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Potential therapeutic role of spermine via Rac1 in osteoporosis:Insights from zebrafish and mice

Zoological Research 2024年第2期45卷 367-380页

作者： Rui-Xue jiang Nan Hu Yu-wei Deng Long-wei Hu Hao Gu Nan Luo Jin Wen xin-Quan jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China college of Stomatology Shanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai 200125China Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Preventive Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200011China

Osteoporosis(OP)is a prevalent metabolic bone *** drug therapy is essential to prevent bone loss in osteoporotic patients,current treatments are limited by side effects and high costs,necessitating the development of more effective and safer targeted *** a zebrafish(Danio rerio)larval model of osteoporosis,we explored the influence of the metabolite spermine on bone *** showed that spermine exhibited dual activity in osteoporotic zebrafish larvae by increasing bone formation and decreasing bone *** not only demonstrated excellent biosafety but also mitigated prednisolone-induced embryonic neurotoxicity and ***,spermine showcased protective attributes in the nervous systems of both zebrafish embryos and *** the molecular level,Rac1 was identified as playing a pivotal role in mediating the antiosteoporotic effects of spermine,with P53 potentially acting downstream of *** findings were confirmed using mouse(Mus musculus)models,in which spermine not only ameliorated osteoporosis but also promoted bone formation and mineralization under healthy conditions,suggesting strong potential as a bonestrengthening *** study underscores the beneficial role of spermine in osteoporotic bone homeostasis and skeletal system development,highlighting pivotal molecular *** their efficacy and safety,human endogenous metabolites like spermine are promising candidates for new anti-osteoporotic drug development and daily bone-fortifying agents.

关键词： Osteoporosis Spermine Rac1 Zebrafish Mice

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Parity-dependent skin effects and topological properties in the multilayer nonreciprocal Su−Schrieffer−Heeger structures

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Frontiers of physics 2024年第3期19卷 115-133页

作者： Jia-Rui Li Cui jiang Han Su Di Qi Lian-Lian Zhang wei-jiang Gong college of sciences Northeastern UniversityShenyang 110819China Basic Department Shenyang Institute of EngineeringShenyang 110136China

We concentrate on the skin effects and topological properties in the multilayer non-Hermitian Su−Schrieffer−Heeger (SSH) structure, by taking into account the nonreciprocal couplings between the different sublattices in the unit cells. Following the detailed demonstration of the theoretical method, we find that in this system, the skin effects and topological phase transitions induced by nonreciprocal couplings display the apparent parity effect, following the increase of the layer number of this SSH structure. On the one hand, the skin effect is determined by the parity of the layer number of this SSH system, as well as the parity of the band index of the bulk states. On the other hand, for the topological edge modes, such an interesting parity effect can also be observed clearly. Next, when the parameter disorders are taken into account, the zero-energy edge modes in the odd-layer structures tend to be more robust, whereas the other edge modes are easy to be destroyed. In view of these results, it can be ascertained that the findings in this work promote to understand the influences of nonreciprocal couplings on the skin effects and topological properties in the multilayer SSH lattices.

关键词： multilayer SSH lattice nonreciprocal couplings band structure skin effect

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Non-destructive buffer enabling near-infrared-transparent inverted inorganic perovskite solar cells toward 1400 h light-soaking stable perovskite/Cu(In,Ga)Se_(2) tandem solar cells

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Journal of Energy Chemistry 2024年第10期97卷 622-629,I0013页

作者： Yu Zhang Zhaoheng Tang Zhongyang Zhang Jiahong Tang Minghua Li Siyuan Zhu Wenyan Tan xi Jin Tongsheng Chen Jinsong Hu Chao Zhou Chunlei Yang Qijie Liang Xugang Guo weimin Li weiqiang Chen Yan jiang MOE Key Laboratory of Laser Life science&Guangdong Provincial Key Laboratory of Laser Life science Guangzhou Key Laboratory of Spectral Analysis and Functional ProbesCollege of BiophotonicsSouth China Normal UniversityGuangzhou 510631GuangdongChina school of Materials science and Engineering Beijing Institute of TechnologyBeijing 100081China Songshan Lake Materials Laboratory Dongguan 523429GuangdongChina Department of Materials science and Engineering Guangdong Provincial Key Laboratory of Functional Oxide Materials and DevicesSouthern University of Science and TechnologyShenzhen 518055GuangdongChina Beijing Advanced Innovation Center for Soft Matter science and Engineering College of Chemical EngineeringCollege of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China Department of Physics Liaoning UniversityShenyang 110036LiaoningChina Beijing National Laboratory for Molecular sciences(BNLMS) Institute of ChemistryChinese Academy of SciencesBeijing 100190China School of Physics and Materials science Guangzhou UniversityGuangzhou 510006GuangdongChina Shenzhen Institute of Advanced technology Chinese Academy of SciencesShenzhen 18055GuangdongChina

Near-infrared(NIR)transparent inverted all-inorganic perovskite solar cells(PSCs)are excellent top cell candidates in tandem *** essential challenge is the replacement of metal contacts with transparent conductive oxide(TCO)electrodes,which requires the introduction of a buffer layer to prevent sputtering *** this study,we show that the conventional buffers(i.e.,small organic molecules and atomic layer deposited metal oxides)used for organic-inorganic hybrid perovskites are not applicable to all-inorganic perovskites,due to non-uniform coverage of the vulnerable layers underneath,deterioration upon ion bombardment and moisture induced perovskite phase transition,A thin film of metal oxide nanoparticles by the spin-coating method serves as a non-destructive buffer layer for inorganic ***-inorganic inverted near-infrared-transparent PSCs deliver a PCE of 17.46%and an average transmittance of 73.7%between 780 and 1200 *** combination with an 18.56%Cu(In,Ga)Se_(2) bottom cell,we further demonstrate the first all-inorganic perovskite/CIGS 4-T tandem solar cell with a PCE of 24.75%,which exhibits excellent illumination stability by maintaining 86.7%of its initial efficiency after 1400 *** non-destructive buffer lays the foundation for efficient and stable NIR-transparent inverted inorganic perovskite solar cells and perovskite-based tandems.

关键词： CsPbI_(3)perovskite Inverted perovskite solar cells Tandem solar cells Buffer layer Stability

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Deep Learning based Efficient Edge Slicing for System Cost Minimization in Wireless Networks

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Journal of Communications and Information Networks 2024年第2期9卷 162-175页

作者： wei jiang Daquan Feng Liping Qian Yao Sun college of Information Engineering Zhejiang University of TechnologyHangzhou 310023China Shenzhen Key Laboratory of Digital Creative technology Guangdong Province Engineering Laboratory for Digital Creative TechnologyCollege of Electronics and Information EngineeringShenzhen UniversityShenzhen 518060China James Watt School of Engineering University of GlasgowG128QQScotlandUK

It is widely recognized that the future wireless networks are able to efficiently slice heterogeneous resources to provide customized services for various use cases. However, it is challenging to meet the diverse requirements of ever-growing applications, especially the stringent requirements of numerous delay-sensitive and/or computation-intensive applications. To tackle this challenge, we should not only consider user admission control to cope with resource limitations, but also make resource management more intelligent and flexible to meet diverse service needs. Taking advantages of mobile edge computing(MEC)and network slicing, in this paper, we propose deep edge slicing(DES),to jointly optimize user admission control and resource scheduling with the aim of minimizing the system cost while guaranteeing multitudinous quality-of-service (QoS) requirements. Specifically, we first apply a deep reinforcement learning approach to select the optimal set of access users with different service requests for maximizing resource *** a deep learning algorithm is employed to predict traffic data for allocating the communication and computing resources to different slices in advance. Finally, we realize the dynamic scheduling of heterogeneous resources by solving the optimization problem of minimizing the system cost. Simulation results demonstrate that DES can greatly reduce the system cost compared to other benchmarks.

关键词： deep learning mobile edge computing user admission control resource scheduling

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A Discrete Spectral Problem and Related Hierarchy of Discrete Hamiltonian Lattice Equations

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Communications in Theoretical Physics 2007年第8期48卷 193-198页

作者： XU xi-xiang college of science,Shandong Uniersity of science and technology,Qingdao 266510,chinaCAO wei-Li college of science,Uniersity of Shanghai for science and technology,Shanghai 200093,china college of science Shandong University of Science and Technology college of science University of Shanghai for Science and Technology

Staring from a discrete matrix spectral problem,a hierarchy of lattice soliton equations is presentedthough discrete zero curvature *** resulting lattice soliton equations possess non-local Lax *** structures are esta... 详细信息

关键词： lattice soliton equation zero curvature representation Hamiltonian structure Liouville integrability

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Characteristics of Particulate Matter Emissions for Low-Sulfur Heavy Oil Used in Low-Speed Two-Stroke Diesel Engines of Ocean-Going Ships

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Journal of Thermal science 2024年第2期33卷 739-750页

作者： WU Gang MA Qianli wei Lijiang jiang Guohe WANG Tengfei LI Tie Merchant Marine college Shanghai Maritime UniversityShanghai201306China State Key Laboratory of Ocean Engineering Shanghai Jiao Tong UniversityShanghai200240China

In this work,particulate matter(PM) emissions from a large two-stroke,low-speed marine diesel engine were investigated when the engine was operated with low-sulfur heavy fuel oil(HFO) at various *** samples were collected in situ from the engine exhaust to determine the detailed physical and chemical *** nanostructure and morphology of the nanoparticles were analyzed using transmission electron microscopy images(TEM).The results show that volatile organic carbon(OC) accounts for more than 80% in the HFO particles and leads to an increase in particle *** thermodynamic conditions of a low-speed engine favor the behavior of capturing the soluble organic components.A large number of spherical char HFO particles with aerodynamic diameters of 0.2 μm-0.5 μm and a suspected inner metal core were *** two peak aerodynamic diameters of the HFO nanoparticles are 15 nm and 86 *** morphological differences among the HFO nanoparticles in varied engine conditions represent the formation process from primary nascent particles to mature graphitized particles caused by *** above study will be valuable for understanding the characteristics of PM emissions from low-sulfur HFO to achieve the ship PM emissions reduction target.

关键词： low-speed diesel engine maritime regulations heavy fuel oil TEM particles size and distribution

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Chromosome-level genome assembly of the glass catfish(Kryptopterus vitreolus)reveals molecular clues to its transparent phenotype

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Zoological Research 2024年第5期45卷 1027-1036页

作者： Chao Bian Rui-Han Li Zhi-Qiang Ruan wei-Ting Chen Yu Huang Li-Yue Liu Hong-Ling Zhou Cheong-Meng Chong xi-Dong Mu Qiong Shi Laboratory of Aquatic Genomics College of Life Sciences and OceanographyShenzhen UniversityShenzhenGuangdong 518057China Key Laboratory of Prevention and Control for Aquatic Invasive Alien Species Ministry of Agriculture and Rural AffairsGuangdong Modern.Recreational Fisheries Engineering Technology CenterPearl River Fisheries Research InstituteChinese Academy of Fishery SciencesGuangzhouGuangdong 510380China Shenzhen Key Lab of Marine Genomics Guangdong Provincial Key Lab of Molecular Breeding in Marine Economic AnimalsBGI Academy of Marine SciencesBGI MarineShenzhenGuangdong 518081China CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of SciencesChengduSichuan 610041China School of Life sciences Jiaying UniversityMeizhouGuangdong 514015China china Zebrafish Resource Center National Aquatic Biological Resource CenterState Key Laboratory of Freshwater Ecology and BiotechnologyInstitute of HydrobiologyChinese Academy of ScienceWuhanHubei 430072China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhenGuangdong 518116China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacaoMacao 999078China Center for Aquatic Genomics College of Life SciencesNeijiang Normal UniversityNeijiangSichuan 641100China

Glass catfish(Kryptopterus vitreolus)are notable in the aquarium trade for their highly transparent body *** transparency is due to the loss of most reflective iridophores and light-absorbing melanophores in the main body,although certain black and silver pigments remain in the face and *** date,however,the molecular mechanisms underlying this transparent phenotype remain largely *** explore the genetic basis of this transparency,we constructed a chromosome-level haplotypic genome assembly for the glass catfish,encompassing 32 chromosomes and 23344 protein-coding genes,using PacBio and Hi-C sequencing technologies and standard assembly and annotation *** revealed a premature stop codon in the putative albinism-related tyrp1b gene,encoding tyrosinase-related protein 1,rendering it a nonfunctional ***,a synteny comparison with over 30 other fish species identified the loss of the endothelin-3(edn3b)gene in the glass catfish *** investigate the role of edn3b,we generated edn3b^(−/−)mutant zebrafish,which exhibited a remarkable reduction in black pigments in body surface stripes compared to wild-type *** findings indicate that edn3b loss contributes to the transparent phenotype of the glass *** high-quality chromosome-scale genome assembly and identification of key genes provide important molecular insights into the transparent phenotype of glass *** findings not only enhance our understanding of the molecular mechanisms underlying transparency in glass catfish,but also offer a valuable genetic resource for further research on pigmentation in various animal species.

关键词： Glass catfish Whole-genome sequencing edn3b−/−mutant Transparent phenotype

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Non-contact wide-field viewing system-assisted scleral buckling surgery for retinal detachment in silicone oilfilled eyes

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 761-766页

作者： Su-Lan Wu Yi-Qi Chen Li-Jun Shen Jian-Bo Mao Li Lin Ji-wei Tao Huan Chen Shi-An Zhang Jia-Feng Yu Chen-xi Wang Center for Rehabilitation Medicine Department of OphthalmologyZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina The Affiliated Eye Hospital of Wenzhou Medical university in Hangzhou Hangzhou 310000Zhejiang ProvinceChina

AIM:To evaluate scleral buckling(SB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(SO)-filled ***:Totally 9 patients(9 eyes)with retinal detachment in SO-filled eyes were retrospectively *** patients underwent non-contact wide-field viewing system-assisted buckling surgery with 23-gauge intraocular *** was removed at an appropriate time based on *** patients were followed up for at least 3mo after SO *** reattachment,complications,visual acuity and intraocular pressure(IOP)before and after surgery were ***:Patients were followed up for a mean of 8.22mo(3-22mo)after SO *** patients had retinal *** the final follow-up,visual acuity showed improvement for 8 patients,and no change for 1 *** IOP was high in 3 patients before surgery,but it stabilized after treatment;it was not affected in the other *** of the patients had infections,hemorrhage,anterior ischemia,or any other ***:This new non-contact wide-field viewing system-assisted SB surgery with 23-gauge intraocular illumination is effective and safe for retinal detachment in SO-filled eyes.

关键词： non-contact wide-field viewing system scleral buckling silicone oil-filled retinal detachment

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Enhancing the electrocatalytic performance of nitrate reduction to ammonia by in-situ nitrogen leaching

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Chinese Chemical Letters 2024年第2期35卷 564-569页

作者： Mimi Fu Yini Mao Hua Wang wei Luo Yimin jiang wei Shen Ming Li Rongxing He college of Chemistry and Chemical Engineering Southwest UniversityChongqing 400715China

Electrochemical nitrate reduction reaction (NITRR) is regarded as a “two birds-one stone” method for the treatment of nitrate contaminant in polluted water and the synthesis of valuable ammonia, which is retarded by the lack of highly reactive and selective electrocatalysts .Herein, for the first time, nickel foam supported Co_(4) N was designed as a high-performance NITRR catalyst by an in-situ nonmetal leaching-induced *** the optimal potential, the Co_(4) N/NF catalyst achieves ultra-high Faraday efficiency and NH_(3) selectivity of 95.4% and 99.4%, *** situ X-ray absorption spectroscopy (XAS), together with other experiments powerfully reveal that the nitrogen vacancies produced by nitrogen leaching are stable and play a key role in boosting nitrate reduction to *** calculations confirm that Co_(4) N with abundant nitrogen vacancies can optimize the adsorption energies of NO_(3)^(-) and intermediates, lower the free energy (Δ G ) of the potential-determining step (*NH_(3) to NH_(3) ) and inhibit the formation of N-containing *** addition, we also conclude that the nitrogen vacancies can stabilize the adsorbed hydrogen, making H_(2) quite difficult to produce, and lowering ΔG from *NO to *NOH, which facilitates the selective reduction of *** study reveals significant insights about the in-situ nonmetal leaching to enhance the NITRR activity.

关键词： Co4N Nitrate reduction In-situ nonmetal leaching Nitrogen vacancy Mechanism

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Computer-assisted three-dimensional individualized extreme liver resection for hepatoblastoma in proximity to the major liver vasculature

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1066-1077页

作者： Wen-Li xiu Jie Liu Jing-Li Zhang Jing-Miao Wang Xue-Feng Wang Fei-Fei Wang Jie Mi xi-wei Hao Nanxia Qian Dong Department of Pediatric Surgery The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pediatric Surgery Yijishan Hospital of Wannan Medical CollegeWuhu 241000Anhui ProvinceChina Shandong Provincial Key Laboratory of Digital Medicine and Computer-assisted Surgery Shandong College Collaborative Innovation Center of Digital Medicine Clinical Treatment and Nutrition HealthQingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND The management of hepatoblastoma(HB)becomes challenging when the tumor remains in close proximity to the major liver vasculature(PMV)even after a full course of neoadjuvant chemotherapy(NAC).In such cases,extreme liver resection can be considered a potential *** To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of *** We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June *** then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of *** Sixty-seven children diagnosed with HB underwent surgical *** age at diagnosis was 21.4±18.8 months,and 40 boys and 27 girls were ***-nine(88.1%)patients had a single tumor,39(58.2%)of which was located in the right lobe of the liver.A total of 47 patients(70.1%)had PRE-TEXT III or ***-nine patients(58.2%)underwent delayed *** a full course of NAC,16 patients still had close PMV(within 1 cm in two patients,touching in 11 patients,compressing in four patients,and showing tumor thrombus in three patients).There were 6 patients of tumors in the middle lobe of the liver,and four of those patients exhibited liver anatomy *** 16 children underwent extreme liver resection after comprehensive preoperative *** procedures were performed according to the preoperative plan,and the operations were successfully ***,the 3-year event-free survival of 67 children with HB is 88%.Among the 16 children who underwent extreme liver resection,three experienced recurrence,and one died due to multiple *** Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and *** approach not only reduces th

关键词： Children Hepatoblastoma Surgery Three-dimensional Computer-assisted

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