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Black tea in chemo-prevention of cancer and other human diseases

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Food Science and Human Wellness 2013年第1期2卷 12-21页

作者： Min-Hsiung Pan Ching-Shu Lai Hong Wang chih-yu lo Chi-Tang Ho Shiming Li Department of Seafood Science National Kaohsiung Marine UniversityKaohsiung 811TaiwanChina Shaklee Corporation 4747 Willow RoadPleasantonCA 94588USA Department of Food Science National Chiayi UniversityChiayi City 60004TaiwanChina Department of Food Science Rutgers UniversityNew BrunswickNJ 08901USA Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization Huanggang Normal UniversityHuanggang 438000China

Tea is the most popular functional beverage in the world and has been gaining more and more attention for its health beneficial *** common teas,black tea is consumed more than green tea and oolong tea *** studies have shown the biological activities of black tea and its polyphenols that include anti-oxidant,anti-tumor,anti-inflammation and metabolic *** polyphenols such as theaflavins and catechins are considered to be multifunctional compounds that could be effective in the prevention or treatment of various cancers,cardiovascular disease,chronic inflammation,obesity,metabolic syndrome,and neurodegenerative *** this review,we summarized the up-to-date research and underlying molecular mechanisms of black tea and its polyphenols.©2013 Beijing Academy of Food *** and hosting by Elsevier *** rights reserved.

关键词： Black tea Theaflavins Catechins Human disease Molecular mechanism Cancer

Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri chih Hung lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Defective lysosomal acidification:a new prognostic marker and therapeutic target for neurodegenerative diseases

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Translational Neurodegeneration 2023年第1期12卷 500-510页

作者： chih Hung lo Jialiu Zeng Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s *** genetic factors have been linked to lysosomal de-acidification through impairing the vacuolar-type ATPase and ion channels on the organelle *** lysosomal abnormalities are also present in sporadic forms of neurodegeneration,although the underlying pathogenic mechanisms are unclear and remain to be ***,recent studies have revealed early occurrence of lysosomal acidification impairment before the onset of neurodegeneration and late-stage ***,there is a lack of methods for organelle pH monitoring in vivo and a dearth of lysosome-acidifying therapeutic ***,we summarize and present evidence for the notion of defective lysosomal acidification as an early indicator of neurodegeneration and urge the critical need for technological advancement in developing tools for lysosomal pH monitoring and detection both in vivo and for clinical *** further discuss current preclinical pharmacological agents that modulate lysosomal acidification,including small molecules and nanomedicine,and their potential clinical translation into lysosome-targeting *** timely detection of lysosomal dysfunction and development of therapeutics that restore lysosomal function represent paradigm shifts in targeting neurodegenerative diseases.

关键词： Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Lysosomal de-acidification Autophagy dysfunction Early detection Prognostic marker Small molecules Nanomedicine Nanoparticles

Bulging intervertebral disc:an asymptotic elasticity solution

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Acta Mechanica Sinica 2018年第6期34卷 1167-1173页

作者： yu-Cheng lo Liu Wang Orthopaedic Department Changhua Christian HospitalChanghuaChina Department of Aerospace Engineering and EngineeringMechanics Center for Mechanics of SolidsStructures andMaterialsUniversity of Texas at AustinAustinTX78712USA

A bulging intervertebral disc (IVD) occurs when pressure on a spinal disc damages the once healthy disc,causing it to compress or change its normal *** medicine,most attention has been paid clinically to diagnosis of and treatment for such problems,which little effect has been made to understand such issues from a mechanics perspective,i.e.,the bulging deformation of the soft IVD induced by excessive compressive *** report herein a simple elasticity solution to understand the bulging disc *** simplicity,the soft IVD is modeled as an incompressible circular composite layer consisting of an inner nucleus and outer annulus,sandwiched between two vertebral segments which are much stiffer than the IVD and can be treated as rigid *** adopting any assumptions regarding prescribed displacements or stresses,we obtained the stress and displacement fields within the composite layer when a certain compressive stain is applied via an asymptotic *** asymptotic approach is very simple and accurate enough for prediction of the bugling profile of the *** also performed finite-element modeling (FEM) to validate our solutions;the predicted stress and displacement fields inside the composite are in good agreement with the FEM results.

关键词： Bulging intervertebral disc (IVD) Elastic composite layer Asymptotic solution Finite element method

Autolysosomal acidification impairment as a mediator for TNFR1 induced neuronal necroptosis in Alzheimer’s disease

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Neural Regeneration Research 2024年第9期19卷 1869-1870页

作者： Evridiki Asimakidou Richard Reynolds Anna M.Barron chih Hung lo Department of Clinical Neurosciences University of CambridgeCambridgeUK Department of Brain Sciences Faculty of MedicineImperial College LondonLondonUK Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

Neuronal necroptosis-an emerging form of regulated cell death associated with neuroinflammatory signaling:Alzheimer’s disease(AD)is characterized by the presence of extracellular amyloid-β(Aβ)plaques and intracellular tau neurofibrillary tangles as well as progressive neuronal *** evidence has suggested that prolonged neuroinflammation with increased levels of cytokines,arising from neuronal injury,innate immune responses from glial cells,and peripheral inflammation,leads to neuronal death and AD progression.

关键词： Alzheimer death tau Aβ

Withdrawal Intention of Farmers from Vacant Rural Homesteads and Its Influencing Mechanism in Northeast China: A Case Study of Jilin Province

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Chinese Geographical Science 2023年第4期33卷 634-648页

作者： yu Jiaping LI Jing lo Kevin HUANG Shanlin Northeast Institute of Geography and Agroecology Chinese Academy of SciencesChangchun 130102China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Department of Geography Hong Kong Baptist UniversityHong Kong 999077China School of Public Administration and Law Northeast Agricultural UniversityHarbin 150030China

The effective use of land in Northeast China is of great significance for ensuring national food security and regional rural *** this study,based on the survey data collected from Jilin Province,Northeast China,we analyzed the vacancy rates of rural homesteads in suburban,outer suburban,and remote villages,as well as the withdrawal intention of rural-settled farmers,urbansettled farmers,and farmers with urban and rural dual residency from vacant *** the perspective of farmers’perceptions,this study constructed a theoretical framework of the influence mechanism of their withdrawal intention and analyzed such mechanism by constructing a structural equation *** results indicated that:1)rural homestead vacancy rates increased with distance from the village to the city.2)rural-settled farmers showed a low withdrawal intention for vacant rural homesteads,followed by urban and rural dual-residence farmers,and urban-settled farmers showed the highest withdrawal intention.3)the relative importance of the factors influencing withdrawal intention is in the following order:policy awareness>interest perception>living environment perception>family ***,this study discussed the reformation of the homestead system and rural homestead transition in Northeast China,which can provide policy support to increase the potential of cultivated land and promote sustainable rural development and urban-rural coordination.

关键词： village hollowing vacant rural homesteads withdrawal intention influence mechanism Northeast China

TagCombine： Recommending Tags to Contents in Software Information Sites

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Journal of Computer Science & Technology 2015年第5期30卷 1017-1035页

作者：王新宇夏鑫 David lo 1.College of Computer Science and Technology Zhejiang University Hangzhou 310027 China 2.School of Information Systems Singapore Management University Singapore Singapore

Nowadays, software engineers use a variety of online media to search and become informed of new and interesting technologies, and to learn from and help one another. We refer to these kinds of online media which help software engineers improve their performance in software development, maintenance, and test processes as software information sites. In this paper, we propose TagCombine, an automatic tag recommendation method which analyzes objects in software information sites. TagCombine has three different components： 1） multi-label ranking component which considers tag recommendation as a multi-label learning problem; 2） similarity-based ranking component which recommends tags from similar objects; 3） tag-term based ranking component which considers the relationship between different terms and tags, and recommends tags after analyzing the terms in the objects. We evaluate TagCombine on four software information sites, Ask Different, Ask Ubuntu, Feecode, and Stack Overflow. On averaging across the four projects, TagCombine achieves recall@5 and recallS10 to 0.619 8 and 0.762 5 respectively, which improves TagRec proposed by Al-Kofahi et al. by 14.56% and 10.55% respectively, and the tag recommendation method proposed by Zangerle et al. by 12.08% and 8.16% respectively.

关键词： software information site online media tag recommendation

Integrative multi-omics and systems bioinformatics in translational neuroscience:A data mining perspective

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Journal of Pharmaceutical Analysis 2023年第8期13卷 836-850页

作者： Lance M.O'Connor Blake A.O'Connor Su Bin Lim Jialiu Zeng chih Hung lo College of Biological Sciences University of MinnesotaMinneapolisMN55455USA School of Pharmacy University of WisconsinMadisonWI53705USA Department of Biochemistry and Molecular Biology Ajou University School of MedicineSuwon16499South Korea Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore308232Singapore

Bioinformatic analysis of large and complex omics datasets has become increasingly useful in modern day biology by providing a great depth of information,with its application to neuroscience termed *** mining of omics datasets has enabled the generation of new hypotheses based on differentially regulated biological molecules associated with disease mechanisms,which can be tested experimentally for improved diagnostic and therapeutic targeting of neurodegenerative ***,integrating multi-omics data using a systems bioinformatics approach will advance the understanding of the layered and interactive network of biological regulation that exchanges systemic knowledge to facilitate the development of a comprehensive human brain *** this review,we first summarize data mining studies utilizing datasets from the individual type of omics analysis,including epigenetics/epigenomics,transcriptomics,proteomics,metabolomics,lipidomics,and spatial omics,pertaining to Alzheimer's disease,Parkinson's disease,and multiple *** then discuss multi-omics integration approaches,including independent biological integration and unsupervised integration methods,for more intuitive and informative interpretation of the biological data obtained across different omics *** further assess studies that integrate multi-omics in data mining which provide convoluted biological insights and offer proof-of-concept proposition towards systems bioinformatics in the reconstruction of brain ***,we recommend a combination of high dimensional bioinformatics analysis with experimental validation to achieve translational neuroscience applications including biomarker discovery,therapeutic development,and elucidation of disease *** conclude by providing future perspectives and opportunities in applying integrative multi-omics and systems bioinformatics to achieve precision phenotyping of neurodegenerative diseases and towards personaliz

关键词： Multi-omics integration Systems bioinformatics Data mining Human brain profile reconstruction Translational neuroscience

STING regulates BCR signaling in normal and malignant B cells

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Cellular & Molecular Immunology 2021年第4期18卷 1016-1031页

作者： chih-Hang Anthony Tang Avery C.Lee Shiun Chang Qin Xu Andong Shao yun lo Walker T.Spalek Javier A.Pinilla-lbarz Juan R.Del Valle chih-Chi Andrew Hu The Wistar Institute 3601 Spruce StreetPhiladelphiaPA 19104USA Department of Malignant Hematology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Department of Chemistry&Biochemistry University of Notre DameNotre DameIN 46556USA

STING is an endoplasmic reticulum(ER)-resident protein critical for sensing cytoplasmic DNA and promoting the production of type Ⅰ interferons;however,the role of STING in B cell receptor(BCR)signaling remains *** generated STING V154M knock-in mice and showed that B cells carrying constitutively activated STING specifically degraded membrane-bound IgM,Ig a and Igβ via SEL1L/HRD1-mediated ER-associated degradation(ERAD).B cells with activated STING were thus less capable of responding to BCR activation by phosphorylating Igα and Syk than those without activated *** immunized with T-independent antigens,STING V154M mice produced significantly fewer antigen-specific plasma cells and antibodies than immunized wild-type(WT)*** further generated B cell-specific STING^(KO) mice and showed that STING^(KO) B cells indeed responded to activation by transducing stronger BCR signals than their STING-proficient *** B cell-specific STING^(KO) mice were T-independently immunized,they produced significantly more antigen-specific plasma cells and antibodies than immunized STIN^(WT)*** both human and m ouse IGHV-unmutated malignant chronic lymphocytic leukemia(CLL)cells downregulated the expression of STING,we explored whether STING downregulation could contribute to the well-established robust BCR signaling phenotype in malignant CLL *** generated a STING-deficient CLL mouse model and showed that STING-deficient CLL cells were indeed more responsive to BCR activation than their STING-proficient *** results revealed a novel B cell-intrinsic role of STING in negatively regulating BCR signaling in both normal and malignant B cells.

关键词： STING BCR ER-associated degradation CLL Plasma cells