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Autologous mobilized peripheral blood CD34^+ cell infusion in non-viral decompensated liver cirrhosis

World Journal of Gastroenterology 2015年第23期21卷 7264-7271页

作者： Mithun Sharma Padaki Nagaraja Rao Mitnala Sasikala Mamata reddy Kuncharam chimpa reddy Vardaraj Gokak BPSS Raju Jagdeesh R Singh Piyal Nag D Nageshwar reddy Department of Gastroenterology and Hepatology Asian Institute of Gastroenterology Asian Healthcare Foundation Asian Healthcare Foundation Department of Interventional Radiology Asian Institute of Gastroenterology

AIM: To study the effect of mobilized peripheral blood autologous CD34 positive(CD34+) cell infusion in patients with non-viral decompensated ***: Cirrhotic patients of non-viral etiology were divided into 2 groups based on their willingness to be listed for deceased donor liver transplant(DDLT)(control, n = 23) or to receive autologous CD34+ cell infusion through the hepatic artery(study group, n= 22). Patients in the study group were admitted to hospital and received granulocyte colony stimulating factor injections 520 μg/d for 3 consecutive days to mobilize CD34+ cells from the bone marrow. On day 4,leukapheresis was done and CD34+ cells were isolated using CliniMAC magnetic cell sorter. The isolated CD34+ cells were infused into the hepatic artery under radiological guidance. The patients were discharged within 48 h. The control group received standard of care treatment for liver cirrhosis and were worked up for DDLT as per protocol of the institute. Both groups were followed up every week for 4 wk and then every month for 3 ***: In the control and the study group, the cause of cirrhosis was cryptogenic in 18(78.2%) and16(72.72%) and alcohol related in 5(21.7%) and6(27.27%), respectively. The mean day 3 cell count(cells/μL) was 27.00 ± 20.43 with a viability of 81.84± 11.99%. and purity of 80%-90%. Primary end point analysis revealed that at 4 wk, the mean serum albumin in the study group increased significantly(2.83± 0.36 vs 2.43 ± 0.42, P = 0.001) when compared with controls. This improvement in albumin was,however, not sustained at 3 mo. However, at the end of3 mo there was a statistically significant improvement in serum creatinine in the study group(0.96 ± 0.33 vs 1.42 ± 0.70, P = 0.01) which translated into a significant improvement in the Model for End-Stage Liver Disease score(15.75 ± 5.13 vs 19.94 ± 6.68,P = 0.04). On statistical analysis of secondary end points, the transplant free survival at the end of 1 mo and 3 mo did not show

关键词： CD34 cell infusion Stem cell Cirrhosis Model for end-stage liver disease Liver transplantation

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CompactChain:an efficient stateless chain for UTXO-model blockchain

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Frontiers of Computer Science 2024年第2期18卷 167-179页

作者： B Swaroopa reddy T Uday Kiran reddy Department of Electrical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In this work,we propose a stateless blockchain called CompactChain,which compacts the entire state of the UTXO(Unspent Transaction Output)based blockchain systems into two RSA *** first accumulator is called Transaction Output(TXO)commitment which represents the TXO *** second one is called Spent Transaction Output(STXO)commitment which represents the STXO *** this work,we discuss three algorithms:(i)To update the TXO and STXO commitments by the *** miner also provides the proofs for the correctness of the updated commitments;(ii)To prove the transaction’s validity by providing a membership witness in TXO commitment and non-membership witness against STXO commitment for a coin being spent by a user;(iii)To update the witness for the coin that is not yet spent;The experimental results evaluate the performance of the CompactChain in terms of time taken by a miner to update the commitments and time taken by a validator to verify the commitments and validate the *** compare the performance of CompactChain with the existing state-of-the-art works on stateless *** shows a reduction in commitments update complexity and transaction witness size which inturn reduces the mempool size and propagation latency without compromising the system throughput(Transactions per second(TPS)).

关键词： stateless blockchain RSA Accumulator STXO commitment TXO commitment UTXO Non-interactive Proof of Exponentiation(NI-PoE) Transactions per second(TPS)

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Enhanced entropy generation and heat transfer characteristics of magnetic nano-encapsulated phase change materials in latent heat thermal energy storage systems

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1051-1070页

作者： P.S.reddy P.SREEDEVI Department of Mathematics Rajeev Gandhi Memorial College of Engineering and TechnologyNandyal 518501India

The objective of the current study is to investigate the importance of entropy generation and thermal radiation on the patterns of velocity,isentropic lines,and temperature contours within a thermal energy storage device filled with magnetic nanoencapsulated phase change materials(NEPCMs).The versatile finite element method(FEM)is implemented to numerically solve the governing *** effects of various parameters,including the viscosity parameter,ranging from 1 to 3,the thermal conductivity parameter,ranging from 1 to 3,the Rayleigh parameter,ranging from 102 to 3×10^(2),the radiation number,ranging from 0.1 to 0.5,the fusion temperature,ranging from 1.0 to 1.2,the volume fraction of NEPCMs,ranging from 2%to 6%,the Stefan number,ranging from 1 to 5,the magnetic number,ranging from 0.1 to 0.5,and the irreversibility parameter,ranging from 0.1 to 0.5,are examined in detail on the temperature contours,isentropic lines,heat capacity ratio,and velocity ***,the heat transfer rates at both the cold and hot walls are analyzed,and the findings are presented *** results indicate that the time taken by the NEPCMs to transition from solid to liquid is prolonged inside the chamber region as the fusion temperatureθf ***,the contours of the heat capacity ratio Cr decrease with the increase in the Stefan number Ste.

关键词： volume fraction of nano-encapsulated phase change material(NEPCM) radiation Stefan number heat capacity ratio entropy generation

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Trusted Certified Auditor Using Cryptography for Secure Data Outsourcing and Privacy Preservation in Fog-Enabled VANETs

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Computers, Materials & Continua 2024年第5期79卷 3089-3110页

作者： Nagaraju Pacharla K.Srinivasa reddy School of Computer Science and Engineering VIT-AP UniversityAmaravatiAndhra Pradesh522237India

With the recent technological developments,massive vehicular ad hoc networks(VANETs)have been established,enabling numerous vehicles and their respective Road Side Unit(RSU)components to communicate with *** best way to enhance traffic flow for vehicles and traffic management departments is to share thedata they *** needs to be more protection for the VANET *** effective and safe methodof outsourcing is suggested,which reduces computation costs by achieving data security using a homomorphicmapping based on the conjugate operation of *** research proposes a VANET-based data outsourcingsystem to fix the *** keep data outsourcing secure,the suggested model takes cryptography models *** will keep the generated keys for the purpose of vehicle *** controlling and overseeingthe outsourced data while preserving privacy,the suggested approach considers the Trusted Certified Auditor(TCA).Using the secret key,TCA can identify the genuine identity of VANETs when harmful messages *** proposed model develops a TCA-based unique static vehicle labeling system using cryptography(TCA-USVLC)for secure data outsourcing and privacy preservation in *** proposed model calculatesthe trust of vehicles in 16 ms for an average of 180 vehicles and achieves 98.6%accuracy for data encryption toprovide *** proposedmodel achieved 98.5%accuracy in data outsourcing and 98.6%accuracy in privacypreservation in fog-enabled *** curve cryptography models can be applied in the future for betterencryption and decryption rates with lightweight cryptography operations.

关键词： Vehicular ad-hoc networks data outsourcing privacy preservation cryptography keys trusted certified auditors data security

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Aldo-keto reductases:Role in cancer development and theranostics

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Oncology Research 2024年第8期32卷 1287-1308页

作者： SIDDAVARAM NAGINI PRATHAP reddy KALLAMADI KRANTHI KIRAN KISHORE TANAGALA GEEreddy BHANUPRAKASH reddy World Neem Organization Mumbai400101India Department of Biochemistry ICMR-National Institute of NutritionHyderabad500007India Department of Pathology and Cell Biology Columbia University Irving Medical CenterNew York10032USA

Aldo-keto reductases(AKRs)are a superfamily of enzymes that play crucial roles in various cellular processes,including the metabolism of xenobiotics,steroids,and carbohydrates.A growing body of evidence has unveiled the involvement of AKRs in the development and progression of various *** are aberrantly expressed in a wide range of malignant *** expression of AKRs enables the acquisition of hallmark traits of cancer by activating oncogenic signaling pathways and contributing to *** have emerged as promising oncotherapeutic targets given their pivotal role in cancer development and *** of aldose reductase(AR),either alone or in combination with chemotherapeutic drugs,has evolved as a pragmatic therapeutic option for *** classes of synthetic aldo-keto reductase(AKR)inhibitors have been developed as potential anticancer agents,some of which have shown promise in clinical *** AKR inhibitors from natural sources also exhibit anticancer *** molecule inhibitors targeting speciﬁc AKR isoforms have shown promise in preclinical *** inhibitors disrupt the activation of oncogenic signaling by modulating transcription factors and kinases and sensitizing cancer cells to *** this review,we discuss the physiological functions of human AKRs,the aberrant expression of AKRs in malignancies,the involvement of AKRs in the acquisition of cancer hallmarks,and the role of AKRs in oncogenic signaling,and drug ***,the potential of aldose reductase inhibitors(ARIs)as anticancer drugs is summarized.

关键词： Aldo-keto reductases(AKRs) Aldo-keto reductase(AKR)inhibitors Cancer Drug-resistance Xenobiotics

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Enhanced saturation magnetization in La^(3+) doped NiCo ferrites prepared by sol-gel auto-combustion method

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Journal of Rare Earths 2024年第8期42卷 1546-1554,I0005页

作者： Maddileti Jelli Vidyasagar Thopudurthy Krishna reddy C.V. Department of Physics Rayalaseema UniversityKurnoolA.P518007.Iindia Department of Physics Government PolytechnicRayachotiA.P516269India

Lanthanum doped nickel-cobalt nano ferrites with chemical formula Ni_(0.5)Co_(0.5)LaxFe_(2-x)O_(4)(x=0.05,0,10,0.15 and 0,20) were prepared using a simple sol-gel auto combustion *** basic structural properties were determined by X-ray diffraction method and the formation of single phased spinel ferrite was *** crystalline size decreased from 25 to 11 nm and lattice parameter a increases with increase of La *** surface morphology of these ferrites was observed by field-emission scanning electron microscopy(FESEM) and agglomerated irregular grains are observed with increase of the rare earth element La ***-dispersive X-ray spectroscopy(EDX) result confirms the presence of the required *** Fourier transform infrared spectroscopy(FTIR) spectrum indicates the formation of the spinel ferrite structure with M-O *** direct band measurements from ultraviolet-visible spectroscopy(UV-Vis) spectroscopy indicate that the direct band gap decreases from 1.39 to 1.19 eV for x=0.05 to x=0.15,then increases to 1.28 eV for x=*** room temperature magnetic properties of these ferrites were studied by a vibrating sample magnetometer(VSM).The enhanced saturation magnetization of 49.73 emu/g is observed for x=0.10 and then saturation magnetizations are gradually decreased for x=0.15 and x=*** the remanent magnetization and coercivity also follow the same trend.

关键词： Ferrites Sol-gel auto combustion La doping Magnetic properties Rare earths

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Vitamin D, selenium in type 2 diabetes and Hashimoto's thyroiditis: Is it effective?

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World Journal of Diabetes 2024年第5期15卷 1048-1050页

作者： Kotha Sugunakar reddy Vishakha Jain Sakthivadivel Varatharajan Janardhana reddy Pallavali Department of General Medicine All India Institute of Medical SciencesTelanganaHyderabad 508126India

The study by Feng et al,explores treatment approaches for these coexisting *** emphasizes the potential advantages of selenium and vitamin D supplementation but also raises methodological and patient selection *** indicate a complex interplay between interventions and disease markers,prompting the need for further *** limitations,the study offers valuable insights into managing the intricate relationship between type 2 diabetes mellitus and Hashimoto's *** authors'contributions shed light on potential treatment avenues,although careful consideration of study design and patient characteristics is warranted for future investigations in this domain.

关键词： Vitamin D Selenium Type 2 diabetes Mellitus Hashimoto’s thyroiditis

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Prediction,prevention and management of gastroesophageal reflux after per-oral endoscopic myotomy:An update

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World Journal of Gastroenterology 2024年第9期30卷 1096-1107页

作者： Zaheer Nabi Pradev Inavolu Nageshwar reddy Duvvuru Department of Gastroenterology Asian Institute of GastroenterologyHyderabad 500082TelanganaIndia Department of Medical Gastroenterology Asian Institute of GastroenterologyHyderabad 500032TelanganaIndia

Achalasia cardia,the most prevalent primary esophageal motility disorder,is predominantly characterized by symptoms of dysphagia and *** principal therapeutic approaches for achalasia encompass pneumatic dilatation(PD),Heller's myotomy,and the more recent per-oral endoscopic myotomy(POEM).POEM has been substantiated as a safe and efficacious modality for the management of *** POEM demonstrates superior efficacy compared to PD and an efficacy parallel to Heller's myotomy,the incidence of gastroesophageal reflux disease(GERD)following POEM is notably higher than with the aforementioned *** symptomatic reflux post-POEM is relatively infrequent,the significant occurrence of erosive esophagitis and heightened esophageal acid exposure necessitates vigilant monitoring to preclude long-term GERD-related *** advancements in the field have enhanced our comprehension of the risk factors,diagnostic methodologies,preventative strategies,and therapeutic management of GERD subsequent to *** review focuses on the limitations inherent in the 24-h pH study for evaluating post-POEM reflux,potential modifications in the POEM technique to mitigate GERD risk,and the strategies for managing reflux following POEM.

关键词： Achalasia cardia Per-oral endoscopic myotomy Gastroesophageal reflux Esophagitis Gastroesophageal reflux disease

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Cooperative Spectrum Sensing Deployment for Cognitive Radio Networks for Internet of Things 5G Wireless Communication

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Tsinghua Science and Technology 2024年第3期29卷 698-720页

作者： Thulasiraman Balachander Kadiyala Ramana Rasineni Madana Mohana Gautam Srivastava Thippa reddy Gadekallu SRM Institute of Science and Technology Tamil Nadu 603203India Lebanese American University Beirut 1102Lebanonand also with Chaitanya Bharathi Institute of TechnologyHyderabad 500075India Chaitanya Bharathi Institute of Technology Hyderabad 500075India Brandon University BrandonR7A 0A1CanadaChinaMedical UniversityTaichung 404327Chinaand Lebanese American UniversityBeirut 1102Lebanon Department of Electrical and Computer Engineering Lebanese American UniversityBeirut 1102Lebanon

Recently,Cooperative Spectrum Sensing(CSS)for Cognitive Radio Networks(CRN)plays a significant role in efficient 5G wireless *** sensing is a significant technology in CRN to identify underutilized *** CSS technique is highly applicable due to its fast and efficient performance.5G wireless communication is widely employed for the continuous development of efficient and accurate Internet of Things(IoT)networks.5G wireless communication will potentially lead the way for next generation IoT *** has established significant consideration as a feasible resource to improve identification performance by developing spatial diversity in receiving signal strength in *** this paper,an optimal CSS for CRN is performed using Offset Quadrature Amplitude Modulation Universal Filtered Multi-Carrier Non-Orthogonal Multiple Access(OQAM/UFMC/NOMA)*** of spectrum and bandwidth utilization is a key challenge in CRN for IoT 5G wireless *** optimal solution for CRN in IoT-based 5G communication should be able to provide optimal bandwidth and CSS,low latency,Signal Noise Ratio(SNR)improvement,maximum capacity,offset synchronization,and Peak Average Power Ratio(PAPR)*** Energy Efficient All-Pass Filter(EEAPF)algorithm is used to eliminate *** deployment approach improves Quality of Service(QoS)in terms of system reliability,throughput,and energy *** in-depth experimental results show that the proposed methodology provides an optimal solution when directly compares against current existing methodologies.

关键词： cooperative spectrum sensing cognitive radio network Internet of Things offset quadratureamplitude modulation universal filtered multi-carrier non-orthogonal multiple access

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Ag-integrated mixed metallic Co-Fe-Ni-Mn hydroxide composite as advanced electrode for high-performance hybrid supercapacitors

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Journal of Energy Chemistry 2024年第1期88卷 579-591,I0013页

作者： Anki reddy Mule Bhimanaboina Ramulu Shaik Junied Arbaz Anand Kurakula Jae Su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee UniversityYongin-siGyeonggi-do 17104Republic of Korea

Direct growth of redox-active noble metals and rational design of multifunctional electrochemical active materials play crucial roles in developing novel electrode materials for energy storage *** this regard,silver(Ag)has attracted great attention in the design of efficient *** by the house/building process,which means electing the right land,it lays a strong foundation and building essential columns for a complex ***,we report the construction of multifaceted heterostructure cobalt-iron hydroxide(CFOH)nanowires(NWs)@nickel cobalt manganese hydroxides and/or hydrate(NCMOH)nanosheets(NSs)on the Ag-deposited nickel foam and carbon cloth(i.e.,Ag/NF and Ag/CC)***,the formation and charge storage mechanism of Ag are described,and these contribute to good conductive and redox chemistry *** switching architectural integrity of metal and redox materials on metallic frames may significantly boost charge storage and rate performance with noticeable drop in *** as-fabricated Ag@CFOH@NCMOH/NF electrode delivered superior areal capacity value of 2081.9μA h cm^(-2)at 5 mA cm^(-2).Moreover,as-assembled hybrid cell based on NF(HC/NF)device exhibited remarkable areal capacity value of 1.82 mA h cm^(-2)at 5 mA cm^(-2)with excellent rate capability of 74.77%even at 70 mA cm^(-2)Furthermore,HC/NF device achieved maximum energy and power densities of 1.39 mW h cm^(-2)and 42.35 mW cm^(-2),*** verify practical applicability,both devices were also tested to serve as a self-charging station for various portable electronic devices.

关键词： Current collectors Redox-active silver Transition metal-hydroxides Electrochemical performance Hybrid supercapacitor

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