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china Textile 2024年第4期 20-21页

作者： Editorial department of china Daily

The robust demand of the Chinese market and the improving business environment in the country make china a big growth opportunity for companies wishing to further expand their operations,said corporates that have registered to participate at this year's china International Import *** 7th edition of the annual CIIE,to be held in Shanghai from Nov 5 to 10,started its 100-day countdown on Saturday.

关键词： companies likely operations

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Serving High-Level Opening up with "TaxExpress"

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Belt and Road Initiative Tax Journal 2024年第1期 97-105页

作者： International Taxation department, State Taxation Administration,the People's Republic of china International Taxation department State Taxation Administrationthe People's Republic of China

Over the past decade,the Chinese tax authorities have been actively supporting the development of the Belt and Road Initiative,by creating a unique cross-border tax and fee service model with Chinese characteristics,which has laid a solid foundation for the establishment of the "TaxExpress" cross-border service *** October 2023,the State Taxation Administration of china(STA) officially launched the "TaxExpress" brand,focusing on one service matrix,two service teams,three service mechanisms,and four knowledge *** brand aims to enhance cooperation between ministries and commissions,promote international exchanges,and establish a framework for effective cross-border tax and fee *** forward,the STA will continue to leverage existing resources to support high-level opening up,by enhancing brand value,improving measures for international tax and fee services,expanding cross-border tax and fee services,strengthening professional talent teams,so as to develop a cross-border tax and fee service system that combines Chinese characteristics with international best practices.

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金融多措并举支持经济高质量发展

中国金融 2024年第19期 9-15页

作者：本刊编辑部不详

2024年9月24日,国务院新闻办公室举行新闻发布会,中国人民银行行长潘功胜、国家金融监督管理总局局长李云泽、中国证券监督管理委员会主席吴清出席发布会并介绍金融支持经济高质量发展有关情况。“新政频出”成为此次发布会的亮点,这让... 详细信息

2024年9月24日,国务院新闻办公室举行新闻发布会,中国人民银行行长潘功胜、国家金融监督管理总局局长李云泽、中国证券监督管理委员会主席吴清出席发布会并介绍金融支持经济高质量发展有关情况。“新政频出”成为此次发布会的亮点,这让公众感受到了金融支持经济高质量发展的力度,支持实体经济发展的深度和提升老百姓生活幸福感、满足感的温度。

关键词：金融监督管理金融支持经济实体经济发展中国证券监督管理委员会高质量发展多措并举生活幸福感新闻发布会

“有效降低全社会物流成本”研讨会专家观点综述

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中国流通经济 2024年第5期38卷 3-17页

作者：本刊编辑部《中国流通经济》编辑部

2024年2月24日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2024年4月24日,北京物资学院党委宣传部、杂志社、科研处... 详细信息

2024年2月24日,习近平总书记主持召开中央财经委员会第四次会议,指出物流是实体经济的“筋络”,强调必须有效降低全社会物流成本,增强产业核心竞争力,提高经济运行效率。基于此,2024年4月24日,北京物资学院党委宣传部、杂志社、科研处联合主办了“有效降低全社会物流成本”研讨会。本次研讨会邀请我国流通物流领域的专家学者,围绕物流服务实体经济和人民群众、物流成本构成、交通运输体系改革、统一高效物流市场构建和现代商贸流通体系完善等问题,发表观点,为探索有效降低全社会物流成本可行路径,构建现代流通体系提供理论支持和实践指导。本刊编辑部对专家阐述的主要观点进行了归纳整理,以飨读者。

关键词：全社会社会物流成本新质生产力流通体系降本增效

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Effect of transforming growth factor-beta on activity of connective tissue growth factor gene promoter in mouse NIH/3T3 fibroblasts

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Acta Pharmacologica Sinica 2004年第4期25卷 87-91页

作者： Qing ZHAO, Nan CHEN2, Wei-ming WANG, Jian LU3,Bing-bing DAI3 department of nephrology, Ruijin Hospital 3department of Biochemistry, Shanghai Second Medical University, Shanghai 200025, china department of nephrology Ruijin Hospital Shanghai Second Medical University 上海 200025 department of Biochemistry Shanghai Second Medical University 上海 200025

AIM: To investigate the regulatory mechanism of transforming growth factor-betaon activity of connective tissue growth factor promoter in mouse NIH/3T3 fibroblasts. METHODS: The regulation fragment of the 5' flanking region of the human CTGF gene was linked to pGL3-Basic vector, a firefly luciferase reporter construct without promoter. The recombinant plasmid pCTGF-luc was transiently transfected to NIH/3T3 fibroblasts. The activity of CTGF promoter after treatment of TGF-β1 and MAPK pathway inhibitors were assayed with luciferase reporter gene assay system. RESULTS: TGF-β1-induced increase of CTGF promoter activity was concentration-dependent, with a plateau at 5 μg/L by 2.67-fold vs control (P3580 (10 μmol/L), the p38 MAP kinaseinhibitor, decreased basal and TGF-β1-induced activation of CTGF promoter. However, inhibition of c-Jun-N-terminal kinase/stress-activated protein kinase by SP600125 (20 μmol/L) was without effect. CONCLUSION: TGF-β1stimulated the transcriptional activity of CTGF gene promoter in NIH/3T3 fibroblasts in a dose- and time-dependent manner. MAPK pathway may play a role in the regulation of TGF-β1-induced CTGF expression.

关键词： transforming growth factor-beta connective tissue growth factor promoter mitogen-activated protein kinases signal transduction

Inhibition of ethanol-induced toxicity by tanshinone ⅡA in PC12 cells

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Acta Pharmacologica Sinica 2006年第6期27卷 659-664页

作者： Xian-fang MENG~2 Xiao-jing ZOU~3 Bin PENG~2 Jing SHI~2 Xin-min GUAN~2 Chun ZHANG~(4,5)2 department of Neurobiology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,china 3 department of Anesthesiology,4 department of nephrology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022.china department of Neurobiology Tongji Medical College Huazhong University of Science and Technology Wuhan China department of Anesthesiology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China department of nephrology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China

Aim:To observe the effects of tanshinone IIA(Tan IIA)on the neurotoxicityinduced by ethanol in PC 12 cells and to explore its protective ***:PC 12cell survival was measured by MTT *** formation of reactive oxygenspecies(ROS)and lactate dehydrogenase(LDH)release were detected by 2′,7′-dichlorofluorescin(DCF)fluorescence and calorimetric method,*** of cell apoptosis was monitored by flow *** expression ofp53 was detected by immuno-fluorescence and flow ***:Ethanolsignificantly impaired the survival of PC12 cells as demonstrated by MTT *** also induced significant ROS formation and increased LDH ***-incubation with Tan IIA in the culture medium significantly reversed these *** caused cell apoptosis and the upregulation of p53 *** anti-apoptosis effects of Tan IIA on ethanol-induced toxicity were accompanied by thedownregulation of pro-apoptotic p53 protein ***:Tan IIAcan protect neurons from apoptosis and might serve as a potential therapeuticdrug for neurological disorders induced by ethanol.

关键词： apoptosis ethanol PC12 cells p53 tanshinone ⅡA

Study on the two and three-parameter working stability regions of 3Y-TZP suspension

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Science china(Technological Sciences) 2006年第5期49卷 547-568页

作者： CHEN Youqiang1, 2, ZHANG Xinni3, CHEN Sha’ou3 & QI Ping3 1. department of Chemistry, Qingdao University, Qingdao 266071, china 2. department of Chemistry, Tsinghua University, Beijing 100084, china 3. department of Physics, Qingdao University, Qingdao 266071, china department of Chemistry Qingdao University Qingdao China department of Chemistry Tsinghua University Beijing China department of Physics Qingdao University Qingdao China

We determined the variation tendency of viscosity (η) at various solids load- ing (α) for 3Y-TZP suspension as a function of dispersant concentration (Cw) using vis- cosity measurement, measured the diameter of particles as a function of Cw in very dilute suspension using light scattering method, and obtained the surface features of the sedi- ment of suspension with different Cw using SEM. We also discussed the influence of the microstructure of adsorbed polymer layers on particles and their interactions in the dis- persing medium on the stability of suspension. Then two different stable states and two different unstable states for 3Y-TZP suspension were given. Accordingly, the (Cw, η), (Cw, α), and (α, η) two-parameter, and (Cw, α, η) three-parameter stability maps were con- structed. Based on the DLVO theory calculations, the dispersant concentration, particle distance (r), and interparticle potential energy (VT) maps with various solids loading for 3Y-TZP aqueous suspension were also constructed. In (Cw, r) two-parameter coordinate system, the stable motion region map for particles was established. The Cw, α, and VT,max (the highest potential energy) surface of the potential barrier map was obtained through calculation and simulation on the basis of the surfaces of Cw, r, VT maps introduced above. The (Cw, α) two-parameter stability map was then obtained from the Cw, α, VT,max map. The results showed that this theoretical map can qualitatively prove the experimentally obtained results—the existence of different dispersed states of particles in suspension system and the variation tendency of suspension stability with changing each parame- ter—were reasonable.

关键词： 3Y-TZP, suspension, stability, DLVO theory, interparticle potential energy.

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Sodium ferulate prevents amyloid-beta-induced neurotoxicity through suppression of p38 MAPK and upregulation of ERK-1/2 and Akt/protein kinase B in rat hippocampus

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Acta Pharmacologica Sinica 2005年第8期26卷 943-951页

作者： Ying JIN~2, En-zhi YAN~3, Ying FAN~3, Zhi-hong ZONG~4, Zhi-min QI~3, Zhi LI~(2,5) ~2department of Ethnopharmacology, china Medical University, Shengyang 110001, china ~3department of Pharmacology, Jinzhou Medical College, Jinzhou 121001, china ~4department of Biochemistry, china Medical University Shengyang 110001, china department of Ethnopharmacology China Medical University Shengyang China department of Pharmacology Jinzhou Medical College Jinzhou China department of Biochemistry China Medical University Shengyang China

Aim: To observe whether an amyloid β （Aβ）-induced increase in interleukin （IL）-1β was accompanied by an increase in the p38 mitogen-activated protein kinase （MAPK） pathway and a decrease in the cell survival pathway, and whether so-dium ferulate （SF） treatment was effective in preventing these Aβ-induced changes. Methods: Rats were injected intracerebroventricularly with Aβ25-35. Seven days after injection, immunohistochemical techniques for glial fibrillary acidic protein （GFAP） were used to determine the astrocyte infiltration and activation in hippo-campal CA1 areas. The expression of IL-1β, extracellular signal-regulated kinase （ERK）, p38 MAPK, Akt/protein kinase B （PKB）, Fas ligand and caspase-3 were determined by Western blotting. The caspase-3 activity was measured by clea-vage of the caspase-3 substrate （Ac-DEVD-pNA）. Reverse transcription-polymerase chain reaction was used to analyze the changes in IL- 1βmRNA levels. Results:Intracerebroventricular injection of Aβ-（25-35） elicited astrocyte activation and infiltration and caused a strong inflammatory reaction characterized by increased IL-1β production and elevated levels of IL-1β mRNA. Increased IL-1β synthesis was accompanied by increased activation of p38 MAPK and downregulation of phospho-ERK and phospho-Akt/PKB in hippocampal CA regions prepared from Aβ-treated rats, leading to cell death as assessed by activa-tion of caspase-3. SF significantly prevented Aβ-induced increases in IL-Iβ and p38 MAPK activation and also Aβ-induced changes in phospho-ERK and phospho-Akt/PKB expression levels. Conclusion: SF prevents Aβ-induced neu-rotoxicity through suppression of p38 MAPK activation and upregulation of phospho-ERK and phospho-Akt/PKB expression.

关键词： ferulic acid amyloid interleukin-1 p38 mitogen-activated protein kinases extra-cellular signal-regulated kinases proto-oncogene proteins c-akt Alzheimer disease

Isoprenaline enhances local Ca2+ release in cardiac myocytes

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Acta Pharmacologica Sinica 2006年第7期27卷 927-932页

作者： Jian-xin SHEN~(2,3,42 department of Physiology,Shantou University Medical College,Shantou 515041,china 3 department of Physiology,Medical School of Xi'an Jiaotong University,Xi'an 710061,china department of Physiology Shantou University Medical College Shantou China department of Physiology Medical School of Xi'an Jiaotong University Xi'an China

Aim:Contraction of cardiac myocytes is controlled by the generation and ampli-fication of intracellular Ca2+*** key step of this process is the couplingbetween sarcolemma L-type Ca2+channels（LCCs）and ryanodine receptors（RyRs）in the sarcoplasmic reticulum（SR）.β-Adrenergic stimulation is an important regu-latory mechanism for this coupling *** the details underlied the globallevel,which require local Ca2+release study are still *** present study isto explore the effects of β-adrenergic stimulation on local Ca2+***:Using confocal microscopy combined with loose-seal patch-clamp approaches,effects of isoprenaline(1 μmol·L-1),a β-adrenergic agonist,on local SR Ca2+re-lease triggered by Ca2+influx through LCCs in intact rat cardiac myocytes ***:Isoprenaline increased the intensity of ensemble averagedlocal Ca2+transients,the peak of which displayed a typical bell-shaped voltage-dependence over the membrane voltages ranging from～-40mV to～+35m ***-ther analysis showed that this enhancement could be explained by the increasedcoupling fidelity（which refers the increased probability of RyRs activation upondepolarization）,and the increased amplitude of evoked Ca2+sparks(due to moreCa2+releases through local RyRs).In addition,isoprenaline decreased the firstlatency,which displayed a typical"U"-shaped voltage-dependence,showing theavailable acceleration and synchronization of β-adrenergic stimulation on intrac-ellular calcium ***:Isoprenaline enhances local Ca2+release incardiac *** results underscore the importance of regulation of β-adrenergic stimulation on local intermolecular signals between LCCs and RyRs inheart cells.

关键词： local calcium release calcium signaling cardiac myocytes isoprenaline confocal microscopy