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STRAIN RATE SENSITIVTTY OF POLYCRYSTALLINE AND SINGLE CRYSTAL NiAl

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Acta Metallurgica Sinica(English Letters) 1995年第Z1期8卷 543-552页

作者： HSU shuen YANG Sycherng HON Weipirn WANG Chienyi LEE Tsangsheau (Chung-Shan Institute of Science and Technology, Lung-Tan, Taiwan,china) HSU Ichung(National Taiwan University, Taipei, Taiwan, china) chin Stephen ANTON Donald L.(United Technologies Res Chung-Shan Inst of Science and Technology Lungtan China

The compressive and tensile strain rate sensitivities of polycrystalline and single crystal NiAl have been evaluated at 877 ℃ which is well above DBTT. Samples were prepared to specific sizes by hot press consolidation of appropriate powder sizes and minimizing past consolidation thermal exposures. NiAl single crystals were grown in the [100]orientation using a modified Bridgeman technique. The yield and tensile strength of polycrystalline NiAl as a function of grain size generally follows a Hall-Petch type relationship . A tensile strain rate effect was found at strain rate of 1 to 10-4 sec-1. The strain rate sensitivity coefficient, m,in the equation of σ = Kε is in the range of 0. 10 to 0. 13. The highest strain rate (1 sec-1) resulted in significantly higher strengths and little or no observed ductility. Compressive strain rate testing al strain rate of 10-5to 10-2 sec-1 and at temperature of 1050°to 1250°K was conducted both for polycrystalline and for single crystal NiAl. The calculated stress exponents and the activation energy for creep were compared with the reference data.

关键词： strain rate sensitivity polycrystalline NiAl single crystal NiAl Symbols

Withaferin A targeting both cancer stem cells and metastatic cancer stem cells in the UP-LN1 carcinoma cell model

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 29-40页

作者： Lai-Lei Ting Andy Shau-Bin Chou chin-Hsuan Hsieh Shih-Chieh Hsiung See-Tong Pang shuen-Kuei Liao Department of Radiation Oncology Cancer CenterTaipei Medical University HospitalTaipei 110TaiwanChina Department of Radiology Tzu-Chi General HospitalHualien 970TaiwanChina Department of Surgery Division of Uro-OncologyChang Gung Memorial HospitalCollege of MedicineChang Gung UniversityTaoyuan 333TaiwanChina The PhD Program of Cancer Biology and Drug Discovery Taipei Medical UniversityTaipei 110TaiwanChina Department of Research and Development Vectorite Biomedica Inc.New Taipei City 221TaiwanChina

Aim:As our understanding of cancer stem cell(CSC)biology improves,search for inhibitory agents of CSCs and metastatic CSCs(mCSCs)positive for CXCR4 is *** A(WA),a withanolide extracted from the medicinal plant Withania somnifera,has been shown to exhibit anti-cancer effects through multiple *** WA could selectively target CSCs,mCSCs,or non CSCs of a gastrointestinal(GI)carcinoma tumor remains ***:Side-population(SP)analysis,flow cytometric phenotyping and sorting,non-invasive imaging in conjunction with xenotransplantation,and immunohistology were used in this ***:Using the lymph node metastatic GI cancer cell line UP-LN1,consisting of CD44^(high)/CD24^(low)floating(F)and CD44^(low)/CD24^(high)adherent(A)cell subsets,this study demonstrated that as compared with parental UP-LN1 cells or A cells,WA preferentially reduced F-cell proliferation,tumor sphere formation,and SP cells in vitro in greater effi ciencies by *** action was mechanistically mediated via the down-regulation of CXCR4/CXCL12 and STAT3/interleukin-6 axes,both of which are instrumental in the acquisition of metastatic *** of interferon-γ-induced CXCR4 expression in F cells by knockdown with siRNA or blocking with an anti-CXCR4 antibody,followed by Western blot analysis,showed signifi cantly reduced metastatic potential in *** extent of in vitro anti-invasive effect of WA on the IFN-γ-treated F cells was signifi cantly greater than on the F cells without WA treatment,or F cells treated with control siRNA or with control IgG *** observed in vitro effects of WA on the CSC and mCSC targeting were validated by data obtained with non-invasive imaging in NOD/SCID mouse ***:WA could effi ciently block the formation of both CSCs and mCSCs in the UP-LN1 cell line,suggesting that WA may be considered an effective therapeutic agent for this type of GI malignancies.

关键词： Cancer stem cells CXCR4 gastrointestinal cancer metastasis metastatic cancer stem cells STAT3 withaferin A

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新型变刚度主动横向稳定杆及防侧倾控制

汽车安全与节能学报 2018年第1期9卷 57-64页

作者：赵树恩张瑞栋重庆交通大学机电与车辆工程学院

为解决重型商用车在紧急避障及不平路面的抗侧翻能力不足的问题,设计了一种新型变扭转刚度非线性主动横向稳定杆。运用车辆系统动力学理论,建立包含主动横向稳定杆的八自由度整车动力学模型,采用遗传算法和线性二次型最优控制理论,对装... 详细信息

为解决重型商用车在紧急避障及不平路面的抗侧翻能力不足的问题,设计了一种新型变扭转刚度非线性主动横向稳定杆。运用车辆系统动力学理论,建立包含主动横向稳定杆的八自由度整车动力学模型,采用遗传算法和线性二次型最优控制理论,对装备新型主动横向稳定杆的车辆进行防侧倾主动控制仿真分析。结果表明:通过直线电机传动机构实现横向稳定杆杆身中部铰接点之间距离的自动变化,使横向稳定杆扭转刚度随路面冲击载荷或车辆高速转弯时车身离心力变化做实时响应;车辆高速激转时,主动横向稳定杆相较于被动横向稳定杆,侧倾角平均值减小约30%,抗侧倾转矩增大13%左右,横向载荷转移率降低20%左右;在小侧向加速度时,主动横向稳定杆施加的抗侧倾转矩比被动稳定杆增大44%、横向载荷转移率降低23%左右,表明该主动横向稳定杆及其控制策略能有效改善车辆的平顺性和抗侧倾能力。

关键词：汽车工程变扭转刚度主动横向稳定杆线性二次型调节器(LQR)控制抗侧翻主动控制

随访间血压变异性预测缺血性卒中患者远期卒中复发：前瞻性病例系列研究

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国际脑血管病杂志 2018年第2期26卷 119-123页

作者：郑伟城石铸曾淑芳李淑恩符小丽东莞市人民医院神经内科 523018

目的探讨缺血性卒中患者随访问血压变异性与远期卒中复发的相关性。方法连续登记首次发病的急性缺血性卒中患者，记录人口统计学和临床资料。出院后每月进行随访，测量随访问血压并计算其平均值和血压变异性指标。完成12个月随访，记录... 详细信息

目的探讨缺血性卒中患者随访问血压变异性与远期卒中复发的相关性。方法连续登记首次发病的急性缺血性卒中患者，记录人口统计学和临床资料。出院后每月进行随访，测量随访问血压并计算其平均值和血压变异性指标。完成12个月随访，记录有无卒中复发事件。单变量分析比较复发组与未复发组人口统计学和临床资料，采用多变量logistic回归分析确定随访问血压变异性与卒中复发的相关性。结果共556例患者完成随访，其中62例（11．2％）复发卒中。复发组随访间收缩压标准差[（16．5±4．7）mmHg对（13．4±4．2）mmHg，1mmHg=0．133kPa；t=1．953，P=0．042]和变异系数[11．9±3．1对9．8±2．4；t=2．287，P=0．001]显著高于非复发组。多变量logistic回归分析显示，随访问血压收缩压变异系数与卒中复发独立相关（优势比1．305，95％可信区间1．004～7．491；P=0．017）。结论随访问血压变异性与缺血性卒中患者远期卒中复发独立相关。

关键词：卒中脑缺血高血压血压复发危险因素时间因素