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Asking one mechanism in glial cells during neuroinflammation

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Neural Regeneration Research 2025年第4期20卷 1077-1078页

作者： Xiaoli Guo chikako harada Takayuki harada Visual Research Project Tokyo Metropolitan Institute of Medical ScienceTokyoJapan

Multiple sclerosis(MS),which is characterized by inflammatory demyelination in the central nervous system(CNS),is the most common neurological disease in the young adult *** autoimmune encephalomyelitis(EAE),an animal model of MS,is often used in preclinical *** data indicate that in addition to immune cells such as T cells and dendritic cells,CNS resident microglia and astrocytes play important roles in demyelinating neuroinflammation(Healy et al.,2022).In particular,microglia are key immune-competent cells that can respond to environmental *** depletion of transforming growth factor-β-activated kinase 1,a mitogen-associated protein kinase kinase kinase,in microglia is reported to reduce CNS inflammation and diminish axonal and myelin damage *** suggests that elucidating the mechanisms of microglia-specific responses during pathologies may help in the development of treatments that reduce EAE/MS disease severity(Goldmann et al.,2013).

关键词： inflammation clinical

MAVEN observation of magnetosonic waves in the Martian magnetotail region

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Earth and Planetary Physics 2024年第2期8卷 317-325页

作者： ShangChun Teng JiCheng Sun JiaWei Gao Y.harada Markus Fraenz DeSheng Han State Key Laboratory of Marine Geology School of Ocean and Earth ScienceTongji UniversityShanghai 200092China MNR Key Laboratory for Polar Science Polar Research Institute of ChinaShanghai 200136China Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Geophysics Kyoto UniversityKyotoJapan Max-Planck-Institute for Solar System Research GoettingenGermany

Magnetosonic waves are an important medium for energy transfer in collisionless space *** waves have been widely investigated in the upstream of the bow shock at *** waves are believed to originate from pickup ions or reflected *** utilizing MAVEN spacecraft data,we have observed the occurrence of quasi-perpendicularly propagating magnetosonic emissions near the proton gyrofrequency in the Martian magnetotail *** plasma waves are associated with a significant enhancement of proton and oxygen *** excited magnetosonic waves could possibly heat the protons through resonance and facilitate the ionospheric plasma *** results could be helpful to better understand the Mars’magnetospheric dynamics and offer insights into possible energy redistribution between waves and plasma in the Martian nightside magnetosphere.

关键词： Martian magnetotail region magnetosonic waves proton escape

Low skeletal muscle mass and high visceral adiposity are associated with recurrence of acute cholecystitis after conservative management:A propensity score-matched cohort study

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 64-70页

作者： Yudai Koya Michihiko Shibata Yuki Maruno Yoshitaka Sakamoto Shinji Oe Koichiro Miyagawa Yuichi Honma Masaru harada Department of Gastroenterology Kyushu Rosai HospitalMoji Medical Center3-1 HigashiminatomachiMoji-kuKitakyushu 801-8502Japan Third Department of Internal Medicine School of MedicineUniversity of Occupational and Environmental HealthKitakyushu 807-8555Japan Department of Surgery Kyushu Rosai Hospital Moji Medical CenterKitakyushu 801-8502Japan

Background:Recurrent acute cholecystitis(RAC)can occur after non-surgical treatment for acute cholecystitis(AC),and can be more severe in comparison to the first episode of *** skeletal muscle mass or adiposity have various effects in several *** aimed to clarify the relationship between RAC and body ***:Patients with AC who were treated at our hospital between January 2011 and March 2022 were *** psoas muscle mass and adipose tissue area at the third lumbar level were measured using computed tomography at the first episode of *** areas were divided by height to obtain the psoas muscle mass index(PMI)and subcutaneous/visceral adipose tissue index(SATI/VATI).According to median VATI,SATI and PMI values by sex,patients were divided into the high and low PMI *** performed propensity score matching to eliminate the baseline differences between the high PMI and low PMI groups and analyzed the cumulative incidence and predictors of ***:The entire cohort was divided into the high PMI(n=81)and low PMI(n=80)*** the propensity score-matched cohort there were 57 patients in each *** Kaplan-Meier analysis,the low PMI group and the high VATI group had a significantly higher cumulative incidence of RAC than their counterparts(log-rank P=0.001 and 0.015,respectively).In a multivariate Cox regression analysis,the hazard ratios of low PMI and low VATI for RAC were 5.250(95%confidence interval 1.083-25.450,P=0.039)and 0.158(95%confidence interval:0.026-0.937,P=0.042),***:Low skeletal muscle mass and high visceral adiposity were independent risk factors for RAC.

关键词： Acute cholecystitis Low skeletal muscle mass Recurrent acute cholecystitis Sarcopenia Visceral adiposity

Correlation between dose-volume parameters and rectal bleeding after 12 fractions of carbon ion radiotherapy for prostate cancer

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World Journal of Radiology 2024年第7期16卷 256-264页

作者： Takashi Ono Hiraku Sato Yuya Miyasaka Yasuhito Hagiwara Natsuko Yano Hiroko Akamatsu Mayumi harada Mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACKGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

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曲线长椅

设计 2013年第1期26卷 33-33页

作者： Jacob chikako harada

这款由Lincoln Kayiwa所设计的JOKI长椅不只是有性感的弧度，同时也完全符合人体工学。长椅材质为桦木板，“JOKI”是芬兰语中河流的意思，也是Kayiwa的灵感来源。JOKI长凳的外形，充满女性身体的曲线美，但这种设计并非是为了外形，而... 详细信息

这款由Lincoln Kayiwa所设计的JOKI长椅不只是有性感的弧度，同时也完全符合人体工学。长椅材质为桦木板，“JOKI”是芬兰语中河流的意思，也是Kayiwa的灵感来源。JOKI长凳的外形，充满女性身体的曲线美，但这种设计并非是为了外形，而是从功能性出发。

关键词：曲线长人体工学曲线美设计外形

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日本心血管疾病患者的安宁疗护及启示

中华护理杂志 2024年第5期59卷 533-539页

作者：彭梦云原田奈穂子齋藤信也岡山大学保健学研究科日本岡山市7008558 岡山大学医学部保健学科日本岡山市7008558

WHO呼吁全球医疗保健工作者重视非癌症患者的安宁疗护实践,目前国内安宁疗护主要以癌症患者为中心,在心血管疾病等慢性病人群中的实践和发展相对薄弱。近年来,日本开展的心血管疾病安宁疗护经实践验证可有效缓解患者的终末期症状,提高... 详细信息

WHO呼吁全球医疗保健工作者重视非癌症患者的安宁疗护实践,目前国内安宁疗护主要以癌症患者为中心,在心血管疾病等慢性病人群中的实践和发展相对薄弱。近年来,日本开展的心血管疾病安宁疗护经实践验证可有效缓解患者的终末期症状,提高患者及家庭成员的生活质量。该文介绍了日本心血管疾病患者安宁疗护的发展历程、规模及需求、团队成员及协作、介入时间、评估与筛查、服务内容与流程、质量评价及困境等,提出对国内心血管疾病患者实施安宁疗护的启示,为开展心血管疾病患者的安宁疗护提供借鉴。

关键词：心血管疾病安宁疗护姑息护理

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月幔底部黏弹性结构研究现状

中国科学：物理学、力学、天文学 2024年第3期54卷 19-29页

作者：肖驰叶茂李斐鄢建国 Yuji harada 郝卫峰邓青云中国地震局地震研究所地震大地测量重点实验室武汉430071 武汉引力与固体潮国家野外科学观测研究站武汉430071 武汉大学测绘遥感信息工程国家重点实验室武汉430079 武汉大学中国南极测绘研究中心武汉430079 澳门科技大学创新工程学院中国澳门999078

长期以来,月球幔层底部是否存在一个部分熔融的S波衰减层一直存在着争议.针对这一争议,本文首先回顾了国内外对月幔底部黏弹性结构的研究成果,梳理总结了争议的提出和发展历程,接着分析这一争议产生的主要原因.本文认为,虽然越来越多的... 详细信息

长期以来,月球幔层底部是否存在一个部分熔融的S波衰减层一直存在着争议.针对这一争议,本文首先回顾了国内外对月幔底部黏弹性结构的研究成果,梳理总结了争议的提出和发展历程,接着分析这一争议产生的主要原因.本文认为,虽然越来越多的研究支持月幔底部存在一个部分熔融的低黏性、低S波波速的转换层,但目前仍缺乏决定性的证据作为支撑.因此,本文进一步讨论了现有研究存在的不足,对未来研究方向进行了展望.

关键词：月球固体潮潮汐勒夫数黏弹性模型内部结构

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规制战略理论的现状及其课题

南大法学 2024年第1期 183-192页

作者： [日]原田大树朱芒(译) 日本京都大学法学院上海交通大学凯原法学院

规制战略理论是行政法学中制度设计方向发展的最前沿成果。其在行政法学方法论近半个世纪的讨论过程中,从传统公法的“权力”“主体”和“利益”定义要素中发展出了新的内容。如突破对“权力”性行政活动的限制,分别在行为形式、行政活... 详细信息

规制战略理论是行政法学中制度设计方向发展的最前沿成果。其在行政法学方法论近半个世纪的讨论过程中,从传统公法的“权力”“主体”和“利益”定义要素中发展出了新的内容。如突破对“权力”性行政活动的限制,分别在行为形式、行政活动复合构成的行政过程以及诉讼之外的立法和制度设计三个方面获得新的开拓。再如在主体要素方面,突破了国行政组织的范围,将民间主体本身、民间主体与行政之间的协作以及法政策的动态形成过程归入了研究对象范围之内。与此同时,规制战略理论本身也在主体与权力方面开拓出新的理论空间,如在组织方面,关注公益实现的意思形成过程中未必明确且分散的行动者和国家立法者的作用;如在权力方面,除了行政固有的权力性外,从作为股东的国家和作为所有权人的国家的角度关注民事法律关系中的国家作用。未来,规制战略理论还需要刑事法学、信息技术之间的联系方面的课题。

关键词：行政规制制度设计行政主体行政权力组织公共利益

Torque control strategy with V2X information for HEVs to minimize fuel consumption

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Control Theory and Technology 2022年第2期20卷 197-209页

作者： Yasutaka Okada Shunki Nishii Akihiro Takeshita Kazuki harada Yudai Yamasaki Department of Mechanical Engineering The University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-8656Japan

Today,much information from traffic infrastructures and sensors of ego vehicle is *** such information has a potential for internal combustion engine vehicle to reduce fuel consumption in real *** this paper,a powertrain controller for a hybrid electric vehicle aiming to reduce fuel consumption is introduced,which uses information from traffic signals,the global positioning system and sensors,and the preceding *** study was carried out as a benchmark problem of engine and powertrain control simulation and modeling 2021(E-COSM 2021).The developed controller firstly decides reference acceleration of the ego vehicle using the traffic signal and the position information and the preceding vehicle *** acceleration and deceleration leading to increase in unnecessary fuel consumption is ***,the reference engine,generator,and motor torques are decided to achieve the reference acceleration and minimize fuel *** addition,the reference engine,generator and motor torques were decided by the given fuel consumption map for the engine,and by the virtual fuel consumption maps for the generator and the *** virtual fuel consumption is derived from the efficiency maps of the generator and the motor using a given equivalent factor,which converts electricity consumption to fuel for the generator and the *** this study,a controller was designed through the benchmark problem of E-COSM 2021 for minimizing total fuel consumption of the engine,the generator,and the *** developed controller was evaluated in driving *** result shows that operating the powertrain in efficient area is a key factor in reducing total fuel consumption.

关键词： Powertrain optimization Fuel consumption minimization Hybrid electric vehicle Speed following system