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Research on stress-induced apoptosis of natural killer cells and the alteration of their killing activity in mouse liver

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World Journal of Gastroenterology 2013年第37期19卷 6258-6264页

作者： Zhen Ma Yang Liu Xin Zhou Hai-Long Yu Ming-Qi Li chikako tomiyama-miyaji Toru Abo Xue-Feng Bai Department of Colorectal Surgery Harbin Medical University Cancer Hospital Department of General Surgery the Second Affiliated Hospital of Harbin Medical University Department of Immunology Niigata University School of Medicine

AIM:To investigate the stress-induced apoptosis of natural killer(NK)cells and the changes in their killing activity in mouse ***:A restraint stress model was established in *** cytometry was employed to measure the percentage of NK cells and the changes in their absolute number in mouse *** cytotoxicity of hepatic and splenic NK cells was assessed against YAC-1 target cells via a 4 h 51Cr-release ***:The restraint stress stimulation induced the apoptosis of NK cells in the liver and the spleen,which decreased the cell *** number and percentage of NK cells in the spleen ***,the number of NK cells in the liver decreased,whereas the percentage of NK cells was significantly *** apoptosis of NK cells increased gradually with prolonged stress time,and the macrophage-1(Mac-1)+NK cells were more susceptible to apoptosis than Mac-1-NK *** numbers of Mac-1-NK cells in the liver,which are more resistant to stress-induced apoptosis,were observed than the Mac-1-NK cells in the *** stress stimulation diminished the killing activity of NK cells in the spleen was significantly decreased,but the retention of numerous Mac-1-NK cells in the liver maintained the killing ***:Significant stress-induced apoptosis was observed among Mac-1+NK cells,but not Mac-1-NK cells in the mouse *** stimulation markedly decreased the killing activity of NK cells in the spleen but remained unchanged in the liver.

关键词： Restraint stress Natural killer cells Cell apoptosis Killing activity

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Internal environment in cancer patients and proposal that carcinogenesis is adaptive response of glycolysis to overcome adverse internal conditions

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Health 2010年第7期2卷 781-788页

作者： Mayumi Watanabe Kenya miyajima Ittoku Matsui chikako tomiyama-miyaji Eisuke Kainuma Masashi Inoue Hiroaki Matsumoto Yuh Kuwano Toru Abo 不详

In a series of our recent studies, stress was found to induce simultaneously hypothermia and hyperglycemia. These conditions are beneficial to obtain prompt force which depends on the glycolysis pathway and to escape emergency. Since we have noticed that such conditions resemble the internal environment seen in some cancer patients, it was investigated whe- ther such conditions were accompanied with other patients. We selected patients with early and advanced cancer. Body temperature and other parameters including blood gas contents were examined. A difference was seen in body temperature, namely, many patients showed hypothermia, irrespective of cancer stages. Fur- ther characterization of other parameters show- ed that hypothermia and hyperglycemia existed in many patients. They had immunosuppressive state and anemia. Blood gas analysis showed that oxygen contents were low and carbon dioxide contents were high in patients. These results suggest a possibility that the internal environment seen in patients is responsible to induce onset of disease and to maintain their cell growth, because cancer cells have an energy system of predominant glycolysis. Although hypothermia, hypoxia and hyperglycemia are important to activate the glycolysis pathway and to escape from emergency, such responses suppress the mitochondrial pathway for long span and may result in carcinogenesis.

关键词： Cancer Hypothermia Hypoxia Hyperglycemia Glycolysis Mitochondria

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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli Guo chikako Harada Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

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Monogenic gene therapy for glaucoma and optic nerve injury

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Neural Regeneration Research 2025年第3期20卷 815-816页

作者： chikako Harada Xiaoli Guo Takayuki Harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

The prevalence of glaucoma, the second leading cause of global blindness, is increasing due to aging populations. In glaucoma, degeneration of the optic nerve and retinal ganglion cells(RGCs) causes visual field defec... 详细信息

关键词： visual glaucoma degeneration

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A Medical Hypothesis: Excessive Adaptation Results in Relative Hypothermia and Lymphocytopenia, as Seen in Carnivorous Aquatic Mammals

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Health 2016年第8期8卷 764-771页

作者： Mayumi Watanabe chikako tomiyama Toru Abo Department of Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Toru Abo Research Centre Niigata Japan

Body temperature is an important clinical indicator of health and illness. Many studies of human body temperature have been conducted;however, there are no studies that compare the body temperatures of humans and other homeothermic animals. Twenty-six homeothermic animal species, including humans, were selected and characteristics of their internal environment were studied based on previous reports. The studied species were divided into two groups based on habitat (eight aquatic and eighteen terrestrial species) and three groups based on diet (carnivores, herbivores, and omnivores). Body temperatures, erythrocyte counts, and lymphocyte percentages were compared between species and between groups. Our results showed that carnivores had lower body temperatures and erythrocyte numbers than herbivores, and lower lymphocyte ratios than both herbivores and omnivores. Aquatic mammals that experienced a second adaptation event during their evolutionary process had lower body temperatures and lymphocyte ratios than terrestrial animals. These results suggest that excessive adaptation induced by stress or a change in environment may result in relative hypothermia and lymphocytopenia, features that aquatic mammals with stressful evolutionary backgrounds share with human cancer patients. However, our study is based on analysis of previous observations and reports, and further research (e.g., larger-scale studies) is needed to support this hypothesis.

关键词： Body Temperature Erythrocyte Lymphocyte Carnivore Adaptation

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A Specific Pattern in the Basal Body Temperature Chart during the First Week of Pregnancy May Warn of a Miscarriage Crisis

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Health 2016年第8期8卷 723-729页

作者： Mayumi Watanabe Yoshinobu Nakamura chikako tomiyama Toru Abo Department of Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan Nakamura Seikotsuin Niigata Japan Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Toru Abo Research Centre Niigata Japan

We studied the efficiency of acupuncture for patients who were unable to give birth though they had experienced conventional infertility treatment for more than 2 years by medical specialists. We then investigated characteristics of difficult pregnancy cases with measurement of body temperature and observation of basal body temperature (BBT) charts. Thirty-three patients had acupuncture every week for more than 2 years and 17 of them delivered. At the same time, their cutaneous body temperature was measured at five locations. Moreover, patients and acupuncturists had a weekly discussion of the patient’s BBT chart. The delivery group showed more balanced and higher cutaneous body temperatures than the miscarriage and no pregnancy groups. The delivery group showed a smooth increase in the BBT chart while the miscarriage group showed a specific pattern in shifting temperatures from low to high zones. Acupuncture might suppress excess sympathetic dominance, which induced hyperthermia as well as interruption of pregnancy. Additionally, weekly discussion and medical advice could help patients. However, further study of males, healthy women, or larger, comparative studies exploring the social and cultural background of other countries were needed to add support to these factors.

关键词： Basal Body Temperature (BBT) Chart Miscarriage Kyusaku Ogino Acupuncture Medical Advice

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Internal environment for growth of cancer cells in mice: hypothermia, anemia and lymphocytopenia

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Health 2011年第4期3卷 238-244页

作者： Mayumi Watanabe Hiroaki Matsumoto chikako tomiyama Kohei Akazawa Toru Abo 不详

The internal environment in tumor-bearing mice was investigated in detail. When EL-4 lymphoma cells (5 × 106 cells/mouse) were intraperitoneally inoculated into C57BL/6 mice, approximately 70% of the mice died by day 24. In this regard, the internal environment was compared between control mice, surviving mice and tumor-bearing mice which died. The most prominent sign was hypothermia (<34?C from day 16) seen in tumor-bearing mice which died. Control mice and surviving mice did not show such hypothermia (around 38?C). Other changes, including anemia and lymphocytopenia, were also seen in tumor-bearing mice which died, but not in control mice and surviving mice. Immunological study revealed that NKT cells, which have been previously identified to be the major effector lymphocytes against EL-4 cells, almost disappeared, especially in the liver of tumor-bearing mice which died. These results suggest that a specific internal environment might be required for continuous tumor growth in vivo. Such internal environmental factors include hypothermia, ane- mia and severe immunosuppression.

关键词： Cancer Hypothermia Anemia Immunosuppression Glycolysis Mitochondria

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Two-dimensional laser-induced periodic surface structures formed on crystalline silicon by GHz burst mode femtosecond laser pulses

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International Journal of Extreme Manufacturing 2023年第1期5卷 212-220页

作者： Shota Kawabata Shi Bai Kotaro Obata Godai miyaji Koji Sugioka RIKEN Center for Advanced Photonics 2-1 HirosawaWakoSaitama 351-0198Japan Department of Applied Physics Tokyo University of Agriculture and Technology2-24-16 NakachoKoganeiTokyo 184-8588Japan

Femtosecond laser pulses with GHz burst mode that consist of a series of trains of ultrashort laser pulses with a pulse interval of several hundred picoseconds offer distinct features in material processing that cannot be obtained by the conventional irradiation scheme of femtosecond laser pulses(single-pulse mode).However,most studies using the GHz burst mode femtosecond laser pulses focus on ablation of materials to achieve high-efficiency and high-quality material *** this study,we explore the ability of the GHz burst mode femtosecond laser processing to form laser-induced periodic surface structures(LIPSS)on *** is well known that the direction of LIPSS formed by the single-pulse mode with linearly polarized laser pulses is typically perpendicular to the laser polarization *** contrast,we find that the GHz burst mode femtosecond laser(wavelength:1030 nm,intra-pulse duration:220 fs,intra-pulse interval time(intra-pulse repetition rate):205 ps(4.88 GHz),burst pulse repetition rate:200 kHz)creates unique two-dimensional(2D)*** regard the formation mechanism of 2D LIPSS as the synergetic contribution of the electromagnetic mechanism and the hydrodynamic ***,generation of hot spots with highly enhanced electric fields by the localized surface plasmon resonance of subsequent pulses in the bursts within the nanogrooves of one-dimensional LIPSS formed by the preceding pulses creates 2D ***,hydrodynamic instability including convection flow determines the final structure of 2D LIPSS.

关键词： GHz burst laser-induced periodic surface structures(LIPSS) surface nanostructuring 2D nanostructures

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Involvement of Dectin-2 in the Innate Inflammatory Response Triggered by Influenza Virus Hemagglutinin

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Advances in Infectious Diseases 2023年第3期13卷 478-497页

作者： Hideki Yamamoto chikako tomiyama Sho Yamasaki Shinobu Saijo Yoichiro Iwakura Kazuyoshi Kawakami Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Department of Molecular Immunology Research Institute for Microbial Diseases Osaka University Osaka Japan Laboratory of Molecular Immunology Immunology Frontier Research Center Osaka University Osaka Japan Project for Cytokine Research Division of Molecular Immunology Medical Mycology Research Center Chiba University Chiba Japan Center for Animal Disease Models Research Institute for Biomedical Sciences Tokyo University of Science Chiba Japan Department of Medical Microbiology Mycology and Immunology Tohoku University Miyagi Japan Department of Internal Medicine Hirose Hospital Miyagi Japan

C-type lectin receptors (CLRs) are representative pattern recognition receptors that recognize microbial polysaccharides expressed on antigen-presenting cells. In the present study, we carried out further detailed analysis on the involvement of Dectin-2, a CLR that senses high mannose polysaccharide, in innate immune responses induced by influenza virus hemagglutinin (HA). Treatment of HA with periodate or PNGase F induced lower interleukin (IL)-12p40 secretion by conventional dendritic cells (DCs) compared with the untreated group. In contrast, treatment with O-glycosidase did not affect cytokine production. Green fluorescent protein expression in canonical Dectin-2-transducing cells was approximately 3% - 12% following HA stimulation, except with the A/H1N1pdm09 subtype HA. This expression was markedly reduced in cells possessing mutated amino acids in the carbohydrate recognition domain of Dectin-2, especially following stimulation with HA derived from the A/H3N2 subtype. Interferon (IFN)-α production from CD11c+Siglec-H+PDCA-1+ plasmacytoid DCs was significantly increased in Dectin-2 knockout mice compared with wild-type mice upon stimulation with HA except for the B/Yamagata lineage HA. These results suggested that Dectin-2 is involved in initiating inflammatory responses via mannose polysaccharide on HA. However, other mechanisms may function in the antiviral response, including the type I IFN axis.

关键词： C-Type Lectin Receptors Influenza Virus Innate Immunity Type I Interferon

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Traditional Japanese Style Bathing May Contribute to Good Health and Longevity

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Health 2016年第8期8卷 756-763页

作者： Mayumi Watanabe Shigeharu Koboshi Hiroshi Yoshimoto Kazuhiro Kobayashi chikako tomiyama Toru Abo Department of Medical Informatics Niigata University Medical and Dental Hospital Niigata Japan Hot Album Tansansen Tablet Inc. Hachiouji Japan Department of Medical Technology Graduate School of Health Sciences Niigata University Niigata Japan Toru Abo Research Centre Niigata Japan

The objective of this study was to determine how traditional Japanese style bathing could promote good health. Using healthy volunteers, we assessed body temperature (core and cutaneous), red blood cells, white blood cells (WBCs), venous blood gas parameters (PO2, SO2, PCO2, TCO2, HCO3, and pH), weight loss (which may indicate sweat volume), and the time until sweating before and after bathing. We simultaneously conducted a double-blind clinical trial using a bath additive group and a control group to investigate the effect of a bath additive on the same parameters. We found that bathing increased the core and cutaneous body temperature, as well as PO2, SO2, and blood pH. All of the subjects also showed increases in heart rate and weight loss (sweat volume). After bathing, the number and ratio of granulocytes increased while the number and ratio of lymphocytes decreased. These results tended to be emphasized in the bath additive group;however, significant between-group differences were not detected. Our results indicated that bathing improved blood circulation and had a modulatory effect on the autonomic nervous system. This suggested that traditional Japanese style bathing might contribute to good health and longevity;however, additional larger-scale studies were needed to confirm or refute this conclusion.

关键词： Body Temperature Bathing Bath Additive Blood Gas Heart Rate Sweat

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