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Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography

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Biomedical and Environmental Sciences 2018年第6期31卷 407-412页

作者： ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI yi feng CUI Rui SHEN Lin WEI Wen Bin Department of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100730China beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Key Laboratory of Ophthalmology and Visual SciencesBeijing 100005China Department of Bioengineering University of WashingtonSeattle Washington 98195United States of America

Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography（OCTA） based on optical microangiography（OMAG） measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA（Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, inc.） scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network： vessel area density（VAD）, vessel skeleton density（VSD）, vessel diameter index（VDI）, vessel perimeter index（VPI）, vessel complexity index（VCI）, flux, and foveal avascular zone（FAZ）. Coefficient of variation（CV） and intraclass correlation coefficient（ICC） were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%（intravisit） and ≤ 4.6%（intervisit）] and interobserver reproducibility（ICCs ≥ 0.923） for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes.

关键词： Optical coherence tomography angiography Repeatability Reproducibility Macular bloodflow Retinal superficial capillary Vascular quantification

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涉氢环境机械部件的摩擦学研究现状

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摩擦学学报 2021年第4期41卷 572-582页

作者：黄辉万善宏易戈文周峰中国科学院兰州化学物理研究所固体润滑国家重点实验室甘肃兰州730000 中国科学院大学材料与光电研究中心北京100049

氢气作为一种清洁、高效、可持续的二次能源,在未来我国终端能源体系占比至少10%,以氢能作为汽车和飞机动力学系统燃料的研究成为热点.机械运动部件表界面与氢介质将发生复杂的物理化学反应,影响着机械运动接触面的摩擦学行为,使役过程... 详细信息

氢气作为一种清洁、高效、可持续的二次能源,在未来我国终端能源体系占比至少10%,以氢能作为汽车和飞机动力学系统燃料的研究成为热点.机械运动部件表界面与氢介质将发生复杂的物理化学反应,影响着机械运动接触面的摩擦学行为,使役过程中氢致疲劳、磨损及腐蚀失效行为,严重制约着机械动力部件运行稳定性、可靠性和安全性.本文中重点调研了国际上氢气气氛环境下机械运动部件材料的摩擦磨损行为研究进展,总结了氢气环境下聚合物基、陶瓷基、金属基及低维度固体颗粒材料的摩擦磨损行为及其损伤失效演变规律,进一步阐述了摩擦工况下氢气和其他气体介质共存与使役材料的摩擦学行为之间的关联性.从摩擦学角度提出了抑制氢致损伤的可行性关键技术及防护材料,并对未来涉氢机械部件服役安全性的科学问题进行了展望.

关键词：氢气摩擦磨损润滑保护

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Production data-based facies analysis for well placement in thinlayered reservoir

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Energy Geoscience 2022年第3期3卷 219-234页

作者： Xuequn Tan Shiwang Chen Taiyuan Hong Yuliang feng Qiang Ding SINOPEC Petroleum Exploration and Production Research Institute Beijing100026China SINOPEC International Petroleum Exploration and Development Corporation Beijing100029China Goldensun Petroleum technologies inc Beijing100107China

The exploitation of a thin-layered reservoir with thickness less than 5 m(16 ft)needs to rely upon sedimentary facies analysis,due to the low resolution of seismic data and sparse well ***,the ambiguity of facies interpretation creates uncertainty in facies and reservoir *** study aims to better define facies distribution,predict sand-body architecture,and consequently reduce risks in planning development wells,by integrating production data(dynamic)with conceptual geological models(static).An example is shown from the M1 Member of the Napo Formation in the B and G Oilfields(Block J),Oriente Basin,*** M1 reservoir is a thin-layered sandstone reservoir below seismic *** and well-log facies interpretation indicates depositional facies of a tidedominated *** data during the water injection phase of field development can delineate the detailed geometry of the sand *** injector-producer rate responses can determine the connectivity of sand *** performance during primary recovery can capture the scale of single reservoirs because the initial production rates and the cumulative oil production of individual wells are generally proportional to the size of sand bodies.A facies model was thereby *** step-out wells were planned using this model and drilled *** results demonstrate that the integration of dynamic and static data is critical to understanding reservoir facies distribution.

关键词： Tide-dominated estuary Well-log facies Sand-body connectivity Well performance Oriente Basin

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基于SVM的多项式循环程序秩函数生成

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软件学报 2019年第7期30卷 1903-1915页

作者：李轶蔡天训樊建峰吴文渊冯勇中国科学院重庆绿色智能技术研究院自动推理与认知重庆市重点实验室重庆400714 萨基姆通讯(深圳)有限公司广东深圳518000 中国科学院大学计算机科学与技术学院北京100093

程序终止性问题是自动程序验证领域中的一个研究热点。秩函数探测是进行终止性分析的主要方法。针对单重无条件分支的多项式循环程序,将其秩函数计算问题归结为二分类问题,从而可利用支持向量机(SVM)算法来计算程序的秩函数。与基于量... 详细信息

程序终止性问题是自动程序验证领域中的一个研究热点。秩函数探测是进行终止性分析的主要方法。针对单重无条件分支的多项式循环程序,将其秩函数计算问题归结为二分类问题,从而可利用支持向量机(SVM)算法来计算程序的秩函数。与基于量词消去技术的秩函数计算方法不同,该方法能在可接受的时间范围内探测到更为复杂的秩函数。

关键词：程序终止性 SVM 机器学习秩函数

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“互联网+”对返乡创业企业经营业绩的影响——基于全国返乡创业企业的调查数据

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中国科技论坛 2021年第7期 137-147页

作者：王轶王香媚冯科北京工商大学经济学院北京100048 北京大学经济学院北京100871

本文基于2019年全国2139家返乡创业企业调查数据,研究"互联网+"对返乡创业企业经营业绩的影响。研究发现:整体上,网络采购、网络销售、网络招聘和网络培训质量对返乡创业企业经营业绩呈显著正向影响;从创业企业发展层次看,网络销售能显... 详细信息

本文基于2019年全国2139家返乡创业企业调查数据,研究"互联网+"对返乡创业企业经营业绩的影响。研究发现:整体上,网络采购、网络销售、网络招聘和网络培训质量对返乡创业企业经营业绩呈显著正向影响;从创业企业发展层次看,网络销售能显著提升生存型创业企业的经营业绩,网络招聘能显著提升发展型和价值型创业企业的经营业绩;从创业企业所在地区看,网络招聘和网络培训质量对中西部返乡创业企业的经营业绩具有显著正向影响;从创业企业所在行业看,网络招聘能显著提升一二三产业返乡创业企业经营业绩,网络采购能显著提升第二产业创业企业的经营业绩。机制分析发现,"互联网+"提升返乡创业企业经营业绩的动力源于创业者的人力资本水平、创新精神、网络基础设施建设的完备程度、突发事件驱动等重要因素。建议地方政府加强和完善返乡创业培训,提高网络培训质量,提升创业者的人力资本水平;激励企业积极运用互联网技术,推动返乡创业企业线上与线下融合发展。

关键词：乡村振兴互联网+ 返乡创业经营业绩融合发展

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手杖式测树仪研制与试验

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中国农业科技导报 2021年第5期23卷 78-85页

作者：田艺冯仲科常晨北京林业大学精准林业北京市重点实验室北京100083

为了在森林资源调查中能够便捷、快速、精准、高效地获取立木胸径和树高,设计研发了一种手杖式测树仪,其以固定长度手杖为主体,搭载智能手机和测树软件。该设备在传统林业调查装备理论的基础上利用了测树学、摄影测量学、机械加工学、... 详细信息

为了在森林资源调查中能够便捷、快速、精准、高效地获取立木胸径和树高,设计研发了一种手杖式测树仪,其以固定长度手杖为主体,搭载智能手机和测树软件。该设备在传统林业调查装备理论的基础上利用了测树学、摄影测量学、机械加工学、机器视觉、影像处理等技术,通过智能手机影像处理软件实现了胸径的自动识别、测量、记录,并通过手动截取完整立木与所得胸径值演算树高等功能,可以统一编辑、存储、导出最终所得胸径树高。分析结果表明,该手杖式测树仪所得胸径和树高的编差Bias分别为0.29、0.48 cm,相对误差Bias%为1.5%、4.2%,RMSE均为0.70 cm,相对RMSE%为3.6%、6.1%,基本满足二类调查A类精度要求,具有一定的应用价值和推广潜力。

关键词：测树仪森林调查胸径树高

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Integrating multi-modal information to detect spatial domains of spatial transcriptomics by graph attention network

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Journal of Genetics and Genomics 2023年第9期50卷 720-733页

作者： Yuying Huo yilang Guo Jiakang Wang Huijie Xue Yujuan feng Weizheng Chen Xiangyu Li School of Software Engineering Beijing Jiaotong UniversityBeijing 100044China School of Software Engineering Beijing University of TechnologyBeijing 100124China Baidu inc. Beijing 100193China

Recent advances in spatially resolved transcriptomic technologies have enabled unprecedented opportunities to elucidate tissue architecture and function in *** transcriptomics can provide multimodal and complementary information simultaneously,inc.uding gene expression profiles,spatial locations,and histology ***,most existing methods have limitations in efficiently utilizing spatial information and matched high-resolution histology *** fully leverage the multi-modal information,we propose a SPAtially embedded Deep Attentional graph Clustering(SpaDAC)method to identify spatial domains while reconstructing denoised gene expression *** method can efficiently learn the low-dimensional embeddings for spatial transcriptomics data by constructing multi-view graph modules to capture both spatial location connectives and morphological *** results demonstrate that SpaDAC outperforms other algorithms on several recent spatial transcriptomics *** is a valuable tool for spatial domain detection,facilitating the comprehension of tissue architecture and cellular *** source code of SpaDAC is freely available at Github(https://***/huoyuying/***).

关键词： Spatialtranscriptomics Spatial domaindetection Multi-modal integration Graph attention network

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中国地震减灾网格试验床计算网格平台的构建

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北京理工大学学报 2005年第1期25卷 41-44页

作者：陈吉荣李凤霞战守义北京理工大学信息科学技术学院计算机科学工程系北京100081

研究构建中国地震减灾网格试验床的关键技术.基于OGSA和GT3体系结构,提出了计算网格平台的编程模型,分析了模型的网格Web应用层、网格Web服务器层和网格资源/服务层之间的关系.设计并实现了模型的关键组件,并给出了基于GSI的模型安全解... 详细信息

研究构建中国地震减灾网格试验床的关键技术.基于OGSA和GT3体系结构,提出了计算网格平台的编程模型,分析了模型的网格Web应用层、网格Web服务器层和网格资源/服务层之间的关系.设计并实现了模型的关键组件,并给出了基于GSI的模型安全解决方案,最终构建了一个计算网格平台,并在平台上实现了云南地区的地震应力触发计算.计算结果表明,该平台满足网格计算的需求,并能提高计算效率.

关键词：计算网格开放网格体系结构网格服务地震

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Clinical outcomes and immune reconstitution in 103 advanced AIDS patients undergoing 12-month highly active antiretroviral therapy

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Chinese Medical Journal 2006年第20期119卷 1677-1682页

作者： DAI yi QIU Zhi-feng LI Tai-sheng HAN Yang ZUO Ling-yan XIE Jing MA Xiao-jun LIU Zheng-yin WANG Ai-xia Department of Infectious Diseases Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Background Highly active antiretroviral therapy （HAART） produces profound suppression of HIV replication, substantial inc.ease in CD4^＋ T cells, and partial reconstitution of the immune system. However, the numbers of subjects were small in previous Chinese studies. This study evaluated the efficacy and side effects of HAART in Chinese advanced AIDS patients.Methods One hundred and three antiretroviral drug naive AIDS patients were enrolled in this study and were divided into two groups by their baseline CD4^＋ count：〈 100 cells/μl or ≥ 100 cells/μl. Clinical, virological and immunological outcomes were monitored at baseline and at 1, 3, 6, 9 and 12 months during the course of treatment with HAART.Results One patient died and another was lost from the follow-up. For the remaining 101 HIV/AIDS patients at the 12th month during the HAART, the plasma viral load （VL） was reduced to （3.2±0.7） lg copies/ml, the CD4^＋ count inc.eased to （168 ±51） cells/μl [among which the naive phenotype （CD45RA^＋CD62L^＋） inc.eased to （49 ±27） cells/μl and the memory phenotype （CD45RA^-） inc.eased to （119 ±55） cells/μl], and the percentage of CD4^＋CD28^＋ cells inc.eased. At the same time, there was a significant reduction of CD8^＋ T cell activation. In the 69 patients with the baseline CD4^＋ count 〈100 cells/μl, 37 had a VL 〈50 copies/ml; while in the 34 patients with the baseline CD4^＋ count ≥ 100 cells/μl, 25 had a VL 〈50 copies/ml, the difference between the two groups was statistically significant. The CD4^＋ T cell count showed a two-phase inc.ease during HAART and a significant positive correlation was shown between the change of CD4^＋ count and plasma VL. Over 12 months of HAART, 10 patients had gastrointestinal side effects, 13 peripheral neuritis, 7 hepatic lesions, 8 hematological side effects, 8 skin rashes, 10 lipodystrophy and 1 renal calculus.Conclusions Immune reconstitution as well as the significantly improved clinical outcomes is observed in Chinese advanced AIDS pat

关键词： acquired immunodeficiency syndrome antiretroviral therapy, highly active CD4 lymphocyte count immune reconstitution adverse effects

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Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)

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Cancer Communications 2022年第12期42卷 1314-1330页

作者： Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao ying Yuan Jifeng feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted DrugsBeijingP.R.China Department II of Thoracic Medicine Hunan Cancer HospitalChangshaHunanP.R.China Department of Medical Oncology Zhejiang Cancer HospitalHangzhouZhejiangP.R.China Department of Respiratory Diseases The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhouZhejiangP.R.China The Third Department of Chemotherapy Weihai Municipal HospitalWeihaiShandongP.R.China Department of Medical Oncology Linyi Cancer HospitalLinyiShandongP.R.China Oncology Department General Hospital of Chinese People’s Liberation ArmyBeijingP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Oncology Beijing Chao-Yang HospitalCapital Medical UniversityBeijingP.R.China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang UniversityHangzhouZhejiangP.R.China Department of Medical Oncology Xuzhou Central HospitalXuzhou Medical UniversityXuzhouJiangsuP.R.China Department of Medical Oncology Shanghai Pulmonary HospitalTongji UniversityShanghaiP.R.China Department of Lung Cancer Tianjin Medical University Cancer Institute and HospitalTianjinP.R.China Department of Medical Oncology Cancer HospitalThe First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen UniversityThe Third Clinical Medical CollegeFujian Medical UniversityXiamenFujianP.R.China Department of Medical Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Oncology Affiliated Hospital of Jining Medical UniversityJiningShandongP.R.China Department of Respiratory and Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingP.R.China Department of Medical Oncology Key L

Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are *** study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic ***:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based *** were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance *** primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints inc.uded progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and ***:Between August 25,2017,and November 7,2018,290 patients were *** FAS,10 patients fromthe docetaxel armwere *** OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;Pinc.uding OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatme

关键词： Non-small cell lung cancer Carcinoma squamous cell Sintilimab Immunotherapy Survival Randomized controlled trial

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