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Clinical Trial of Cancer Therapy with Heavy Ions at Heavy Ion Research Facility in lanzhou （HIRFL）

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Clinical Trial of Cancer Therapy with Heavy Ions at Heavy Io...

Results of Carbon Ion Radiotherapy for Skin Carcinomas in 33 Patients

第14届国际自由基学术大会

作者： Hong Zhang 1 2 Sha Li3 Xiaohu Wang 4 Qiang Li1 2 Shihua Wei3 Liying Gao4 Weiping Zhao1 2 Zhengguo Hu1 Ruishi Mao1 Hushan Xu1 Juntao Ran 4 Yangjun Yue3 Guoqing Xiao1 1 Institute of Modern Physics Chinese Academy of Sciences lanzhou 730000 china 2 Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province lanzhou 730000 china 3 the general hospital of lanzhou command lanzhou 730050 china 4 Tumor hospital of Gansu Province lanzhou 730050 china

＜正＞From November 2006 to March 2008, 66 patients with superficially-placed tumors were treated with carbon ions at Heavy Ion Research Facility in lanzhou （HIRFL） within six beam time blocks of 4-11 days, collaborating with the general hospital of lanzhou command and the Tumor hospital of Gansu Province. Patients and Methods

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Results of Carbon Ion Radiotherapy for Skin Carcinomas in 33...

Expression of liver cancer associated gene HCCA3

第十一次中国生物物理学术大会暨第九届全国会员代表大会

作者： H.Zhang1 ,2,S.Li 3,X.H.Wang 4,Q.Li 1,2,S.H.Wei 3,L.Y.Gao 4,W.P.Zhao 1,2,Z.G.Hu 1, R.S.Mao1,H.S.Xu 1,H.Y.Cai 4,Y.Y.Yue 3,G.Q.Xiao 1 1 Institute of Modern Physics,CAS,lanzhou 730000,china 2 Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province,lanzhou 730000,china 3The general hospital of lanzhou command,lanzhou 730050,china 4Tumor hospital of Gansu Province,lanzhou 730050,china

＜正＞Purpose:To evaluate outcome and toxicity after carbon ion radiotherapy（RT）in skin *** and Methods:Between November 2006 to September 2008,

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World Journal of Gastroenterology 2001年第6期7卷 821-825页

作者： Zheng-Xu Wang~1 Gui-Fang Hu~1 Hong-Yang Wang~2 Meng-Chao Wu~2 1 Department of general Surgery,Chinese PEA general hospital of lanzhou Military command,lanzhou 730050,Gansu Province,china2 Eastern Hepatobilliary Surgical hospital,Second Military Medical University,Shanghai 200438,china Department of general Surgery Chinese PLA General Hospital of Lanzhou Military Command Gansu Province China. zhxwang18@***

AIM: To study and clone a novel liver cancer related gene, and to explore the molecular basis of liver cancer genesis. METHODS: Using mRNA differential display polymerase chain reaction (DDPCR), we investigated the difference of mRNA in human hepatocellular carcinoma (HCC) and paired surrounding liver tissues, and got a gene probe. By screening a human placenta cDNA library and genomic homologous extend, we obtained a full-length cDNA named HCCA3. We analyzed the expression of this novel gene in 42 pairs of HCC and the surrounding liver tissues, and distribution in human normal tissues by means of Northern blot assay. RESULTS: A full-length cDNA of liver cancer associated gene HCCA3 has been submitted to the GeneBank nucleotide sequence databases (Accession No. AF276707). The positive expression rate of this gene was 78.6% (33/42) in HCC tissues, and the clinical pathological data showed that the HCCA3 was closely associated with the invasion of tumor capsule (P=0.023) and adjacant small metastasis satellite nodules lesions (P=0.041). The HCCA3 was widely distributed in the human normal tissues, which was intensively expressed in lungs, brain and colon tissues, while lowly expressed in the liver tissues. CONCLUSION: A novel full-length cDNA was cloned and differentiated, which was highly expressed in liver cancer tissues. The high expression was closely related to the tumor invasiveness and metastasis,that may be the late heredited change in HCC genesis.

关键词： Gene Expression Adult Aged Amino Acid Sequence Base Sequence Female Humans Liver Neoplasms Male Middle Aged Molecular Sequence Data Proteins Research Support, Non-U.S. Gov't

Silencing phospholipid scramblase 1 expression by RNA interference in colorectal cancer and metastatic liver cancer

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Hepatobiliary & Pancreatic Diseases International 2012年第4期11卷 393-400页

作者： Wei Cui,Shi-Yong Li,Jun-Feng Du,Zi-Man Zhu and Ping An Department of general Surgery,general Surgery Center of the PLA,general hospital of Beijing Military command,Beijing 100700,china Department of Hepatobiliary Surgery,First Affiliated hospital,general hospital of the PLA,Beijing 100037,china Department of general Surgery General Surgery Center of the PLA General Hospital of Beijing Military Command Beijing 100700 China Department of Hepatobiliary Surgery First Affiliated Hospital General Hospital of the PLA Beijing 100037 China

BACKGROUND:Phospholipid scramblase 1(PLSCR1) not only participates in the transbilayer movement of phospholipids,but also plays a role in the pathogenesis and progression of *** present study aimed to evaluate the effect of silencing PLSCR1 expression by RNA interference in colorectal cancer(CRC) and metastatic liver ***:The expression of PLSCR1 in CRC and metastatic liver cancer samples was assessed by *** cultured cells with the highest expression were selected for subsequent *** designed three siRNA oligonucleotide segments targeted at *** transfection was *** biological behavior of the cells in proliferation,adhesion,migration and invasion was ***:PLSCR1 protein expression increased significantly in the majority of CRC and metastatic liver cancer samples compared with normal *** cells had the highest expression of *** siRNA-390 oligonucleotide segment had the best silencing *** transfection,Lovo cell proliferation was significantly inhibited compared with the controls in the MTT *** and fibronectin adhesion assays showed Lovo cell adhesion was also significantly *** the migration assay,the number of migrating cells in the PLSCR1 siRNA-390 group was 50±12,significantly lower than the number in the siRNA-N group(115±28) and in the control group(118±31).In an invasion test,the number of invading cells in the PLSCR1 siRNA-390 group was 60±18,significantly lower than that in the siRNA-N group(97±26) and the control group(103±24).CONCLUSIONS:PLSCR1 is overexpressed in CRC and metastatic liver *** of PLSCR1 by siRNA inhibits the proliferation,adhesion,migration and invasion of Lovo cells,which suggests that PLSCR1 contributes to the tumorigenesis and tumor progression of ***1 may be a potential gene therapy target for CRC and associated metastatic liver cancer.

关键词： phospholipid scramblase 1 colorectal cancer metastatic liver cancer RNA interference

Perioperative nutrition support in hepatobiliary and pancreatic surgery

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 9-10页

作者： Ning Li Research Institute of general Surgery,Nanjing general hospital of Nanjing Military command,PLA,Nanjing 210002, china PLA Nanjing Gen Hosp Nanjing Mil Command Res Inst Gen Surg Nanjing 210002 Peoples R China

Early in 1936,Stduley found that there was a E close relationship between nutritional status and postoperative outcome in surgical *** modern surgery combined with use of prophylactic antibiotics,better anesthesia,improved suture materials and optimal physiotherapy,the rate of postoperative complications in malnourished patients has significantly *** recent studies [1,2]

关键词： Perioperative nutrition support in hepatobiliary and pancreatic surgery body

Tanshinone IIA inhibits endothelin-1 production in TNF-α-induced brain microvascular endothelial cells through suppression of endothelin-con-verting enzyme-1 synthesis

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Acta Pharmacologica Sinica 2007年第8期28卷 1116-1122页

作者： Chao TANG~1 An-hua WU~(1,3) Hong-li XUE~2 Yurl-jie WANG~1 ~1Department of Neurosurgery,the First Affiliated hospital,china Medical University ~2Department of Neurosurgery,general hospital of Shenyang Military command,Shenyang 110001,china. Department of Neurosurgery the First Affiliated Hospital China Medical University Shenyang China Department of Neurosurgery General Hospital of Shenyang Military Command Shenyang China

Aim:To investigate the effects of tanshinone ⅡA（Tan ⅡA）on the regulation ofthe production of endothelin（ET）-1（including large ET-1）,mRNA levels of ET-1,endothelin-converting enzyme-1（ECE-1）,endothelin-A receptor（ETA）andendothelin-B receptor（ETB）induced by TNF-α in rat brain microvascular endo-thelial cells（BMVEC）.Methods:The ET-1 release（including large ET-1）into theculture medium was determined by enzyme *** levels of ET-1,ECE- 1,ETA,and ETBmRNA were measured by *** receptor bind-ing was also ***:The induction of ET-1 release by TNF-α from cul-tured BMVEC was dose-dependently reduced by Tan IIA,but large ET-1 levelsprogressively increased in response to Tan ⅡA;the mRNA expression of ET-1 *** ⅡA also caused a decrease in ETAreceptor mRNA and ECE-1expression in a dose-dependent *** receptor binding was unal-tered in BMVEC stimulated with TNF-α alone or a combination of TNF-α and TanⅡ***:These findings suggest that Tan ⅡA may inhibit ET-1 produc-tion in TNF-α-induced BMVEC through the suppression of ECE-1 synthesis.

关键词： tanshinone IIA endothelin-1 TNF-α brain microvascular endothelial cells

New development of biliary surgery in china

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World Journal of Gastroenterology 2000年第2期6卷 187-192页

作者： Zhi Qiang Huang The Research Institute of general Surgery,The general hospital of PLA,Beijing 100853,china 解放军总医院北京

CHARACTERISTICS OF BILIARY CALCULOUSDISEASES IN china:THE CHANGING SCOPEDiseases of the biliary tract in china is complicatedwith the prevalence of primary infection of the bileduct *** the middle of the 20th century,biliary infection,biliary parasitic infestation,andbiliary stones made up the three chief componentsof biliary diseases in *** to the

关键词： biliary surgery cholelithiasis intrahepatic stones carcinoma gallbladder carcinoma bile duct

Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis

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Asian Journal of Andrology 2001年第1期3卷 75-77页

作者： Xin-Hua ZHANG Gui-Qin SUN Yu YANG Tai-He ZHANG Department of Pathology, general hospital of Nanjing command, PLA, Nanjing 210002, china Department of Pathology General Hospital of Nanjing Command China.

Aim: To determine the immunoreactive pattern of human papillomavirus (HPV) antigen and p53 protein in condylo-mata acuminatum (CA) and squamous cell carcinoma (SCC) of penis. Methods: Immunohistochemistry for HPVand p53 were performed in 40 specimens of formalin fixed, paraffin embedded tissues using a polyclonal (rabbit) anti-body against HPV and a monoclonal (mouse) antibody against human p53 protein. Twenty one cases of CA and nine-teen cases of SCC were examined. Results: HPV antigen was detected in all 21 CA and 2 penile SCC. p53 proteinoverexpression was observed in 12 of 19 (63%) SCC in which 6 cases were strong positive. Five of 21 CA (24%)showed low-grade p53 protein overexpression. Conclusion; CA is related to HPV infection and some cases showp53 protein low-grade overexpression. In contrast, p53 protein overexpression is common in penile SCC, which is sel-dom related to HPV infection. (Asian J Androl 2001 Mar; 3: 75-77)

关键词： condylomata acuminata penile diseases carcinoma HPV protein p53

Human hepatopoietin augmenter of liver regeneration──A hepatotrophic factor for liver regeneration, and its potential antihepatitis effect in vivo

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Chinese Science Bulletin 1998年第12期43卷 1026-1031页

作者： YANG Xiaoming 1, WANG Aimin 2, ZHOU Ping 3, XIE Ling 1, WANG Qingming 1, WU Zuze 1 and HE Fuchu 1 1. Institute of Radiation Medicine, Beijing 100850, china 2. No. 252 hospital of PLA, Baoding 071000, china 3. general hospital of the Air Institute of Radiation Medicine Beijing China No. 252 hospital of PLA Baoding China general hospital of the Air Force of PLA Beijing China

The effect of human hapatopoietin i.e. augmenter of liver regeneration (hALR) was determined on hepatocyte DNA synthesis, and on CCl 4-induced hepatitis in animal in vitro and in vivo. It is found that ALR could directly stimulate DNA synthesis of hepatocytes in primary culture in a dose-dependent manner. In 30% hepatectomied rats, significant DNA synthesis occurred in control rats ; even so, exogenous hALR gene encoding protein increased DNA synthesis of regeneration liver by 2.3 fold compared with control rats. A lower dose of CCl 4 was administrated in rats and the effect of ALR on DNA synthesis of regenerating liver 48 h after CCl 4 administration was analyzed. Few Budr-labeled hepatocytes were visible in control rats. However, exogenous hALR markedly increased the number of labeled cells in a dose-dependent manner. Statistical analysis showed that 10 or 40 μg·kg -1 ALR protein stimulated DNA synthesis by 1.7 and 4.8 fold respectively. In addition to enhancing cell growth, adiministration of hALR achieved a significant improvement in reversing the lethality of rat hepatic failure when compared with that of control group; the elevation of cytosolic enzymes was dramatically suppressed by exogenous hALR in CCl 4-treated mice in vivo and in vitro; histologically, hepatocytes around the central vein were necrotic, and the degree of hepatocyte necrosis in control mice was more prominent than that in the mice given 40 μg·kg-1 hALR 48 h after CCl 4 administration. We also noted that hALR had a strong antihepatitis effect in vitro which was determined with primary cultured rat hepatocytes. These findings suggest that hALR protects the integrity of hepatocytes against severe hepatitis, and indicate that ALR may be an important regulator of liver regeneration and play a major role in liver injury repair. It proves ALR adminstration to be a useful treatment to accelerate liver regeneration and to prevent the onset of hepatitis or intrahepatic cholestasis induced by toxin.

关键词： liver regeneration hepatopoietin DNA synthesis hepatitis.