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Hepatitis B virus coinfection in human immunodeficiency virus-infected patients: A review

World Journal of Gastroenterology 2014年第40期20卷 14598-14614页

作者： Hsin-Yun Sun Wang-Huei Sheng Mao-Song Tsai Kuan-yeh Lee Sui-Yuan Chang chien-Ching Hung Department of Internal Medicine National Taiwan University Hospital National Taiwan University College of Medicine Department of Internal Medicine Far Eastern Memorial Hospital Department of Internal Medicine National Taiwan University Hospital Hsin-Chu Branch Department of Clinical Laboratory Sciences and Medical Biotechnology National Taiwan University College of Medicine Department of Laboratory Medicine National Taiwan University Hospital Department of Medical Research China Medical University Hospital China Medical University

Hepatitis B virus(HBV)infection is a leading cause of chronic hepatitis,liver cirrhosis,and hepatocellular carcinoma *** to the shared modes of transmission,coinfection with HBV and human immunodeficiency virus(HIV)is not *** is estimatedthat 10%of HIV-infected patients worldwide are coinfected with *** areas where an HBV vaccination program is implemented,the HBV seroprevalence has declined *** HIV/HBV-coinfected patients,HBV coinfection accelerates immunologic and clinical progression of HIV infection and increases the risk of hepatotoxicity when combination antiretroviral therapy(cART)is initiated,while HIV infection increases the risk of hepatitis events,cirrhosis,and end-stage liver disease related to chronic HBV *** the advances in antiviral therapy,concurrent,successful longterm suppression of HIV and HBV replication can be achieved in the cART *** reduce the disease burden of HBV infection among HIV-infected patients,adoption of safe sex practices,avoidance of sharing needles and diluent,HBV vaccination and use of cART containing tenofovir disoproxil fumarate plus emtricitabine or lamivudine are the most effective ***,due to HIV-related immunosuppression,using increased doses of HBV vaccine and novel approaches to HBV vaccination are needed to improve the immunogenicity of HBV vaccine among HIV-infected patients.

关键词： Viral hepatitis Seroepidemiology Sexually transmitted diseases Nucleoside reverse-transcriptase inhibitor Vaccination

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A concise review about fracture assessments of brittle solids with V-notches

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Frontiers of Structural and Civil Engineering 2019年第2期13卷 478-485页

作者： Hsien-Yang yeh Bin YANG Department of Mechanical and Aerospace Engineering California State UniversityLong BeachCA 90801USA Department of Chemical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

A concise review of recent studies about the fracture assessments of elastic brittle solid materials containing V-notches is presented. In this preliminary and brief survey, elastic stress distributions in V-notched solids are discussed first. The concept of notch stress intensity factor is introduced. Combine the digital image correlation method with numerical computation techniques to analyze the stress distribution near the notches. Fracture criteria such as strain energy density, J-integral, theory of critical distance are used. However, various new materials are developed in different engineering fields, thus, the establishment of reliable and accurate material strength theory or failure criterion is imperative. Therefore, predicting fracture for various modem materials would require more experiments to infer material dependent parameters in the local fracture model.

关键词： fracture assessment brittle solids V-notches review

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Aberrant activation of nuclear factor of activated T cell 2 in lamina propria mononuclear cells in ulcerative colitis

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World Journal of Gastroenterology 2008年第11期14卷 1759-1767页

作者： Tsung-Chieh Shih Sen-Yung Hsieh Yi-Yueh Hsieh Tse-Chin Chen chien-Yu yeh Chun-Jung Lin Deng-Yn Lin Cheng-Tang Chiu Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Clinical Proteomics Center Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-GastroenterologyChang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan Department of Anatomic Pathology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Colorecto-Surgery Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Hepato-Gastroenterology Chang Gung Memorial HospitalChang Gung University School of Medicine Taoyuan 333Taiwan

AIM:To investigate the role of nuclear factor of activated T cell 2(NFAT2),the major NFAT protein in peripheral T cells,in sustained T cell activation and intractable inflammation in human ulcerative colitis(UC). METHODS:We used two-dimensional gel-electrophoresis, immunohistochemistry,double immunohistochemical staining,and confocal microscopy to inspect the expression of NFAT2 in 107,15,48 and 5 cases of UC, Crohn's disease(CD),non-specific colitis,and 5 healthy individuals,respectively. RESULTS:Up-regulation with profound nucleo- translocation/activation of NFAT2 of lamina propria mononuclear cells(LPMC)of colonic mucosa was found specifically in the affected colonic mucosa from patients with UC,as compared to CD or NC(P<0.001,Kruskal- Wallis test).Nucleo-translocation/activation of NFAT2 primarily occurred in CD8+T,but was less prominent in CD4+T cells or CD20+B *** was strongly associated with the disease activity,including endoscopic stage (τ=0.2145,P=0.0281)and histologic grade(τ=0.4167, P<0.001). CONCLUSION:We disclose for the first time the nucleo-translocation/activatin of NFAT2 in lamina propria mononuclear cells in ulcerative *** of NFAT2 was specific for ulcerative colitis and highly associated with disease *** activation of NFAT2is implicated in an auto-regulatory positive feedback loop of sustained T-cell activation and NFAT proteins play key roles in the calcium/calcineurin signaling pathways,our results not only provide new insights into the mechanism for sustained intractable inflammation,but also suggest the calcium-calcineurin/NFAT pathway as a new therapeutic target for ulcerative colitis.

关键词： Nuclear factor of activated T cells Ulcerative colitis Inflammatory bowel disease Nuclear factor of activated T cells cl Nuclear factor of activated T cells 2

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In situ formation of Zr_2Al_3C_4/Al_2O_3 composites by combustion synthesis with PTFE and thermal activations

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Transactions of Nonferrous Metals Society of China 2018年第10期28卷 2011-2016页

作者： Chun-liang yeh Yi-Chang CHEN Department of Aerospace and Systems Engineering Feng Chia University100 Wenhwa RoadSeatwenTaichung 40724TaiwanChina

Preparation of Zr2Al3C4-Al2O3 in situ composites was investigated by self-propagating high-temperature synthesis(SHS)involving both aluminothermic reduction of ZrO2 and chemical activation of PTFE(Teflon).The starting materials included ZrO2,Al,carbon black and *** addition to the conventional SHS method,the experiments were conducted by a chemical-oven SHS(COSHS)route to thermally assist the synthesis *** threshold amount of 2%(mass fraction)PTFE was required to induce self-sustaining *** the conventional SHS scheme was utilized,due to low combustion temperatures between 1152 and 1272°C and insufficient reaction time,the dominant carbide forming in the composite was ZrC instead of *** the other hand,the COSHS technique increased the combustion temperature of the reactant compact to about 1576°C,lengthened the high-temperature duration for the reaction,and prevented Al vapor from escaping *** a consequence,Zr2Al3C4-Al2O3 composites with a small amount of Zr3Al3C5 were *** microstructure of the COSHS-derived product showed that plate-like Zr2Al3C4 grains were about 2μm in thickness and 10-30μm in length,and most of them were closely stacked into a laminated configuration.

关键词： Zr2Al3C4 combustion synthesis PTFE activation chemical-oven SHS aluminothermic reduction

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Clinical and pathological correlation of the microdeletion of Y chromosome for the 30 patients with azoospermia and severe oligoasthenospermia

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Asian Journal of Andrology 2004年第4期6卷 369-375页

作者： Han-Sun Chiang Shauh-Der yeh chien-Chih Wu Boo-Chung Huang Hui-Ju Tsai Chia-Lang Fang College of Medicine Fu Jen Catholic University Taipei China Department of Urology Taipei Medical University Hospital Taipei China Graduate Institute of Medical Sciences Department of Pathology Taipei Medical UniversityTaipeiChina

Aim: To review the accumulated 30 patients with different area of Y chromosome microdeletions, focusing on their correlation with the clinical and pathological findings. Methods: A total of 334 consecutive infertile men with azoospermia (218 patients) and severe oligoasthenospermia (116 patients) were screened. Complete physical and endocrinological examinations, general chromosome study and multiplex polymerase chain reaction assay to evaluate the Y chromosome microdeletion were performed. Ten patients received testicular biopsy. Then the clinical and pathological findings were analyzed with reference to the areas of Y chromosome microdeletion. Results: There is a decline of the percentage of sperm appearing in semen in the group that the gene deletion region from AZFc to AZFb. The clinical evidence of the impairment (decreased testicular size and elevated serum FSH) is also relevantly aggravated in this group. However, the pathology of testicular biopsy specimen was poorly correlated with the different deletion areas of the Y chromosome, which may be due to the limited number of specimens. Conclusion: The clinical correlation of spermatogenic impairment to the different AZF deletion regions may provide the information for the infertile couples in pre-treatment counseling.

关键词： chromosome deletion male infertility azoospermia factor azoospermia oligoasthenospermia Y chromosome

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Biomimetic flexible plate actuators are faster and more efficient with a passive attachment

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Acta Mechanica Sinica 2016年第6期32卷 1001-1011页

作者： Peter D.yeh Alexander Alexeev George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology

Using three-dimensional computer simulations, we probe biomimetic free swimming of an internally actuated flexible plate in the regime near the first natural frequency. The plate is driven by an oscillating internal moment approximating the actuation mechanism of a piezoelectric macro fiber composite (MFC) bimorph. We show in our simulations that the addition of a passive attachment increases both swimming velocity and efficiency. Specifically, if the active and passive sections are of similar size, the overall performance is the best. We determine that this optimum is a result of two competing factors. If the passive section is too large, then the actuated portion is unable to generate substantial deflection to create sufficient thrust. On the other hand, a large actuated section leads to a bending pattern that is inefficient at generating thrust especially at higher frequencies.

关键词： Flexible plate Biomimetic Lattice Boltzmann Fluid-structure interaction Robotic fish Piezoelectric actuator

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Porous Cube-like In_2O_3 Nanoparticles and Their Sensing Characteristics toward Ethanol

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Journal of Materials Science & Technology 2008年第4期24卷 667-674页

作者： Chih-Chia HUANG Chen-Sheng yeh Department of Chemistry National Cheng Kung University Tainan Taiwan Department of Chemistry Purdue University West Lafayette IN 47907 United States

Porous cube-like crystalline In2O3 nanoparticles with an average diagonal length of 34.8 nm were fabricated by a laser ablation-reflux process to form In（OH）3, followed by a calcination treatment to yield porous In2O3. HRTEM （high-resolution transmission electronic microscopy）, XRD （X-ray diffraction）, BET （Brunauer-Emmett-Teller）, and XPS （X-ray photoelectron spectroscopy） analysis were used to characterize their crystalline structures, grain sizes, surface areas, and surface compositions. The as-prepared porous in-dium oxides were tested for their sensing properties toward ethanol. Non-porous In2O3 nanopowder （about 40 nm） was also examined in order to compare the results with the as-prepared porous In2O3 nanomaterials. The porous In2O3 exhibited much better performance than that of non-porosus In2O3, and showed enhanced sensitivity with a lower detection limit than other reported In2O3-based materials when exposed to ethanol. Good gas sensitivity and linear behavior as a function of ethanol concentration were observed in the porous In2O3 nanoparticles.

关键词： In2O3 Porosity Nanoparticles Gas sensor

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Integration of multiscale entropy and BASED scale of electroencephalography after adrenocorticotropic hormone therapy predict relapse of infantile spasms

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World Journal of Pediatrics 2022年第11期18卷 761-770页

作者： Lin Wan Chu-Ting Zhang Gang Zhu Jian Chen Xiu-Yu Shi Jing Wang Li-Ping Zou Bo Zhang Wen-Bin Shi chien-Hung yeh Guang Yang Senior Department of Pediatrics Chinese PLA General HospitalBeijing100000China Department of Pediatrics the First Medical CentreChinese PLA General HospitalBeijingChina Medical School of Chinese People’s Liberation Army BeijingChina School of Information and Electronics Beijing Institute of TechnologyBeijing100081China The Second School of Clinical Medicine Southern Medical UniversityGuangzhouChina Department of Neurology and ICCTR Biostatistics and Research Design Center Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA

Background Even though adrenocorticotropic hormone(ACTH)demonstrated powerful efficacy in the initially successful treatment of infantile spasms(IS),nearly half of patients have experienced a *** sought to investigate whether features of electroencephalogram(EEG)predict relapse in those IS patients without structural brain *** We retrospectively reviewed data from children with IS who achieved initial response after ACTH treatment,along with EEG recorded within the last two days of *** recurrence of epileptic spasms following treatment was tracked for 12 *** were categorized as either non-relapse or relapse *** clinical and EEG recordings were collected,burden of amplitudes and epileptiform discharges(BASED)score and multiscale entropy(MSE)were carefully explored for cross-group *** Forty-one patients were enrolled in the study,of which 26(63.4%)experienced a *** BASED score was significantly higher in the relapse *** in the non-relapse group was significantly lower than the relapse group in theγband but higher in the lower frequency range(δ,θ,α).Sensitivity and specificity were 85.71%and 92.31%,respectively,when combining MSE in theδ/γfrequency of the occipital region,plus BASED score were used to distinguish relapse from non-relapse *** BASED score and MSE of EEG after ACTH treatment could be used to predict relapse for IS patients without brain structural *** with BASED score≥3,MSE increased in higher frequency,and decreased in lower frequency had a high risk of relapse.

关键词： Burden of amplitudes and epileptiform discharges score Infantile spasms Multiscale entropy Prediction Relapse

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Prognostic analysis of surgical treatment of peripheral cholangiocarcinoma: Two decades of experience at Chang Gung Memorial Hospital

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World Journal of Gastroenterology 2005年第12期11卷 1779-1784页

作者： Yi-Yin Jan Chun-Nan yeh Ta-Sen yeh Tse-Ching Chen Department of Surgery Department of Pathology

AIM: To analyze the prognostic factors influencing the overall survival of peripheral cholangiocarcinoma (PCC) patients undergoing surgical treatment during 25 years at a single institution. METHODS: This study retrospectively reviewed prospectively collecting data about 373 patients with historically proven PCC who underwent surgical treatment between 1977 and 2001. RESULTS: Three hundred and seventy-three PCC patients (159 men and 214 women) underwent surgical treatment from 1977 to 2001. Among them, 187 PCC patients underwent hepatectomy and 135 had curative resection (curative resectability rate: 36.2%). The follow-up duration ranged from 1.05 to 167.6 mo (mean/median = 14.1/7.2 mo). Overall cumulative survival rates at 1, 3, and 5 years were 32.5%, 9.2%, and 4.1%, respectively. Univariate log-rank analysis identified the following as adverse influences on overall survival: presence of symptoms, absence of mucobilia, elevated CEA and CA 19-9 levels, non-papillary tumor type, receiving non-hepatectomy, advanced tumor staging, lack of post-operative chemotherapy, and radiotherapy. Meanwhile, multivariate Cox's proportional hazard analysis demonstrated that absence of mucobilia, non-papillary tumor type, advanced tumor staging, non-hepatectomy, and lack of post-operative chemotherapy were the five independent prognostic factors that adversely affected overall survival. CONCLUSION: Favorable overall survival of PCC patients undergoing surgical treatment depends on early tumor stage, presence of mucobilia, papillary tumor type, hepatic resection, and post-operative chemotherapy.

关键词： Prognostic factor Surgical treatment Peripheral cholangiocarcinoma

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Vedolizumab in Crohn’s disease with rectal fistulas and presacral abscess:A case report

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World Journal of Gastroenterology 2021年第5期27卷 442-448页

作者： Heng yeh Chia-Jung Kuo Ren-Chin Wu chien-Ming Chen Wen-Sy Tsai Ming-Yao Su Cheng-Tang Chiu Puo-Hsien Le School of Medicine Chang Gung UniversityTaoyuan City 333323Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Taiwan Association of the Study of Small Intestine Disease Taoyuan 333Taiwan Department of Pathology Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Colon and Rectal Surgery Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan Department of Gastroenterology and Hepatology New Taipei City Municipal Tucheng HospitalNew Taipei City 236017Taiwan Liver Research Center Chang Gung Memorial HospitalLinkou BranchTaoyuan 333Taiwan

BACKGROUND Fistula and intraabdominal abscess are common complications of Crohn’s disease(CD),but complex rectal fistula with abscess formation is *** necrosis factor antagonists combined with percutaneous drainage or surgical intervention is optimal treatment for fistulizing CD with intraabdominal *** is no study showing the efficacy of vedolizumab in such complicated *** SUMMARY A 47-year-old man has decompensated liver cirrhosis,Child *** suffered from abdominal pain,bloody diarrhea,fever,and body weight *** with rectoprostatic fistula,rectopresacral fistula,presacral abscess and cytomegalovirus(CMV)infection were *** received antibiotics,anti-viral therapy,transverse colostomy and vedolizumab *** months later,he had deep remission and complete fistula tracts *** Early vedolizumab and stool diversion are effective and safe in treating CD with complex rectal fistula with abscess formation.

关键词： Vedolizumab Crohn's disease Rectoprostatic fistula Rectal presacral fistula Presacral abscess Case report

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