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Cyclooxygenase-2 polymorphisms and susceptibility to gastric carcinoma: A meta-analysis

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World Journal of Gastroenterology 2010年第43期16卷 5510-5517页

作者： Jia-Li Liu, Zhen-Ning Wang, Department of Surgical Oncology and General Surgery, the First Affiliated Hospital of china medical university, Shenyang 110001, Liaoning Province, china Yuan Liang, Department of Oncology, the Shengjing Affiliated Hospital of china medical university, Shenyang 110001, Liaoning Province, china Xin Zhou, Department of Obstetrics and Gynecology, the Shengjing Affiliated Hospital of china medical university, Shenyang 110001, Liaoning Province, china Li-Li Xing, Department of Oncology, the Fourth Affiliated Hospital of china medical university, Shenyang 110032, Liaoning Province, china Department of Surgical Oncology and General Surgery the First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China. josieon826@***

AIM: To investigate the association of the cyclooxygenases-2 (COX-2) polymorphisms and susceptibility to gastric cancer (GC) by means of meta-analysis. METHODS: Publications addressing the association between polymorphisms of COX-2 and susceptibility to GC were selected from the MEDLINE, EMBASE and CBMdisc databases. Data was extracted from the studies by 2 independent reviewers. The meta-analyses were performed by RevMan 5.0.23. From these data, odds ratio (OR) with 95% confidence interval (CI) was ***: Ten studies were retrieved reporting a total of 11 COX-2 polymorphisms. Carriers of -765C, -1195A, -1290G, *2430T alleles and *429TT genotype revealed increased risk for GC (OR = 1.71, 95% CI: 1.01-2.90, P = 0.05; OR = 1.58, 95% CI: 1.05-2.38, P = 0.03; OR = 1.55, 95% CI: 1.01-2.39, P = 0.05; OR = 2.62, 95% CI: 1.20-5.73, P = 0.02 and OR = 0.74, 95% CI: 0.59-0.95, P = 0.02, respectively). CONCLUSION: The -765C, -1195A, -1290G, *2430T alleles and *429TT genotype of COX-2 polymorphisms were determined a significant association with susceptibility to GC.

关键词： Cyclooxygenases-2 Gastric cancer Polymorphisms Susceptibility Meta-analysis

Corticosteroids or non-corticosteroids: a fresh perspective on alcoholic hepatitis treatment

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 458-464页

作者： Fei Wang and Bing-Yuan Wang Department of Gastroenterology, First Affiliated Hospital, china medical university, Shenyang 110001, china Department of Gastroenterology First Affiliated Hospital China Medical University Shenyang 110001 China

BACKGROUND: Alcoholic hepatitis (AH) is a necrotizing inflammatory process caused by alcoholic liver injury. It carries a significant short-term mortality. The management of AH is challenging. Although corticosteroids have been demonstrated to exert anti-inflammatory and antifibrotic effects, their efficacy for the treatment of AH remains debatable. DATA SOURCES: A literature search was performed of MEDLINE, ScienceDirect, SpringerLink and Wiley InterScience using the key words 'alcoholic hepatitis', 'alcoholic liver disease', and 'corticosteroids'. The available data reported in the relevant literature were analyzed. RESULTS: More than 17 controlled trials and at least 13 meta-analyses have reported the efficacy of corticosteroids in the treatment of AH in the past 40 years. Many were poorly designed and used different inclusion/exclusion criteria, making it difficult to reach a consensus. In this review, we summarized all the controversial data in the past decade and analyzed the potential causes for the varying therapeutic effects of corticosteroids in AH. The focus of the controversy has changed from 'whether steroids are beneficial or harmful for AH patients' to 'how to accurately identify responders to steroids early and rationalize corticosteroid treatment'. An early response to glucocorticoids, as determined by calculating the Lille score after 7 days of treatment, has been shown to be a clinically useful indicator. Moreover, down-regulation of steroid sensitivity, risk of infection, and a rational therapeutic strategy of corticosteroids in AH patients are all crucial for therapeutic ***: An early and accurate determination of steroid sensitivity is important. Besides, we need to overcome the down-regulation of steroid sensitivity, reduce the infection risk and rationalize the therapeutic strategy of corticosteroids. A fresh perspective is needed on the use of corticosteroids in AH patients.

关键词： corticosteroids alcoholic liver disease alcoholic hepatitis steroid sensitivity scoring system

^(103)Pd-induced apoptosis of proliferative smooth muscle cells in bile ducts of dogs:significance and effects on related genes

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Hepatobiliary & Pancreatic Diseases International 2007年第5期6卷 521-526页

作者： Gui-Jin He,Fa-Qiang Yu,Rong Wu,Qin-Yi Gao,Shu-He Xu,Hong Gao, Wei-Guo Jiang,Tao Jiang and Xian-Wei Dai Department of General Surgery,Second Affiliated Hospital(Shengjing Hospital),china medical university,Shenyang 110004,china,Radiotherapy Center,Second Affiliated Hospital(Shengjing Hospital),china medical university,Shenyang 110004,china,Pediatrics Surgery Laboratory,Second Affiliated Hospital(Shengjing Hospital),china medical university,Shenyang 110004,china,Department of Pathology,Second Affiliated Hospital(Shengjing Hospital),china medical university,Shenyang 110004,china Isotope Unit,First Affiliated Hospital,china medical university,Shenyang 110001,china and Isotope Research Institute,china Institute of Atomic Energy,Beijing 100050,china Department of General Surgery Second Affiliated Hospital (Shengjing Hospital) China Medical University Shenyang 110004 China. 23318199@***

BACKGROUND:With the objective of developing a locally- produced radioactive stent,the present study used in vivo animal experiments to explore apoptosis of proliferative smooth muscle cells resulting from facilitation of the expression of genes caused byγ-radiation in order to prevent bile duct *** therefore explored the effects and significance ofγ-radiation on the activity of caspase-3,Fas and Bcl-2 genes in apoptosis of proliferative smooth muscle cells in the bile duct walls of dogs. METHODS:Twelve dogs were randomly divided into 2 groups(6 in each group).A postinjury bile duct stenosis model was established and radioactive 103 Pd( 103 palladium) or ordinary bile duct stents were implanted into the bile *** staining,RT-PCR and immunohistochemistry were used to detect the proliferation and apoptosis of bile duct smooth muscle cells in proliferative endomembrane and the expression of related caspase-3,Bcl-2 and Fas genes. RESULTS:The expression of caspase-3 and Fas genes in the bile duct tissues of dogs with radioactive stents was higher than that of dogs with ordinary *** was significant apoptosis of proliferative smooth muscle cells in the bile *** expression of the Bcl-2 gene in the bile duct tissues of dogs with radioactive stents was lower than that in those with ordinary *** was significant apoptosis of proliferative smooth muscle cells in the dogs with low Bcl-2 gene expression. CONCLUSIONS:Radiation increases the activity of caspase-3 and Fas genes and is associated with apoptosis. The radioactive 103 Pd stent may facilitate apoptosis of proliferative smooth muscle cells in the bile ducts of dogs by activating these *** Bcl-2 gene expression level is correlated with the occurrence of apoptosis and the radiosusceptibility of cells.

关键词： radioactive 103 Pd stent γ-radiation caspase-3 gene Fas gene Bcl-2 gene apoptosis

Quantitative analysis of the ribbon synapse number of cochlear inner hair cells in C57BL/6J mice using the three-dimensional modeling method

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Science china(Life Sciences) 2009年第9期52卷 807-812页

作者： LIU Ke,LI ShuNa & JIANG XueJun Department of Otolaryngology,the First Affiliated Hospital,china medical university,Shenyang 110001,china Department of Otolaryngology the First Affiliated Hospital China Medical University Shenyang 110001 China

In mammals,the ribbon synapses of cochlear inner hair cells are a synaptic structure of the first sensory nerve in the pathway of acoustical signal transmission to the acoustic center,and it is directly involved in voice coding and neurotransmitter release. It is difficult to quantitatively analyze the ribbon synaptic number only using an electron microscope,because the ribbon synaptic number is relatively limited and their location is deep. In this study,the specific presynaptic structure-RIBEYE,and non-specific postsynaptic structure-GluR 2 & 3 in C57BL/6J mouse basilar membrane samples were treated by immunofluorescent labeling. Serial section was performed on the samples using a laser scanning confocal microscope,and then the serial sections were used to build three-dimensional models using 3DS MAX software. Each fluorescein color pair indicates one synapse,so the number of ribbon synapses of inner hair cells is obtained. The spatial distribution and the number of ribbon synapses of cochlear inner hair cells were clearly shown in this experiment,and the mean number of ribbon synapses per inner hair cell was 16.10±1.03. Our results have demonstrated the number of ribbon synapses is accurately calculated by double immunofluorescent labeling to presynaptic and postsynaptic structures,serial sections obtained using a laser scanning confocal microscope,and three-dimensional modeling obtained using 3DS MAX software. The method above is feasible and has important significance for further exploring the mechanism of sensorineural deafness.

关键词： inner hair cells Ribbon synapses laser scanning confocal microscope three-dimensional modeling

Polymorphism of p16INK4a gene and rare mutation of p15INK4b gene exon2 in primary hepatocarcinoma

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World Journal of Gastroenterology 2000年第3期6卷 411-414页

作者： Yang Qin Bo Li Yong Shu Tan Zhi Lin Sun Feng Qiong Zuo Ze Fang Sun Institute of Biochemistry and Molecular Biology,West china university of medical Sciences,Chengdu 610041,Sichuan Province,china Department of General Surgery,The First Affiliated Hospital,West china university of medical Sciences,Chengdu 610041,Sichuan Province,china Department of Pathology,The First Affiliated Hospital,West china university of medical Sciences,Chengdu 610041,Sichuan Province,china 华西医科大学四川成都

INTRODUCTION Hepatocellular carcinoma(HCC)is the mostcommon cause of death from cancer in *** of hepatocarcinogenesis are not yetknown clearly,p16INK4a gene,the multiple tumorsuppressor gene 1(MTS1),encodes P16 protei... 详细信息

关键词： p16INK4a gene p15INK4b gene polymorphism mutation hepatocarcinoma

Apoptosis Induced by Zinc Deficiency in Rat Osteoblast:Possible Involvement of Protein Kinase C

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Biomedical and Environmental Sciences 1999年第3期12卷 101-109页

作者： CEN XIAO-BO WANG RUI-SHU AND WANG HANG(medical Experimeatel Center, the First Hospital of West china university of medical Sciences (WCUMS), Chengdu 610041, china Derpartment of Public of Health (WCUMS) Department of Stomatology (WCUMS)) medical Experimental Center First Hospital of West China University of Medical Sciences Chengdu China

Ra ostcobasts were isolated from the 21-day fetal rat calvchas. The cells were grown in DMEM Plus 10% FBS, and were treated for 24 h. with 10 μmol/L TPEN or 10 μmol/L TPEN supplemented with 10 μmol/L Zn2+. Apoptosis of osteoblasts were measured by fiow cytometry, electron microscopy and DNA fragmentation analyzed by gel elecmphoresis. In addition, IP3 production and PKC activity were measmed in ordr to show whether they are involved in apoptosis in osteoblast induced by alnc deficiency. The results showed that 10 μmol/L TPEN could induce apoptosis in osteoblast in 24 h. But cells ed with 10μmol/L TPEN supplemented with 10 μmol/L Zn2+ showed no apoptotic changs in 24 h. TPEN significantly reduced the formation of IP3 and PKC activity after 24 h incubation. No differences were observed between the cells treated with TPEN supPlemented with Zn2+ simulaneosly and the untreated cells. It can be inferred that apoptosis induced by ainc deficiency may be due to the decreased activity of PKC which is impaired by reduced formation of IP3.

关键词： Apoptosis Induced by Zinc Deficiency in Rat Osteoblast Cell cell

Synthesis of Oxa-Steroidal-Estrogen Analogues

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Chinese Chemical Letters 1998年第3期9卷 249-250页

作者： Yong ZOU Ling Ling WENG Hu ZHENG(School of Pharmacy, West china university of medical Sciences, Chengdu 610041) W china Univ Med Sci Sch Pharm Chengdu 610041 Peoples R China

The total synthesis of (+/-)-6-oxa-13 beta-ethyl-3-methoxy-8 alpha-gona-1.3.5(10)-trien-17-one and (+/-)-6-oxa-13 beta-ethyl-2-methoxy-8 alpha-gona-1.3.5(10)-trien-17-one was described.

关键词： oxa-steroidal-estrogen osteoporosis total-systhesis

Hepatic blood inflow occlusion without hemihepatic artery control in treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第46期16卷 5895-5900页

作者： Shan Jin,Department of General Surgery,Affiliated Hospital of Inner Mongolia medical College,Hohhot 010050,Inner Mongolia Autonomous Region,china Chao-Liu Dai,Department of Hepatobiliary Surgery,Shengjing Hospital,china medical university,Shenyang,Liaoning Province,china Department of General Surgery Affiliated Hospital of Inner Mongolia Medical College Hohhot 010050 Inner Mongolia Autonomous Region China. jinshangood@***

AIM:To investigate the clinical significance of hepatic blood inflow occlusion without hemihepatic artery control (BIOwHAC) in the treatment of hepatocellular carcinoma (HCC).METHODS:Fifty-nine patients with HCC were divided into 3 groups based on the technique used for achieving hepatic vascular occlusion:group 1,vascular occlusion was achieved by the Pringle maneuver (n=20);group 2,by hemihepatic vascular occlusion (HVO) (n=20);and group 3,by BIOwHAC (n=19).We compared the procedures among the three groups in term of operation time,intraoperative bleeding,postoperative liver function,postoperative complications,and length of hospital ***:There were no statistically significant differences (P > 0.05) in age,sex,pathological diagnosis,preoperative Child's disease grade,hepatic function,and tumor size among the three *** intraoperative complications or deaths occurrred,and there were no significant intergroup differences (P > 0.05) in intraoperative bleeding,hepatic function change 3 and 7 d after operation,the incidence of complications,and length of hospital *** and Pringle maneuver required a significantly shorter operation time than HVO;the difference in the serum alanine aminotransferase or aspartate aminotransferase levels before and 1 d after operation was more significant in the BIOwHAC and HVO groups than in the Pringle maneuver group (P < 0.05).CONCLUSION:BIOwHAC is convenient and safe;this technique causes slight hepatic ischemia-reperfusion injury similar to HVO.

关键词： Hepatic blood inflow occlusion without hemihepatic artery control Hepatocellular carcinoma Intraoperative bleeding Ischemia-reperfusion injury

Foundation and Clinical Research on the Effect of Traditional Chinese Herbs on Gastrointestinal Motility

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Chinese Journal of Integrative Medicine 2009年第2期15卷 86-88页

作者：李岩 Department of Gastroenterology Shengjing Hospital of China Medical University

Gastric dyskinesis functional dyspepsia is a commonly clinical condition characterized as epigastric discomfort,distension after meals,early satiety and belching,which are commonly associated with the dysfunction of g... 详细信息

关键词： Foundation and Clinical Research on the Effect of Traditional Chinese Herbs on Gastrointestinal Motility