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New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis Ma Krystyna Rytel Yu chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

Energizing Yiwu with Language Learning Yiwu businesswomen are picking up more English as business booms

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China Report ASEAN 2024年第7期9卷 50-52页

作者： chen Ke 不详

Recently,a video of a businesswoman in Yiwu practicing English received impressive views and *** echoed sentiments like,“Yiwu businesswomen are so dedicated,”and“They are either making money or studying to make mon... 详细信息

关键词： money business women

Analysis of Hospital Budget Management Control Based on Smart Hospital

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Journal of Clinical and Nursing Research 2024年第5期8卷 169-173页

作者： Yuqi chen Changzhou Wujin People’s Hospital Changzhou Eighth People’s HospitalChangzhou 213000China

Hospitals are crucial healthcare facilities where patients seek treatment,and effective budget management within hospitals significantly impacts their operational efficiency and financial *** the age of information technology and advanced healthcare solutions,the emergence of smart hospitals represents a new trend in the medical industry’s *** modern information technology can enhance the development of hospital IT systems and drive budget management toward greater *** paper begins by analyzing the influence of smart hospitals on hospital budget *** then examines the current state of budget management control within smart ***,it proposes several strategies for budget management control in smart hospitals,aiming to provide guidance for relevant stakeholders.

关键词： Smart hospital Hospital management Budget management Financial control Control strategies

Analysis of Influencing Factors of Work Motivation of Government Employees Based on MaxDiff Model:Evidence from Jiangmen City

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Proceedings of Business and Economic Studies 2024年第4期7卷 226-230页

作者： Weijie chen School of Economics and Management Guangxi Normal UniversityGuilin 541006Guangxi Zhuang Autonomous RegionChina

The purpose of this paper is to use the MaxDiff model to explore the factors influencing the work motivation of staff in certain government agencies in Jiangmen City,and to conduct relevant empirical *** study aims to propose strategies for improving work motivation among these staff *** results indicate that the most significant factors affecting the work motivation of staff in Jiangmen government agencies are salary and remuneration,additional welfare benefits,and the power to make decisions about their own *** contrast,factors such as a sense of belonging to the work unit,recognition of their work,and job security are less ***,it is recommended that government agencies in Jiangmen City increase the salaries and benefits of their staff and provide them with more decision-making *** approach will stimulate their desire to work,enhance their motivation,improve the efficiency of government agencies,and elevate the level of public ***,these measures will support the construction of a harmonious,stable,and orderly society.

关键词： Government agency workers Job motivation MaxDiff model

Intensive care unit-acquired weakness: Recent insights

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Journal of Intensive Medicine 2024年第1期4卷 73-80页

作者： Juan chen Man Huang Department of General Intensive Care Unit The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009ZhejiangChina

Intensive care unit-acquired weakness(ICU-AW)is a common complication in critically ill patients and is associated with a variety of adverse *** include the need for prolonged mechanical ventilation and ICU stay;higher ICU,in-hospital,and 1-year mortality;and increased in-hospital ***-AW is associated with multiple risk factors including age,underlying disease,severity of illness,organ failure,sepsis,immobilization,receipt of mechanical ventilation,and other factors related to critical *** pathological mechanism of ICUAW remains unclear and may be considerably *** review aimed to evaluate recent insights into ICU-AW from several aspects including risk factors,pathophysiology,diagnosis,and treatment strategies;this provides new perspectives for future research.

关键词： Intensive care unit-acquired weakness Muscle weakness Muscle atrophy Risk factor Mechanism Treatment

Polygonatum sibiricum polysaccharides attenuated colitis via regulating gut microbiota mediated colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway

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Food Science and Human Wellness 2024年

作者： Zhong-Yu Yuan Xin-Yu Wang Jun Wang Yuan Xu Jing chen Shu-Qi Yu Zhi-Ming chen Pei-Lu chen Ji-Xiao Zhu Wei-Feng Huang Guang-Hui Xu Li-Tao Yi Department of Chemical and Pharmaceutical Engineering， College of Chemical Engineering， Huaqiao University Xiamen Medicine Research Institute Research Center of Traditional Chinese Medicine Resources and Ethnic Medicine， Jiangxi University of Chinese Medicine Department of Gastroenterology and Hepatology， The First Affiliated Hospital of Xiamen University， Xiamen University Institute of Pharmaceutical Engineering， Huaqiao University Fujian Provincial Key Laboratory of Biochemical Technology， Huaqiao University

Polygonatum sibiricum has long been a popular functional food in Asia， known for its anti-inflammatory properties. However， its efficacy in alleviating colitis has yet to be investigated. This study aimed to explore the therapeutic potential of Polygonatum sibiricum polysaccharides (PSP) in dextran sulfate sodium (DSS)-induced colitis， focusing on the related pyroptosis mechanisms. Scanning electron microscopy (SEM) analysis showed that PSP possesses a smooth surface with no pore structure and a dense， lamellar structure adorned with numerous spherical entities. PSP treatment significantly reduced colitis symptoms and decreased pro-inflammatory cytokines， likely through suppression of the TLR4/NF-κB signaling pathway. Additionally， PSP attenuated NLRP3/ASC/Caspase-1/GSDMD-mediated pyroptosis and mitochondria damage in the colon， while enhanced the expression of tight junction and adherens junction proteins. Microbiota sequencing showed that PSP increased the abundance of phylum Bacteroidota and genus such as Muribaculaceae， Lactobacillus， Clostridia， and Lachnospiraceae， while decreased the phylum Proteobacteria and the genus Enterobacter， Escherichia-Shigella， and Blautia. In conclusion， this study demonstrates that PSP exerts the potential therapeutic role against colitis， which was mediated by the regulation of gut microbiota and the inhibition of colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway.

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Effect of exogenous free N^(ε)-(carboxymethyl)lysine on diabetes-associated cognitive dysfunction:neuroinflammation,and metabolic disorders

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Food Science and Human Wellness 2024年第5期13卷 2970-2981页

作者： Huang Zhang Lan Mo Xi chen Mei Li Maiquan Li Yang Xu Maomao Zeng Zhiyong He Qingwu Shen Jie chen Wei Quan College of Food Science and Technology Hunan Agricultural UniversityChangsha 410128China Henan University of Animal Husbandry and Economy Zhengzhou 450046China College of Food Science and Engineering Northwest A&F UniversityYangling 712100China State Key Laboratory of Food Science and Technology Jiangnan UniversityWuxi 214122China

Diabetes-associated cognitive dysfunction has already been attracted considerable *** glycation end products(AGEs)from daily diets are thought to be a vital contributor to the development of this ***,the effect of one of the best-characterized exogenous AGEs N^(ε)-(carboxymethyl)lysine(CML)on cognitive function is not fully *** the present study,diabetical Goto-Kakizaki(GK)rats were treated with free CML for *** was found that oral consumption of exogenous CML significantly aggravated diabetes-associated cognitive dysfunction in behavioral *** details,exogenous CML increased levels of oxidative stress,promoted the activation of glial cells in the brain,up-regulated the release of inflammatory cytokines interleukin-6,inhibited the protein expression of the brain-derived neurotrophic factor and thus led to ***,exogenous CML promoted the amyloidogenesis in the brain of GK rats,and inhibited the expression of ***,several tricarboxylic acid cycle and glutamate-glutamine/γ-aminobutyric acid cycle intermediates including pyruvate,succinic acid,glutamine,glutamate were significantly changed in brain of GK rats treated with exogenous free *** conclusion,exogenous free CML is a potentially noxious compounds led to aggravated diabetes-associated cognitive dysfunction which could be possibly explained by its effects on neuroinflammation,energy and neurotransmitter amino acid homeostasis.

关键词： Diabetes Cognitive dysfunction N^(ε)-(carboxymethyl)lysine Neuroinflammation Metabolomic

Effect of strain on structure and electronic properties of monolayer C_(4)N_(4)

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Chinese Physics B 2024年第5期33卷 595-600页

作者：陈昊徐瑛赵家石周丹 School of Physics Changchun University of Science and TechnologyChangchun 130022China School of Computer Science and Technology Changchun University of Science and TechnologyChangchun 130022China

The first-principles calculations are performed to examine structural,mechanical,and electronic properties at large strain for a monolayer C_(4)N_(4),which has been predicted as an anchoring promising material to attenuate shuttle effect in Li–S batteries stemming from its large absorption energy and low diffusion energy *** results show that the ideal strengths of C_(4)N_(4)under tension and pure shear deformation conditions reach 13.9 GPa and 12.5 GPa when the strains are 0.07 and 0.28,*** folded five-membered rings and diverse bonding modes between carbon and nitrogen atoms enhance the ability to resist plastic deformation of C_(4)N_(4).The orderly bond-rearranging behaviors under the weak tensile loading path along the[100]direction cause the impressive semiconductor–metal transition and inverse semiconductor–metal *** present results enrich the knowledge of the structure and electronic properties of C_(4)N_(4)under deformations and shed light on exploring other two-dimensional materials under diverse loading conditions.

关键词： two-dimensional materials strain effect structural evolution electronic properties

Tai Chi Master Class in Sweden

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China & The World Cultural Exchange 2024年第6期 14-15页

作者： chen Juan 不详

As a carrier of traditional Chinese culture,the spread of Tai Chi has far-reaching significance,which can not only spread the elements of traditional Chinese culture to people all over the world to strengthen the international dissemination and exchange of Chinese culture,but also promote the harmonious coexistence and common development of different cultures.

关键词： culture has Tai