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常见线粒体DNA病的分子遗传学研究进展(英文)

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北京大学学报（医学版） 2005年第1期37卷 26-31页

作者： lee-Jun C. WONG Institute for Molecular and Human Genetics Georgetown University Medical Center Washington DC 20007USA

Diagnosis of mitochondrial disorders has been difficult due to the clinical and genetic heterogeneity, as well as unique features of mitochondrial genetics. Definitive diagnosis requires the identification of molecular defects in either the mitochondrial or the nuclear genome. We describe the clinical and molecular characteristic of some common mitochondrial syndromes and molecular methodologies available for the detection of mitochondrial DNA mutations. This review provides overview of current molecular diagnosis of mitochondrial DNA disorders that is useful in patient care and genetic counseling.

关键词：常见分子遗传学研究进展线粒体DNA

Structural Changes ofαPhase in Furnace Cooled Eutectoid Zn-Al Based Alloy

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Journal of Materials Science & Technology 2007年第3期23卷 347-352页

作者： Y.H.Zhu K.C.Chan G.K.H.Pang T.M.Yue W.B.lee Advanced Manufacturing Technology Research Center Department of Industrial and Systems Engineering The Hong Kong Polytechnic University Hong Kong China Department of Applied Physics The Hong Kong Polytechnic University Hong Kong China

Furnace cooling is a slow cooling process. It is of importance to study structural evolution and its effects on the properties of alloys during the furnace cooling. Decomposition of aluminium rich α phase in a furnace cooled eutectoid Zn-Al based alloy was studied by transmission electron microscopy. Two kinds of precipitates in the α phase were detected in the FCZA22 alloy during ageing at 170℃. One was the hcp transitional α＂ m phase which aooears as directional rods and the round precipitates. The other was the fcc α＇m phase. 〈101〉. The orientation relationship between the a phase and transitional phase α＇m was determined as （022）α＇m （fcc）//（022^-）α（fcc）, [1^-11]α＇m, （fcc）//[2^-33]α（fcc）. The non-equilibrium phase decomposition of the α phase is discussed in correlation with the equilibrium phase relationships.

关键词： Phase decomposition Microstructural evolution Zn-Al alloys

Long-term survival and prognostic implications of Chinese type 2 diabetic patients with coronary artery disease after coronary artery bypass grafting

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Health 2009年第3期1卷 139-145页

作者： Ming C Hsiung Tao-Hsin Tung Chung-Yi Chang Yi-Cheng Chuang Kuo-Chen lee Sung-How Sue Yi-Pen Chou Richard Hsiung chien-Ming Huang Chang-Chyi Lin Wei-Hsian Yin Mason S Young Jeng Wei 不详

This study was conducted to determine the sur-vival rates of type 2 diabetic patients after coro-nary artery bypass grafting (CABG) surgery, and the prognostic factors related to all-cause mor-tality during a 7-year follow-up. The medical re-cords of 816 type 2 diabetic patients who un-derwent primary, isolated CABG surgery during 1997-2003 were studied. The Kaplan-Meier me- thod and Cox regression were used to estimate survival and the independence of prognostic factors associated with all-cause mortality. One hundred and five out of 816 patients expired during the 7-year period. The overall survival rate was 83.5% (95%CI: 78.7-88.3%). Associated prog- nostic factors varied by gender. For males, but not for females, smoking (RR=3.44, 95%CI: 1.01- 11.70), myocardial infarction (RR=4.77, 95% CI: 1.23-18.86), respiratory failure (RR=4.21, 95% CI: 1.48-7.99), cardiogenic shock (RR=12.58, 95% CI: 3.25-20.77), and congestive heart failure (RR= 3.77, 95%CI: 1.10-13.45) were significantly related to all-cause mortality. Older age at sur-gery (RR= 1.15, 95%CI: 1.04-1.27), emergent op-eration (RR= 21.29, 95%CI: 10.03-39.43), pul-monary ede-ma (RR=7.72, 95%CI: 1.89-15.59), and days of ICU stay (RR=1.05, 95%CI: 1.02-1.09) were significant- ly related to all-cause mortality in females only. In conclusion, several gen-der-related differences were noted pertaining to all-cause mortality and its relationship to smok- ing, myocardial infarction, respiratory failure, cardiogenic shock, congestive heart failure, older age at surgery, emergent operation, pul-monary edema, and days of ICU stay.

关键词： Coronary Artery Bypass Grafting Gender Difference Prognostic Factors Survival Type 2 Diabetes

Path to the fabrication of efficient, stable and commercially viable large-area organic solar cells

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Materials Futures 2023年第3期2卷 38-52页

作者： Shafket Rasool Jiwoo Yeop Hye Won Cho Woojin lee Jae Won Kim Dohun Yuk JinYoung Kim School of Energy and Chemical Engineering Ulsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Graduate School of Carbon Neutrality Ulsan National Institute of Science and TechnologyUlsan44919Republic of Korea

Organic solar cells(OSCs)have reached an outstanding certified power conversion efficiency(PCE)of over 19%in single junction and 20%in tandem architecture *** high PCEs have emerged with outstanding Y-shaped Y6 non-fullerene acceptors(NFAs),together with PM6 electron donor *** are on the rise for small-area ***,large-area OSC sub-modules are still unable to achieve such high PCEs,and the highest certified PCE reported so far is∼12%having an area of 58 *** fabricate efficient large-area OSCs,new custom-designed NFAs for large-area systems are imminent along with improvements in the sub-module fabrication ***,the search for stable yet efficient OSCs is still in *** this review,progress in small-area OSCs is presented with reference to the advancement in the chemical structure of NFAs and donor ***,the life-cycle assessment of OSCs is presented and the energy payback time of the efficient and stable OSCs is discussed and lastly,an outlook for the OSCs is given.

关键词： organic solar cells non-fullerene acceptors OSC morphology interfacial modification light-soaking stability solar energy large-area OSCs

Dynamic enhanced computed tomography imaging findings of an inflammatory fibroid polyp with massive fibrosis in the stomach

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World Journal of Gastroenterology 2017年第11期23卷 2090-2094页

作者： Eun Jung Shim Sung Eun Ahn Dong Ho lee Seong Jin Park Youn Wha Kim Department of Radiology Kyung Hee University HospitalGraduate SchoolKyung Hee University Department of Pathology Kyung Hee University HospitalGraduate SchoolKyung Hee University

Inflammatory fibroid polyp(IFP) is a rare benign lesion of the gastrointestinal tract. We report a case of computed tomography(CT) imaging finding of a gastric IFP with massive fibrosis. CT scans showed thickening of submucosal layer with overlying mucosal hyperenhancement in the gastric antrum. The submucosal layer showed increased enhancement on delayed phase imaging. An antrectomy with gastroduodenostomy was performed because gastric cancer was suspected, particularly signet ring cell carcinoma. The histopathological diagnosis was an IFP with massive fibrosis. The authors suggest that when the submucosal layer of the gastric wall is markedly thickened with delayed enhancement and preservation of the mucosal layer, an IFP with massive fibrosis should be considered in the differential diagnosis.

关键词： Inflammatory fibroid polyp Gastric polyp Gastric submucosal tumor Signet ring cell carcinoma Computed tomography imaging finding

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果胶酶对苹果渣中多酚类物质的提取效果研究

分析化学 2008年第3期36卷 306-310页

作者：郑虎哲 Hye-Ryun lee Sang-Han lee Chang-Seob Kim Shin-Kyo Chung 国立庆北大学校食品工学科浦项大学营养烹饪产业学院

具有多种生理活性的多酚类物质在苹果渣中主要以聚合体的形态存在。本研究利用果胶酶分解果胶质,把聚合态的多酚类物质转变为游离态,并提高多酚类物质的提取率。实验得出果胶酶释放总多酚类物质的最佳反应条件是温度为37℃,pH为3.6,酶/... 详细信息

具有多种生理活性的多酚类物质在苹果渣中主要以聚合体的形态存在。本研究利用果胶酶分解果胶质,把聚合态的多酚类物质转变为游离态,并提高多酚类物质的提取率。实验得出果胶酶释放总多酚类物质的最佳反应条件是温度为37℃,pH为3.6,酶/基质比例为12%,反应时间为11h。在此条件下,总多酚类物质(total phenolic compounds,TPC)和总黄酮类物质(total flavonoid compounds,TFC)含量分别达到9.08g/kg和1.38g/kg,比对照组的7.05g/kg和0.91g/kg分别提高1.3倍和1.5倍。果胶酶处理组比对照组多检出咖啡酸、香豆酸、阿魏酸、根皮素和未知物U3。以上结果表明,果胶酶具有较强的分解果胶质的功能,并能提高总多酚类物质的含量。

关键词：苹果渣果胶酶多酚类提取

Numerical Simulation for Investigation and Design of Steel Strip Induction Heating Lines for Rolling Mills

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Journal of Iron and Steel Research International 2012年第S2期19卷 658-661页

作者： NIKANOROV Aleksandr NACKE Bernard lee Dukman YOU Jongwoo Institute of Electrotechnology Leibniz Universitt Hannover POSCO Technical Research Laboratories

Continuous steel strip casting lines in rolling miles are under active *** to high thermal losses the thin strip is cooling down very fast and therefore a sufficient heating system is necessary before final *** induction heaters can realize the necessary fast heating of the strip and a good energy efEciency of *** of induction heating lines for rolling mills are of extremely high power,all even small improvements in their design and operating modes have significant technical and economical ***,the heating lines need an optimal design of the complex induction systems and only numerical simulation is a way to solve the *** two- and threedimensional numerical simulation approaches developed and applied for investigation and design of longitudinal induction heaters are described in the *** numerical models have been successfully used for development of modified coils allowing high efficient heating of thinner strip using the same operating *** electrical impedance of the modified coils has been provided on the level necessary for using the existing power supplies and matching *** high electrical efficiency,the modified coils improve the temperature distribution over the strip width by increased heating of the strip *** optimized and modifies induction coils have been successfully tested in industrial line.

关键词： steel strip induction heating rolling mills numerical simulation

Undifferentiated pleomorphic sarcoma of the liver presenting as a unilocular cyst

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Hepatobiliary & Pancreatic Diseases International 2009年第5期8卷 541-543页

作者： Hyun-Soo Kim Gou Young Kim Sung-Jig Lim Sang Mok lee Youn Wha Kim Departments of Pathology School of MedicineKyung Hee University1 Hoegi-dongDongdaemun-gu130-702 SeoulSouth Korea Departments of Surgery School of MedicineKyung Hee University1 Hoegi-dongDongdaemun-gu130-702 SeoulSouth Korea

BACKGROUND:A malignant fibrous histiocytoma,recently referred to as an undifferentiated pleomorphic sarcoma (UPS),is very rare in the liver,and only 34 cases of primary hepatic malignant fibrous histiocytoma have been reported in the English literature. METHODS:We report a rare case of a hepatic UPS presenting as a unilocular cystic lesion with respect to histopathologic features,the newly revised diagnostic criteria,and the differential diagnosis. RESULTS:A 60-year-old man presented for evaluation of epigastric pain of 7 months *** computed tomography revealed a hypodense,unilocular cystic mass in the right lobe of the liver,measuring 14.0×11.1 cm.A right lobectomy was ***,the cut surface showed a single,well-circumscribed unilocular cystic tumor mass containing dark red-brown necrotic debris and blood clots, which occupied most of the ***,the tumor consisted of haphazardly arranged mononuclear pleomorphic tumor cells,admixed with abundant osteoclast- like multinucleated giant ***,the tumor cells expressed vimentin *** histopathologic and immunohistochemical findings were compatible with a *** patient is alive and well 41 months after surgery without recurrence. CONCLUSIONS:Clinically,most of the hepatic UPSs are solid *** two cases have presented as multilocular cystic masses.A primary hepatic UPS presenting as a unilocular cyst has never been reported.A UPS should be included in the differential diagnosis of unilocular cystic lesions in the liver.

关键词： undifferentiated pleomorphic sarcoma malignant fibrous histiocytoma liver unilocular cyst

Publisher Correction to:Highly Elastic,Bioresorbable Polymeric Materials for Stretchable,Transient Electronic Systems

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Nano-Micro Letters 2024年第8期16卷 417-417页

作者： Jeong‑Woong Shin Dong‑Je Kim Tae‑Min Jang Won Bae Han Joong Hoon lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi Eom Amay JBandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of Electrical and Computer Engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative Energy Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Due to typesetting mistake,Hanul Min was missed to be denoted as a corresponding author in the *** type-setter apologizes for *** original article has been *** Access This article is licensed under a Creative Commons Attribution 4.0 International License,which permits use,sharing,adaptation,distribution and reproduction in any medium or format,as long as you give appropriate credit to the original author(s)and the source,provide a link to the Creative Commons licence,and indicate if changes were *** images or other third party material in this article are included in the article’s Creative Commons licence,unless indicated otherwise in a credit line to the *** material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use,you will need to obtain permission directly from the copyright holder.

关键词： Creative Elastic Highly