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Role of body mass index in colon cancer patients in Taiwan

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World Journal of Gastroenterology 2012年第31期18卷 4191-4198页

作者： Chih-chien Chin Yi-Hung Kuo chien-yuh yeh Jinn-Shiun Chen Reiping Tang Chung-Rong Changchien Jeng-Yi Wang Wen-Shih Huang Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial HospitalChiayi 613Taiwan Graduate Institute of Clinical Medical Science College of MedicineChang Gung UniversityTaoyuan 333Taiwan Division of Colon and Rectal Surgery Department of SurgeryChang Gung Memorial HospitalLinko 333Taiwan

AIM： To determine the effect of body mass index （BMI） on the characteristics and overall outcome of colon cancer in Taiwan. METHODS： From January 1995 to July 2003, 2138 patients with colon cancer were enrolled in this study. BMI categories （in kg/m2） were established according to the classification of the Department of Health of Tai- wan. Postoperative morbidities and mortality, and survival analysis including overall survival （OS）, disease- free survival （DFS）, and cancer-specific survival （CSS） were compared across the BMI categories.27 kg/m2） patients. Being female, apparently anemic, hypoalbuminemic, and having body weight loss was more likely among underweight patients than among the other patients （P 〈 0.001）. Underweight patients had higher mortality rate （P = 0.00.7） and lower OS （P 〈 0.001） and DFS （P = 0.002） than the other pa- tients. OS and DFS did not differ significantly between normal-weight, overweight, and obese patients, while CSS did not differ significantly with the BMI category. CONCLUSION： In Taiwan, BMI does not significantly affect colon-CSS. Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients. Obesity does not predict a worse survival.

关键词： Body mass index Colon cancer Survival IVlorbidity Outcome

Evaluation of contrast-enhanced computed tomographic colonography in detection of local recurrent colorectal cancer

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World Journal of Gastroenterology 2006年第1期12卷 123-126页

作者： Yau-Tong You Chung-Rong Chang chien Jeng-Yi Wang Koon-Kwan Ng Jinn-Shiun Chen Reiping Tang Jy-Ming Chiang chien-yuh yeh Pao-Shiu Hsieh Division of Colon and Rectal Surgery Chang Gung Memorial HospitalLin-KouTaiwanChina Division of Colon and Rectal Surgery Chang Gung Memorial HospitalJia-YiTaiwanChina Department of Radiology Chang Gung Memorial HospitalKee-LungTaiwanChina

AIM： TO evaluate the diagnostic accuracy, sensitivity, specificity of contrast-enhanced computed tomographic colonography in detecting local recurrence of colorectal cancer. METHODS： From January 2000 to December 2004, 434 patients after potentially curative resection for invasive colorectal cancer were followed up for a period ranging from 20 to 55 mo. Eighty of the four hundred and thirty-four patients showing strong clinical evidence for recurring colorectal cancer during the last followup were enrolled in this study. Each patient underwent contrast-enhanced computed tomographic colonography and colonoscopy on the same day. Any lesions, biopsies, identified during the colonoscopic examination, immediate complications and the duration of the procedure were recorded. The results of contrast-enhanced computed tomographic colonography were evaluated by comparing to those of colonoscopy, surgical finding, and clinical follow-up. RESULTS： Contrast-enhanced computed tomographic colonography had a sensitivity of 100%, a specificity of 83% and an overall accuracy of 94% in detecting local recurrent colorectal cancer. CONCLUSION： Conventional colonoscopy and contrastenhanced tomographic colonography can complement each other in detecting local recurrence of colorectal cancer.

关键词： Computed tomographic colonography Recurrent colorectal cancer

Membrane Proteins as Potential Colon Cancer Biomarkers: Verification of 4 Candidates from a Secretome Dataset

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Surgical Science 2014年第10期5卷 418-438页

作者： Sum-Fu Chiang Ming-Hung Tsai Reiping Tang Ling-Ling Hsieh Jy-Ming Chiang chien-yuh yeh Pao-Shiu Hsieh Wen-Sy Tsai Ya-Ping Liu Ying Liang Jinn-Shiun Chen Jau-Song Yu Division of Colon and Rectal Surgery Chang Gung Memorial Hospital Linkou Chinese Taipei Graduate Institute of Clinical Medical Sciences College of Medicine Chang Gung University Taoyuan Chinese Taipei Graduate Institute of Biomedical Sciences Chang Gung University Taoyuan Chinese Taipei College of Medicine Chang Gung University Linkou Chinese Taipei Department of Public Health Chang Gung University Taoyuan Chinese Taipei Pathology Core of the Chang Gung Molecular Medicine Research Center Taoyuan Chinese Taipei Department of Biochemistry and Molecular Biology Chang Gung University Taoyuan Chinese Taipei

Colorectal cancer (CRC) is an important health issue in Taiwan. There were over ten thousand newly diagnosed CRC patients each year. The outcome of late stage CRC still remains to be improved, and tumor markers are expected to improve CRC detection and management. From a colorectal cancer cell secretome database, we chose four proteins as candidates for clinical verification, including tumor-associated calcium signal transducer 2 (TROP2, TACSTD2), transmembrane 9 superfamily member 2 (TM9SF2), and tetraspanin-6 (TSPAN6), and tumor necrosis factor receptor superfamily member 16 (NGFR). Different groups of 30 CRC patients’ tissue samples collected from Chang Gung Memorial Hospital were analyzed by immunohistochemistry (IHC) for the four proteins, and the results were scored by pathologist. For all the four candidate proteins, marked differences of IHC score existed between tumor and adjacent non-tumor counterpart. However, there were only trends between higher protein expression levels and worse outcome. Three proteins (TROP2, TM9SF2 and NGFR) had trends between higher tissue expression and tumor stage or lymph node metastasis. Our study revealed that tissue expression of four proteins (TROP2, TM9SF2, TSPAN6, and NGFR) was markedly different between tumor and adjacent non-tumor counterparts. Overexpression of all these four proteins showed some trends with poorer survival.

关键词： Biomarker Colorectal Cancer Immunohistochemistry Membrane Protein Secretome Tetraspanin-6 Transmembrane 9 Superfamily Member 2 Tumor-Associated Calcium Signal Transducer 2 Tumor Necrosis Factor Receptor Superfamily Member 16 Verification

Microbial diversity of soil bacteria in agricultural field contaminated with heavy metals

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Journal of Environmental Sciences 2008年第3期20卷 359-363页

作者： chien Chihching KUO Yumei CHEN Changchieh HUNG Chunwei yeh Chihwei yeh Weijen Graduate School of Biotechnology and Bioengineering Yuan Ze University Chung-Li Taiwan 320 China Department of Occupational Safety and Health Chung Hwa University of Medical Technology Tainan Taiwan China

In this study we evaluated the bacterial diversity in a soil sample from a site next to a chemical industrial factory previously contaminated with heavy metals. Analysis of 16S rDNA sequences amplified from DNA directly extracted from the soil revealed 17 different bacterial types （genera and/or species）. They included Polyangium spp., Sphingomonas spp., Variovorax spp., Hafina spp., Clostridia, Acidobacteria, the enterics and some uncultured strains. Microbes able to tolerate high concentrations of cadmium （500μmol/L and above） were also isolated from the soil. These isolates included strains of Acinetobacter （strain CD06）, Enterobacter sp. （strains CD01, CD03, CD04 and CD08）（similar strains also identified in culture-independent approach） and a strain of Stenotrophomonas sp. The results indicated that the species identified from direct analysis of 16S rDNA of the soil can be quite different from those strains obtained from enrichment cultures and the microbial activities for heavy metal resistance might be more appropriately addressed by the actual isolates.

关键词： cadmium heavy metal heavy metal resistant microbial diversity soil bacteria

Effect of transcutaneous electrical nerve stimulation through acupoints of Pucan (BL 61) and Shenmai (BL 62) on intraocular pressure in patients with glaucoma： a randomized controlled trial

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Journal of Traditional Chinese Medicine 2016年第1期36卷 51-56页

作者： yeh Tsui-Yun Lin Jen-chien Liu Chi-Feng Graduate Institute of Integration of Traditional Chinese Medicine with Western Nursing National Taipei University of Nursing and Health Sciences Taipei City Hospital Taipei 10065 China Department of Ophthalmology Taipei CityHospitaI Taipei 10065 China

OBJECTIVE： To investigate the effects of transcutaneous electrical nerve stimulation （TENS） through acupoints on the intraocular pressure （lOP） in patients with glaucoma. METHODS： A single-blinded, randomized experimental design study was conducted. Patients from the North of Taipei Ophthalmology outpatient department diagnosed with intraocular hypertension were selected and were further enrolled if they met the research subject criteria. The patients who met all criteria, and who met no exclusion criteria became the participants. Participants were randomly assigned into the treated group, wherein the TENS electrodes （Qing Ming Medical Device Co., Ltd., New Taipei City, China） were applied with direct current （DC） on the acupoints Pucan （BL 61） and Shenmai （BL 62） for 20 min. The control group received no TENS electrode treatments. Measurements of lOP were taken four times using a pneumotonometer （Clinico Co., Ltd., New Taipei City, China）, before, immediately after, 30 min after, and 60 min after TENS electrode treatments. RESULTS： Eighty-two participants completed the experiment, lOP decreased more in the group treated with DC （P 〈 0.01） than in the control *** lOPs were not affected by the age of the patients and their usage of medications. CONCLUSION： TENS of acupoints of Pucan （BL 61） and Shenmai （BL 62） could significantly reduce the lOP in patients with glaucoma.

关键词： Glaucoma Intraocular pressure Ocularhypertension Acupuncture points Transcutaneous electrical nerve stimulation Randomized con-trolled trial

Peanut consumption and reduced risk of colorectal cancer in women:A prospective study in Taiwan

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World Journal of Gastroenterology 2006年第2期12卷 222-227页

作者： Chih-Ching yeh San-Lin You chien-Jen Chen Fung-Chang Sung Department of Risk Management China Medical University College of Public Health Taichung 404Taiwan China Institutes of Epidemiology National Taiwan University College of Public Health Taipei 100Taiwan China Institute of Environment Health China Medical University College of Public Health Taichung 404 Taiwan and Institute of Environment Health National Taiwan University College of Public Health Taipei 100 Taiwan China

AIM： To examine whether peanut consumption is associated with a reduced risk of colorectal cancer in a prospective cohort with a 10-year follow-up. METHODS： In 1990-1992, residents （12026 men and 11917 women aged 30 to 65 years） in 7 townships, Taiwan, were interviewed and recruited into a cancerscreening cohort and annually followed up. Colorectal cancer cases in this cohort were identified from cancer registry and death certificates. Incidence rates of this disease by the end of 2001 were calculated by gender for the primary study variable and covariates. The dietary intake was assessed by means of weekly food frequency measures, including frequently consumed food groups and folk dishes including sweet potato, bean products, peanut products, pickled foodstuffs, nitrated or smoked foodstuffs. RESULTS： During the study period, 107 new colorectal cancer cases （68 men and 39 women） were confirmed. The multivariate Cox＇s proportional hazard model showed that the relative risk （RR） of peanut consumption was 0.73 [95% confidence interval （CI） = 0.44-1.21] for men and 0.42 （95% CI = 0.21-0.84） for women. However, frequent intake of pickled foodstuffs was harmful for women （RR= 2.15, 95% CI=0.99-4.65）. The risk of colorectal cancer was also elevated among cigarette smokers but not significant （P〈 0.05）.CONCLUSION： This study suggests that frequent intake of peanut and its products may reduce colorectal cancer risk in women, demonstrating the anti-proliferating effect of peanut intake.

关键词： Peanuts Colorectal cancer Diet Gender difference Prospective study Taiwan

Meteorological influences on dengue transmission in Pakistan

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 932-938页

作者： Suleman Atique Shabbir Syed Abdul chien-yeh Hsu Ting-Wu Chuang Graduate Institute of Biomedical Informatics College of Medical Science and TechnologyTaipei Medical University Master Program in Global Health and Development Taipei Medical University Department of Information Management National Taipei University of Nursing and Health Sciences Department of Molecular Parasitology and Tropical Diseases School of MedicineCollege of MedicineTaipei Medical University

Objective: To identify the influences of local and regional climate phenomena on dengue transmission in Lahore District of Pakistan, from 2006 to 2014. Methods: Time-series models were applied to analyze associations between reported cases of dengue and climatic parameters. The coherence trend of regional climate phenomena(IOD and ENSO) was evaluated with wavelet analysis. Results: The minimum temperature 4 months before the dengue outbreak played the most important role in the Lahore District(P=0.03). A NINO 3.4 index 9 months before the outbreaks exhibited a significant negative effect on dengue transmission(P=0.02). The IOD exhibited a synchronized pattern with dengue outbreak from 2010 to 2012. The ENSO effect(NINO 3.4 index) might have played a more important role after 2012. Conclusions: This study provides preliminary results of climate influences on dengue transmission in the Lahore District of Pakistan. An increasing dengue transmission risk accompanied by frequent climate changes should be noted. Integrating the influences of climate variability into disease prevention strategies should be considered by public health authorities.

关键词： Dengue Fever Pakistan Climate IOD NINO 3.4

Mucosal patterns of Helicobacter pylori-related gastritis without atrophy in the gastric corpus using standard endoscopy

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World Journal of Gastroenterology 2010年第4期16卷 496-500页

作者： Shwu-Tzy Wu chien-Hua Chen yeh-Huang Hung Tsung-Hsun Yang Vun-Siew Pang Yung-Hsiang yeh Department and Graduate Program of Bioindustrial Technology Dayeh UniversityChanghua County 51591TaiwanChina Division of Gastroenterology Department of Internal MedicineShow-Chwan Memorial HospitalChanghuaCity 500TaiwanChina Division of Gastroenterology Department of Internal MedicineChang Bing Show-Chwan Memorial HospitalChanghua County 505TaiwanChina

AIM:To identify the mucosal patterns of Helicobacter pylori(*** )-related gastritis in the gastric corpus using standard endoscopy and to evaluate their ***:A total of 112 consecutive patients underwent upper gastrointestinal *** endoscopists classified the endoscopic findings into 4 *** the second part of the study,90 images were shown to 3 endoscopists in order to evaluate the inter-observer and intra-observer variability in image ***:The mucosal patterns of the gastric bodywere categorized into 4 *** 1 pattern was defined as cleft-like appearance,type 2 as regular arrangement of red dots,type 3 pattern as the mosaic mucosal pattern and type 4 pattern as the mosaic pattern with a focal area of *** 1 and type 2 mucosal patterns were statistically significant in predicting *** status as compared with other mucosal types(χ 2 = 12.79 and 61.25 respectively,P < 0.01).Type 3 and type 4 mucosal patterns were statistically significant in predicting a ***-positive status as compared with other mucosal types(χ 2 = 21.22 and 11.02 respectively,P < 0.01).Furthermore,the sensitivity,specificity,positive and negative predictive values of type 3 plus type 4 patterns for predicting ***-positive gastric mucosa were 100%,86%,94%,and 100%,*** mean κ values for inter-and intra-observer agreement in assessing the various endoscopic patterns were 0.808(95% CI,0.678-0.938) and 0.826(95% CI,0.727-0.925) ***:Our study suggests that mucosal patterns in ***-infected gastric mucosa without atrophy can be reliably identified using standard endoscopy in the gastric corpus.

关键词： Gastric mucosa Helicobacter pylori Gastritis Digestive system diagnostic techniques Endoscopy

Dynamic Gain-Clamped Amplifier with Backward-Injection of a Fabry-Perot Laser

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光学学报 2003年第S1期23卷 499-500页

作者： chien-Hung yeh Chih-Yang Chen chien-Chung Lee Sien Chi Institute of Electro-Optical Engineering Chiao-Tung University 1001 Ta Hsueh Road Hsinchu Taiwan 300

We have been experimentally demonstrated an active control technique of dynamic gain-clamped spectra for theerbium-doped fiber amplifiers (EDFA's) by a backward-injected Fabry-Perot (F-P) laser into this EDFA. In addition, employing a short length erbium-doped fiber (EDF) that not cause any gain saturation for preamplification in front of this amplifier module, it can reduce the noise figure degradation and simultaneously achieve gain variation from 11.1 dB to 0.5 dB for 10 dB input power level change.

关键词： control technique fiber amplifiers noise figure input power