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用相差显微鏡观察白細胞完全吞噬作用的研究 Ⅱ.在“鏡下换液培养室”中兔白細胞对金黃色葡萄球菌的吞噬作用及其后果

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微生物学报 1965年第1期 52-56页

作者：李文簡沈惠仙齐齐哈尔医学院

研究细胞免疫时,解决完全吞噬的研究方法是一个重要问题。在我们前一篇实验报告中曾报导了用相差显微镜研究完全吞噬,为进一步解决细胞外细菌繁殖对细胞的影响、标本中营养及pH的维持问题,和进一步确定被吞噬的细菌在细胞内的归宿等问题... 详细信息

研究细胞免疫时,解决完全吞噬的研究方法是一个重要问题。在我们前一篇实验报告中曾报导了用相差显微镜研究完全吞噬,为进一步解决细胞外细菌繁殖对细胞的影响、标本中营养及pH的维持问题,和进一步确定被吞噬的细菌在细胞内的归宿等问题,我们设计了一种能在镜下更换营养液的培养室。并通过镜下培养、染色、白细胞电休克等措施,研究了兔白细胞对金黄色葡萄球菌的完全吞噬。现将所得结果报导如下:

关键词：吞噬作用完全吞噬噬菌作用葡萄球菌培养室

Cerebral fat embolism following autologous fat injection in facial reconstruction:A case report

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World Journal of Clinical Cases 2025年第2期13卷 50-58页

作者： Xiu-Ying Chen Fa shen Chang Cheng Yu-Han Wang wen-Chao Cheng De-Zhi Yuan wen Huang Department of Neurology Chongqing Emergency Medical CenterChongqing University Central HospitalChongqing 400000China Department of Neurology Xinqiao HospitalThe Army Medical University(Third Military Medical University)Chongqing 400000China

BACKGROUND Autologous fat injection in facial reconstruction is a common cosmetic *** cerebral fat embolism(CFE)as a complication is rare,it carries serious health *** SUMMARY We present a case of a 29-year-old female patient who developed acute CFE following facial fat filling *** the surgery,the patient experienced symptoms including headache,nausea,vomiting,and difficulty breathing,which was followed by neurological symptoms such as slurred speech and left-sided *** physical examination and auxiliary investigations,including blood tests,head and neck computed tomography angiography,and cranial magnetic resonance diffusion-weighted imaging,were performed upon *** clinical diagnosis was acute cerebral embolism following facial fat filling *** included measures to improve cerebral circulation,dehydration for intracranial pressure reduction,nutritional support,and rehabilitation therapy for left limb *** patient showed a significant improvement in symptoms after 2 weeks of *** recovered left limb muscle strength to grade 5,had clear speech,and experienced complete relief of *** Our case highlights the potential occurrence of severe complications in patients undergoing fat injection in facial *** prevent these complications,plastic surgeons should enhance their professional knowledge and skills.

关键词： Cerebral fat embolism Mechanical thrombectomy Thrombolysis Steroid therapy Symptomatic treatment Case report

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轨道系统地下场站消防安全设计之探讨

隧道建设 2007年第S2期27卷 224-228页

作者：简贤文林庆元沈子胜许文胜李婉菁吴贯远中央警察大学消防学系台湾科技大学建筑学系行政院原子能委员会核能研究所

轨道运输系统地下场站之消防安全长久为岛内外所重视之公共安全,本文藉由探讨轨道运输系统地下场站之火灾特性与境况分析,分析地下场站可能火灾情景,并针对台湾现行轨道运输系统之消防安全设计适用「各类场所消防安全设备设置标准」实... 详细信息

轨道运输系统地下场站之消防安全长久为岛内外所重视之公共安全,本文藉由探讨轨道运输系统地下场站之火灾特性与境况分析,分析地下场站可能火灾情景,并针对台湾现行轨道运输系统之消防安全设计适用「各类场所消防安全设备设置标准」实务问题,参酌美国国家防火协会NFPA 130 Standard for Fixed Guideway Transit and Passenger Rail Systems、欧盟UNECE隧道规章、日本地下铁相关标准等,提出建议与对策;另依据「各类场所消防安全设备设置标准」为基础,以铁路地下场站及隧道为主要对象,拟定「铁路隧道及地下场站防火避难设施及消防安全设备设置标准(规范)」条文草案。该草案已由灾害防救委员会所推行之「公共安全管理白皮书」执行项目进行列管,刻正进入立法程序,为台湾地区之轨道运输系统地下场站提供专用、适当之法规依循。

关键词：轨道运输系统地下场站隧道消防安全设备特种建筑物

On Three Differential Equations Associated with Chebyshev Polynomials of Degrees 3,4 and 6

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Acta Mathematica Sinica,English Series 2017年第1期33卷 21-36页

作者： Li chien shen Department of Mathematics University of Florida Gainesville FL 32611-8105

We shall study the differential equation y^l2=Tn（y）-（1-2μ2）;where μ2 is a constant, Tn（x） are the Chebyshev polynomials with n = 3,4,6. The solutions of the differential equations will be expressed explicitly in terms of the Weierstrass elliptic function which can be used to construct theories of elliptic functions based on 2F1 （1/4, 3/4; 1; z）, 2F1 （l/3, 2/3; 1; z）, 2F1 （1/6, 5/6; 1; z） and provide a unified approach to a set of identities of Rmanujan involving these hypergeometric functions.

关键词： Chebyshev polynomials Eisenstein series Jacobi theta functions Weierstrass ellipticfunction

On Schwarzian Triangle Functions, Automorphic Forms and a Generalization of Ramanujan’s Triple Differential Equations

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Acta Mathematica Sinica,English Series 2018年第11期34卷 1648-1662页

作者： Li chien shen Department of Mathematics University of Florida

Let G be the group of the fractional linear transformations generated by T（τ）=τ ＋ λ, S（τ）=（τ cos π/n ＋ sin π/n）/（-τ sin π/n ＋ cos π/n）;where λ=2（cos π/m ＋ cos π/n）/sin π/n;m, n is a pair of integers with either n ≥ 2, m ≥ 3 or n ≥ 3, m ≥ 2; τ lies in the upper half plane H.A fundamental set of functions f0, fi and f∞ automorphic with respect to G will be constructed from the conformal mapping of the fundamental domain of G. We derive an analogue of Ramanujan＇s triple differential equations associated with the group G and establish the connection of f0, fi and f∞ with a family of hypergeometric functions.

关键词： Hypergeometric function Schwarzian triangle function Jacobi theta functions Ramanu-jan's triple differential equations

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru shen Zheng Song Dinggang Fan Bing Hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

Investigation of bubbles escape behavior from low basicity mold flux for high-Mn high-Al steels using 3D X-ray microscope

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 102-110页

作者： Qiang Liu Xiang Li shen Du Ming Gao Yanbin Yin Jiongming Zhang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

During the continuous casting process of high-Mn high-Al steels,various types of gases such as Ar need to escape through the top of the *** which,the behavior of bubbles traversing the liquid slag serves as a restrictive link,closely associated with viscosity and the thickness of liquid *** contrast to two-dimensional surface observation,three-dimensional(3D)analysis method can offer a more intuitive,accurate,and comprehensive ***,this study employs a 3D X-ray microscope(3D-XRM)to obtained spatial distribution and 3D morphological characteristics of residual bubbles in mold flux under different basicity of liquid slag,different temperatures,and different holding *** results indicate that as basicity of slag increases from 0.52 to 1.03,temperature increases from 1423 to 1573 K,the viscosity of slag decreases,the floating rate of bubbles *** addition,when holding time increases from 10 to 30 s,the bubbles floating distance increases,and the volume fraction and average equivalent sphere diameter of the bubbles solidified in the mold flux gradually *** one word,increasing the basicity,temperature,and holding time leading to an increase in the removal rate of bubbles especially for the *** findings of bubbles escape behavior provide valuable insights into optimizing low basicity mold flux for high-Mn high-Al steels.

关键词： mold flux low basicity bubbles three-dimensional X-ray microscope viscosity

Coagulation indices and fibrinogen degradation products as predictive biomarkers for tumor-node-metastasis staging and metastasis in gastric cancer

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 110-120页

作者： Yi-Qing shen Qiu-Wan Wei Yi-Ren Tian Yun-Zhi Ling Min Zhang Clinical Laboratory Civil Aviation Shanghai HospitalGubei Branch of Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200000China Clinical Laboratory Tongji Hospital of Tongji UniversityShanghai 200000China

BACKGROUND Gastric cancer(GC)is a prevalent malignancy with a substantial health burden and high mortality rate,despite advances in prevention,early detection,and *** with the global average,Asia,notably China,reports disproportionately high GC *** disease often progresses asymptoma-tically in the early stages,leading to delayed diagnosis and compromised ***,it is crucial to identify early diagnostic biomarkers and enhance treatment strategies to improve patient outcomes and reduce *** Retrospectively analyzed the clinical data of 148 patients with GC treated at the Civil Aviation Shanghai Hospital between December 2022 and December *** associations of coagulation indices-partial thromboplastin time(APTT),prothrombin time(PT),thrombin time(TT),fibrinogen,fibrinogen degradation products(FDP),fasting blood glucose,and D-dimer(D-D)with TNM stage and distant metastasis were *** Prolongation of APTT,PT,and TT was significantly correlated with the GC TNM ***,abnormal coagulation system activation was closely related to disease *** FDP and D-D were significantly associated with distant metastasis in GC(P<0.05),suggesting that increased fibrinolytic activity contributes to increased metastatic *** Our Results reveal coagulation indices,FDPs as GC biomarkers,reflecting abnormal coagulation/fibrinolysis,aiding disease progression,metastasis prediction,and helping clinicians assess thrombotic risk for early intervention and personalized treatment plans.

关键词： Coagulation indexes Fibrinogen degradation products Gastric cancer Tumor-node-metastasis staging Distant metastasis

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen Gu Hua Yan Dingding shen Xiaosong Gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated Hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction