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Effects of Bacillus subtilis Var. Natto Products on Capillary Blood Flow in Healthy Subjects with Peripheral Coldness: A Double-Blind, Placebo-Controlled, Randomized Parallel Study

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Food and Nutrition Sciences 2022年第3期13卷 211-223页

作者： chiharu fujita Yukio Usui Masanori Inoue Laboratory of Cell Applied Technology Kawasaki Kanagawa Japan

Purpose: NKCP®, a natto-derived dietary food supplement whose main component is bacillopeptidase F produced by Bacillus subtilis var. natto, has antithrombotic, fibrinolytic, and pressure-lowering effects, and also is suggested to improve peripheral coldness. However, existing data are based on subjective evaluations with no scientific basis about the effects on peripheral coldness. Therefore, we aimed to investigate the effectiveness of NKCP®for peripheral coldness by measuring changes in blood flow using a laser doppler rheometer and biochemical indices. Patients and Methods: This was a double-blind, randomized, controlled study of individuals aged 30 - 70 years who complained of subjective symptoms of cold hands and feet. They were randomly divided into the NKCP®group and the placebo group to receive NKCP®250 mg once daily and dextrin 250 mg as placebo once daily, respectively. The experiment lasted 8 weeks, with an intervention period of 4 weeks and a washout period of 4 weeks. Results: One-month intake of NKCP®significantly increased blood flow rate for 1 min between 4 and 5 minutes after the end of cold loading compared to that before feeding (p = 0.038). Also, analysis of the 5-minute blood flow rate before and after 4 weeks of feeding showed a significant improvement in the NKCP®group (p = 0.007), although there was no significant difference in the placebo group (p = 0.215). Furthermore, the 5-minute blood flow at 4 weeks after the end of feeding was significantly improved compared to that before feeding in the NKCP®group (p = 0.049). Therefore, the effect continued for at least 1 month after discontinuation of administration. Conclusions: It is possible that NKCP®intake effectively improves blood flow in subjects with peripheral coldness. Therefore, continuous intake of NKCP®is expected to reduce the symptoms of peripheral coldness. In the future, it needs to investigate whether the effect of increasing blood flo

关键词： Peripheral Coldness Blood Flow Bacillus subtilis Functional Foods

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Detection of active bleeding from gastric antral vascular ectasia by capsule endoscopy

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World Journal of Gastrointestinal Endoscopy 2013年第3期5卷 138-140页

作者： Tetsuya Ohira Akira Hokama Nagisa Kinjo Manabu Nakamoto chiharu Kobashigawa Yuya Kise Satoshi Yamashiro Fukunori Kinjo Yukio Kuniyoshi Jiro fujita Department of Endoscopy University Hospital of the RyukyusOkinawa 903-0125Japan Department of Infectious Respiratory and Digestive MedicineGraduate School of MedicineUniversity of the RyukyusOkinawa 903-0125Japan Division of Thoracic and Cardiovascular Surgery Graduate School of MedicineUniversity of the RyukyusOkinawa 903-0125Japan

Gastric antral vascular ectasia(GAVE) has been recognized as one of the important causes of occult and obscure gastrointestinal *** diagnosis is typically made based on the characteristic endoscopic features,including longitudinal row of flat,reddish stripes radiating from the pylorus into the antrum that resemble the stripes on a *** appearances,however,can easily be misinterpreted as moderate to severe *** it is believed that capsule endoscopy(CE) is not helpful for the study of the stomach with its large lumen,GAVE can be more likely to be detected at CE rather than conventional *** can be regarded as "physiologic" endoscopy,without the need for gastric inflation and subsequent compression of the *** blood flow of the ecstatic vessels may be diminished in an inflated ***,GAVE may be prominent in *** herein describe a case of active bleeding from GAVE detected by CE and would like to emphasize a possibility that CE can improve diagnostic yields for GAVE.

关键词： Gastrointestinal bleeding Gastrointestinal endoscopy Capsule endoscopy Gastric antral vascular ectasia Argon plasma coagulation

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Esophagitis dissecans superficialis and autoimmune bullous dermatoses: A review

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World Journal of Gastrointestinal Endoscopy 2010年第7期2卷 252-256页

作者： Akira Hokama Yu-ichi Yamamoto Kiyohito Taira Mitsuteru Nakamura chiharu Kobashigawa Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Fukunori Kinjo Kenzo Takahashi Jiro fujita Department of Infectious Respiratory and Digestive MedicineFaculty of Medicine University of the RyukyusOkinawa 903-0125Japan Department of Dermatology Faculty of MedicineUniversity of the RyukyusOkinawa 903-0125Japan Department of Endoscopy University Hospital of the RyukyusOkinawa 903-0125Japan

Esophagitis dissecans superficialis(EDS)is a rare and severe endoscopic finding characterized by sloughing of large fragments of esophageal mucosal *** EDS has been reported in association with serious illnesses and certain medications,the pathophysiological association of autoimmune bullous dermatoses with EDS has gained remarkable *** these dermatoses,pemphigus vulgaris and pemphigoid frequently present with various types of esophageal involvement including *** review the pathophysiology and clinical features of this involvement with the presentation of our *** importance of endoscopic evaluation of this entity is discussed.

关键词： Esophagitis dissecans superficialis Endoscopy Autoimmune bullous dermatoses Pemphigus vulgaris Mucous membrane pemphigoid Bullous pemphigoid Desmoglein

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Endoscopic and radiographic features of gastrointestinal involvement in vasculitis

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World Journal of Gastrointestinal Endoscopy 2012年第3期4卷 50-56页

作者： Akira Hokama Kazuto Kishimoto Yasushi Ihama chiharu Kobashigawa Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Futoshi Higa Masao Tateyama Fukunori Kinjo Kunitoshi Iseki Seiya Kato Jiro fujita Department of Infectious Respiratory and Digestive MedicineFaculty of MedicineUniversity of the Ryukyus Endoscopy Unit University Hospital of the Ryukyus Dialysis Unit University Hospital of the Ryukyus Department of Pathology and Cell Biology Faculty of MedicineUniversity of the Ryukyus

Vasculitis is an inflammation of vessel walls,followed by alteration of the blood flow and damage to the dependent *** can cause local or diffuse pathologic changes in the gastrointestinal (GI) *** variety of GI lesions includes ulcer,submucosal edema,hemorrhage,paralytic ileus,mesenteric ischemia,bowel obstruction,and life-threatening *** endoscopic and radiographic features of GI involvement in vasculitisare reviewed with the emphasis on small-vessel vasculitis by presenting our typicalcases,including Churg-Strauss syndrome,HenochSch nlein purpura,systemic lupus erythematosus,and Beh et's *** endoscopic features are ischemic enterocolitis and *** computed tomographic findings include bowel wall thickening with the target sign and engorgement of mesenteric vessels with comb *** of endoscopic and radiographic GI manifestations can help make an early diagnosis and establish treatment strategy.

关键词： Behcet’s disease Churg-Strauss syndrome Computed tomography Endoscopy Gastrointestinal tract Henoch-Schonlein purpura Histopathology Lupus mesenteric vasculitis Systemic lupus erythematosus Vasculitis

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胃肠的淀粉样变性病的内视镜、组织病理学说的特征

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World Journal of Gastrointestinal Endoscopy 2011年第8期3卷 157-161页

作者： Akira Hokama Kazuto Kishimoto Manabu Nakamoto chiharu Kobashigawa Tetsuo Hirata Nagisa Kinjo Fukunori Kinjo Seiya Kato Jiro fujita Department of Infectious Respiratory and Digestive Medicine Faculty of Medicine University of the Ryukyus Okinawa 903-0125 Japan Department of Endoscopy University Hospital of the Ryukyus Okinawa 903-0125 Japan Department of Pathology and Cell Biology Faculty of Medicine University of the Ryukyus Okinawa 903-0125 Japan

Amyloidosis is a rare disorder, characterized by the extracellular deposition of an abnormal fibrillar protein, which disrupts tissue structure and function. Amyloidosis can be acquired or hereditary, and systemic or localized to a single organ, such as the gastrointestinal (GI) tract. Clinical manifestations may vary from asymptomatic to fatal forms. Primary amyloidosis (monoclonal immunoglobulin light chains, AL) is the most common form of amyloidosis. AL amyloidosis has been associated with plasma cell dyscrasias, such as, mul- tiple myeloma. Secondary amyloidosis is caused by the deposition of fragments of the circulating acute-phase reactant, serum amyloid A protein (SAA). Common causes of AA amyloidosis are chronic inflammatory dis-orders. Although GI symptoms are usually nonspecific, histopathological patterns of amyloid deposition are associated with clinical and endoscopic features. Amyloid deposition in the muscularis mucosae, submucosa, and muscularis propria has been dominant in AL amyloidosis, leading to polypoid protrusions and thickening of the valvulae conniventes, whereas granular amyloid deposition mainly in the propria mucosae has been related to AA amyloidosis, resulting in the fine granular appearance, mucosal friability, and erosions. As a result, AL amyloidosis usually presents with constipation, mechanical obstruction, or chronic intestinal pseudoobstruction while AA amyloidosis presents with diarrhea and malabsorption Amyloidotic GI symptoms are mostly refractory and have a negative impact on quality of life and survival. Diagnosing GI amyloidosis requires high suspicion of evaluating endoscopists. Because of the absence of specific treatments for reducing the abundance of the amyloidogenic precursor protein, we should be aware of certain associations between patterns of amyloid deposition and clinical and endoscopic features.

关键词： Amyloidosis Amyloid Congo red Endoscopy Gastrointestinal tract Histopathology

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