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Chinese Chemical Letters 2007年第2期18卷 124-126页

作者： Guo Qiang Hu, Song Qiang Xie, Wen Long Huang Institute of Pharmacy, Henan university, Kaifeng 475001, china china pharmaceutical university, Nanjing 210009, china [a]Institute of Pharmacy Henan University Kaifeng 475001 China [b]china pharmaceutical university Nanjing 210009 China

Five water-soluble poly(aminoheterocyclic amine)s containing s-triazole ring were synthesized as respective HC1 salts (5a-5e). Biological activities in L1210 (murine leukemia) and Chinese hamster ovary (CHO) cell lines were investigated via IC50 cytotoxicity determinations. The tide compounds represented moderate cytotoxicity (low IC50 values between 15 and 68μmol/L) in L1210 but high cytotoxicity (lower IC50 values: 0.25,0.018,0.014μmol/L for Sa-5e, respectively) in CHO cell lines, while the corresponding HC1 salts of the intermediates (3a-3e) without polyamine tether and starting materials amino-s-triazoles (1a-1e) showed poor or no activities against the above cell lines.

关键词： Triazole Polyamine Water-soluble Antitumor activity

Hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration in mice

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Acta Pharmacologica Sinica 2004年第7期25卷 120-126页

作者： Zheng-hong WU, Qi-neng PING2, Yi WEI, Jia-ming LAI Department of Pharmaceutics, china pharmaceutical university, Nanjing 210009, china Department of Pharmaceutics China Pharmaceutical University Nanjing 210009 China

AIM: To evaluate the hypoglycemic efficacy of insulin liposomes coated by chitosan with different molecular weights and concentrations after oral administration in mice. METHODS: Insulin-liposomes were prepared by reversed-phase evaporation. Chitosan coating was carried out by incubation of the liposomal suspensions with the chitosan solution. The hypoglycemic efficacies of chitosan-coated insulin liposomes were investigated by monitor- ing the blood glucose level using the glucose oxidase method after oral administration to healthy mice. RESULTS: In all the insulin liposomes, the insulin liposomes coated by 0.2 % chitosan (Mr 1000 kDa) showed a better hypogly- cemic efficacy as compared with the other liposomes coated by chitosan. The minimum blood glucose level was 15.1 %±6.0 % of the initial (n=6). The hypoglycemic efficacy lasted for 4 h after oral administration to mice. CONCLUSION: Chitosan-coated liposomes could reduce tryptic digestion on insulin, and enhance enteral absorp- tion of insulin. The molecular weights and concentrations of chitosan had significant effects on hypoglycemic efficacy of chitosan-coated insulin liposomes after oral administration to healthy mice.

关键词： chitin chitosan insulin liposomes blood glucose oral administration

A New Azafluorenone Alkaloid from Alphonsea Monogyma

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Chinese Chemical Letters 1999年第8期10卷 671-672页

作者： Ning XIE Nian Yun YANG (Department of Phytochemistry.china pharmaceutical university Nanjing 210009) china Pharmaceut Univ Dept Phytochem Nanjing 210009 Peoples R China

A new azafluorenone (onychine) alkaloid, 6,7-dimethoxy-5-hydroxy-onychine, was isolated from the stem and branch of Alphonsea monogyma. Its structure was established mainly on the basis of spectral analysis.

关键词： Alphonsea monogyma 6,7-dimethoxy-5-hydroxy-onychine

Design,synthesis and antitumor activity of 6,7-disubstituted-4-(heteroarylamino)quinoline-3-carbonitrile derivatives

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Chinese Chemical Letters 2010年第5期21卷 554-557页

作者： Bao Liu,Qi Dong You,Zhi Yu Li Department of Medicinal Chemistry,china pharmaceutical university,Nanjing 210009,china [a] Department of Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of new 6,7-disubstituted-4-(benzothiazol-6-ylamino)quinoline-3-carbonitrile derivatives(12a-l) were *** cytotoxicity of 12 new compounds was evaluated in AGS,HepG2 and HT-29 cell *** results showed that compounds 12g, 12h,12i,12k and 12l displayed more potent cytotoxic activities than Bosutinib,compound 12l exhibited the most potent antitumor activity among the tested compounds.

关键词： 3-Quinolinecarbonitrile derivatives Synthesis Antitumor

ABSOLUTELY E-PURE MODULES AND E-PURE SPLIT MODULES

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Acta Mathematica Scientia 2011年第1期31卷 207-220页

作者：阎舫宇 Department of Mathematics Nanjing University Department of Basic Courses China Pharmaceutical University

We first introduce the concepts of absolutely E-pure modules and E-pure split modules. Then, we characterize the IF rings in terms of absolutely E-pure modules. The E-pure split modules are also characterized.

关键词： Absolutely E-pure module E-pure split module IF ring copure flat module

Doxepin protects cultured neurons against oxidative stress-induced injury

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Acta Pharmacologica Sinica 2004年第3期25卷 43-46页

作者： Bian-sheng JI,He JI1,Guo-qing LIU2 Department of Pharmacology,china pharmaceutical university,Nanjing 210009 1Department of Medicine,Henan university,Kaifeng 475001,china Department of Pharmacology China Pharmaceutical University Department of Medicine Henan University

AIM: To investigate protective effects of doxepin (Dox) on cultured neuronal injury induced by oxidative stress. METHODS: Cytotoxicities of glutamate (Glu 0.5 mmol/L, 15 min), sodium dithionite (0.5 mmol/L, 24 h) or hemo- globin (Hb100 mg/L,24 h)and the protective effects of Dox were observed. RESULTS: Exposure of cultured neurons to Glu, sodium dithionite and Hb developed a neurotoxicity expressed in the thiazol blue tetrazolium bro- mide (MTT) assay, the increase of lactate dehydrogenase (LDH) leakage, malondialdehyde (MDA) content and intracellular [Ca2+]i accumulation, as well as the decrease of superoxide dismutase (SOD) activity. DOX 1-100 nmol/L significantly inhibited all above changes. CONCLUSION: Dox protects cultured neurons against oxidative stress-induced injury by suppressing intracellular [Ca2+]iaccumulation, decreasing lipid peroxide generation and stimulating antioxidant enzyme.

关键词： doxepin ischemia glutamic acid hemoglobins neurons

New Coumarins From Peacedanum Decursivum

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Chinese Chemical Letters 1999年第6期10卷 477-480页

作者： Nian Huan YAO Ling Yi KONG(Department of phytochemistry. china pharmaceutical university. Nan-ling 210038) china Pharmaceut Univ Dept Phytochem Nanjing 210038 Peoples R China

Four new Coumarins named Decursitin B, C, D. F have been isolated from traditional Chinese medicine - the root of Peacedanum decursivum. Their structures were elucidated by chemical evidences and spectral analysis.

关键词： Peacedanum decursivum decursitin B decursitin C decursitin D decursitin F

A New Enolate Furostanoside from Asparagus Filicinus

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Chinese Chemical Letters 2000年第9期11卷 793-794页

作者： Xiao Dong CONG Wen Cai YE Chun Tao CHE Department of Pharmacohnosy china pharmaceutical university Nanjing 210009 Department of Phytochemistry china pharmaceutical university Nanjing 210009 School of Chinese Medicine The Chinese university of Hong Kon china Pharmaceut Univ Dept Pharmacognosy Nanjing 210009 Peoples R China china Pharmaceut Univ Dept Phytochem Nanjing 210009 Peoples R China Chinese Univ Hong Kong Sch Chinese Med Hong Kong Hong Kong Peoples R China

A new enolate derivative of furostanol glycoside, named asparagusin A, was isolated from the roots of Asparagus filicinus and established as 3-O-beta-D-xylopyranosyl(1-->4)-beta-D-glucopyranosyl (25S)-furost-20(22)-ene-3 beta, 26-diol 26-O-beta-D-glucopyranoside (1) by spectroscopic and chemical methods. Asparagusin A (1) exhibited a cytotoxic activity effect on PC12 cells.

关键词： Asparagus filicinus Liliaceae furostanol glycoside asparagusin A cytotoxic activity

The Influence of Ketones on the Formation of Symmetrical Secondary Amine: A New Method for Preparation of N, N-Bis-(dimethoxyphenylethyl)amine

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Chinese Chemical Letters 1999年第11期10卷 895-898页

作者： Chong Zhao RAN Lin XIA Pei Zhou NI(Division of Medicinal Chemistry, china pharmaceutical university,Naming 210009) china Pharmaceut Univ Div Med Chem Nanjing 210009 Peoples R China

The influence of some ketones on the formation of symmetrical secondary amine N, N-bis-(3, 4-dimethoxyphenylethyl)amine 1 were discussed and a new method For preparing 1 was described.

关键词： symmetrical secondary amine N,N-bis-(3-4-dimethoxyphenylethyl)amine ketone

Coumarin-glycoside and Ferulate from Peucedanum decursivum

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Chinese Chemical Letters 2000年第4期11卷 315-318页

作者： Ling Yi KONG Nian Huan YAO (Department of Natural Medicinal Chemistry, china pharmaceutical university. Nanjing 210038) china Pharmaceut Univ Dept Nat Med Chem Nanjing 210038 Peoples R China

Two new compounds named decuroside VI(1) and decursidate (2) were isolated from the roots of Peucedanum decursivum - a traditional Chinese medicine. Their structures were elucidated on the basis of chemical evidence a... 详细信息

关键词： Peucedanum decursivum decuroside VI decursidate