检索结果-南通市图书馆

Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan

World Journal of Gastroenterology 2016年第12期22卷 3372-3380页

作者： ching-Yu Lai Ling-Ling Hsieh Reiping Tang Regina M Santella Chung Rong Chang-Chieh chih-ching yeh School of Public Health College of Public Health and Nutrition Taipei Medical University Taipei 11031 Taiwan Department of Public Health Chang Gung University Taoyuan 333 Taiwan Colorectal Section Chang Gung Memorial Hospital Taoyuan 333 Taiwan Department of Environmental Health Sciences Mailman School of Public Health Columbia University New York NY 10032 United States Department of Public Health College of Public Health China Medical University Taichung 404 Taiwan

AIM: To evaluate the effects of OGG1(Ser326Cys, 11657A/G, and Arg154His) and APE1(Asp148Glu, and T-656G) polymorphisms on colorectal cancer(CRC) ***: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses onthe basis of sex, age at diagnosis, and tumor subsite and stage were ***: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype(OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage Ⅲ + Ⅳ cancer(OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657 G allele carriers had a 41% reduced CRC risk among stage 0-Ⅱ patients(OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele(OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656 G haplotype was also associated with a significant CRC risk in females(OR = 1.36, 95%CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwan Residents population.

关键词： APE1 OGG1 Taiwan Colorectal cancer Polymorphisms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Peanut consumption and reduced risk of colorectal cancer in women:A prospective study in Taiwan

引用

World Journal of Gastroenterology 2006年第2期12卷 222-227页

作者： chih-ching yeh San-Lin You Chien-Jen Chen Fung-Chang Sung Department of Risk Management China Medical University College of Public Health Taichung 404Taiwan China Institutes of Epidemiology National Taiwan University College of Public Health Taipei 100Taiwan China Institute of Environment Health China Medical University College of Public Health Taichung 404 Taiwan and Institute of Environment Health National Taiwan University College of Public Health Taipei 100 Taiwan China

AIM： To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS： In 1990-1992, residents （12026 men and 11917 women aged 30 to 65 years） in 7 townships, Taiwan, were interviewed and recruited into a cancerscreening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS： During the study period, 107 new colorectal cancer cases （68 men and 39 women） were confirmed. The multivariate Cox＇s proportional hazard model showed that the relative risk （RR） of peanut consumption was 0.73 [95% confidence interval （CI） = 0.44-1.21] for men and 0.42 （95% CI = 0.21-0.84） for women. However, frequent intake of pickled foodstuffs was harmful for women （RR= 2.15, 95% CI=0.99-4.65）. The risk of colorectal cancer was also elevated among cigarette smokers but not significant （P〈 0.05）.CONCLUSION： This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake.

关键词： Peanuts Colorectal cancer Diet Gender difference Prospective study Taiwan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Vegetable/fruit, smoking, glutathione S-transferase polymorphisms and risk for colorectal cancer in Taiwan

引用

World Journal of Gastroenterology 2005年第10期11卷 1473-1480页

作者： chih-ching yeh Ling-Ling Hsieh Reiping Tang Chung Rong Chang-Chieh Fung-Chang Sung Institute of Environmental Health Department of Public Health Colorectal Section

AIM: To investigate the colorectal cancer risk associated with polymorphic GSTM1, GSTT1 and GSTP1 and the effect of diet and ***: With consents, genotypes of the genes were determined using PCR methods for 727 cases and 736sex and age-matched healthy controls recruited at a medical center in the Northern Taiwan. Nurses who were blind to the study hypothesis conducted interviews with study participants for the information of socio-demographic variables, diet and ***: There was no significant association between GSTM1 genotypes and the disease. Men, not women, with GSTT1 null genotype were at significant risk of colorectal cancer, but limited to rectal tumor, and in men aged 60 years and less. The corresponding association with the GSTP1 with G allele compared to GSTP1 A/A genotype was at borderline significance. Compared to men with GSTT1 present and GSTP1 A/A combined, men with both GSTT1 null and GSTP1 with G allele genotypes were at significant risk (odds ratio (OR) = 1.91, 95% confidence interval (CI) = 1.21-3.02), also limited to the rectal tumor and younger men. The beneficial effects of vegetable/fruit intake on colorectal cancer were much higher for men with GSTT1 present (OR = 0.32, 95%CI = 0.20-0.50) or GSTP1 A/A genotypes (OR = 0.40, 95%CI = 0.25-0.64).These effects remained significant for women. But, the greatest protective effect from vegetable/fruit intake for women was observed in those with GSTT1 null or GSTP1 with G allele genotypes. In addition, non-smoking men benefitted significantly from combined effect of higher vegetable/fruit intake and GSTT1 present or GSTP1 A/A genotypes with OR = 0.17 and 0.21 ***: This study suggests that the GSTT1 gene can modulate the colorectal cancer risk and vegetable/fruit-related colorectal cancer risk, particularly in men of no smoking history.

关键词： Colorectal cancer Glutathione S-transferase Polymorphisms Vegetables Smoking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Porous Cube-like In_2O_3 Nanoparticles and Their Sensing Characteristics toward Ethanol

引用

Journal of Materials Science & Technology 2008年第4期24卷 667-674页

作者： chih-Chia HUANG Chen-Sheng yeh Natl Cheng Kung Univ Dept Chem Tainan 70101 Taiwan

Porous cube-like crystalline In2O3 nanoparticles with an average diagonal length of 34.8 nm were fabricated by a laser ablation-reflux process to form In（OH）3, followed by a calcination treatment to yield porous In2O3. HRTEM （high-resolution transmission electronic microscopy）, XRD （X-ray diffraction）, BET （Brunauer-Emmett-Teller）, and XPS （X-ray photoelectron spectroscopy） analysis were used to characterize their crystalline structures, grain sizes, surface areas, and surface compositions. The as-prepared porous in-dium oxides were tested for their sensing properties toward ethanol. Non-porous In2O3 nanopowder （about 40 nm） was also examined in order to compare the results with the as-prepared porous In2O3 nanomaterials. The porous In2O3 exhibited much better performance than that of non-porosus In2O3, and showed enhanced sensitivity with a lower detection limit than other reported In2O3-based materials when exposed to ethanol. Good gas sensitivity and linear behavior as a function of ethanol concentration were observed in the porous In2O3 nanoparticles.

关键词： In2O3 Porosity Nanoparticles Gas sensor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ToMFIR-based fault detection approach in frequency domain

引用

Journal of Systems Engineering and Electronics 2011年第1期22卷 33-37页

作者： Wen Chen chih Ping yeh Hanlong Yang Division of Engineering Technology Wayne State University Detroit M148202 USA Vehicle Group Eaton Corporation Southfield MI 48076 USA

This paper is to explore further results for total measurable fault information-based residual（ToMFIR） approach to fault detection in dynamic *** ToMFIR contains the essential fault information and remains unaffected by control actions in a closed-loop *** is composed of controller residual and output residual and some of further results are developed in frequency *** the ability of detecting actuator and sensor faults,it is able to detect faults/failures resulting from the computer used for control purpose that generates control ***,all of existing fault detection schemes cannot achieve the same task at all.A practical DC motor example,with a PID controller,is used to demonstrate the effectiveness of the ToMFIR-based fault detection.A comparison with the standard observer-based technique is also provided.

关键词： fault detection total measurable fault informationbased residual(ToMFIR) output residuals controller residuals frequency domain.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Descriptions of four new species of the genus Reticunassa Iredale,1936(Gastropoda:Nassariidae)from the northeastern coast of Taiwan Island and the South China Sea

引用

Acta Oceanologica Sinica 2022年第8期41卷 74-77页

作者： Shuqian Zhang Suping Zhang chih-yeh Lee Institute of Oceanology Chinese Academy of SciencesQingdao 266071China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China 233 Wusheng Street Keelung 204010TaiwanChina

In the present study,four new species of the genus Reticunassa Iredale,1936 collected from Chinese waters are described and *** hugokooli ***.,Reticunassa jungi *** Reticunassa aureolineata *** collected from the northeastern coast of Taiwan Island,whereas Reticunassa fuscofasciata *** collected from the northeastern coast of Taiwan Island and the South China *** four new species can be distinguished conchologically from other congeners mainly in protoconch,shell shape,sculpture,and *** findings demonstrate that the biodiversity of this group in China might be largely underestimated.

关键词： Gastropoda Buccinoidea Nassariidae new species South China Sea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reduced prostate branching morphogenes,s in stromal fibroblast, but not in epithelial, estrogen receptor a knockout mice

引用

Asian Journal of Andrology 2012年第4期14卷 546-555页

作者： Ming Chen Chiuan-Ren yeh chih-Rong Shyr Hsiu-Hsia Lin Iun Da Shuyuan yeh Departments of Urology and Pathology University of Rochester Medical Center Rochester New York 14642 USA Sex Hormone Research Center China Medical University Hospital Taichung 40402 Taiwan China

Early studies suggested that estrogen receptor alpha （ERa） is involved in estrogen-mediated imprinting effects in prostate development. We recently reported a more complete ERa knockout （KO） mouse model via mating β-actin Cre transgenic mice with floxed ERa mice. These ACTB-ERaKO male mice showed defects in prostatic branching morphogenesis, which demonstrates that ERa is necessary to maintain proliferative events in the prostate. However, within which prostate cell type ERa exerts those important functions remains to be elucidated. To address this, we have bred floxed ERa mice with either fibroblast-specific protein （FSP）-Cre or probasin-Cre transgenic mice to generate a mouse model that has deleted ERa gene in either stromal fibroblast （FSP-ERaKO） or epithelial （pes-ERaKO） prostate cells. We found that circulating testosterone and fertility were not altered in *** and pes-ERaKO male mice. Prostates of FSP-ERaKO mice have less branching morphogenesis compared to that of wild-type littermates. Further analyses indicated that loss of stromal ERa leads to increased stromal apoptosis, reduced expression of insulin-likegrowth factor-1 （IGF-1） and FGFIO, and increased expression of BMP4. Collectively, we have established the first in vivo prostate stromal and epithelial selective ERaKO mouse models and the results from these mice indicated that stromal fibroblast ERa plays important roles in prostatic branching morphogenesis via a paracrine fashion. Selective deletion of the ERa gene in mouse prostate epithelial cells by probasin-Cre does not affect the regular prostate development and homeostasis.

关键词： Cre-loxP estrogen receptor knockout prostate stromal-epithelial interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of the number of neoadjuvant therapy cycles on clinical outcomes, safety, and survival in patients with metastatic colorectal cancer undergoing metastasectomy

引用

Oncology Research 2022年第2期30卷 65-76页

作者： YUNG-SUNG yeh HSIANG-LIN TSAI YEN-CHENG CHEN WEI-chih SU PO-JUNG CHEN TSUNG-KUN CHANG ching-CHUN LI ching-WEN HUANG JAW-YUAN WANG Division of Trauma and Surgical Critical Care Department of SurgeryKaohsiungMedical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Emergency Medicine Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Injury Prevention and Control College of Public HealthTaipei Medical UniversityTaipeiTaiwanChina Division of Colorectal Surgery Department of SurgeryKaohsiung Medical University HospitalKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Clinical Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Department of Surgery Faculty of Post-Baccalaureate MedicineCollege of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Graduate Institute of Medicine College of MedicineKaohsiung Medical UniversityKaohsiungTaiwanChina Center for Cancer Research Kaohsiung Medical UniversityKaohsiungTaiwanChina Pingtung Hospital Ministry of Health and WelfarePingtungTaiwanChina

The controversial outcomes in patients with metastatic colorectal cancer(mCRC)highlight the need for developing effective systemic neoadjuvant treatment strategies to improve clinical *** optimal treatment cycles in patients with mCRC for metastasectomy remain undeﬁ*** retrospective study compared the efﬁcacy,safety,and survival of cycles of neoadjuvant chemotherapy/targeted therapy for such ***-four patients with mCRC who received neoadjuvant chemotherapy/targeted therapy following metastasectomy were enrolled between January 2018 and April ***-eight patients received 6 cycles of chemotherapy/targeted therapy,whereas 36 patients received≥7 cycles(median,13;range,7–20).Clinical outcomes,including response,progression-free survival(PFS),overall survival(OS),and adverse events,were compared between these two *** the 64 patients,47(73.4%)were included in the response group,and 17(26.6%)were included in the nonresponse *** analysis revealed chemotherapy/targeted therapy cycle and pretreatment serum carcinoembryonic antigen(CEA)level as independent predictors of the response as well as overall survival and chemotherapy/targeted therapy cycle as an independent predictor of progression(all p0.05).The median OS and PFS were 48 months(95%CI,40.855–55.145)and 28 months(95%CI,18.952–37.48)in the≥7-cycle group and 24 months(95%CI,22.038–25.962)and 13 months(95%CI,11.674–14.326)in the 6-cycle group,respectively(both p<0.001).The oncological outcomes in the≥7-cycle group were signiﬁcantly better than those in the 6-cycle group,without signiﬁcant increases in adverse ***,prospective randomized trials are mand

关键词： Metastatic colorectal cancer Neoadjuvant chemotherapy/targeted therapy Treatment cycles Metastasectomy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of overtime work and obesity with needle stick and sharp injuries in medical practice

引用

World Journal of Clinical Cases 2021年第35期9卷 10937-10947页

作者： Yong-Hsin Chen chih-Jung yeh Gwo-Ping Jong Department of Occupational Safety and Health Chung Shan Medical University HospitalTaichung 40201Taiwan Department of Public Health Chung Shan Medical UniversityTaichung 40201Taiwan Department of Internal Medicine Chung Shan Medical University Hospital and Chung Shan Medical UniversityTaichung 40201Taiwan

BACKGROUND Needle stick and sharps injuries(NSIs)may cause infections among medical *** and overtime work among medical personnel increase the incidence of work *** To investigate whether overtime work and obesity increase the risk of *** This cross-sectional study used the data of 847 hospital personnel,including 104 doctors,613 nurses,67 medical laboratory scientists,54 specialist technicians,and nine surgical *** them,29 participants notified the hospital of having at least one NSI in *** data collected included age,overtime work,body mass index,medical specialty such as doctor or nurse,and professional grade such as attending physician or ***χ2 and Fisher’s exact tests were used to compare categorical *** logistic regression analysis and the Sobel test were used to assess the risk of *** Overtime work,body weight,and medical specialty were significantly associated with NSIs(P<0.05).After adjustment for risk factors,heavy overtime work was an independent risk factor for NSIs,and healthy body weight and nursing specialty were independent protective factors against *** adjustment for risk factors,medical personnel with healthy body weight has half as many NSIs as those with unhealthy body weight;the proportion of NSIs in doctors with healthy body weight was 0.2 times that in doctors with unhealthy body weight;the proportion of injuries among residents was 17.3 times higher than that among attending physicians;the proportion of injuries among junior nurses was 3.9 times higher than that among experienced nurses;the proportion of injuries among nurses with heavy overtime work was 6.6 times higher than that among nurses with mild overtime work;and the proportion of injuries among residents was 19.5 times higher than that among junior *** overtime work mediated the association of medical specialty with *** In addition to promoting the use of safety needles and pr

关键词： Medical staff Needle stick and sharps injuries Overtime work Healthy body weight Obesity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient and secure three-party authenticated key exchange protocol for mobile environments

引用

Journal of Zhejiang University-Science C(Computers and Electronics) 2013年第5期14卷 347-355页

作者： chih-ho CHOU Kuo-yu TSAI Tzong-chen WU Kuo-hui yeh Department of Information Management National Taiwan University of Science and Technology Department of Management Information Systems Hwa Hsia Institute of Technology Department of Information Management National Dong Hwa University

Yang and Chang (2009) proposed a three-party authenticated key exchange protocol for securing communications in mobile-commerce environments. Their protocol reduces computation and communication costs by employing elliptic curve cryptosystems. However, Tan (2010) pointed out that Yang and Chang (2009)'s protocol cannot withstand impersonation and parallel attacks, and further proposed an enhanced protocol to resist these attacks. This paper demonstrates that Tan (2010)'s approach still suffers from impersonation attacks, and presents an efficient and secure three-party authenticated key exchange protocol to overcome shown weaknesses.

关键词： Three-party Key exchange Authentication Mobile environments

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：