检索结果-南通市图书馆

Angiosperm-wide analysis of fruit and ovary evolution aided by a new nuclear phylogeny supports association of the same ovary type with both dry and fleshy fruits

引用

Journal of Integrative Plant Biology 2024年第2期66卷 228-251页

作者： Yezi Xiang Taikui Zhang Yiyong Zhao Hongjin Dong Hongyi Chen Yi Hu chien-hsun huang Jun Xiang Hong Ma State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Biodiversity and Ecological EngineeringInstitute of Plant BiologyCenter of Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200438China Department of Biology Howard Hughes Medical InstituteDuke UniversityDurhamNC 27708USA Department of Biology the Eberly College of Scienceand the Huck Institutes of the Life Sciencesthe Pennsylvania State UniversityUniversity ParkPA 16802USA Hubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization College of Biology and Agricultural ResourcesHuanggang Normal UniversityHuanggang 438000China

Fruit functions in seed protection and dispersal and belongs to many dry and fleshy types,yet their evolutionary pattern remains unclear in part due to uncertainties in the phylogenetic relationships among several orders and *** we used nuclear genes of 502 angiosperm species representing 231 families to reconstruct a well supported phylogeny,with resolved relationships for orders and families with previously uncertain *** this phylogeny as a framework,molecular dating supports a Triassic origin of the crown angiosperms,followed by the emergence of most orders in the Jurassic and Cretaceous and their rise to ecological dominance during the Cretaceous Terrestrial *** robust phylogeny allowed an examination of the evolutionary pattern of fruit and ovary types,revealing a trend of parallel carpel fusions during early diversifications in eudicots,monocots,and ***,taxa in the same order or family with the same ovary type can develop either dry or fleshy fruits with strong correlations between specific types of dry and fleshy fruits;such associations of ovary,dry and fleshy fruits define several ovaryfruit"modules"each found in multiple *** of the frequent modules has an ovary containing multiple ovules,capsules and berries,and another with an ovary having one or two ovules,achenes(or other single-seeded dry fruits)and *** new perspective of relationships among fruit types highlights the closeness of specific dry and fleshy fruit types,such as capsule and berry,that develop from the same ovary type and belong to the same module relative to dry and fleshy fruits of other modules(such as achenes and drupes).Further analyses of gene families containing known genes for ovary and fruit development identified phylogenetic nodes with multiple gene duplications,supporting a possible role of whole-genome duplications,in combination with climate changes and animal behaviors,in angiosperm fruit and ovary diversificat

关键词： angiosperm fruit evolution MADS-box molecular clock nuclear phylogeny ovary and fruit developmental genes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A well-supported nuclear phylogeny of Poaceae and implications for the evolution of C4 photosynthesis

引用

Molecular Plant 2022年第4期15卷 755-777页

作者： Weichen huang Lin Zhang JTravis Columbus Yi Hu Yiyong Zhao Lin Tang Zhenhua Guo Wenli Chen Michael McKain Madelaine Bartlett chien-hsun huang De-Zhu Li Song Ge Hong Ma Department of Biology 510 Mueller LaboratoryHuck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkState CollegePA 16802USA Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering and State Key Laboratory of Genetic Engineering Institute of Biodiversity Sciences and Institute of Plant BiologySchool of Life SciencesFudan University2005 Songhu RoadShanghai 200438China Rancho Santa Ana Botanic Garden and Claremont Graduate University 1500 North College AvenueClaremontCA 91711USA College of Life Sciences Zhejiang UniversityHangzhouZhejiang 310058China Plant Germplasm and Genomics Center Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201 China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of SciencesBeijing 100093China Department of Biological Sciences University of Alabama411 Mary Harmon Bryant HallTuscaloosaAL 35487USA Biology Department University of Massachusetts Amherst611 North Pleasant Street221 Morrill 3AmherstMA 01003 USA

Poaceae(the grasses)includes rice,maize,wheat,and other crops,and is the most economically important angiosperm *** is also one of the largest plant families,consisting of over 11000 species with a global distribution that contributes to diverse *** species are classified into 12 subfamilies,with generally strong phylogenetic support for their ***,many relationships within subfamilies,among tribes and/or subtribes,remain *** better resolve the Poaceae phylogeny,we generated 342 transcriptomic and seven genomic datasets;these were combined with other genomic and transcriptomic datasets to provide sequences for 357 Poaceae species in 231 genera,representing 45 tribes and all 12 *** 1200 low-copy nuclear genes were retrieved from these datasets,with several subsets obtained using additional criteria,and used for coalescent analyses to reconstruct a Poaceae *** results strongly support the monophyly of 11 subfamilies;however,the subfamily Puelioideae was separated into two non-sister clades,one for each of the two previously defined tribes,supporting a hypothesis that places each tribe in a separate *** clock analyses estimated the crown age of Poaceae to be101 million years *** character reconstruction of C3/C4 photosynthesis supports the hypothesis of multiple independent origins of C4 *** origins are further supported by phylogenetic analysis of the ppc gene family that encodes the phosphoenolpyruvate carboxylase,which suggests that members of three paralogous subclades(ppc-aL1a,ppc-aL1b,and ppcB2)were recruited as functional C4 ppc *** study provides valuable resources and a robust phylogenetic framework for evolutionary analyses of the grass family.

关键词： Gramineae transcriptome nuclear phylogeny molecular clock C4 photosynthesis ppc gene evolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phylogenomic conflict analyses in the apple genus Malus *** widespread hybridization and allopolyploidy driving diversification,with insights into the complex biogeographic history in the Northern Hemisphere

引用

Journal of Integrative Plant Biology 2022年第5期64卷 1020-1043页

作者： Bin-Bin Liu Chen Ren Myounghai Kwak Richard GJHodel Chao Xu Jian He Wen-Bin Zhou chien-hsun huang Hong Ma Guan-Ze Qian De-Yuan Hong Jun Wen State Key Laboratory of Systematic and Evolutionary Botany Institute of Botanythe Chinese Academy of SciencesBeijing 100093China Department of Botany National Museum of Natural HistorySmithsonian InstitutionPO Box 37012Washington 20013–7012DCUSA Key Laboratory of Plant Resources Conservation and Sustainable Utilization South China Botanical GardenThe Chinese Academy of SciencesGuangzhou 510650China Guangdong Provincial Key Laboratory of Applied Botany South China Botanical GardenThe Chinese Academy of SciencesGuangzhou 510650China National Institute of Biological Resources Incheon 22689South Korea School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China Department of Plant and Microbial Biology North Carolina State UniversityRaleigh 27965NCUSA State Key Laboratory of Genetic Engineering and Collaborative Innovation Center of Genetics and Development Ministry of Education Key Laboratory of Biodiversity and Ecological EngineeringInstitute of Plant BiologyCenter of Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200433China Department of Biology Huck Institutes of the Life SciencesPennsylvania State University510D Mueller LaboratoryUniversity ParkPennsylvania 16802USA College of Life Sciences Liaocheng UniversityLiaocheng 252059China

Phylogenomic evidence from an increasing number of studies has demonstrated that different data sets and analytical approaches often reconstruct strongly supported but conflicting *** this study,785 single-copy nuclear genes and 75 complete plastomes were used to infer the phylogenetic relationships and estimate the historical biogeography of the apple genus Malus sensu lato,an economically important lineage disjunctly distributed in the Northern Hemisphere and involved in known and suspected hybridization and allopolyploidy *** nuclear phylogeny recovered the monophyly of Malus s.l.(including Docynia);however,the genus was supported to be biphyletic in the plastid *** ancient chloroplast capture event in the Eocene in western North America best explains the cytonuclear *** conflict analysis demonstrated that ILS,hybridization,and allopolyploidy could explain the widespread nuclear gene tree *** deep hybridization event(Malus doumeri)and one recent event(Malus coronaria)were detected in Malus ***,our historical biogeographic analysis integrating living and fossil data supported a widespread East Asianwestern North American origin of Malus *** the Eocene,followed by several extinction and dispersal events in the Northern *** also propose a general workflow for assessing phylogenomic discordance and biogeographic analysis using deep genome skimming data sets.

关键词： deep genome skimming genomic discordance historical biogeography massive extinction reticulate evolution single-copy nuclear genes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recurrent genome duplication events likely contributed to both the ancient and recent rise of ferns^FA

引用

Journal of Integrative Plant Biology 2020年第4期62卷 433-455页

作者： chien-hsun huang Xinping Qi Duoyuan Chen Ji Qi Hong Ma Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological Engineering and State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentInstitute of Plant BiologyInstitute of Biodiversity SciencesCenter for Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200433China Department of Biology The Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkUniversity ParkPA 16802USA

Ferns, the second largest group of vascular plants, originated ~400 mil ion years ago(Mya). They became dominant in the ancient Earth landscape before the angiosperms and are stil important in current *** ferns have exceptional y high chromosome numbers,possibly resulting from whole-genome duplications(WGDs).However, WGDs have not been investigated molecularly across fern diversity. Here we detected and dated fern WGDs using a phylogenomic approach and by calculating synonymous substitution rates(Ks). We also investigated a possible correlation between proposed WGDs and shifts in species diversification rates. We identified 19 WGDs: three ancient events along the fern phylogenetic backbone that are shared by 66%–97% of extant ferns, with additional lineage-specific WGDs for eight orders, providing strongevidence for recurring genome duplications across fern evolutionary history. We also observed similar Ks peak values for more than half of these WGDs, with multiple WGDs occurring close to the Cretaceous(~145–66 Mya). Despite the repeated WGD events, the biodiversity of ferns declined during the Cretaceous, implying that other factors probably contributed to the floristic turnover from ferns to angiosperms. This study provides molecular evidence for recurring WGDs in ferns and offers important clues to the genomic evolutionary history of ferns.

关键词： likely Cretaceous backbone

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phylotranscriptomics in Cucurbitaceae Reveal Multiple Whole-Genome Duplications and Key Morphological and Molecular Innovations

引用

Molecular Plant 2020年第8期13卷 1117-1133页

作者： Jing Guo Weibin Xu Yi Hu Jie huang Yiyong Zhao Lin Zhang chien-hsun huang Hong Ma Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological Engineering and State Key Laboratory of Genetic Engineering Institute of Biodiversity Sciences and Institute of Plant BiologySchool of Life SciencesFudan University2005 Songhu RoadShanghai 200438China Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain Guangxi Institute of BotanyGuangxi Zhuangzu Autonomous Region and Chinese Academy of SciencesGuilin 541006China Department of Biology the Huck Institutes of Life Sciencesthe Pennsylvania State UniversityUniversity ParkPA 16802USA

The ability of climbing plants to grow upward along others to reach the canopy for photosynthesis is hypothesized as a key innovation in flowering *** members of the Cucurbitaceae,a family containing^1000 species and many important crops,are climbers and have characteristic tendrils and pepo ***,we present 127 newly sequenced transcdptomes and genomes along with other datasets for a total of 136 cucurbits representing all tribes to establish a robust Cucurbitaceae phylogeny containing eight highly resolved major *** analyzed whole-genome duplication,diversification dynamics,and ancestral morphologies,and found that after early genome duplication event(s),a burst of diversification and morphological innovations in flower,fruit,and root characters occurred under the climate optimum in the Early *** radiation during the Mid-Eocene Climatic Optimum also coincided with several morphological changes shared by 80%of *** found that the cucurbit-specific tendril identity gene TEN originated from a paleo-polyploidization event at the origin of the *** results support the hypothesis that cucurbit diversifications were probably driven by increased genetic diversity following polyploidizations and by trait morphological innovations under paleo-climate *** study provides a phylogenetic framework and new insights into morphological and genomic changes underlying the adaptive evolution of Cucurbitaceae.

关键词： Cucurbitaceae transcriptome phylogeny divergence time genome duplication diversification morphology adaptive evolution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phylotranscriptomic insights into Asteraceae diversity,polyploidy,and morphological innovation

引用

Journal of Integrative Plant Biology 2021年第7期63卷 1273-1293页

作者： Caifei Zhang chien‐hsun huang Mian Liu YiHu Jose L.Panero Federico Luebert Tiangang Gao Hong Ma State Key Laboratory of Genetic Engineering and Collaborative Innovation Center of Genetics and Development Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological EngineeringInstitute of Biodiversity SciencesInstitute of Plant BiologyCenter for Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200438China Department of Biology the Huck Institutes of the Life Sciencesthe Pennsylvania State UniversityUniversity ParkPennslyvania 16802USA Department of Integrative Biology The University of TexasUniversity Station C0930AustinTexas 78712USA Institut für Bodiversität der Pflanzen Universität BonnBonn D–53115Germany Department of Silviculture and Nature Conservation University of ChileSantiago 9206Chile State Key Laboratory of Evolutionary and Systematic Botany Institute of Botanythe Chinese Academy of SciencesBeijing 100093China

Biodiversity is not evenly distributed among relatedgroups,raising questions about the factors con-tributing to such *** sunflower family(Asteraceae,>26,000 species)is among the largestand most diverse plant families,but its species di-versity is concentrated in a few subfamilies,pro-viding an opportunity to study the factors *** analyses here of244 transcriptomes and genomes produced a phy-logeny with strong support for the monophyly ofAsteraceae and the monophyly of most subfamiliesand *** phylogeny provides a reference fordetecting changes in diversification rates and pos-sible factors affecting Asteraceae diversity,whichinclude global climate shifts,whole‐genome dupli-cations(WGDs),and morphological *** of Asteraceae was estimated at~83 Mya,with most subfamilies having diverged before theCretaceous–Paleocene ***-scriptomic analyses supported the existence of 41WGDs in *** to herbaceousnessand capitulescence with multipleflower‐like capitula,often with distinctflorets and scaly pappus/re-ceptacular bracts,are associated with multiple up-shifts in diversification *** might have con-tributed to the survival of early Asteraceae byproviding new genetic materials to support mor-phological *** resulting competitive ad-vantage for adapting to different niches would haveincreased biodiversity in Asteraceae.

关键词： biodiversity compositae morphological characterevolution phylogeny transcriptome whole‐genome duplication

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nuclear phylogeny and insights into wholegenome duplications and reproductive development of Solanaceae plants

引用

Plant Communications 2023年第4期4卷 301-322页

作者： Jie huang Weibin Xu Junwen Zhai Yi Hu Jing Guo Caifei Zhang Yiyong Zhao Lin Zhang Christopher Martine Hong Ma chien-hsun huang State Key Laboratory of Genetic Engineering and Collaborative Innovation Center of Genetics and Development Ministry of Education Key Laboratory of Biodiversity and Ecological EngineeringInstitute of Plant BiologyCenter of Evolutionary BiologySchool of Life SciencesFudan UniversityShanghai 200438China Guangxi Key Laboratory of Plant Conservation and Restoration Ecology in Karst Terrain Guangxi Institute of BotanyGuangxi Zhuangzu Autonomous Region and Chinese Academy of SciencesGuilin 541006China Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization Fujian Agriculture and Forestry UniversityFuzhou 350002China Department of Biology the Huck Institutes of Life Sciencesthe Pennsylvania State UniversityUniversity ParkState CollegePA 16802USA Department of Biology Bucknell UniversityLewisburgPA 17837USA

Solanaceae,the nightshade family,have2700 species,including the important crops potato and tomato,ornamentals,and medicinal *** sequenced Solanaceae genomes show evidence for wholegenome duplication(WGD),providing an excellent opportunity to investigate WGD and its ***,we generated 93 transcriptomes/genomes and combined them with 87 public datasets,for a total of 180 Solanaceae species representing all four subfamilies and 14 of 15 *** 1700 nuclear genes from these transcriptomic/genomic datasets were used to reconstruct a highly resolved Solanaceae phylogenetic tree with six major *** Solanaceae tree supports four previously recognized subfamilies(Goetzeioideae,Cestroideae,Nicotianoideae,and Solanoideae)and the designation of three other subfamilies(Schizanthoideae,Schwenckioideae,and Petunioideae),with the placement of several previously unassigned *** placed a Solanaceae-specific whole-genome triplication(WGT1)at81 million years ago(mya),before the divergence of Schizanthoideae from other Solanaceae subfamilies at73 *** addition,we detected two gene duplication bursts(GDBs)supporting proposed WGD events and four other *** investigation of the evolutionary histories of homologs of carpel and fruit developmental genes in 14 gene(sub)families revealed that 21 gene clades have retained gene *** were likely generated by the Solanaceae WGT1 and may have promoted fleshy fruit *** study presents a well-resolved Solanaceae phylogeny and a new perspective on retained gene duplicates and carpel/fruit development,providing an improved understanding of Solanaceae evolution.

关键词： Solanaceae phylogeny transcriptome carpel and fruit development whole-genome duplication

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phylogenomic Insights into Deep Phylogeny of Angiosperms Based on Broad Nuclear Gene Sampling

引用

Plant Communications 2020年第2期1卷 77-87页

作者： Lingxiao Yang Danyan Su Xin Chang Charles SPFoster Linhua Sun chien-hsun huang Xiaofan Zhou Liping Zeng Hong Ma Bojian Zhong College of Life Sciences Nanjing Normal UniversityNanjingChina School of Life and Environmental Sciences University of SydneySydneyAustralia Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijingChina State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development Ministry of Education Key Laboratory of Biodiversity Sciences and Ecological EngineeringSchool of Life SciencesFudan UniversityShanghaiChina Guangdong Province Key Laboratory of Microbial Signals and Disease Control Integrative Microbiology Research CentreSouth China Agricultural UniversityGuangzhouChina Institute for Integrative Genome Biology and Department of Botany and Plant Sciences University of CaliforniaRiversideCAUSA Department of Biology Huck Institutes of the Life SciencesPennsylvania State UniversityUniversity ParkPAUSA

Angiosperms(flowering plants)are the most diverse and species-rich group of *** vast majority(99.95%)of angiosperms form a clade called Mesangiospermae,which is subdivided into five major groups:eudicots,monocots,magnoliids,Chloranthales,and *** relationships among these Mesangiospermae groups have been the subject of long *** this study,we assembled a phylogenomic dataset of 1594 genes from 151 angiosperm taxa,including representatives of all five lineages,to investigate the phylogeny of major angiosperm lineages under both coalescent-and concatenationbased *** dissected the phylogenetic signal and found that more than half of the genes lack phylogenetic information for the backbone of angiosperm *** further removed the genes with weak phylogenetic signal and showed that eudicots,Ceratophyllales,and Chloranthales form a clade,with magnoliids and monocots being the next successive sister *** frequencies of gene tree conflict are suggestive of incomplete lineage sorting along the backbone of the angiosperm *** analyses suggest that a fully bifurcating species tree may not be the best way to represent the early radiation of ***,we inferred that the crown-group angiosperms originated approximately between 255.1 and 222.2 million years ago,and Mesangiospermae diversified into the five extant groups in a short time span(27 million years)at the Early to Late Jurassic.

关键词： Mesangiospermae gene tree conflict phylogenomics phylogenetic signal divergence times

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear phylotranscriptomics and phylogenomics support numerous polyploidization events and hypotheses for the evolution of rhizobial nitrogenfixing symbiosis in Fabaceae

引用

Molecular Plant 2021年第5期14卷 748-773页

作者： Yiyong Zhao Rong Zhang Kai-Wen Jiang Ji Qi Yi Hu Jing Guo Renbin Zhu Taikui Zhang Ashley N.Egan Ting-Shuang Yi chien-hsun huang Hong Ma State Key Laboratory of Genetic Engineering and Collaborative Innovation Center of Genetics and Development Ministry of Education Key Laboratory of Biodiversity and Ecological EngineeringInstitute of Plant BiologyCenter of Evolutionary BiologySchool of Life SciencesFudan University2005 Songhu RoadShanghai 200433China Department of Biology The Huck Institutes of the Life SciencesThe Pennsylvania State UniversityUniversity ParkPA 16802USA Germplasm Bank of Wild Species Kunming Institute of BotanyChinese Academy of SciencesLanhei RoadKunming 650201China Key Laboratory of Biodiversity Conservation in Southwest China State Forestry AdministrationSouthwest Forestry UniversityKunming 650224PR China Ningbo Botanical Garden Herbarium Ningbo 315201PR China Xishuangbanna Tropical Botanical Garden Chinese Academy of SciencesMenglunYunnan 666303PR China Department of Biology Utah Valley UniversityOremUT 84058USA

Fabaceae are the third largest angiosperm family,with 765 genera and~19500 *** are important both economically and ecologically,and global Fabaceae crops are intensively studied in part for their nitrogen-fixing ***,resolution of the intrasubfamilial Fabaceae phylogeny and divergence times has remained elusive,precluding a reconstruction of the evolutionary history of symbiotic nitrogen fixation in ***,we report a highly resolved phylogeny using>1500 nuclear genes from newly sequenced transcriptomes and genomes of 391 species,along with other datasets,for a total of 463 legumes spanning all 6 subfamilies and 333 of 765 *** subfamilies are maximally supported as *** clade comprising subfamilies Cercidoideae and Detarioideae is sister to the remaining legumes,and Duparquetioideae and Dialioideae are successive sisters to the clade of Papilionoideae and *** clock estimation revealed an early radiation of subfamilies near the K/Pg boundary,marked by mass extinction,and subsequent divergence of most tribe-level clades within~15 million *** analyses of thousands of gene families support 28 proposed putative whole-genome duplication/whole-genome triplication events across Fabaceae,including those at the ancestors of Fabaceae and five of the subfamilies,and further analyses supported the Fabaceae ancestral *** evolution of rhizobial nitrogen-fixing nodulation in Fabaceae was probed by ancestral character reconstruction and phylogenetic analyses of related gene families and the results support the hypotheses of one or two switches)to rhizobial nodulation followed by multiple ***,these results provide a foundation for further morphological and functional evolutionary analyses across Fabaceae.

关键词： Fabaceae Leguminosae nuclear phylogeny divergence times whole-genome duplication rhizobial nodulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese herbal medicine decreases incidence of hepatocellular carcinoma in diabetes mellitus patients with regular insulin management

引用

World Journal of Gastrointestinal Oncology 2024年第3期16卷 716-731页

作者： Hsiang-Chun Lai Ju-chien Cheng Hei-Tung Yip Long-Bin Jeng Sheng-Teng huang Graduate Institute of Chinese Medicine School of Chinese MedicineCollege of Chinese MedicineChina Medical UniversityTaichung 404328TaiwanChina Department of Medical Laboratory Science and Biotechnology China Medical UniversityTaichung 404TaiwanChina Management Office for Health Data China Medical University HospitalTaichung 404327TaiwanChina Organ Transplantation Center China Medical University HospitalTaichung 40447TaiwanChina Department of Chinese Medicine China Medical University HospitalSchool of Chinese MedicineChina Medical UniversityTaichung 40447TaiwanChina

BACKGROUND Type 2 diabetes mellitus(DM)is an independent risk factor for hepatocellular carcinoma(HCC),while insulin is a potent *** a new therapeutic modality for preventing insulin users from developing HCC is a critical goal for *** To investigate whether regular herbal medicine use can decrease HCC risk in DM patients with regular insulin *** We used data acquired from the Taiwan,Chinaese National Health Insurance research database between 2000 and *** identified patients with DM who were prescribed insulin for>3 *** herb user group was further defined as patients prescribed herbal medication for DM for>3 months per annum during RESULTS We initially enrolled 657144 DM patients with regular insulin use from 2000 to *** these,46849 patients had used a herbal treatment for DM,and 140547 patients were included as the matched control *** baseline variables were similar between the herb users and *** patients with regular herb use had a 12%decreased risk of HCC compared with the control group[adjusted hazard ratio(aHR)=0.88,95%CI=0.80–0.97].The cumulative incidence of HCC in the herb users was significantly lower than that of the *** with a herb use of>5 years cumulatively exhibited a protective effect against development of HCC(aHR=0.82,Phuang Qi)plus Salvia miltiorrhiza Bunge(Dan Shen),and Astragalus propinquus(huang Qi)plus Trichosanthes kirilowii Maxim.(Tian Hua Fen)were the most frequent combination of single ***,Ji Sheng Shen Qi Wan plus Dan Shen was the most frequent combination of herbs and *** This large-scale retrospective cohort study reveals th

关键词： Hepatocellular carcinoma Diabetes mellitus Insulin Herb Taiwan,Chinaese National health insurance research database

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：