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Diabetes but not insulin is associated with higher colon cancer mortality

World Journal of Gastroenterology 2012年第31期18卷 4182-4190页

作者： chin-hsiao tseng Department of Internal Medicine National Taiwan University College of MedicineTaipei 100Taiwan Division of Endocrinology and Metabolism Department of Internal MedicineNational Taiwan University HospitalTaipei 100Taiwan

AIM： To evaluate whether diabetic patients had a higher risk of colon cancer mortality and its associated risk factors. METHODS： The sex-specific crude and age-standard- ized （to the 2000 World Health Organization popula- tion） mortality rates of colon cancer in the Taiwan Residents general population were first calculated from 1995 to 2006. The trends were evaluated by linear regression. A total of 113 347 diabetic men and 131 573 diabetic women aged ~〉 25 years at recruitment from 1995 to 1998 were followed up until the end of 2006. Age/sex- specific colon cancer mortality rate ratios were cal- culated comparing the mortality rates of the diabetic patients with the average mortality rates of the general population within 12 years （1995-2006）. A sub-cohort of diabetic patients （42 260 men and 49 405 women） was interviewed using a baseline questionnaire and Cox＇s regression was used to evaluate the risk factors for colon cancer mortality in these diabetic ***： The crude and age-standardized trends of colon cancer mortality from 1995 to 2006 increased significantly for both sexes in the general population. A total of 641 diabetic men and 573 diabetic women died of colon cancer, with a mortality rate of 74.4 and 54.3 per 100 000 person-years, respectively. Mortality rate ratios [95% confidence intervals （CIs）] showed a significantly higher risk of mortality from colon can- cer for the diabetic patients compared to the general population, with the magnitude increasing with de- creasing age： 1.65 （1.40-1.95）, 2.01 （1.78-2.27）, 2.75 （2.36-3.21） and 5.69 （4.65-6.96） for /〉 75, 65-74, 55-64 and 25-54 years old, respectively, for men; and 1.46 （1.24-1.72）, 2.09 （1.84-2.38）, 2.67 （2.27-3.14） and 3.05 （2.29-4.06）, respectively, for women. Among the sub-cohort of diabetic patients who had been in- terviewed with the baseline questionnaire, including information on age, sex, diabetes duration, diabe- tes type, body mass index, smoking, insulin use and area of resid

关键词： Colon cancer Diabetes mellitus Mortality Secular trend

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Diabetes and gastric cancer: The potential links

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World Journal of Gastroenterology 2014年第7期20卷 1701-1711页

作者： chin-hsiao tseng Farn-Hsuan tseng Department of Internal Medicine National Taiwan University College of Medicine Division of Endocrinology and Metabolism Department of Internal MedicineNational Taiwan University Hospital Dana and David Dornsife College of Letters Arts and SciencesDepartment of Biological SciencesUniversity of Southern CaliforniaLos AngelesCA 90007United States

This article reviews the epidemiological evidence linking diabetes and gastric cancer and discusses some of the potential mechanisms,confounders and biases in the evaluation of such an *** from four meta-analyses published from 2011 to 2013 suggest a positive link,which may be more remarkable in females and in the Asian *** mechanisms may involve shared risk factors,hyperglycemia,Helicobacter pylori(***)infection,high salt intake,medications and *** may increase the risk of gastric cancer through shared risk factors including obesity,insulin resistance,hyperinsulinemia and ***,even before the clinical diagnosis of diabetes,may predict gastric cancer in some epidemiological studies,which is supported by in vitro,and in vivo *** with diabetes may also have a higher risk of gastric cancer through the higher infection rate,lower eradication rate and higher reinfection rate of *** salt intake can act synergistically with *** infection in the induction of gastric *** a higher risk of gastric cancer in patients with diabetes may be ascribed to a higher intake of salt due to the loss of taste sensation awaits further *** use of medications such as insulin,metformin,sulfonylureas,aspirin,statins and antibiotics may also influence the risk of gastric cancer,but most of them have not been extensively *** may affect the development of gastric cancer through the use of medications and changes in lifestyle,dietary intake,and the metabolism of ***,a potential detection bias related to gastrointestinal symptoms more commonly seen in patients with diabetes and with multiple comorbidities should be pointed *** into account the inconsistent findings and the potential confounders and detection bias in previous epidemiological studies,it is expected that there are still more to be explored for the clarification of the associa

关键词： Diabetes mellitus Gastric cancer Epidemiology Meta-analysis Literature review

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台湾乌脚病:它与饮用水中无机砷接触的关系

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AMBIO－人类环境杂志 2007年第1期36卷 78-80页

作者： chin-hsiao tseng Choon-Khim Chong ching-Ping tseng Jose A. Centeno 王胜（译）徐化成（校） Department of Internal Medicine National Taiwan University Hospital NO. 7 Chung-Shan South Road Taipei Taiwan Department of Rehabilitation and Ching-Ping Tseng School of Medical Technology Chang Gung University Taoyuan Taiwan 不详 armed Forces Institute of Pathology Division of Biophysical Toxicology Department of Environmental and Infectious Disease Sciences Washington DC USA

乌脚病（BFD）是台湾西南沿海地区的一种地方性外周血管疾病。其典型症状和迹象为进行性动脉梗塞，主要见于下肢，但在少数情况下也会发生上肢的动脉梗塞。其典型结果为溃烂、坏疽，及自然断离或外科截肢。早在20世纪初乌脚病就偶有发生... 详细信息

乌脚病（BFD）是台湾西南沿海地区的一种地方性外周血管疾病。其典型症状和迹象为进行性动脉梗塞，主要见于下肢，但在少数情况下也会发生上肢的动脉梗塞。其典型结果为溃烂、坏疽，及自然断离或外科截肢。早在20世纪初乌脚病就偶有发生，1956～1960年是其发病的高峰期，在不同村庄发病率在6．51‰～18．85‰之间。该病年龄范围很大，

关键词：台湾西南脚病无机砷饮用水血管疾病沿海地区典型症状发病率

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Apolipoprotein E elicits targetdirected miRNA degradation to maintain neuronal integrity

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Neural Regeneration Research 2025年第9期20卷 2577-2578页

作者： Jiazi Tan chin-Tong Ong Temasek Life Sciences Laboratory National University of SingaporeSingapore Department of Biological Sciences National University of SingaporeSingapore

Apolipoprotein E has diverse functions in neurons:Apolipoprotein E(ApoE)is a glycoprotein that primarily regulates lipid metabolism and transport in the central nervous *** are three predominant human ApoE protein isoforms with cysteine and arginine substitutions at amino acid positions 112 and 158 that impact their lipidation and related functions(Flowers and Rebeck,2020).ApoE2 is characterized by Cys112 and Cys158,ApoE3 by Cys112 and Arg158,whereas ApoE4 contains Arg112 and Arg158.

关键词： metabolism glycoprotein maintain

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地成砷的全球影响:一个医学地质学研究案例

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AMBIO－人类环境杂志 2007年第1期36卷 74-77页

作者： Jose A. Centeno chin-hsiao tseng Gijsbert B. Van der Voet Robert B. Finkelman 王胜（译）徐化成（校） Division of Biophysical Toxicology．Department of Environmental and Infectious Disease Sciences Armed Forces Institute of PathologyWashington DC20306-6000 Division of Endocrinology and Metabolism Department of Internal Medicineand Department of Medical Research and DevelopmentNational Taiwan University．Hospital Yun-Lin BranchYun-LinTaiwan Division of Biophysical Toxicology Department of Environmental and Infectious Disease SciencesArmed Forces Institute of PathologyWashington DC．20306-6000 Department of Geosciences RichardsonTX750830688 不详

砷（As）是一种普遍存在的元素，在地壳中最丰富元素中排名第20位。人类可通过饮食或从自然环境来源（如被污染的地下水、土壤、或燃烧的煤）接触到砷。砷接触的人为来源包括药物中砷（如福勒溶剂或AsO3）、工业污染、采矿及经铬酸盐铜... 详细信息

砷（As）是一种普遍存在的元素，在地壳中最丰富元素中排名第20位。人类可通过饮食或从自然环境来源（如被污染的地下水、土壤、或燃烧的煤）接触到砷。砷接触的人为来源包括药物中砷（如福勒溶剂或AsO3）、工业污染、采矿及经铬酸盐铜砷酸盐处理过的木材的燃烧。

关键词：砷酸地质学案例医学工业污染自然环境地下水盐处理

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Microplastic and nanoplastic exposure and risk of diabetes mellitus

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World Journal of Clinical Cases 2025年第3期13卷 24-29页

作者： Hui-Yi hsiao Chung-Yi Nien Ruei-Feng Shiu Wei-Chun chin Tzung-Hai Yen Department of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina Center for Tissue Engineering Chang Gung Memorial HospitalLinkouTaoyuan 33305TaiwanChina Department of Life Sciences National Central UniversityZhongli 320317TaoyuanTaiwanChina Center of Excellence for The Oceans Taiwan Ocean UniversityKeelung 20224TaiwanChina Institute of Marine Environment and Ecology Taiwan Ocean UniversityKeelung 20224TaiwanChina Department of Chemical and Materials Engineering University of California MercedMercedCA 95343United States Department of Nephrology Clinical Poison CenterChang Gung Memorial HospitalLinkou 33305TaoyuanTaiwanChina School of Traditional chinese Medicine College of MedicineChang Gung UniversityTaoyuan 33302TaiwanChina

The issue of plastic pollutants has become a growing *** microplastics(MPs)(particle size<5 mm)and nanoplastics(NPs)(particle size<1μm)can cause DNA damage,cytotoxicity,and oxidative stress in various *** primary known impacts of microplastic/nanoplastic are observed in the liver and respiratory system,leading to hepatotoxicity and chronic obstructive pulmonary *** research on the effects of MPs and NPs on diabetes is still in its early stages,there are potential *** editorial highlights the risk to diabetics from co-exposure to contaminants and MPs/NPs,supported by evidence from animal studies and the various chemical compositions of MPs/NPs.

关键词： Microplastics Nanoplastics Plastic pollution,Diabetes mellitus Insulin resistance

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Study of a Dual-sided Multiple Fans System with a Piezoelectric Actuator

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Journal of Thermal Science 2015年第5期24卷 432-441页

作者： hsiao-Kang Ma Yi-tseng Li ching-Po Lin Department of Mechanical Engineering Taiwan University

A dual-sided multiple fans system with a piezoelectric actuator （＂D-MFPA＂）, which is able to drive eight passive vibrating fans and provide two-directional air flows by using only one piezoelectric actuator, has been investigated in this study. Moreover, two types of the fan designs, viz. magnetic fan （MF） and composite magnetic fan （CMF） were also explored. In the investigation of the MF, the results indicated that the resonance frequency of the D-MFPA increased from 27.6 Hz to 66 Hz as the length of the carbon fiber plate （L） decreased from 55 mm to 35 mm. It also decreased the amplitude of the D-MFPA from 12.4mm to 4.8 mm. For CMF, the results showed that the resonance frequency decreased when the length of the Mylar plate （Et） increased, and the maximum decrease was from 66 Hz to 45 Hz when L= 35 mm and Er= 30 mm. Dimensionless heat convection number （MD_MFPA） was defined to describe and quantify the improvement in the thermal performance. The results showed that the optimal MO-MFPA of the single piezoelectric fan was 1,58 for cooling one heat source. By contrast, under the same power consumption, the D-MFPA not only cooled two heat sources but also displayed better thermal performance.

关键词： D-MFPA resonance frequency composite magnetic fan thermal performance

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An Explicit Formula for Szeg? Kernels on the Heisenberg Group

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Acta Mathematica Sinica,English Series 2018年第8期34卷 1225-1247页

作者： Hendrik HERRMANN chin Yu hsiao Xiao Shan LI Mathematical Institute University of Cologne Weyertal 86-90 50931 Cologne Germany Institute of Mathematics Academia Sinica and National Center for Theoretical Sciences Astronomy-Mathematics Building No. 1 Sec. 4 Roosevelt Road Taipei 10617 Taiwan China School of Mathematics and Statistics Wuhan University Wuhan 430072 P. R. China

In this paper, we give an explicit formula for the Szego kernel for （0, q） forms on the Heisenberg group Hn＋1.

关键词： Heisenberg group Szego kernels complex Fourier integral operators

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Interactions between nano-TiO2 particles and algal cells at moderate particle concentration

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Frontiers of Chemical Science and Engineering 2015年第2期9卷 242-257页

作者： Mingyu LIN Yao Hsiang tseng chin-Pao HUANG Department of Civil and Environmental Engineering University of Delaware Newark DE 19716 USA Department of Chemical Engineering Taiwan University of Science and Technology Taipei Taiwan China

Nano-sized titanium dioxide （nano-TiO2） has wide industrial applications and therefore considerable chances of exposure are created for human beings and ecosystems. To better understand the interactions between nano-TiO2 and aquatic organisms, we first studied TiO2 uptake by algae exemplified by Pseudokirchneriella subcapitata. P. subcapitata were exposed to nano-TiO2 in a series of concentrations and at various pH. TiO2 uptake was quantified using a sedimentation curve analysis technique. After exposure of algae to TiO2, the variation of zeta potential was measured and the morphology of algae-TiO2 aggregate was observed with scanning electron microscopy and the optical microscopy. The steady-state TiO2 uptake was found to be pH-dependent and the isotherms can be described well by Freundlich model. TiO2 deposited on algal surfaces causes the shift of pHzpc of TiO2-covered algae from that of algae toward that of TiO2. The attraction between TiO2-covered algal cells induces the agglomeration of algae and TiO2 and thus the formation of algae-TiO2 aggregates in the size of 12 to 50 μm. The 2-D fractal dimension of the aggregates is pH- dependent and ranges from 1.31 to 1.67. The theoretical analysis of the Gibbs energy of interaction indicates that both TiO2 uptake by algae and the formation of algae-TiO2 aggregate are influenced by the interaction between TiO2 particles.

关键词： nano-TiO2 Pseudokirchneriella subcapitata,algal cells titanium dioxide uptake

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Experiments on Channel Evolution Caused by Check-dam Failure

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Journal of Mountain Science 2012年第2期9卷 175-184页

作者： Wen-hsiao tseng hsiao-Wen WANG Shih-Chieh CHOU Yu-Lin KAO Chjeng-Lun Shieh Department of Hydraulic and Ocean Engineering National Cheng Kung University

A 10 m long,0.2 m wide flume was employed to simulate the channel bed evolution of check-dam *** experiment longitudinal profiles,the gradient of channel bed,head-cutting propagation distance and deposition length were compared with the theoretical solution derived from a sediment transport diffusion *** contrast with the theoretical solution,two different gradients were obtained upstream and downstream of the *** theoretical solution provides a good description of the changes upstream of the check-dam. The ratio of clear water depth to sediment moving layer thickness in the experiment was analyzed and showed that high concentration sediment laden flow was taken in the incipient of check-dam failure,which may be the reason why the experiment result was slightly different from the theoretical solution in the downstream of check-dam.

关键词： Check-dam failure Diffusion equation Debris flow

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