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Glutamine addiction and therapeutic strategies in pancreatic cancer

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1852-1863页

作者： lin-lin Ren Tao Mao pin Meng Li Zhang Hong-Yun Wei Zi-Bin Tian Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina Department of Pathology The Affiliated Hospital of Qingdao UniversityQingdao 266000China

Pancreatic cancer remains one of the most lethal diseases worldwide owing to its late diagnosis,early metastasis,and poor *** current therapeutic options are limited,there is an urgent need to investigate novel targeted treatment *** cancer faces significant metabolic challenges,principally hypoxia and nutrient deprivation,due to specific microenvironmental constraints,including an extensive desmoplastic stromal *** cancer cells have been shown to rewire their metabolism and energy production networks to support rapid survival and *** glucose uptake and glycolytic pathway activity during this process have been extensively ***,growing evidence suggests that pancreatic cancer cells are glutamine *** a nitrogen source,glutamine directly(or indirectly via glutamate conversion)contributes to many anabolic processes in pancreatic cancer,including amino acids,nucleobases,and hexosamine *** also plays an important role in redox homeostasis,and when converted toα-ketoglutarate,glutamine serves as an energy and anaplerotic carbon source,replenishing the tricarboxylic acid cycle *** present study aims to provide a comprehensive overview of glutamine metabolic reprogramming in pancreatic cancer,focusing on potential therapeutic approaches targeting glutamine metabolism in pancreatic cancer.

关键词： Pancreatic cancer Glutamine metabolism Cancer treatment Therapeutic strategies

Clinical utility of hepatitis B surface antigen kinetics in treatment-na?ve chronic hepatitis B patients during longterm entecavir therapy

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World Journal of Gastroenterology 2018年第6期24卷 725-736页

作者： Tien-Ching lin Yen-Cheng Chiu Hung-chih Chiu Wen-Chun Liu pin-Nan Cheng Chiung-Yu Chen Ting-Tsung Chang I-Chin Wu Department of Internal Medicine National Cheng Kung University HospitalCollege of MedicineNational Cheng Kung UniversityTainan City70403Taiwan Infectious Disease and Signaling Research Center National Cheng Kung UniversityTainan 70403Taiwan

AIM To investigate the utility of hepatitis B surface antigen(HBsAg) kinetics in chronic hepatitis B patients during long-term entecavir *** This retrospective study included treatment-na?ve chronic hepatitis B patients who received at least 2 years of consecutive entecavir treatment. Patients were followed up at three to six month intervals with liver biochemistry, hepatitis B virus DNA, and abdominal sonography. In hepatitis B e antigen(HBeAg)-positive patients, HBeAg levels were assessed every three to six month until results became negative. Serum HBsAg levels were determined at the baseline, oneyear and five-year time points. Liver cirrhosis was diagnosed through liver biopsy, imaging examinations, or clinical findings of portal hypertension. Hepatocellular carcinoma was diagnosed by histological examination or dynamic image *** A total of 211 patients were enrolled. The median treatment time was 5.24(2.00-9.62) years. Multivariate analysis showed that lower baseline HBsAg levels were associated with an earlier virological response, earlier hepatitis B e antigen(HBeAg) seroconversion, and earlier biochemical response in HBeAg-positive patients(cut-off value: 4 log IU/mL) and an earlier virological response in HBeAg-negative non-cirrhotic patients(cut-off value: 2.4 log IU/mL). Although HBsAg levels decreased slowly during long-term entecavir treatment, higher HBsAg decrease rates were found in the first year for HBeAg-positive non-cirrhotic patients, and patients with higher baseline HBsAg levels. More favorable clinical outcomes were not observed by a rapid HBsAg decline per se, but depended on lower baseline HBsAg *** Baseline HBsAg can be used to predict treatment responses. HBsAg levels and decrease rates should be considered together according to disease status while interpreting HBsAg changes.

关键词： Chronic hepatitis B Entecavir Hepatitis B e antigen Hepatitis B surface antigen Kinetics

An Efficient Second-Order Convergent Scheme for One-Side Space Fractional Diffusion Equations with Variable Coefficients

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Communications on Applied Mathematics and Computation 2020年第2期2卷 215-239页

作者： Xue-lei lin pin Lyu Michael KNg Hai-Wei Sun Seakweng Vong Department of Mathematics Hong Kong Baptist UniversityHong KongChina School of Economic Mathematics Southwestern University of Finance and EconomicsChengdu 611130China Department of Mathematics The University of Hong KongHong KongChina Department of Mathematics University of MacaoMacaoChina

In this paper,a second-order fnite-diference scheme is investigated for time-dependent space fractional difusion equations with variable *** the presented scheme,the Crank-Nicolson temporal discretization and a second-order weighted-and-shifted Grünwald-Letnikov spatial discretization are ***,the unconditional stability and the second-order convergence in time and space of the proposed scheme are established under some conditions on the variable ***,a Toeplitz preconditioner is proposed for linear systems arising from the proposed *** condition number of the preconditioned matrix is proven to be bounded by a constant independent of the discretization step-sizes,so that the Krylov subspace solver for the preconditioned linear systems converges *** results are reported to show the convergence rate and the efciency of the proposed scheme.

关键词： One-side space fractional difusion equation Variable difusion coefcients Stability and convergence High-order fnite-diference scheme Preconditioner

Optimization Design and Finite Element Analysis of Core Cutter

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Journal of China University of Mining and Technology 2007年第3期17卷 399-402页

作者： CAO pin-lu YIN Kun PENG Jian-ming LIU Jian-lin College of Construction Engineering Jilin University Changchun Jilin 130026 China Key Laboratory of Geo-exploration Instrumentation Ministry of Eduction Changchun Jilin 130026 China

The hydro-hammer sampler is a new type of sampler compared with traditional ones. An important part of this new offshore sampler is that the structure of the core cutter has a significant effect on penetration and core recovery. In our experiments, a commercial finite element code with a capability of simulating large-strain frictional contact between two or more solid bodies is used to simulate the core cutter-soil interaction. The effects of the cutting edge shape, the diameter and the edge angle on penetration are analyzed by non-liner transient dynamic analysis using a finite element method （FEM）. Simulation results show that the cutter shape clearly has an effect on the penetration and core recovery. In addition, the penetration of the sampler increases with an increase in the inside diameter of the cutter, but decreases with an increase in the cutting angle. Based on these analyses, an optimum structure of the core cutter is designed and tested in the north margin of the Dalian gulf. Experiment results show that the penetration rate is about 16.5 m/h in silty clay and 15.4 m/h in cohesive clay, while the recovery is 68% and 83.3% resoectively.

关键词： hydro-hammer sampler finite element analysis core cutter-soil interaction optimum design

基于第一性原理和热力学计算的TiAl-Nb金属间化合物稳定性和相关系研究

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原子与分子物理学报 2025年第5期42卷 151-162页

作者：汪文洋徐勇田彬甘信柱王志刚梁永锋林均品山东建筑大学材料科学与工程学院济南250101 北京科技大学新金属材料国家重点实验室北京100083

采用基于广义梯度近似密度泛函理论的第一性原理计算和相图计算方法,研究了TiAl-Nb合金中γ、α_(2)、O_(2)和ωo相的热力学和力学性质以及相转变关系.研究表明,第一性原理计算得到的化合物相的参数是准确的,且分析结果与相图计算结果... 详细信息

采用基于广义梯度近似密度泛函理论的第一性原理计算和相图计算方法,研究了TiAl-Nb合金中γ、α_(2)、O_(2)和ωo相的热力学和力学性质以及相转变关系.研究表明,第一性原理计算得到的化合物相的参数是准确的,且分析结果与相图计算结果相一致.四个化合物相都是能够稳定存在的相.通过热力学和力学性质的分析,发现α_(2)相更容易转变为O_(2)相,并且在一定条件下可以通过相变反应生成ωo相.而γ相更容易转变为ωo相,但无法生成O_(2)相.

关键词： TiAl合金第一性原理相图声子谱及态密度热力学性质

Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites

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World Journal of Gastroenterology 2016年第12期22卷 3363-3371页

作者： Chao Chen Ren-pin Chen Hai-Hua lin Wen-You Zhang Xie-lin Huang Zhi-Ming Huang Department of Gastroenterology the First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China Ren-Ji College of Wenzhou Medical University Wenzhou 325000 Zhejiang Province China

AIM: To investigate the role of tolvaptan in regulating aquaporin(AQP)-2 expression and fecal water content in cirrhotic rats with ***: Cirrhosis with ascites was induced in rats by repetitive dorsal injection of CCl4 for 14 wk. In total, 84 cirrhotic rats with ascites divided into three groups(vehicle, 3 mg/kg and 5 mg/kg tolvaptan), and then further divided into five subgroups(days 1, 2, 3, 4, and 5). Blood samples were obtained to measure vasopressin and sodium concentrations. Rats were killed and colonic mucosa was scraped for analysis of protein expression and AQP-2 transcriptional level. The whole layer was fixed for hematoxylin&eosin(HE) staining and feces were collected for determination of fecal water content. CONCLUSION: Compared with vehicle, vasopressin decreased significantly in the tolvaptan groups from day 2 to a similar level in each treatment group. AQP-2 showed significant upregulation in cirrhotic rats with ascites compared with an untreated control group(100% ± 22.9% vs 22.2% ± 10.23%, P line at day 4 at the latest in both treatment groups, and did not correspond to the change in AQP-2 expression. HE staining of the colonic mucosa showed no mucosal damage related to ***: Upregulation of AQP-2 in the distal colon is found in cirrhotic rats with ascites. Tolvaptan inhibits its expression and may decrease water reabsorption and induce diarrhea.

关键词： Tolvaptan Aquaporin-2 Cirrhosis Ascites

Efficient circularly polarized photoluminescence and electroluminescence of chiral spiro-skeleton-based thermally activated delayed fluorescence molecules

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Science China Chemistry 2022年第7期65卷 1347-1355页

作者： Yi-pin Zhang Shi-Quan Song Meng-Xi Mao Cheng-Hui Li You-Xuan Zheng Jing-lin Zuo State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China MaAnShan High-Tech Research Institute of Nanjing University Maanshan 238200China

Chiral thermally activated delayed fluorescence(TADF) molecules showing circularly polarized luminescence(CPL) have great potential in 3D displays. However, the relationships among CPL property, device performance and molecule structure are still not clear. In this article, we develop a strategy to promote dissymmetry factors without sacrifice in device performance and study the impact of molecule structures towards CPL property. Three novel TADF enantiomers are synthesized and studied.(R/S)-SCN with diminutive cyano group as an acceptor shows dissymmetry factor |gPL| ≈ 1.4×10^(-3) and noticeable organic light-emitting diode(OLED) performances with a maximum external quantum efficiency(EQEmax) of 23.0%. For(R/S)-SPHCN, the prolonged electron withdrawing group benzonitrile enhances |gPL| up to 3.6×10^(-3) with decreased device EQEmaxof 15.4%. By further replacing benzonitrile with(trifluoromethyl)pyridine, the enantiomers of(R/S)-SCFPY show similar |gPL| factors of 3.5×10^(-3) and device EQE_(max)up to 23.3%, which represents the highest efficiency among sprio-type TADF materials based OLEDs. Furthermore, the OLEDs also show obvious circularly polarized electroluminescence with gELfactors of-1.4/1.8×10^(-3),-3.6/3.6×10^(-3) and-3.7/3.6×10^(-3), respectively. These results indecate by delicate functional group engineering, high g factor can be achieved while maintaining decent device performances. Besides,(R/S)-SCFPY represents an impressive TADF emitter, which shows promoted g factor and recorded high device EQE_(max)among similar molecules.

关键词： chiral spiro-skeleton thermally activated delayed fluorescence circularly polarized photoluminescence circularly polarized electroluminescence dissymmetry factor

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The role of magmatism in the thinning and breakup of the South China Sea continental margin

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National Science Review 2019年第5期6卷 871-876页

作者： Zhen Sun Jian lin Ning Qiu Zhimin Jian pin Xian Wang Xiong Pang Jinyun Zheng Benduo Zhu CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of Sciences Innovation Academy of South China Sea Ecology and Environmental Engineering Chinese Academy of Sciences Department of Geology and Geophysics Woods Hole Oceanographic Institution School of Ocean and Earth Science Tongji University East South China Sea Petroleum Research Institute Shenzhen branch of China National Offshore Oil Corporation Guangzhou Marine Geological Survey Ministry of Natural Resources

INTRODUCTION Magmatism plays a key role in the process of continental margin breakup and ocean *** in the extremely magma-poor Iberia and Newfoundland margin, studies of field outcrops have shown that syn-rift magmati... 详细信息

关键词： SCS The role of magmatism in the thinning and breakup of the South China Sea continental margin China

An Intelligent Recommendation System for Real Estate Commodity

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Computer Systems Science & Engineering 2022年第9期42卷 881-897页

作者： Tsung-Yin Ou Guan-Yu lin Hsin-pin Fu Shih-Chia Wei Wen-Lung Tsai Department of Marketing and Distribution Management National Kaohsiung University of Science and TechnologyKaohsiung824Taiwan College of Management National Kaohsiung University of Science and TechnologyKaohsiung824Taiwan Department of Information Management Asia Eastern University of Science and TechnologyNew Taipei220Taiwan

Most real estate agents develop new objects by visiting unfamiliar clients, distributing leaflets, or browsing other real estate trading website platforms,whereas consumers often rely on websites to search and compare prices when purchasing real property. In addition to being time consuming, this search processrenders it difficult for agents and consumers to understand the status changes ofobjects. In this study, Python is used to write web crawler and image recognitionprograms to capture object information from the web pages of real estate agents;perform data screening, arranging, and cleaning;compare the text of real estateobject information;as well as integrate and use the convolutional neural networkof a deep learning algorithm to implement image recognition. In this study, dataare acquired from two business-to-consumer real estate agency networks, i.e., theSinyi real estate agent and the Yungching real estate agent, and one consumer-toconsumer real estate agency platform, i.e., the, FiveNineOne real estate agent. Theresults indicate that text mining can reveal the similarities and differences betweenthe objects, list the number of days that the object has been available for sale onthe website, and provide the price fluctuations and fluctuation times during thesales period. In addition, 213,325 object amplification images are used as a database for training using deep learning algorithms, and the maximum image recognition accuracy achieved is 95%. The dynamic recommendation system for realestate objects constructed by combining text mining and image recognition systems enables developers in the real estate industry to understand the differencesbetween their commodities and other businesses in approximately 2 min, as wellas rapidly determine developable objects via comparison results provided by thesystem. Meanwhile, consumers require less time in searching and comparingprices after they have understood the commodity dynamic information, therebyallowing the

关键词： Real estate agency web crawler image comparison text mining deep learning real estate object dynamic recommendation system