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Clinical outcomes in patients with ICU-related pancreatitis

World Journal of Gastroenterology 2009年第39期15卷 4938-4944页

作者： Chia-cheng Tseng Wen-Feng Fang Yu-Hsiu Chung Yi-Hsi Wang Ivor S Douglas Meng-chih Lin Division of Pulmonary and Critical Care Medicine Department of Internal Medicine Chang Gung Memorial Hospital-Kaohsiung Medical Center Chang Gung University College of Medicine Kaohsiung Hsien 83301 Taiwan. China Department of Respiratory Care Chang Gung Institute of Technology Chiayi Hsien 61363 Taiwan China Division of Pulmonary Sciences and Critical Care Medicine University of Colorado at Denver and Health Sciences Center Denver Colorado Denver Health Medical Center Denver 80204 Colorado

AIM:To identify risk factors predictive of intensive care unit(ICU) mortality in patients with ventilator-related *** clinical outcomes of patients with ventilator-related pancreatitis were compared with those of patients with pancreatitis-related respiratory failure as well as ***:One hundred and forty-eight patients with respiratory failure requiring mechanical ventilation and concomitant acute pancreatitis were identified from a prospectively collected dataset of 9108 consecutive patients admitted with respiratory failure over a period of five *** patients met the criteria for ventilator-related pancreatitis,and 88(control patients),for pancreatitis-related respiratory ***:Mortality rate in ventilator-related pancreatitis was comparable to that in ICU patients without pancreatitis by case-control methodology(P=0.544).Multivariate logistic regression analysis identified low PaO2/FiO2(OR:1.032,95% CI:1.006-1.059,P=0.016) as an independent risk factor for mortality in patients with ventilator-related *** mortality rate in patients with ventilator-related pancreatitis was lower than that in patients with acute pancreatitis-related respiratory failure(P<0.001).CONCLUSION:We found that low PaO2/FiO2 was an independent clinical parameter predictive of ICU mortality in patients with ventilator-related pancreatitis.

关键词： Acute pancreatitis Hyperamylasemia Hyperlipasemia Mechanical ventilation Respiratory failure

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Prominent juxtacortical white matter lesion hallmarks NOTCH3-related intracerebral haemorrhage

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Stroke & Vascular Neurology 2022年第1期7卷 38-46页

作者： chih-Hao Chen Hao-Chia Hsu Yu-Wen cheng Ya-Fang Chen Sung-Chun Tang Jiann-Shing Jeng Neurology National Taiwan University HospitalTaipeiTaiwan Department of Neurology National Taiwan University HospitalTaipeiTaiwan Department of Neurology National Taiwan University Hospital Hsinchu BranchHsinchuTaiwan Medical Imaging National Taiwan University HospitalTaipeiTaiwan

Background and purpose NOTCH3 p.R544C mutation accounts for 5%of spontaneous intracerebral haemorrhage(ICH)in East Asian *** investigated whether certain CT features are associated with NOTCH3-related *** Patients with spontaneous ICH from a prospective stroke registry were screened for NOTCH3 p.R544C *** neuroimaging features on the initial non-contrast CT scans selected to predict NOTCH3 p.R544C mutation,including burden of white matter lesion(WML),degree of brain atrophy,number of lacunes,prominent juxtacortical WML and prominent lobar lacunes,were analysed by neuroradiologists blinded to the mutation *** Of 299 patients with spontaneous ICH(mean age,61 years;male,68%;ICH volumes,14.1±17.8 mL),13 patients(4.3%)carried NOTCH3 p.R544C *** clinical features,haematoma size and location were similar between NOTCH3 p.R544C mutation carriers and *** CT scan revealed that patients with NOTCH3 p.R544C mutation had more severe WML and more frequently had prominent juxtacortical WML(69.2%vs 17.8%,p<0.001),and the effects were not driven by ageing as seen in patients without *** juxtacortical WML(area under receiver operating characteristic curve=0.76)outperformed the total WML score and prominent lobar lacunes and significantly predicted NOTCH3 p.R544C mutation in a multivariable-adjusted model(OR,20.9;95%CI 4.94 to 88.6).Conclusion In patients with spontaneous ICH,the severity and topographic distribution of WML can help in identifying potential NOTCH3 mutation-related ICH.

关键词： NOTCH3 intracerebral white

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Process development for producing a food-grade glucose solution from rice straws

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Chinese Journal of Chemical Engineering 2018年第2期26卷 386-392页

作者： chih-Heng Wang Wen-Hua Chen Hwai-Shen Liu Jinn-Tsyy Lai cheng-Che Hsu Ben-Zu Wan Department of Chemical Engineering Norional Taiwan UniversityTaipeiChina Institute of Nuclear Energy Research TaoyuanChina Food Industry Research and Development Institute HsinchuChina

In this paper, processes for producing a food-grade glucose solution through enzymatic hydrolysis of celluloserich solids obtained from rice straws are presented. The rice straws were pretreated by acid-catalyzed steam explosion, and the reaction efficiency, toxicity control, and process economic feasibility were studied. Mass transfer resistance to the hydrolysis reaction was reduced by grinding with glass beads. A higher glucose concentration could be obtained by feeding more cellulose in the hydrolysis reaction; however, this also resulted in the production of undesired byproducts. Thus, a soaking process for the cellulose solids in water was developed to effectively reduce the generation of byproducts in the hydrolysis reaction. The resulting food-grade glucose solution can provide 414 kilocalories per liter, and could be used during a food-shortage crisis in the *** current production cost is estimated to be 0.82 USD·L^(-1).

关键词： Cellulose Enzymatic hydrolysis Food-grade glucose solution Rice straw Biochemical engineering

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Recent upper gastrointestinal panendoscopy increases the risk of pyogenic liver abscess

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World Journal of Gastroenterology 2017年第16期23卷 2948-2956页

作者： Ming-Jen Tsai Chin-Li Lu Ying C Huang Chung Hsien Liu Wan-Ting Huang Kai-Yuan cheng Solomon chih-cheng Chen Department of Emergency Medicine Ditmanson Medical Foundation Chia-Yi Christian HospitalChiayi 60002Taiwan Department of Sports Management Chia Nan University of Pharmacy and ScienceTainan 71710Taiwan Department of Public Health College of MedicineNational Cheng-Kung UniversityTainan 70101Taiwan Department of Emergency Medicine Medical Center and School of MedicineKaohsiung Medical UniversityKaohsiung 807Taiwan Department of Medical Research Ditmanson Medical Foundation Chia-Yi Christian HospitalChiayi 60002Taiwan Heng Chun Christian Hospital Pingtung County 946Taiwan

AIM To investigate the association between a recent gastrointestinal(GI) endoscopy and the subsequent risk of pyogenic liver abscess(PLA).METHODS We designed a nested case control study. Using the Taiwan National Health Insurance Research Database, 2135 patients with a first diagnosis of PLA were identified from 1998 to 2011. Another 10675 patients without PLA matched by age and sex were selected as reference controls. We identified and compared the possible risk factors for PLA and GI endoscopies performed before the index date(when PLA was diagnosed) between the two cohorts. Multivariate analysis was conducted to examine the risk of PLA within the 90 d after the GI *** Patients with a history of diabetes [adjusted odds ratio(a OR) = 4.92, 95%CI: 1.78-13.61], end-stage renal disease(a OR = 3.98, 95%CI: 1.45-10.91), biliary tract infection(a OR = 2.68, 95%CI: 2.11-3.40), liver cirrhosis(a OR = 2.19, 95%CI: 1.39-3.46), GI malignancies(a OR = 5.68, 95%CI: 4.23-7.64), appendicitis(a OR = 3.16, 95%CI: 2.27-4.41), diverticulitis(a OR = 1.64, 95%CI: 1.01-2.64), and recent endoscopic retrograde cholangiopancreatography(a OR = 27.04, 95%CI: 11.65-62.72) were significantly associated with an increased risk of PLA. After adjusting for the above risk factors and the frequency of outpatient department visits and abdominal ultrasounds during 90 d before the index date, an upper GI panendoscopy(a OR = 2.75, 95%CI: 2.05-3.69) but not a lower GI endoscopy(a OR = 1.07, 95%CI: 0.62-1.86) was significantly associated with *** An upper GI panendoscopy performed before 90 d may increase the risk of PLA.

关键词： Appendicitis Colonoscopy Diverticulitis Gastrointestinal endoscopy Panendoscopy Pyogenic liver abscess

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Staged ligation of large portosystemic collaterals in living donor liver transplantation using a small-for-size graft

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 555-557页

作者： Chao-Long Chen Chee-Chien Yong Jeffrey Samuel Co chih-Yi Chen Aldwin Ong chih-Che Lin Yu-Fan cheng Liver Transplantation Center Department of SurgeryKaohsiung Chang Gung Memorial HospitalKaohsiung Diagnostic Radiology Kaohsiung Chang Gung Memorial HospitalKaohsiung

The success of using a partial graft for liver transplantation depends highly on portal venous flow as it is the primary determinant of graft *** collaterals(PSCs)are not uncommon,with an incidence reported to be as h... 详细信息

关键词： collateral graft donor

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Advanced liquid crystal devices for augmented reality and virtual reality displays:principles and applications

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Light(Science & Applications) 2022年第7期11卷 1344-1365页

作者： Kun Yin En-Lin Hsiang Junyu Zou Yannanqi Li Zhiyong Yang Qian Yang Po-cheng Lai chih-Lung Lin Shin-Tson Wu College of Optics and Photonics University of Central FloridaOrlandoFL 32816USA

Liquid crystal displays(LCDs)and photonic devices play a pivotal role to augmented reality(AR)and virtual reality(VR).The recently emerging high-dynamic-range(HDR)mini-LED backlit LCDs significantly boost the image quality and brightness and reduce the power consumption for VR *** a light engine is particularly attractive for compensating the optical loss of pancake structure to achieve compact and lightweight VR *** the other hand,high-resolution-density,and high-brightness liquid-crystal-on-siilicon(LCoS)is a promising image source for the see-through AR displays,especially under high ambient lighting ***,the high-speed LCoS spatial light modulators open a new door for holographic displays and focal surface ***,the ultrathin planar diffractive LC optical elements,such as geometric phase LC grating and lens,have found useful applications in AR and VR for enhancing resolution,widening fiield-of-view,suppressing chromatic aberrations,creating multiplanes to overcome the vergence-accommodation conflict,and dynamic pupil steering to achieve gaze-matched Maxwellian displays,just to name a *** operation principles,potential applications,and future challenges of these advanced LC devices will be discussed.

关键词： crystal principles overcome

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Five-year sequential changes in secondary antibiotic resistance of Helicobacter pylori in Taiwan

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World Journal of Gastroenterology 2015年第37期21卷 10669-10674页

作者： I-Ting Wu Seng-Kee Chuah Chen-Hsiang Lee chih-Ming Liang Lung-Sheng Lu Yuan-Hung Kuo Yi-Hao Yen Ming-Luen Hu Yeh-Pin Chou Shih-cheng Yang Chung-Mou Kuo Chung-Huang Kuo Chun-chih Chien Yu-Shao chiang Shue-Shian Chiou Tsung-Hui Hu Wei-Chen Tai Division of Hepatogastroenterology Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Division of Infectious Diseases Department of Internal Medicine Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine Department of Laboratory Medicine Kaohsiung Chang Gung Memorial Hospital

AIM: To determine changes in the antibiotic resistance of Helicobacter pylori(H. pylori) in southern Taiwan after failure of first-line standard triple ***: We analyzed 137 H. pylori-infected isolates from patients who experienced eradication failure after standard first-line triple therapy from January2010 to December 2014. The H. pylori strains were tested for susceptibility to amoxicillin, clarithromycin,levofloxacin, metronidazole and tetracycline using the E-test method. The minimal inhibitory concentration(MIC) was determined by the agar dilution *** values of ≥ 0.5, ≥ 1, ≥ 1, ≥ 4 and ≥ 8 mg/L were considered to be the resistance breakpoints for amoxicillin, clarithromycin, levofloxacin, tetracycline and metronidazole, ***: A high resistance rate was found for clarithromycin(65%-75%) and metronidazole(30%-40%)among patients who failed first-line standard *** resistance levels to amoxicillin and tetracycline remained very low; however, levofloxacin resistance was as high as 37.5% in 2010 but did not increase any further during the past 5 years. The rates of resistance to these antibiotics did not show a statistically significant upward or downward ***: Antibiotic resistance of H. pylori remains a problem for the effective eradication of this pathogen and its associated diseases in Taiwan. High clarithromycin resistance indicated that this antibiotic should not be prescribed as a second-line H. pylori eradication therapy. Moreover, levofloxacin-based second-line therapy should be used cautiously, and the local resistance rates should be carefully monitored.

关键词： Helicobacter pylori Antibiotic resistance Five-yea

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融合情感和常识知识的对话生成模型

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计算机科学 2025年第1期52卷 307-314页

作者：程金凤蒋宗礼北京工业大学信息学部北京100124

随着深度学习技术的发展,开放域对话系统作为人机对话系统的重要分支也得到了快速发展。但目前开放域对话模型生成的回复语句依然存在同理心较差、多样性较低等问题。对此,提出一种融合情感和常识知识的对话生成模型。首先依据情感词典... 详细信息

随着深度学习技术的发展,开放域对话系统作为人机对话系统的重要分支也得到了快速发展。但目前开放域对话模型生成的回复语句依然存在同理心较差、多样性较低等问题。对此,提出一种融合情感和常识知识的对话生成模型。首先依据情感词典和常识知识图谱获取每个单词对应的常识知识向量,然后将该向量和单词本身的词嵌入向量一同输入编码器中进行编码,接着通过两阶段解码来生成回复语句:第一个解码阶段预测要生成单词的情感强度,并据此获得该单词对应的情感向量,第二阶段解码结合第一阶段编码的结果和已生成单词的词嵌入向量及其对应的常识知识向量作为输入,预测要生成的单词。实验结果表明,该模型生成的回复语句更具同理心和多样性,并且在PPL,BLEU,ACC和DISTINCT等指标上相比基线模型都有一定提升。

关键词：对话模型情感词典常识知识图谱两阶段解码情感强度

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Quercetin inhibits truncated isoform of dopamine-and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer

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Food Science and Human Wellness 2024年第5期13卷 2653-2667页

作者： Han-Sheng Chang Tzu-Chun cheng Shih-Hsin Tu chih-Hsiung Wu You-cheng Liao Jungshan Chang Min-Hsiung Pan Li-Ching Chen Yuan-Soon Ho Department of Biological Science&Technology College of Life SciencesChina Medical UniversityTaichung 406TaiwanChina Institute of Biochemistry and Molecular Biology College of Life SciencesChina Medical UniversityTaichung 406TaiwanChina Department of Surgery School of MedicineCollege of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Department of Surgery Taipei Medical University HospitalTaipei 110TaiwanChina Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 110TaiwanChina Institute of Food Sciences and Technology National Taiwan UniversityTaipei 106TaiwanChina

Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2(HER2)-positive(HER2+)breast cancer(BC).The truncated isoform of dopamine-and cAMPregulated phosphoprotein(t-DARPP)has been reported to be involved in trastuzumab therapy resistance and promoting tumor *** evaluate the t-DARPP expression in BC,paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+BC tumor *** established 2 patient-derived xenografts(PDX)mice models to test the efficacy of trastuzumab,named model 1(non-responder)and model 2(responder).t-DARPP and p95-HER2 protein-protein interactions were detected in PDX tumor tissue from non-responders using Förster resonance energy transfer ***,there is no response from the ***,mechanistic studies using transwell and western blot assays demonstrated that t-DARPP could upregulate epithelial-mesenchymal transition signaling proteins,enhance p95-HER2 expression and promote cell *** found that quercetin effectively reduced t-DARPP expression in HER2+BC *** t-DARPP ShRNA-suppressed cells,quercetin synergistically enhanced trastuzumab-induced apoptotic cell death and G2/M phase *** conclusion,the combination of quercetin and trastuzumab treatment by targeting t-DARPP in HER2+BC patients has the potential as a biomarker for mitigating drug resistance.

关键词： p95-Human epidermal growth factor receptor 2 (HER2) HER2-positive breast cancer Quercetin Trastuzumab resistance Truncated isoform of dopamine-and cAMPregulated phosphoprotein

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庭院经济高质量发展赋能脱贫地区乡村产业振兴的内在机理与实践路径

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重庆文理学院学报（社会科学版） 2025年第1期44卷 14-25页

作者：刘承陕西师范大学马克思主义学院陕西西安710119

庭院经济作为一种乡村产业形态,是乡村经济的重要组成部分,为乡村产业振兴注入了新动能。脱贫地区高质量发展庭院经济,是发展乡村特色产业的重要途径,对赋能脱贫地区乡村产业振兴意义重大。从生成逻辑看:庭院经济自身优势契合脱贫地区... 详细信息

庭院经济作为一种乡村产业形态,是乡村经济的重要组成部分,为乡村产业振兴注入了新动能。脱贫地区高质量发展庭院经济,是发展乡村特色产业的重要途径,对赋能脱贫地区乡村产业振兴意义重大。从生成逻辑看:庭院经济自身优势契合脱贫地区发展要求;脱贫地区乡村振兴重点帮扶政策引领庭院经济发展;脱贫地区具备一定的产业基础支持庭院经济发展;脱贫地区结对帮扶利益联结带动庭院经济发展;脱贫地区通信畅通、网络普及支撑庭院经济发展。从内在机理看:庭院经济盘活资源资产,为乡村产业振兴增添动力;降低生产成本,为乡村产业振兴提供助力;升级产业结构,为乡村产业振兴贡献力量;促进业态融合,为乡村产业振兴注入活力;扩大经营规模,为乡村产业振兴夯实基础。从实践路径看:坚持和加强党对脱贫地区庭院经济高质量发展的全面领导;引导农民积极融入市场经济体系,强化产品产销对接;充分发挥当地资源禀赋优势,制定多层合理规划;多业态多模式跨界融合协同发展,逐步扩大经营规模;强化现代信息技术支撑,做好“引进来”和“走出去”。

关键词：庭院经济高质量发展脱贫地区产业振兴乡村振兴

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