎病毒(HeV)引起的一种急慢性传染病。全球每年约发生2000万例HeV感染,其中约有330万例戊型肝炎,7万例与HeV感染相关的死亡病例。过去10年我们对戊型肝炎的认识发生了巨大变化,我国仍有大部分HeV感染者,尤其是重症及慢性戊型肝炎患者被漏诊或误诊。根据世界卫生组织提出的到2030年消除病毒性肝炎这一公共卫生危害的目标,并基于医疗机构是目前我国诊断和治疗HeV的主要场所这一事实,中国戊型肝炎研究协助组(CCSHe)、中国医师协会感染科医师分会和国家感染性疾病临床医学研究中心共同制订了共识,希望促进医疗机构管理、疾病预防控制、临床、检验、感染控制的多学科、多部门联合,有效筛查和诊断HeV感染人群;帮助戊型肝炎患者及时会诊和转诊,优化患者随访及复诊管理流程,提供正确的治疗方法。同时加强非感染、非肝病专科医师对戊型肝炎的认知,以便在日常医疗活动中及时发现HeV感染者。

关键词：戊型肝炎普查诊断治疗学专家共识

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Formadinium Cation Doping Stabilized Ultra-deep-blue Lead Halide Perovskite Nanocrystal Light-emitting Diodes

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Chemical Research in chinese Universities 2024年第3期40卷 556-560页

作者： Pui Kei KO Jonathan e.HALPeRT Department of Chemistry The Hong Kong University of Science and TechnologyKowloonHong Kong 999077P.R.China

The halide migration effect in mixed-halide lead-based perovskite is a serious problem hindering the development of its display *** this study,we have successfully addressed this issue by reporting formadinium(FA)doped mixed-halide perovskite nanocrystals(NCs)with ultra-deep-blue emission of 450 nm,narrow bandwidth of 16 nm,and a high photoluminescence quantum yield(PLQY)of 66%.The perovskite nanocrystal light-emitting diodes(NC-LeDs)using this nanocrystal as an active layer achieved a maximum external quantum efficiency(eQe)of 0.32%,30-fold improved compared to that of pristine and stable electroluminescence(eL)spectra at 450 nm under a 4.9–8.0 V *** findings demonstrate the potential of our approach in developing stable and efficient deep blue perovskite NC-LeDs.

关键词： Halide perovskite Light-emitting diode Deep-blue

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High Impact Polylactide Based on Organosilicon Nucleation Agent

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chinese Journal of Polymer Science 2024年第6期42卷 787-797页

作者： Daria Pakuła Bogna Sztorch eliza Romańczuk-Ruszuk Bogdan Marciniec Robert e.Przekop Faculty of Chemistry Adam Mickiewicz University in PoznańUniwersytetu Poznańskiego 861-614PoznańPoland Centre for Advanced Technologies Adam Mickiewicz University in PoznańUniwersytetu Poznańskiego 1061-614PoznańPoland Institute of Biomedical engineering Faculty of Mechanical EngineeringBialystok University of TechnologyWiejska 45C15-351BialystokPoland

Various sectors of the industry are searching for new materials with specific requirements,providing improved *** study presents novel composite materials based on polylactide that have been modified with the organosilicon compound,(3-thiopropyl)polysilsesquioxane(SSQ-SH).The SSQ-SH compound is a mixture of cage structures and not fully condensed random *** composite materials were obtained through injection *** study includes a comprehensive characterization of the new materials that analyze their functional properties,such as rheology(MFR),mechanical strength(tensile strength,Charpy impact strength),and thermal *** microscopic photos were also taken to analyze the microstructure of the *** addition of a 5%by-weight organosilicon compound to polylactide resulted in a significant increase in MFR by 73.8%compared to the neat *** greatest improvement in impact strength was achieved for the 5%SSQ-SH/PLA composite,increasing it by 32.0 kJ/m^(2)compared to PLA,which represents an increase of up to 187%.The conducted research confirms the possibility of modifying the properties of the polymer by employing organosilicon compounds.

关键词： Octa(3-thiopropyl)silsesquioxane 8SH-POSS Polylactide(PLA) Injection moulding Composites

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extractable and kerogen-bound hopanoids from typical eocene oil shales in China

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energy Geoscience 2024年第2期5卷 171-179页

作者： Changbo Zhai Zhirong Zhang John K.Volkman Hong Lu Yan'e Chen SINOPeC Key Laboratory of Petroleum Accumulation Mechanisms Wuxi Institute of Petroleum GeologySINOPEC2060 Lihu RoadWuxiJiangsu213126China SINOPeC Petroleum exploration and Production Research Institute 31 Xueyuan RoadBeijing100083China State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of ScienceGuangzhou510640GuangdongChina

This study conducted a comparative analysis of extractable hopanoid hydrocarbons and those released via stepwise pyrolysis of typical eocene immature oil shales in China,namely the Huadian,Maoming,and Fushun *** the Huadian and Maoming shales exhibit immature indicators in extractable and kerogen-bound hopanoids(notably,high abundance of C_(29)to C_(32)17β,21β-hopanes and unsaturated hopenes).In contrast,the Fushun oil shale's hopanoids from extracts and pyrolyzates suggest a higher maturity *** absence of neohopenes in the pyrolyzates of the shales underpins that the kerogenbound hopanoid skeletons resist ***,the Huadian oil shale's asymmetric distribution of C_(29)and C_(30)hopenes and neohopenes hints at the presence of an additional *** unsaturated hopenes,such as hop-20(21)-enes,identified in pyrolyzates of the three kerogens at various pyrolysis temperatures,reveal the occurrence of double bonds in kerogen-bound hopanoid skeletons without methyl *** absence of hop-20-(21)-ene in extracts suggests that it might act as an intermediate of these novel hopenes during the epimerization of hopanoid skeletons within *** extractable and pyrolytic hopanoids'stereochemical alignment indicates that epimerization may occur in both ring systems and alkyl side chains of kerogen-bound hopanoid *** stepwise pyrolysis proves to be a quick screening method for geological hopanoids without causing any significant alteration to the original skeletons even when cracking multiple covalent bonds is necessary.

关键词： Hopanoid Hopane Hopene Neohopene Stepwise pyrolysis Kerogen eocene oil shale

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An inulin-type fructan CP-A from Codonopsis pilosula attenuates experimental colitis in mice by promoting autophagy-mediated inactivation of NLRP3 inflammasome

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chinese Journal of Natural Medicines 2024年第3期22卷 249-264页

作者： ZHOU Jiangtao WANG Jun WANG Jiajing LI Deyun HOU Jing LI Jiankuan BAI Yun’e GAO Jianping School of Pharmaceutical Science Shanxi Medical UniversityJinzhong 030600China

Inulin-type fructan CP-A,a predominant polysaccharide in Codonopsis pilosula,demonstrates regulatory effects on immune activity and *** efficacy of CP-A in treating ulcerative colitis(UC)is,however,not *** study employed an in vitro lipopolysaccharide(LPS)-induced colonic epithelial cell model(NCM460)and an in vivo dextran sulfate sodium(DSS)-induced colitis mouse model to explore CP-A’s protective effects against experimental colitis and its underlying *** monitored the clinical symptoms in mice using various parameters:body weight,disease activity index(DAI),colon length,spleen weight,and histopathological ***,molecular markers were assessed through enzyme-linked immunosorbent assay(eLISA),quantitative real-time polymerase chain reaction(qRT-PCR),immunofluorescence(IF),immunohistochemistry(IHC),and Western blotting *** showed that CP-A significantly reduced reactive oxygen species(ROS),tumor necrosis factor-alpha(TNF-α),and interleukins(IL-6,IL-1β,IL-18)in LPS-induced cells while increasing IL-4 and IL-10 levels and enhancing the expression of Claudin-1,ZO-1,and occludin proteins in NCM460 ***,in vivo findings revealed that CPA administration markedly improved DAI,reduced colon shortening,and decreased the production of myeloperoxidase(MPO),malondialdehyde(MDA),ROS,IL-1β,IL-18,and NOD-like receptor protein 3(NLRP3)inflammasome-associated genes/proteins in UC ***-A treatment also elevated glutathione(GSH)and superoxide dismutase(SOD)levels,stimulated autophagy(LC3B,P62,Beclin-1,and ATG5),and reinforced Claudin-1 and ZO-1 expression,thereby aiding in intestinal epithelial barrier repair in colitis ***,the inhibition of autophagy via chloroquine(CQ)diminished CP-A’s protective impact against colitis in *** findings elucidate that CP-A’s therapeutic effect on experimental colitis possibly involves mitigating intestinal inflammation through autophagymediated N

关键词： Inulin-type fructan CP-A Codonopsis pilosula Ulcerative colitis NLRP3 inflammasome Autophagy

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Challenges and countermeasures for developing countries in addressing loss and damage caused by climate change

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Advances in Climate Change Research 2024年第2期15卷 353-363页

作者： Shuo LIU Yu-e LI Bin WANG An-Dong CAI Chao FeNG Hua LAN Ruo-Chen ZHAO Institute of environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Agricultural environment Ministry of Agriculture and Rural AffairsBeijing 100081China China Clean Development Mechanism Fund Management Center Beijing 100045China School of International Law China University of Political Science and LawBeijing 100088China

Loss and damage caused by extreme climate events have attracted increasing *** 28th Conference of the Parties to the United Nations Framework Convention on Climate Change(hereinafter referred to as the Convention)has agreed to adopt Loss and Damage Fund agreement,which identified the source of funding and the funds to be entrusted to the World ***,there is still ambiguous that how to allocate the funds could accelerate the effectiveness of meeting the needs for developing ***-disaster prevention and preparedness is one of the most effective measures to deal with loss and damage,which closely related to *** studies rarely analyzed quantitatively the financial needs of pre-disaster prevention and preparedness relating to adaptation to reduce loss and *** on the official reports submitted by countries under the Convention,this study analyzes the annual change in the total financial support provided by developed countries to developing countries,the proportion of pre-disaster prevention and preparedness in the adaptation needs of developing countries,and the progress in raising the current annual funding target of 100 billion USD for developed countries,to reveal the financial and technical challenges facing by developing countries on addressing loss and *** results show that by 2030,the total adaptation financial needs of developing countries are estimated to be about 3.8 trillion USD,of which pre-disaster prevention matters account for about 9%.Therefore,by 2030,developing countries will need about 342 billion USD in pre-disaster prevention and preparedness finance to withstand loss and *** addition,developing countries face a lack of technical methods to quantify information about their *** on the above analysis,this study puts forward countermeasures and suggestions,including strengthening the allocation amount of loss and damage fund on pre-disaster warning,prevention and control actions,and

关键词： Loss and damage Funding mechanism Pre-disaster warning and preparedness Convention negotiations Countermeasures

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Analysis of cancer-specific survival in patients with metastatic colorectal cancer: A evidence-based medicine study

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1791-1802页

作者： Yin-Jie Zhou Zhi-e Tan Wei-Da Zhuang Xin-Hua Xu Department of Oncology The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Department of Nuclear Medicine The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People's HospitalYichang 443000Hubei ProvinceChina Department of Athe and Intestinal Surgery Cancer Hospital of The Chinese Academy of Medical SciencesBeijing 100021China

BACKGROUND Metastatic colorectal cancer(mCRC)is a common malignancy whose treatment has been a clinical ***-specific survival(CSS)plays a crucial role in assessing patient prognosis and treatment ***,there is still li-mited research on the factors affecting CSS in mCRC patients and their *** To predict CSS,we developed a new nomogram model and risk grading system to classify risk levels in patients with *** Data were extracted from the United States Surveillance,epidemiology,and end Results database from 2018 to *** eligible patients were randomly divided into a training cohort and a validation *** Cox proportional hazards model was used to investigate the independent risk factors for CSS.A new nomogram model was developed to predict CSS and was evaluated through internal and external *** A multivariate Cox proportional risk model was used to identify independent risk factors for ***,new CSS columns were developed based on these *** consistency index(C-index)of the histogram was 0.718(95%CI:0.712-0.725),and that of the validation cohort was 0.722(95%CI:0.711-0.732),indicating good discrimination ability and better performance than tumor-node-metastasis staging(C-index:0.712-0.732).For the training set,0.533,95%CI:0.525-0.540;for the verification set,0.524,95%CI:*** calibration map and clinical decision curve showed good agreement and good potential clinical *** risk grading system divided all patients into three groups,and the Kaplan-Meier curve showed good stratification and differentiation of CSS between different *** median CSS times in the low-risk,medium-risk,and high-risk groups were 36 months(95%CI:34.987-37.013),18 months(95%CI:17.273-18.727),and 5 months(95%CI:4.503-5.497),*** Our study developed a new nomogram model to predict CSS in patients with synchronous *** addition,the risk-grading system helps to accurately ass

关键词： Colorectal tumor Surveillance epidemiology and end results database Nomogram analysis Survival prognosis Retrospective study

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