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Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma

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World Journal of Gastroenterology 2005年第33期11卷 5151-5155页

作者： Yuji Toiyama Akira Mizoguchi Kazushi Kimura Toshimitsu Araki Shigeyuki Yoshiyama Kouhei Sakaguchi chikao miki Masato Kusunoki The Second Department of Surgery Mie University School of Medicine 2-174 EdobashiTsuMie 514-8507Japan the Department of Anatomy Faculty of Medicine Mie UniversityEdobashiTsu Mie 514-8507 Japan The Second Department of Surgery Mie University School of Medicine 2-174 Edobashi Tsu Mie 514-8507Japan the Department of Anatomy Faculty of Medicine Mie University Edobashi Tsu Mie 514-8507 Japan The Second Department of Surgery Mie University School of Medicine 2-174 Edobashi Tsu Mie 514-8507 Japan

AIM： A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis （UC）. We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication. METHODS： Non-inflamed mucosa was obtained from 6 UC patients who received total colectomy. The gene expression of UC in noninflamed mucosa was monitored with a microarray. For a selected gene, RT-PCR was performed to verify array results and to further examine expression pattern in inflamed mucosa of UC, colorectal cancer tissue and normal mucosa using additional matched pairs. RESULTS： Two genes showing 2.5-fold decreased expression with significance set at in UC samples were borneo box a4 （HOXa4） and mads box transcription enhancer factor 2, polypeptide B （MEF2b）. RT-PCR showed that MEF2b expression in non-inflamed mucosa was significantly downregulated, whereas the expression of MEF2b increased in accordance with the severity of mucosal inflammation. HOXa4 expression both in inflamed and non-inflamed mucosa in UC was consistently downregulated, and the downregulation of HOXa4 was also found in colorectal carcinoma. CONCLUSION： It is suggested that the MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. In contrast the downregulation of HOXa4 may be partly involved in the pathogenesis of disease including UC and UC-related carcinogenesis.

关键词： Ulcerative colitis OligonucleoUde array Geneexpression

TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation

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World Journal of Gastroenterology 2007年第19期13卷 2717-2721页

作者： Yuji Toiyama Akira Mizoguchi Kazushi Kimura Junichirou Hiro Yasuhiro Inoue Tomonari Tutumi chikao miki Masato Kusunoki Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Mie University Graduate School of Medicine Japan Department of Anatomy Faculty of Medicine Mie University 2-174 EdobashiTsu Mie 514-8507 Japan

AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell ***: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation ***: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell ***: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer.

关键词： TTYH2 Colorectal carcinoma Cell proliferation Cell aggregation

Intranasal administration of stem cell-derived exosomes for central nervous system diseases

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Neural Regeneration Research 2024年第6期19卷 1249-1255页

作者： Shuho Gotoh Masahito Kawabori miki Fujimura Department of Neurosurgery Hokkaido University Graduate School of Medicine

Exosomes, lipid bilayer-enclosed small cellular vesicles, are actively secreted by various cells and play crucial roles in intercellular communication. These nanosized vesicles transport internalized proteins, mRNA, miRNA, and other bioactive molecules. Recent findings have provided compelling evidence that exosomes derived from stem cells hold great promise as a therapeutic modality for central nervous system disorders. These exosomes exhibit multifaceted properties including antiapoptotic, anti-inflammatory, neurogenic, and vasculogenic effects. Furthermore, exosomes offer several advantages over stem cell therapy, such as high preservation capacity, low immunogenicity, the ability to traverse the blood-brain barrier, and the potential for drug encapsulation. Consequently, researchers have turned their attention to exosomes as a novel therapeutic avenue. Nonetheless, akin to the limitations of stem cell treatment, the limited accumulation of exosomes in the injured brain poses a challenge to their clinical application. To overcome this hurdle, intranasal administration has emerged as a non-invasive and efficacious route for delivering drugs to the central nervous system. By exploiting the olfactory and trigeminal nerve axons, this approach enables the direct transport of therapeutics to the brain while bypassing the blood-brain barrier. Notably, exosomes, owing to their small size, can readily access the nerve pathways using this method. As a result, intranasal administration has gained increasing recognition as an optimal therapeutic strategy for exosomebased treatments. In this comprehensive review, we aim to provide an overview of both basic and clinical research studies investigating the intranasal administration of exosomes for the treatment of central nervous system diseases. Furthermore, we elucidate the underlying therapeutic mechanisms and offer insights into the prospect of this approach.

关键词： central nervous system disease exosome extracellular vesicle intranasal administration stem cell

A Hydrogen-Bonded,Hexagonally Networked,Layered Framework with Large Aperture Designed by Structural Synchronization of a Macrocycle and Supramolecular Synthon

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Precision Chemistry 2024年第5期2卷 221-228页

作者： Hiroki Yoshimura Ryusei Oketani miki Naruoka Norimitsu Tohnai Ichiro Hisaki Division of Chemistry Graduate School of Engineering ScienceOsaka UniversityToyonakaOsaka 560-8531Japan Department of Applied Chemistry Graduate School of EngineeringOsaka UniversitySuitaOsaka 565-0871Japan

To develop porous organic frameworks,precise control of the stacking manner of two-dimensional porous motifs and structural characterization of the resultant framework are *** these points of view,porous molecular crystals formed through reversible intermolecular hydrogen bonds,such as;hydrogen-bonded organic frameworks(HOFs),can provide deep insight because of their high crystallinity,affording single-crystalline X-ray diffraction *** this study,we demonstrate that the stacking manner of hydrogen-bonded hexagonal network(HexNet)sheets can be controlled by synchronizing a homological triangular macrocyclic tecton and a hydrogen-bonded cyclic supramolecular synthon called the phenylene triangle.A structure of the resultant HOF was crystallographically characterized and revealed to have a large channel aperture of 2.4 *** HOF also shows thermal stability up to 290°C,which is higher than that of the conventional HexNet frameworks.

关键词： hydrogen-bonded organicframeworks hexagonalnetwork macrocycle carboxylicacid porosity

中日高中生汉语教材比较研究 ——以《高校生からの中国語》（从高中学起的汉语）与《跟我学汉语》（日语版）为例

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中日高中生汉语教材比较研究 ——以《高校生からの中国語》（从...

作者：本夛美季（HONDA miki）华东师范大学

学位级别：硕士

日本具有悠久的学习和使用汉语的历史,并且一直致力于推广汉语教育,这一点与其他国家相比尤其特殊。自中国汉朝开始,日本就着力推进汉语教育,而明治时期出版的教材《亚细亚言语集》,是日本第一部北京官方语言的教材,由日本学者广部精编... 详细信息

日本具有悠久的学习和使用汉语的历史,并且一直致力于推广汉语教育,这一点与其他国家相比尤其特殊。自中国汉朝开始,日本就着力推进汉语教育,而明治时期出版的教材《亚细亚言语集》,是日本第一部北京官方语言的教材,由日本学者广部精编写,它对日本汉语教育的发展起到了极其重要的作用。中国的改革开放在日本也快速掀起了一股“汉语热”。尽管日本本土出版了众多版本的汉语教材,但是缺乏具有权威性的汉语教材,而中国编辑出版的对日汉语教材在针对性方面又值得商榷。目前,针对对日汉语教材的比较研究寥寥无几,各种版本的日本汉语教材各自的特色与优缺点无法体现。因此有必要对这些教材进行比较研究,为编写具有针对性的对日汉语教材提供依据,以满足如此众多汉语学习者,特别是青少年汉语学习者的需求。本文基于实用性、针对性、趣味性、丰富性等教材编写理论,利用文献资料法、数据统计法与比较归纳法等方法,从语音、词汇、语法、汉字、练习、话题、文化、插图和课文等多个方面入手,对两套具有代表性的对日汉语教材《高校生からの中国語》(从高中学起的汉语)与《跟我学汉语》(日语版)进行全面的量化比较研究,揭示两套教材在选材、编写理念、文化内涵、侧重点等方面的异同,获得关于两套教材内容逐项量化统计与比较分析结果,佐证两套教材存在的优缺点,指出两部教材的互补性,并提出了相应的建议。希望本文的研究结果将有助于教材编写者,结合日本文化背景以及日本人的思维习惯,编写具有针对性的高质量的初级对日汉语教材。

关键词：《高校生からの中国語》(从高中学起的汉语) 《跟我学汉语》(日语版) 国际中文教育初级汉语教材教材对比

Giant Brunner's gland hyperplasia of the duodenum successfully resected en bloc by endoscopic mucosal resection: A case report

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 368-375页

作者： Makomo Makazu Akiko Sasaki Chikamasa Ichita Chihiro Sumida Takashi Nishino miki Nagayama Shinichi Teshima Gastroenterology Medicine Center Shonan Kamakura General HospitalKamakura 247-8533Japan Department of Gastroenterology Shonan Kamakura General HospitalKanagawa 247-8533Japan Department of Pathology Shonan Kamakura General HospitalKamakura 247-8533Japan

BACKGROUND Duodenal Brunner's gland hyperplasia(BGH)is a therapeutic target when complications such as bleeding or gastrointestinal obstruction occur or when malignancy cannot be ruled ***,we present a case of large BGH treated with endoscopic mucosal resection(EMR).CASE SUMMARY An 83-year-old woman presented at our hospital with *** tests revealed severe anemia,esophagogastroduodenoscopy showed a 6.5 cm lesion protruding from the anterior wall of the duodenal bulb,and biopsy revealed the presence of glandular *** ultrasonography(EUS)demonstr-ated relatively high echogenicity with a cystic *** muscularis propria was slightly elevated at the base of the *** was performed without *** formalin-fixed lesion size was 6 cm×3.5 cm×3 cm,showing nodular proliferation of non-dysplastic Brunner's glands compartmentalized by fibrous septa,confirming the diagnosis of *** of EMR or hot snare polypectomy are rare for duodenal BGH>6 *** this case,the choice of EMR was made by obtaining information on the base of the lesion as well as on the internal characteristics through *** Large duodenal lesions with good endoscopic maneuverability and no evident muscular layer involvement on EUS may be resectable via EMR.

关键词： Duodenum Brunner’s gland hyperplasia Brunner’s gland hamartoma Brunner’s gland adenoma Endoscopic mucosal resection Case report

Quest towards ultimate performance in superconducting nanowire single photon detectors

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Science China(Physics,Mechanics & Astronomy) 2018年第2期61卷 80-81页

作者： Shigehito miki Advanced ICT Research Institute National Institute of Information and Communications Technology

In 2007, superconducting nanowire single photon detectors （SSPD or SNSPD） [ 1 ] made an outstanding impact in the field of quantum information technology by demonstrating quan- tum key distribution （QKD） over a 200-kin optical fiber with a 42-dB optical loss using a practical SNSPD system [2]. This successful demonstration was realized thanks to its extremely low dark count rate （DCR） of a few Hz and short timing jitter of 60 ps, while the system detection efficiency （SDE） showed a poor value of 0.7% at a wavelength of 1550 nm.

关键词： Quest towards ultimate performance superconducting nanowire single photon detectors

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Activity coefficients of NiO and CoO in CaO–Al_2O_3–SiO_2 slag and their application to the recycling of Ni–Co–Fe-based end-of-life superalloys via remelting

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International Journal of Minerals,Metallurgy and Materials 2017年第1期24卷 25-36页

作者： Xin Lu Takahiro miki Tetsuya Nagasaka Graduate School of Engineering Tohoku University

To design optimal pyrometallurgical processes for nickel and cobalt recycling, and more particularly for the end-of-life process of Ni-Co-Fe-based end-of-life（EoL） superalloys, knowledge of their activity coefficients in slags is essential. In this study, the activity coefficients of NiO and CoO in CaO-Al_2O_3-SiO_2 slag, a candidate slag used for the EoL superalloy remelting process, were measured using gas/slag/metal equilibrium experiments. These activity coefficients were then used to consider the recycling efficiency of nickel and cobalt by remelting EoL superalloys using CaO-Al_2O_3-SiO_2 slag. The activity coefficients of NiO and CoO in CaO-Al_2O_3-SiO_2 slag both show a positive deviation from Raoult＇s law, with values that vary from 1 to 5 depending on the change in basicity. The activity coefficients of NiO and CoO peak in the slag with a composition near B =（%CaO）/（%SiO_2） = 1, where B is the basicity. We observed that controlling the slag composition at approximately B = 1 effectively reduces the cobalt and nickel oxidation losses and promotes the oxidation removal of iron during the remelting process of EoL superalloys.

关键词： recycling nickel cobalt end-of-life superalloys activity coefficients remelting slag

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A facile method for preparation of uniformly decorated-spherical SnO2 by CuO nanoparticles for highly responsive toluene detection at high temperature

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Journal of Materials Science & Technology 2020年第16期47卷 119-129页

作者： Angga Hermawan Yusuke Asakura miki Inada Shu Yin Institute of Multidisciplinary Research for Advanced Materials(IMRAM) Tohoku University2-1-1 KatahiraAoba-kuSendaiMiyagi980-857乙Japan Center of Advanced Instrumental Analysis Kyushu University6-1 Kasuga-Koen Kasuga-ShiFukuoka816-8580Japan

We reported a facile preparation of a uniform decoration of spherical n-type SnO2 by p-type CuO nanopa rticles as well as their utilization for enhanced performance on toluene gas *** nanoparticles and spherical SnO2 were synthesized by a facile non-hydrolytic solvothermal reaction,which could easily control their morphology.A uniform CuO nanoparticles decoration onto spherical SnO2 was achieved by a simple sonication and vigorous stirring at room tempe *** revealed orga nic solvents used in the oxide synthesis had a considerable influence on its surface charge that was beneficial for a uniformly electrostatic self-decoration between positively charged p-type CuO nanoparticles and negatively charged n-type spherical ***,CuO was partially reduced to Cu metal during high concentration of toluene exposure destroying p-n contact and developing new metal-semiconductor contact so-called ohmic junction,resulting in extraordinarily responsive and selective to toluene gas at 400℃as compared to a single p-CuO and *** was also found that the amount of particle decoration had an influence on sensor response and *** optimum amount of CuO nanoparticle decoration was0.1 mmol on 0.5 mmol *** re s ponse(S=Ra/Rg)and selectivity of CuO/S nO2 based material toward the exposure of 75 ppm toluene had reached to such high as 540 and 5,*** effect of p-n heterojunction and metal-semiconductor contact on the gas sensing mechanism of p-type CuO/n-type SnO2 was ***,by decorating with CuO nanoparticles,CuO/SnO2 morphology was well-maintained after gas sensing evaluation demonstrated its excellency for high temperature toluene gas sensor application.

关键词： CuO SnO2 p-n heterojunction Toluene gas sensor

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