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Logarithmic sensitivity ratio elucidates thermal transport physics in multivariate thermoreflectance experiments

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Fundamental Research 2025年第1期5卷 288-295页

作者： Tu, jing Haque, Md Azimul Baran, Derya ong, Wee-Liat ZjU-UIUC Institute College of Energy Engineering Zhejiang University Jiaxing Haining 314400 China KAUST Solar Center Physical Science and Engineering Division King Abdullah University of Science and Technology Thuwal 23955-6900 Saudi Arabia State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

We mathematically derived a sensitivity-based method that identifies the thermal transport physics and parameters suitable for multivariate nonlinear fits in a frequency-domain thermoreflectance (FDTR) experiment. Modern electronic devices often consist of heterogeneous nanolayers with multiple unknown thermal transport properties. However, simultaneous fitting in a single experiment for these unknown parameters will produce unreliable results if they are correlated. Current methods to identify such correlations are unreliable. This unreliability has impeded the accuracy and speed of characterizing the unknown thermal properties of such multilayer stacks. Our proposed logarithmic sensitivity ratio (LSR) analysis can evaluate the feasibility of fitting a pair of unknown parameters and clarify the governing thermal transport physics. The effectiveness and convenience of this analysis were studied using Monte Carlo simulations and actual FDTR experiments for fitting up to three unknown parameters. The principle behind this method can be extended to other techniques where multivariate fits are needed. © 2023

关键词： Correlation Frequency-domain thermoreflectance Monte Carlo Multivariables Sensitivity Thermal conductivity Thermal properties Thermoreflectance

Biomarkers in Barrett's esophagus and esophageal adenocarcinoma:Predictors of progression and prognosis

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World journal of Gastroenterology 2010年第45期16卷 5669-5681页

作者： chin-ann j.ong Pierre Lao-Sirieix Rebecca C Fitzgerald MRC Cancer Cell Unit Hutchison-MRC Research CentreCambridgeCB20XZUnited Kingdom

Barrett’s esophagus is a well-known premalignant lesion of the lower esophagus that is characterized by intestinal metaplasia of the squamous epithelium. It is clinically important due to the increased risk (0.5% per annum) of progression to esophageal adenocarcinoma (EA), which has a poor outcome unless diagnosed early. The current clinical management of Barrett’s esophagus is hampered by the lack of accurate predictors of progression. In addition, when patients develop EA, the current staging modalities are limited in stratifying patients into different prognostic groups in order to guide the optimal therapy for an individual patient. Biomarkers have the potential to improve radically the clinical management of patients with Barrett’s esophagus and EA but have not yet entered mainstream clinical practice. This is in contrast to other cancers like breast and prostate for which biomarkers are utilized routinely to inform clinical decisions. This review aims to highlight the most promising predictive and prognostic biomarkers in Barrett’s esophagus and EA and to discuss what is required to move the field forward towards clinical application.

关键词： Barrett’s esophagus Esophageal adenocar cinoma Esophageal dysplasia Prognosis

CDK5-mediated phosphorylation of CP190 may regulate locomotor activity in adult female Drosophila

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journal of Genetics and Genomics 2018年第3期45卷 177-181页

作者： chin-Tong ong Wei-Qi Lin Temasek Life Sciences Laboratory National University of Singapore Department of Biological Sciences National University of Singapore

The three-dimensional organization of the genome plays a crucial role in regulating gene expression patterns in metazoans（ong and Corces,2014）.The nuclear architectural proteins are known to facilitate the formation of topological domains within the genome through mediating inter-and intra-chromosomal *** vertebrate,CCCTC-binding factor（CTCF）is the main architectural protein that mediates long-range chromosomal interactions among its DNA binding sites through a process that is stabilized by cohesin （Parelho et al., 2008; Wendt et al., 2008）.

关键词： CP CDK5-mediated phosphorylation of CP190 may regulate locomotor activity in adult female Drosophila

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

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岳池县小麦抗逆种植技术推广策略

南方农业 2025年第4期19卷 53-55页

作者：龙君蓉岳池县白庙镇农业服务中心四川岳池638300

小麦作为我国主要的粮食作物,实现其稳产增产至关重要。为提高四川省岳池县小麦产量和品质,分析其当前小麦抗逆种植技术推广存在的农户参与度低、技术培训不到位、示范带动效果有限、基层服务能力薄弱及市场机制不健全等问题,并在此基... 详细信息

小麦作为我国主要的粮食作物,实现其稳产增产至关重要。为提高四川省岳池县小麦产量和品质,分析其当前小麦抗逆种植技术推广存在的农户参与度低、技术培训不到位、示范带动效果有限、基层服务能力薄弱及市场机制不健全等问题,并在此基础上提出加强宣传引导,转变农民观念;强化技术培训,增强农户技能;强化示范带动效应,以点带面推广技术;完善市场机制,保障农户收益;强化基层农业技术推广队伍建设,提升服务水平等小麦抗逆种植技术推广策略。

关键词：小麦抗逆种植技术推广四川省岳池县

均质黏土中桩靴基础贯入阻力系数Nc的解析解

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工程力学 2025年第1期42卷 233-240页

作者：李大勇王召龙吴宇旗中国石油大学(华东)储运与建筑工程学院山东青岛266580

自升式平台的桩靴基础需逐级预压入海床一定深度,使其承载力满足承受上部平台自重荷载及所受到的海洋环境荷载的要求。随着压入深度的增加,土体将绕过桩靴基础侧面逐渐回流至基础顶部。桩靴基础在不同压入深度处,土体的回流模式不同,导... 详细信息

自升式平台的桩靴基础需逐级预压入海床一定深度,使其承载力满足承受上部平台自重荷载及所受到的海洋环境荷载的要求。随着压入深度的增加,土体将绕过桩靴基础侧面逐渐回流至基础顶部。桩靴基础在不同压入深度处,土体的回流模式不同,导致基础的贯入阻力发生变化。考虑完全回流和不回流两种极端情况下的土体破坏模式,利用特征线法推导了桩靴基础贯入阻力系数N_(c),采用有限元极限分析法验证了计算模型的合理性。与已发表的文献中的离心机试验数据和数值模拟结果进行对比研究,验证了所提的理论方法的准确性。研究表明:光滑基底底部形成两个左右对称的弹性楔体,随着桩靴基础基底剪应力的增加,弹性楔体体积逐渐减小,当基底剪应力达到土体抗剪强度时,弹性楔体消失。贯入阻力系数N_(c)随着桩靴基础基底剪应力的增加呈线性增加,土体不回流情况下的贯入阻力系数比完全回流情况下的贯入阻力系数低约20%。

关键词：桩靴基础贯入阻力系数解析解均质黏土破坏模式

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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Calcium Phosphate Coating over Silk Fibroin Film by Biomimetic Methods

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journal of Wuhan University of Technology(Materials Science) 2005年第B12期20卷 92-94页

作者：赵勇陈治清 ong j West china College of Stomatology Sichuan University Chengdu 610041 China Department of Biomedical Engineering and Orthopedic Surgery University of Tennessee Health Science Center Memphis 38163USA

To investigate the biomincralization behavior of silk fibroin and to valuate the biodegradation and biocompatibility of the hybrid biomaterial, the calcium phosphate deposits were identified with SEM, EDX, XRD and FTIR. The results reveal that supersaturated calcification solution is an effective method for the mineralization of fibroin film. Enzymatic degradation experiment demonstrates the biodegradability of the composites. Osteoblasts incubation shows an excellent cytocompatibility on the mincralized fibroin films.

关键词： biomineralization degradation apatite fibroin/HAP composite