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Numerical analysis of pile–slope stability and the soil arching around two adjacent piles

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Journal of Mountain Science 2022年第11期19卷 3270-3285页

作者： chien-yuan chen Chun-Kai CHANG Yu-Shan LIN Department of Civil and Water Resources Engineering National Chiayi UniversityChiayi City 60004Chinese Taipei

Seismic pile–slope stability analysis and the formation mechanism of soil arching have not been well studied. This study used a threedimensional(3D) finite difference to determine soil and pile parameter changes in the static and seismic stability of the pile–slope caused by the interaction between stabilizing piles. Pile–slope stability analysis was performed to determine the optimal design of piles along a slope and the corresponding failure mode involving the formation of soil arching around two adjacent piles. The Factor of Safety(FS) of the slope was evaluated using the shear strength reduction method for static and seismic analyses. The results of the analysis show that suitable pile spacing(S) and a suitable pile diameter(D) in the middle of a slope result in the maximum FS for the pile–slope system and the formation of soil arching around two adjacent piles. FS of the pile–slope increased negligibly in the seismic analysis of piles located at the slope crest and toe. An optimized pile diameter and installation location afforded the maximum FS for the slope that corresponded to a specified slope failure mode for different pile locations. A pile spacing S ≤ 2.5D for piles installed in the middle of the slope is suggested for increasing the static and seismic pile–slope stability.

关键词： Numerical modeling Slope stability Stabilizing pile Arching effect Seismic analysis Failure mode

GIS-based Evaluation on the Fault Motion-Induced Coseismic Landslides

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Journal of Mountain Science 2012年第5期9卷 601-612页

作者： Ming-Wey HUANG chien-yuan chen Tzu-Hsiu WU Chi-Ling CHANG Sheu-Yien LIU Ching-Yun KAO Taiwan Science & Technology Center for Disaster Reduction Sindian City Taipei County 231 Chinese Taipei Taiwan Chiayi University Department of Civil & Water Resources Engineering Chiayi City 60004 Chinese Taipei Chia Nan University of Pharmacy and Science Institute of Industrial Safety & Disaster Prevention Tainan City 71710 Chinese Taipei

Earthquake-induced potential landslides are commonly estimated using landslide susceptibility maps. Nevertheless, the fault location is not identified and the ground motion caused by it is unavailable in the map. Thus, potential coseismic landslides for a specific fault motion-induced earthquake could not be predicted using the map. It is meaningful to incorporate the fault location and ground motion characteristics into the landslide predication model. A new method for a specific fault motion-induced coseismic landslide prediction model using GIS （Geographic Information System） is proposed herein. Location of mountain ridges, slope gradients over 45~, PVGA （Peak Vertical Ground Accelerations） exceeded o.15 g, and PHGA （Peak Horizontal Ground Accelerations） exceeded o.25 g of slope units were representing locations that initiated landslides during the 1999 Chi-Chi earthquake in Taiwan. These coseismic landslide characteristics were used to identify areas where landslides occurred during Meishan fault motion-induced strong ground motions in Chiayi County in Taiwan. The strong ground motion （over 8 Gal in the database, 1 Gal = 0.0l m/s2, and 1 g = 981 GaD characteristics were evaluated by the fault length, site distance to the fault, and topography, and their attenuation relations are presented in GIS. The results of the analysis show that coseismic landslide areas could be identified promptly using GIS. The earthquake intensity and focus depthhave visible effects on ground motion. The shallower the focus depth, the larger the magnitude increase of the landslides. The GIS-based landslide predication method is valuable combining the geomorphic characteristics and ground motion attenuation relationships for a potential region landslide hazard assessment and in disaster mitigation planning.

关键词： Coseismic landslide GIS Chi-Chiearthquake

Toward Artificial Peptide Nanocapsules

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Nano-Micro Letters 2024年第10期16卷 240-243页

作者： yuan Wang Bing chen Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023People's Republic of China

HIGHLIGHTS The formation of peptide nanocapsules is facilitated by a gradient interface,where the differential solvent concentration drives the peptides to preferentially localize and *** peptide nanocapsules,characterized by their hollow structures,demonstrated potential as carriers for targeted drug delivery.1 Introduction Peptide nanocapsules are a type of nanoscale delivery system that encapsulates active substances within a shell composed of peptides,leveraging the unique properties of peptides such as biocompatibility and biodegradability[1].Historically,the development of peptide nanocapsules was inspired primordially by the natural biological processes.

关键词： Peptide nanocapsules Self-assembly Drug delivery Nanomedicine

When mRNA meets gene editing

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Nano Research 2024年第8期17卷 7337-7356页

作者： Weijie Li chen Wang yuan Lu Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China

The critical challenge of gene therapy lies in delivering gene editing *** with DNA,while RNA is less stable and more accessible to degrade,it comes with the benefit of lower off-target effects since permanent insertion is not *** review focuses on mRNA-based delivery of gene editing agents,highlighting novel mRNA delivery *** provide context,a comparison is made between three main gene editing agents:programmable nucleases,base editors,and prime *** potential of Cas\pi and transposons is also discussed in this ***,a summary of four main barriers to mRNAbased in vivo delivery is ***,this review detailedly introduced different delivery systems,both viral(lentivirus)and non-viral vectors(genome editing via oviductal nucleic acids delivery,lipid nanoparticles,polymer-based nanoparticles,viruslike-particles,extracellular vesicles,and migrasome).Each delivery strategy is assessed by comparing its advantages and disadvantages to offer a comprehensive and objective overview of the delivery ***,we emphasized the vital role of the protein corona as a critical regulator for ***,we concluded the challenges of mRNA-based gene editing strategies(RNA stability,targeting,potential immunogenicity,cytotoxicity,heterogeneity,and rational design).The purpose of this review is to guide further research and provide a comprehensive analysis of mRNA-based in vivo delivery of gene editing agents in this promising field.

关键词： gene editing mRNA delivery viral vectors non-viral vectors CRISPR

SDGNN: Symmetry-Preserving Dual-Stream Graph Neural Networks

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1717-1719页

作者： Jiufang chen Ye yuan Xin Luo the College of Computer Science and Technology Chongqing University of Posts and TelecommunicationsChongqing 400065 the Chongqing Key Laboratory of Big Data and Intelligent Computing Chongqing Institute of Green and Intelligent TechnologyChinese Academy of SciencesChongqing 400714China the College of Computer and Information Science Southwest UniversityChongqing 400715China IEEE

Dear Editor,This letter proposes a symmetry-preserving dual-stream graph neural network(SDGNN) for precise representation learning to an undirected weighted graph(UWG). Although existing graph neural networks(GNNs) are influential instruments for representation learning to a UWG, they invariably adopt a unique node feature matrix for illustrating the sole node set of a UWG.

关键词： representation preserving undirected

Formation of the Tibetan Plateau during the India-Eurasia Convergence:Insight from 3-D Multi-Terrane Thermomechanical Modeling

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Journal of Earth Science 2024年第1期35卷 112-130页

作者： Jile chen Peimin Zhu Yuefeng yuan Guifan chen School of Geophysics and Geomatics China University of GeosciencesWuhan 430074China Geothermal Engineering Research Center Three Gorges Geotechnical Consultants Co.Ltd.Wuhan 430074China

Various models exist to explain the formation of the Tibetan Plateau,including“tectonic escape”,“pure shear thickening”,“convective removal of the lithospheric mantle”,and“lower crustal flow”*** first two models are primarily constructed on pure mechanical models but are unable to reasonably explain the tension and shear phenomena inside the *** latter two are rheological dynamic models based on deep geophysical ***,the spatial range of the lower crustal flow and its role in the plateau formation/uplift remain *** multi-terrane viscoplastic thermomechanical models were constructed to simulate the uplift and lithospheric structure change of the Tibetan Plateau during the post-collision stage(since 35 Ma)under the convergence of the Indian *** show that the plateau's formation begins with crustal thickening,blocked by strong terranes at the northern plateau,and expanded laterally to the *** lithosphere thickens gradually and experiences delamination at its base,elevating temperature within the crust and forming partial melting layers in the central *** convergence persists on the southern side,the northern plateau's lithosphere bends downward and undergoes delamination,further heating the crust and promoting the northward and eastward flow of partial melting layers,leading to secondary uplift around the plateau.

关键词： 3-D thermomechanical modeling Tibetan Plateau plateau uplift crustal flow

Research on Credit Regulation Mechanism of E-commerce Platform Based on Evolutionary Game Theory

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Journal of Systems Science and Systems Engineering 2024年第3期33卷 330-359页

作者： Zeguo Qiu Yuchen Yin Yao yuan Yunhao chen School of Computer and Information Engineering Harbin University of CommerceHarbin150028China School of Management Harbin University of CommerceHarbin150028China

In the growing e-commerce industry,the problem of malicious business operations has become increasingly prominent,exposing many problems such as weak supervision of e-commerce platforms and no way for consumers to *** order to solve the problems of counterfeit and shoddy products on e-commerce platforms and promote the sustainable development of the e-commerce industry in China,this paper constructs a three-party evolutionary game model of e-commerce platforms,merchants,and consumers,investigates the influence of each influencing factor on each party’s strategy choice,and provides targeted suggestions to e-commerce platforms based on relevant ***,the impact of several important parameters on the equilibrium solution is discussed through sensitivity *** results show that:1)the smaller the cost difference between active and negative regulation,the more the e-commerce platform tends to active regulation strategy,but increasing fines for dishonest merchants and consumer complaints have little impact on the e-commerce platform;2)increasing consumer compensation,creating an honest business environment,and reducing the cost of honest business all help companies tend to operate in good faith;3)the only factor that affects the tendency of consumer complaint strategies is the cost of *** loss suffered by silence and the compensation given to consumers have little effect on consumers’tendency to complain *** results can provide theoretical guidance for participants to make useful strategic decisions in the e-commerce market.

关键词： Evolutionary game e-commerce data simulation

Rotor cross-tilt optimization for yaw control improvement of multi-rotor eVTOL aircraft

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Chinese Journal of Aeronautics 2024年第3期37卷 153-167页

作者： Xufei YAN Ye yuan Yanqin ZHAO Renliang chen Zhejiang Lab Hangzhou 311100China Department of Aerospace Engineering Swansea UniversitySwanseaWales SA28PPUK National Key Laboratory of Rotorcraft Aeromechanics Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Manned multi-rotor electric Vertical Takeoff and Landing(eVTOL)aircraft is prone to actuator saturation due to its weak yaw control *** address this inherent problem,a rotor cross-tilt configuration is applied in this paper,with an optimization method proposed to improve the overall control efficiency of the ***,a flight dynamics model of a 500-kg manned multi-rotor eVTOL aircraft is *** accuracy of the co-axial rotor model is verified using a single arm test bench,and the accuracy of the flight dynamics model is verified by the flight test ***,an optimization method is designed based on the flight dynamics model to calculate an optimal rotor cross-tilt mounting angle,which not only improves the yaw control efficiency,but also basically maintains the efficiency of other control *** ideal rotor cross-tilt mounting angle for the prototype is determined by comprehensively considering the optimal results with different payloads,forward flight speeds,and rotor mounting angle ***,the feasibility of the rotor cross-tilt mounting angle is proved by analyzing the control derivatives of the flight dynamics model,the test data of a ground three Degree-of-Freedom(3DOF)platform,and the actual flight data of the *** results show that a fixed rotor cross-tilt mounting angle can achieve ideal yaw control effectiveness,improving yaw angle tracking and hold ability,increasing endurance time,and achieving good yaw control performance with different payloads and forward speeds.

关键词： Multi-rotor eVTOL Control efficiency Flight dynamics model Cross-tilt optimization Endurance time

Evidence-Based Dampness-Heat ZHENG(Syndrome) in Cancer: Current Progress toward Establishing Relevant Animal Model with Pancreatic Tumor

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Chinese Journal of Integrative Medicine 2024年第1期30卷 85-95页

作者： JIAO Ju-ying chenG chien-shan CAO Zhang-qi chen Lian-yu chen Zhen Department of Integrative Oncology Fudan University Shanghai Cancer CenterShanghai(200032)China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai(200032)China

Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. Chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and ZHENG(syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat ZHENG(DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized ZHENG-based cancer animal model.

关键词： cancer Chinese medicine syndrome ZHENG dampness-heat syndrome animal model pancreatic tumor evaluation methods