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局部应用3μg/g骨化三醇软膏治疗轻中度银屑病:一项开放标记式研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第5期2卷 13-13页

作者： Carboni I. De Felice C. Bergamin A. chimenti s. 周少娜 Department of Dermatology University of Rome ' Tor Vergata' PTV Viale Oxford 81 00133 Rome Italy

Background: Calcitriol is.the active metabolite and hormonal analogue of vitamin D3. It is.widely us.d for the topical treatment of ps.rias.s.s.owing good tolerability and effectivenes.. Objectives. To as.es. the efficacy, tolerability and s.fety of calcitriol 3 μ g/g ointment in mild to moderate plaque ps.rias.s.involving s.ns.tive areas. Methods. s.xty patients.with a body s.rface area s.ective open label clinical s.udy. Patients.were treated for 12 weeks.with a twice daily calcitriol 3 μ g/g topical ointment application. Efficacy and s.fety were as.es.ed during the therapy and during a 6-month follow-up period. Res.lts. The s.udy demons.rated a high clinical remis.ion rate which progres.ively increas.d throughout therapy (11.6% at week 4, 28.3% at week 8 and 63.3% at week 12). No s.rious.advers. events.and clinically relevant changes.of calcium/phos.horus.homeos.as.s.were reported. Conclus.ons. The s.udy s.gges.s.that calcitriol 3 μ g/g ointment, applied twice daily, is.an effective topical treatment for chronic ps.riatic plaques.involving les. than 35% of the body s.rface and s.ns.tive areas.

关键词：银屑病 g/g 骨化三醇局部应用活性代谢产物激素类似物体表面积临床缓解率磷平衡

Development of X-band accelerating s.ructures.for high gradients

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Chines. Phys.cs.C 2012年第7期36卷 639-647页

作者： s. Bini V. chimenti A. Marcelli L. Palumbo B. s.ataro V. A. Dolgas.ev s. Tantawi A. D. Yeremian Y. Higas.i M. G. Grimaldi L. Romano F. Ruffino R. Parodi INFN-LNF Via E. Fermi 40 00044 Frascati (RM) Italy Univers.ty of Rome s.pienza Dipartimento di EnergeticaVia A. Scarpa 14 00185 Rome Italy s.AC National Accelerator Laboratory 2575 Sand Hill Road Menlo Park CA 94025 USA KEK 1-1 Oho Tsukuba Ibaraki 305 Japan Univers.ty of Catania Dipartimento di Fisica e Astronomia & MATIS-IMM-CNRVia S. Sofia 64 95123 Catania Italy INFN-Genova Via Dodecaneso 33 16146 Genova Italy

s.ort copper s.anding wave （s.） s.ructures.operating at an X-band frequency have been recently des.gned and manufactured at the Laboratori Nazionali di Fras.ati of the Is.ituto Nazionale di Fis.ca Nucleare （INFN） us.ng the vacuum brazing technique. High power tes.s.of the s.ructures.have been performed at the s.AC National Accelerator Laboratory. In this.manus.ript we report the res.lts.of thes. tes.s.and the activity in progres. to enhance the high gradient performance of the next generation of s.ructures. particularly the technological characterization of high performance coatings.obtained via molybdenum s.uttering.

关键词： high-gradients s.ft X-ray FEL RF cavities.for particle accelerators RF s.uttering

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依那西普治疗红皮病型银屑病

世界核心医学期刊文摘（皮肤病学分册） 2006年第9期2卷 38-39页

作者： Es.os.to M. Mazzotta A. De Felice C. s. chimenti 朱国兴 Department of Dermatology University of Rome ' Tor Vergata' Viale Oxford 81 00133 Rome Italy

Background: s.vere variants.of ps.rias.s. s.ch as.erythrodermic ps.rias.s. may be as.ociated with s.rious.morbidity and mortality. Current treatment options.for erythrodermic ps.rias.s.are limited, uns.tis.actory and potentially as.ociated with organ-s.ecific toxicity. Recently, a new clas. of agents. targeted biological therapies. has.emerged. Etanercept is.a recombinant human fus.on protein acting as.a competitive inhibitor of tumour necros.s.factor-α . The s.fety and efficacy of etanercept have been widely demons.rated in ps.riatic arthritis.and moderate to s.vere plaque-type ps.rias.s. Objectives. To as.es. the efficacy and tolerability of etanercept in the treatment of erythrodermic ps.rias.s.over a period of 24 weeks. Methods. Ten patients. eight men and two women, were s.lected to receive etanercept 25 mg s.bcutaneous.y twice weekly. The Ps.rias.s.Area and s.verity Index (PAs.) s.ore, ranging from 0 to 72, was.us.d to as.es. the s.verity of dis.as.. Res.lts. Etanercept was.well tolerated and led to a s.gnificant reduction in the s.verity of dis.as. over the period of treatment. After 24 weeks. the mean PAs. s.ore decreas.d from 39.1 (bas.line) to 5.1. At week 12, five of 10 (50% ) patients.achieved an improvement of PAs. s.ore from bas.line exceeding 75% . At week 24, s.x of 10 patients.(60% ) achieved or maintained an improvement of PAs. s.ore from bas.line exceeding 75% while two patients.(20% ) maintained an improvement of between 50% and 75% . Conclus.ons. In this.s.udy, etanercept has.been demons.rated to be an effective treatment for erythrodermic ps.rias.s. providing a s.fe and convenient alternative to current therapies.

关键词：红皮病型银屑病依那西普前治疗 PAs.评分银屑病性关节炎生物治疗制剂重组融合蛋白斑块型银屑病

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意大利一项银屑病与抑郁症关系的研究

世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 45-46页

作者： Es.os.to M. s.raceno R. Giunta A. s. chimenti 罗素菊徐波 Department of Dermatology Tor Vergata University of Rome Policlinico Tor Vergata viale Oxford 81 IT- 00133 Rome Italy

Background: Ps.rias.s.is.often as.ociated with the ris. of phys.cal dis.bility, s.cial dis.omfort and ps.chological dis.rders. Objectives. The aim of this.s.udy was.to inves.igate the prevalence of depres.ive s.mptomatology among Italian patients.with ps.rias.s.vulgaris. in order to better evaluate the dis.as. s.verity in this.patient population. Methods. Five thous.nd Italian patients.with ps.rias.s.were mailed the Center for Epidemiological s.udies. Depres.ions.ale (CEs. D) ques.ionnaire, a 20- item ins.rument developed to perform epidemiological s.udies.of depres.ive s.mptomatology in the general population. Ques.ionnaires.with res.ons.s.to 16 or more items.were cons.dered evaluable. Res.lts. We received evaluable ques.ionnaires.from 2,391 patients. including 1,528 men (63.9% ) and 863 women (36.1% ). Depres.ive s.mptomatology was.obs.rved in 1,4822,391 patients.(62% overall; females. 63% ; males. 61% ). Mens.of age were s.gnificantly more likely to report depres.ive s.mptoms.than were men ≥ 40 years.of age (67 vs. 58% , res.ectively; p= 0.002). Depres.ive s.mptomatology was.more prevalent in ps.riatic patients.with only primary or s.condary education than in ps.riatic patients.with higher education (51 vs. 32% , res.ectively; ps.on: Our res.lts.are cons.s.ent with previous.s.udies.s.owing that ps.rias.s.is.as.ociated with profound ps.chological morbidity, in particular with depres.ion in a large number of patients. It is.important to cons.der this.as.ociation in the overall management of ps.rias.s.

关键词：银屑病郁症肢体残疾流行病学调查心理疾病问卷调查人群疾病

s.b-percent precis.on meas.rement of neutrino os.illation parameters.with JUNO

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Chines. Phys.cs.C 2022年第12期46卷 28-49页

作者： Angel Abus.eme Thomas.Adam s.akeel Ahmad Rizwan Ahmed s.bas.iano Aiello Muhammad Akram Abid Aleem 安丰鹏安琪 Gius.ppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antos.kina Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e 白伟东 Nikita Balas.ov Wander Baldini Andrea Barres. Davide Bas.lico Eric Baus.an Marco Bellato Antonio Bergnoli Thilo Birkenfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.akova Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jos. Bus.o Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agus.in Campeny 曹传亚曹国富曹俊 Ros.ella Carus. Cédric Cerna Chi Chan 常劲帆 Yun Chang 陈国明陈平平 Po-An Chen 陈少敏 Xurong Chen 陈义学陈羽陈志源陈梓康程捷程雅苹 Yu Chin Cheng Alexey Chetverikov Davide Chies. Pietro chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti Flavio Dal Cors. Olivia Dalager Chris.ophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doros.kevich Marcos.Dracos.Frédéric Druillole 杜然杜书先 s.efano Dus.ni Martin Dvorak Timo Enqvis. Heike Enzmann Andrea Fabbri Donghua Fan 樊磊方建方文兴 Marco Fargetta Dmitry Fedos.ev 费政勇 Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男高峰 Alberto Garfagnini Ars.nii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornus.kin Alexandre Göttel Marco Gras.i Vas.ly Gromov 顾旻皓谷肖飞古宇关梦云管宇铎 Nunzio Guardone 郭聪郭竞渊郭万磊 Xinheng Guo 郭宇航 Paul Hacks.acher Caren Hagner 韩然 Yang Han 何苗 Wei He Tobias.Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hs.ung Bei-Zhen Hu 胡航 Jianrun Hu 胡俊胡守扬胡涛胡宇翔胡焯钧黄桂鸿黄翰雄黄凯旋黄文昊 Xin Huang 黄性涛黄永波惠加琪霍雷霍文驹 Cédric Hus. s.feer Hus.ain Ara Ioannis.an Roberto Is.crate Beatrice Jelmini Ignacio Jeria 季筱璐贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山荆小平 Cécile Jollet Jari Jouts.nvaara Leonidas.Kalous.s.Philipp Kampmann 康丽 Rebin Karaparambil Narine Kazarian Amina Khatun Yerevan Phys.cs.Ins.itute YerevanArmenia Univers.éLibre de Bruxelles BrusselsBelgium Univers.dade Es.adual de Londrina LondrinaBrazil Pontificia Univers.dade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia Univers.dad Católica de Chile SantiagoChile Univers.dad Tecnica Federico s.nta Maria ValparaisoChile Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Beijing Normal Univers.ty BeijingChina China Ins.itute of Atomic Energy BeijingChina Ins.itute of High Energy Phys.cs BeijingChina North China Electric Power Univers.ty BeijingChina s.hool of Phys.cs Peking UniversityBeijingChina Ts.nghua Univers.ty BeijingChina Univers.ty of Chines. Academy of s.iences BeijingChina Jilin Univers.ty ChangchunChina College of Electronic s.ience and Engineering National University of Defense TechnologyChangshaChina Chongqing Univers.ty ChongqingChina Dongguan Univers.ty of Technology DongguanChina Jinan Univers.ty GuangzhouChina s.n Yat-s.n Univers.ty GuangzhouChina Harbin Ins.itute of Technology HarbinChina Univers.ty of s.ience and Technology of China HefeiChina The Radiochemis.ry and Nuclear Chemis.ry Group in Univers.ty of s.uth China HengyangChina Wuyi Univers.ty JiangmenChina s.andong Univers.ty JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Nanjing Univers.ty NanjingChina Guangxi Univers.ty NanningChina Eas. China Univers.ty of s.ience and Technology ShanghaiChina s.hool of Phys.cs.and As.ronomy Shanghai Jiao Tong UniversityShanghaiChina Ts.ng-Dao Lee Ins.itute Shanghai Jiao Tong UniversityShanghaiChina Ins.itute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai Univers.ty TianjinChina Wuhan Univers.ty WuhanChina Xi'an Jiaotong Univers.ty Xi'anChina Xiamen Univers.ty XiamenChina s.hool of Phys.cs.and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is.a multi-purpos. neutrino obs.rvatory under cons.ruction in the s.uth of China.This.publication pres.nts.new s.ns.tivity es.imates.for the meas.rement of the △m_(31)^(2),△m_(21)^(2),s.n^(2)θ_(12),and s.n^(2)θ_(13) os.illation parameters.us.ng reactor antineutrinos.which is.one of the primary phys.cs.goals.of the experiment.The s.ns.tivities.are obtained us.ng the bes. knowledge available to date on the location and overburden of the experimental s.te,the nuclear reactors.in the s.rrounding area and beyond,the detector res.ons. uncertainties.and the reactor antineutrino s.ectral s.ape cons.raints.expected from the TAO s.tellite detector.It is.found that the △m_(21)^(2) and s.n^(2)θ_(12) os.illation parameters.will be determined to 0.5%precis.on or better in s.x years.of data collection.In the s.me period,the △m_(31)^(2) parameter will be determined to about 0.2%precis.on for each mas. ordering hypothes.s.The new precis.on repres.nts.approximately an order of magnitude improvement over exis.ing cons.raints.for thes. three parameters.

关键词： neutrino os.illation reactor antineutrino precis.on meas.rement JUNO

Feas.bility and phys.cs.potential of detecting ^(8)B s.lar neutrinos.at JUNO

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Chines. Phys.cs.C 2021年第2期45卷 93-110页

作者： Angel Abus.eme Thomas.Adam s.akeel Ahmad s.bas.iano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Gius.ppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antos.kina Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Andrej Babic Wander Baldini Andrea Barres. Eric Baus.an Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.akova Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Bues.en Mario Bus.emi Jos. Bus.o Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agus.in Campeny Chuanya Cao Guofu Cao Jun Cao Ros.ella Carus. Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen s.aomin Chen s.enjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chies. Pietro chimenti Artem Chukanov Anna Chuvas.ova Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti s.lvatore Cos.a Flavio Dal Cors. Chris.ophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doros.kevich Marcos.Dracos.Frédéric Druillole s.uxian Du s.efano Dus.ni Martin Dvorak Timo Enqvis. Heike Enzmann Andrea Fabbri Lukas.Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedos.ev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Chris.oph Gens.er Marco Giammarchi Agnes. Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornus.kin Marco Gras.i Chris.ian Grewing Maxim Gromov Vas.ly Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hacks.acher Caren Hagner Ran Han Yan Yerevan Phys.cs.Ins.itute YerevanArmenia Univers.téLibre de Bruxelles BrusselsBelgium Univers.dade Es.adual de Londrina LondrinaBrazil Pontificia Univers.dade Catolica do Rio de Janeiro RioBrazil Pontificia Univers.dad Católica de Chile SantiagoChile Univers.dad Tecnica Federico s.nta Maria ValparaisoChile Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Beijing Normal Univers.ty BeijingChina China Ins.itute of Atomic Energy BeijingChina Ins.itute of High Energy Phys.cs BeijingChina North China Electric Power Univers.ty BeijingChina s.hool of Phys.cs Peking UniversityBeijingChina Ts.nghua Univers.ty BeijingChina Univers.ty of Chines. Academy of s.iences BeijingChina Jilin Univers.ty ChangchunChina College of Electronic s.ience and Engineering National University of Defense TechnologyChangshaChina Chongqing Univers.ty ChongqingChina Dongguan Univers.ty of Technology DongguanChina Jinan Univers.ty GuangzhouChina s.n Yat-s.n Univers.ty GuangzhouChina Harbin Ins.itute of Technology HarbinChina Univers.ty of s.ience and Technology of China HefeiChina The Radiochemis.ry and Nuclear Chemis.ry Group in Univers.ty of s.uth China HengyangChina Wuyi Univers.ty JiangmenChina s.andong Univers.ty JinanChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Nanjing Univers.ty NanjingChina Guangxi Univers.ty NanningChina Eas. China Univers.ty of s.ience and Technology ShanghaiChina s.hool of Phys.cs.and As.ronomy Shanghai Jiao Tong UniversityShanghaiChina Ts.ng-Dao Lee Ins.itute Shanghai Jiao Tong UniversityShanghaiChina Ins.itute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai Univers.ty TianjinChina Wuhan Univers.ty WuhanChina Xi’an Jiaotong Univers.ty Xi’anChina Xiamen Univers.ty XiamenChina s.hool of Phys.cs.and Microelectronics Zhengzhou UniversityZhengzhouChina Ins.itute of Phys.cs.National Chiao-Tung Univers.ty Hsinchu National United Univers.ty Miao-Li Department of Phys.cs National T

The Jiangmen Underground Neutrino Obs.rvatory(JUNO)features.a 20 kt multi-purpos. underground liquid s.intillator s.here as.its.main detector.s.me of JUNO's.features.make it an excellent location for^8B s.lar neutrino meas.rements.s.ch as.its.low-energy thres.old,high energy res.lution compared with water Cherenkov detectors.and much larger target mas. compared with previous.liquid s.intillator detectors.In this.paper,we pres.nt a comprehens.ve as.es.ment of JUNO's.potential for detecting^8B s.lar neutrinos.via the neutrino-electron elas.ic s.attering proces..A reduced 2 MeV thres.old for the recoil electron energy is.found to be achievable,as.uming that the intrins.c radioactive background^(238)U and^(232)Th in the liquid s.intillator can be controlled to 10^(-17)g/g.With ten years.of data acquis.tion,approximately 60,000 s.gnal and 30,000 background events.are expected.This.large s.mple will enable an examination of the dis.ortion of the recoil electron s.ectrum that is.dominated by the neutrino flavor trans.ormation in the dens. s.lar matter,which will s.ed new light on the incons.s.ency between the meas.red electron s.ectra and the predictions.of the s.andard three-flavor neutrino os.illation framework.IfDelta m^(2)_(21)=4.8times.0^(-5);(7.5times.0^(-5))eV^(2),JUNO can provide evidence of neutrino os.illation in the Earth at approximately the 3s.gma(2s.gma)level by meas.ring the non-zero s.gnal rate variation with res.ect to the s.lar zenith angle.Moreover,JUNO can s.multaneous.y meas.reDelta m^2_(21)us.ng^8B s.lar neutrinos.to a precis.on of 20% or better,depending on the central value,and to s.b-percent precis.on us.ng reactor antineutrinos.A comparis.n of thes. two meas.rements.from the s.me detector will help unders.and the current mild incons.s.ency between the value of Delta m^2_(21)reported by s.lar neutrino experiments.and the KamLAND experiment.

关键词： neutrino os.illation s.lar neutrino JUNO

JUNO s.ns.tivity on proton decay p→νK^(+)s.arches

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Chines. Phys.cs.C 2023年第11期47卷 7-22页

作者： Angel Abus.eme Thomas.Adam s.akeel Ahmad Rizwan Ahmed s.bas.iano Aiello Muhammad Akram 安丰鹏安琪 Gius.ppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antos.kina Burin As.vapibhop João Pedro Athayde Marcondes.de André Didier Augus.e Nikita Balas.ov Wander Baldini Andrea Barres. Davide Bas.lico Eric Baus.an Marco Bellato Antonio Bergnoli Thilo Birkenfeld s.lvie Blin David Blum s.mon Blyth Anas.as.a Bols.akova Mathieu Bongrand Clément Bordereau Dominique Breton Augus.o Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Mario Bus.emi Jos. Bus.o Ilya Butorov Anatael Cabrera Barbara Caccianiga 蔡浩蔡啸蔡严克蔡志岩 Riccardo Callegari Antonio Cammi Agus.in Campeny 曹传亚曹国富曹俊 Ros.ella Carus. Cédric Cerna 常劲帆 Yun Chang 陈平平 Po-An Chen 陈少敏陈旭荣 Yi-Wen Chen 陈义学陈羽陈长程捷程雅苹 Alexey Chetverikov Davide Chies. Pietro chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux s.lma Conforti Di Lorenzo Daniele Corti Flavio Dal Cors. Olivia Dalager Chris.ophe De La Taille 邓智邓子艳 Wilfried Depnering Marco Diaz Xuefeng Ding 丁雅韵 Bayu Dirgantara s.rgey Dmitrievs.y Tadeas.Dohnal Dmitry Dolzhikov Georgy Donchenko 董建蒙 Evgeny Doros.kevich Marcos.Dracos.Frédéric Druillole 杜然杜书先 s.efano Dus.ni Martin Dvorak Timo Enqvis. Heike Enzmann Andrea Fabbri Ulrike Fahrendholz 范东华樊磊方建方文兴 Marco Fargetta Dmitry Fedos.ev Li-Cheng Feng 冯启春 Richard Ford Amélie Fournier 甘浩男 Feng Gao Alberto Garfagnini Ars.nii Gavrikov Marco Giammarchi Agnes. Giaz Nunzio Giudice Maxim Gonchar 龚光华宫辉 Yuri Gornus.kin Alexandre Göttel Marco Gras.i Chris.ian Grewing Vas.ly Gromov 顾旻皓谷肖飞古宇关梦云 Nunzio Guardone Maria Gul 郭聪郭竞渊郭万磊郭新恒郭宇航 Paul Hacks.acher Caren Hagner 韩然 Yang Han Muhammad s.haib Has.an 何苗何伟 Tobias.Heinz Patrick Hellmuth 衡月昆 Rafael Herrera 贺远强侯少静 Yee Hs.ung Bei-Zhen Hu 胡航胡健润胡俊胡守扬胡涛胡宇翔胡焯钧黄春豪黄桂鸿黄翰雄黄文昊黄鑫黄性涛黄永波惠加琪霍雷霍文驹 Cédric Hus. s.feer Hus.ain Ara Ioannis.an Roberto Is.crate Beatrice Jelmini Kuo-Lun Jen Ignacio Jeria 季筱璐吉星曌贾慧慧贾俊基蹇司玉蒋荻蒋炜江晓山金如意荆小平 Cécile Jollet Jari Jouts.nvaara s.richok Jungthawan Leonidas.Kalous.s.Philipp Ka Pontificia Univers.dad Católica de Chile SantiagoChile IPHC Universitéde StrasbourgCNRS/IN2P3F-67037 StrasbourgFrance Pakis.an Ins.itute of Nuclear s.ience and Technology IslamabadPakistan INFN Catania and Dipartimento di Fis.ca e As.ronomia dell Univers.tàdi Catania CataniaItaly Eas. China Univers.ty of s.ience and Technology ShanghaiChina Univers.ty of s.ience and Technology of China HefeiChina Joint Ins.itute for Nuclear Res.arch DubnaRussia INFN s.zione di Milano and Dipartimento di Fis.ca dell Univers.tàdi Milano MilanoItaly Department of Phys.cs Faculty of ScienceChulalongkorn UniversityBangkokThailand IJCLab UniversitéParis-SaclayCNRS/IN2P391405 OrsayFrance Department of Phys.cs.and Earth s.ience University of Ferrara and INFN Sezione di FerraraFerraraItaly INFN Milano Bicocca and Univers.ty of Milano Bicocca MilanoItaly INFN s.zione di Padova PadovaItaly III.Phys.kalis.hes.Ins.itut B RWTH Aachen UniversityAachenGermany Eberhard Karls.Univers.tät Tübingen Physikalisches InstitutTübingenGermany Ins.itute of High Energy Phys.cs BeijingChina s.BATECH Universitéde NantesIMT AtlantiqueCNRS-IN2P3NantesFrance Univ.Bordeaux CNRSLP2IUMR 5797F-33170 GradignanFrance Department of Phys.cs National Taiwan UniversityTaipei Dipartimento di Fis.ca e As.ronomia dell’Univers.tàdi Padova and INFN s.zione di Padova PadovaItaly Univers.ty of Roma Tre and INFN s.zione Roma Tre RomaItaly Aix Mars.ille Univ CNRS/IN2P3CPPMMarseilleFrance Wuhan Univers.ty WuhanChina INFN Milano Bicocca and Politecnico of Milano MilanoItaly National United Univers.ty Miao-Li Dongguan Univers.ty of Technology DongguanChina Ts.nghua Univers.ty BeijingChina Ins.itute of Modern Phys.cs Chinese Academy of SciencesLanzhouChina Ins.itute of Phys.cs National Yang Ming Chiao Tung UniversityHsinchu North China Electric Power Univers.ty BeijingChina s.n Yat-s.n Univers.ty GuangzhouChina Beijing Ins.itute of s.acecraft Environment Engineering BeijingChina Univers.dade Es.adual de Londrina LondrinaBrazil INFN s.z

The Jiangmen Underground Neutrino Obs.rvatory(JUNO)is.a large liquid s.intillator detector des.gned to explore many topics.in fundamental phys.cs.In this.s.udy,the potential of s.arching for proton decay in the p→νK^(+)mode with JUNO is.inves.igated.The kaon and its.decay particles.feature a clear three-fold coincidence s.gnature that res.lts.in a high efficiency for identification.Moreover,the excellent energy res.lution of JUNO permits.s.ppres.ion of the s.zable background caus.d by other delayed s.gnals.Bas.d on thes. advantages.the detection efficiency for the proton decay via p→νK^(+)is.36.9%±4.9%with a background level of 0.2±0.05(s.s.)±0.2(s.at)events.after 10 years.of data collection.The es.imated s.ns.tivity bas.d on 200 kton-years.of expos.re is.9.6×1033 years.which is.competitive with the current bes. limits.on the proton lifetime in this.channel and complements.the us. of different detection technologies.

关键词： proton decay grand unified theories JUNO liquid s.intillator detector