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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 16-19页

作者： Dae-Ki Joung Young-Seob lee Sin-Hee Han Sang-Won lee Seon-Woo Cha Su-Hyun Mun Ryong Kong Ok-Hwa Kang Ho-Jun Song Dong-Won Shin Dong-Yeul Kwon Department of Oriental Pharmacy College of Pharmacy and Wonkwang-Oriental Medicines Research Institute.Wonkwang University Department of Herbal Crop Research National Institute of Horticultural & Herbal ScienceRDA BK21 Plus Team Professional Graduate School of Oriental MedicineWonkwang University Department of Oriental Medicine Resources Sunchon National University

Objective:To investigate the mechanism of antibacterial activity of luteoiin(LUT) against methicillin-resistant Staphylococcus aureus(MRSA).Methods:The mechanism of anti-MRSA activity of LUT was analyzed by the viability assay in membrane permeabilizing agent ATPase inhibitors,and peptidoglycan(PGN) derived from Staphylococcus aureus(***).Also,transmission electron microscopy was used to monitor survival characteristics and changes in *** ***:Compared to the LUT alone,the optical density of suspensions treated with the combination of 125 μg/mL Tris and 230 μg/mL DCCD were reduced to 60%and 46%,***(15.6 μg/mL) gradually impeded the activity of LUT,and PGN(62.5 μg/mL) completely blocked the activity of LUT on ***:Increased susceptibility to LUT with me Tris and DCCD combinations is evident in all tested MRSA *** results indicate LUT synergy in increasing cytoplasmic membrane permeability and inhibiting *** PGN directly blocks the antibacterial activity of LUT,suggesting the direct binding of LUT with *** findings may be validated for the development of antibacterial agent for low MRSA resistance.

关键词： Iuteolin Methicillin-resistant Staphylococcus aureus Membrane permeabilizing agent ATPase inhibitor Peptidoglycan

Fabrication and characterization of the Ti-Ca-P composites by vacuum sintering

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Journal of Biomedical Science and Engineering 2011年第9期4卷 583-590页

作者： Dibakar Mondal Swapan Kumar Sarkar Dong-Won lee Young-Seon lee Byong-Taek lee 不详

Using Ti and biphasic calcium phosphate (BCP) pow-ders, Ti-Ca-P composites which contained 0 - 30 vol.% BCP powders initially, were fabricated by vac-uum sintering at two different sintering temperatures, 1300°C and 1400°C. Detailed microstructural char-acteristics of the resulting composites were investi-gated. Mechanical properties like compressive strength, Vickers hardness were evaluated and they showed decreasing trend with the increasing initial BCP content. The x-ray diffraction (XRD) profiles revealed that extensive chemical reaction occurred and the initial BCP was degraded and formed CaO, TiO2, TiP, CaTiO3. However, the cell viability by MTT assay and cell proliferation behavior through one cell morphology analysis showed excellent in-creasing trend in biocompatibility which makes this materials suitable for hard tissue aid *** the composite containing 30 vol.% BCP content with Ti sintered at 1400°C showed excellent biocompati-bility with the Vickers Hardness value 108.8 HV and the compressive strength value 303.7 MPa.

关键词： Ti Calcium Phosphate Biocompatibility Bio-ceramic

Athletes ECG Stress Characteristics in Division Ⅱ College Athletes:A Preliminary Analysis

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Journal of Science in Sport and Exercise 2020年第2期2卷 183-187页

作者： Ludmila Cosio-Lima Lauren Adlof Jeffrey Simpson Amy Crawley Youngil lee University of West Florida 11000 University Parkway#72/220PensacolaFL 32514USA

Purpose Two-thirds of sudden cardiac deaths are attributable to underlying cardiovascular conditions in young collegiate athletes.A 12-lead exercise stress test is a screening tool that can detect these abnormalities that may predispose collegiate athletes to sudden cardiac death,and can ensure athletes meet the physical demands of training and *** pur-pose of this study was to evaluate the electrocardiographic(ECG)characteristics of DivisionⅡcollegiate athletes using the Seattle *** Fifty two athletes(males=26;females=26)of various ethnicities(Caucasian=65%,Latino/Hispanic=20%,and African American=15%);from soccer(27%),tennis(17%),basketball(15%),softball(14%),cross country(9%),volleyball(6%),football(6%),and swimming(6%)completed cardiovascular screening with resting and exercise 12-lead ECG *** abnormalities and anthropometrics were compared across race,gender,and sports using an ***-square analysis was used to test for differences in the frequency of ECG findings across gender,race,and *** Although sport was not a predictor for an abnormal ECG,73%of the athletes presented with athletes'heart con-figuration,which was significantly higher in males than females(P=0.02).The highest occurrence of these adaptations was observed in 100%of Latino/Hispanic athletes,compared to 75%of African American and 64%of Caucasian *** With newer and more sensitive ECG screening criteria,the prevalence of false-positive tests is *** research should focus on advancing the sensitivity and specificity of ECG interpretation in more diverse athletic populations regarding race and *** increasing incidence of sudden cardiac death in collegiate athletes warrants future research that evaluates the impact of implementing the 12-lead ECG as a standard screening tool for collegiate athletes.

关键词： Sudden cardiac death 12-Lead ECG Athlete's heart

热处理工艺对A356/SiCp性能及干滑动摩擦磨损特性的影响

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中国有色金属学报 2008年第8期18卷 1458-1465页

作者：金云学 lee Jung-moo KANG Suk-bong 江苏科技大学先进焊接技术省级重点实验室镇江212003 Advanced Materials Division Korea Institute of Machinery and Materials Changwon 641-010 Korea

研究分析热处理工艺对A356/SiCp复合材料的硬度、导电率及微观组织的影响,在此基础上研究复合材料的干滑动摩擦磨损特性。结果表明:固溶和T6热处理可显著提高复合材料的硬度,但降低导电率,而低温退火却比较显著地提高导电率;导电率高的... 详细信息

研究分析热处理工艺对A356/SiCp复合材料的硬度、导电率及微观组织的影响,在此基础上研究复合材料的干滑动摩擦磨损特性。结果表明:固溶和T6热处理可显著提高复合材料的硬度,但降低导电率,而低温退火却比较显著地提高导电率;导电率高的低温退火态磨损特性基本与铸态一致,固溶处理及时效处理虽可有效提高硬度,但不提高耐磨性能,这表明T6热处理是否作为制动盘材料时的最佳热处理工艺,有待进一步研究;复合材料的磨损率随载荷的增加而增加,但低载荷时增加缓慢,高载荷时增加迅速;摩擦因数随着热处理工艺而变化,但对载荷变化不敏感,都在较小的范围内波动,基本是稳定的。

关键词： Al/SiCp 复合材料干摩擦热处理摩擦磨损特性

Prediction of forming limit curve for pure titanium sheet

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Transactions of Nonferrous Metals Society of China 2018年第2期28卷 319-327页

作者： Young-Suk KIM Bong-Hyun lee Seung-Han YANG School of Mechanical Engineering Kyungpook National University Daegu-Gyeongbuk Center Korea Automotive Technology Institute

Commercially pure titanium（CP Ti） has been actively used in the plate heat exchanger due to its light weight, high specific strength, and excellent corrosion resistance. However, researches for the plastic deformation characteristics and press formability of the CP Ti sheet are not much in comparison with automotive steels and aluminum alloys. The mechanical properties and hardening behavior evaluated in stress-strain relation of the CP Ti sheet are clarified in relation with press formability. The flow curve denoting true stress-true strain relation for CP Ti sheet is fitted well by the Kim-Tuan hardening equation rather than Voce and Swift models. The forming limit curve（FLC） of CP Ti sheet as a criterion for press formability was experimentally evaluated by punch stretching test and analytically predicted via Hora＇s modified maximum force criterion. The predicted FLC by adopting Kim-Tuan hardening model and appropriate yield function shows good correlation with the experimental results of punch stretching test.

关键词： Kim-Tuan hardening equation Hora modified maximum force criterion pure titanium sheet forming limit curve

A novel combined multi-battery dataset based approach for enhanced prediction accuracy of data driven prognostic models in capacity estimation of lithium ion batteries

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能源与人工智能(英文) 2021年第3期5卷 141-149页

作者： Vijay Mohan Nagulapati Hyunjun lee DaWoon Jung SalaiSargunan S Paramanantham Boris Brigljevic Yunseok Choi Hankwon Lim School of Energy and Chemical Engineering UNISTUlsanRepublic of Korea Xynergypower Corp Gyeonggi-doRepublic of Korea Department of Energy Engineering UNISTUlsanRepublic of Korea

To ensure smooth and reliable operations of battery systems,reliable prognosis with accurate prediction of State of Health of lithium ion batteries is of utmost ***,battery degradation is a complex challenge involving many electrochemical reactions at anode,separator,cathode and electrolyte/electrode ***,there is significant effect of the operating conditions on the battery *** machine learning tech-niques have been applied to estimate the capacity and State of Health of lithium ion batteries to ensure reliable operation and timely *** this paper,we study the Gaussian Process Regression(GPR)and Support Vector Machine(SVM)model-based approaches in estimating the capacity and State of Health of ***-tery capacity and State of Health estimations are carried out using GPR and SVM models and the predictions comparatively studied for accuracy based on RMSE *** prediction accuracy is further compared with re-spect to single sensor and multi sensor ***,a combined multi battery data set model is used to improve the prediction *** the data of multiple batteries with similar operating conditions for training a model resulted in higher prediction accuracy.

关键词： Capacity estimation State of health Gaussian process regression Support vector machine Lithium ion battery

Aptamer-coded DNA nanoparticles for targeted doxorubicin delivery using pH-sensitive spacer

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Frontiers of Chemical Science and Engineering 2017年第4期11卷 529-536页

作者： Pengwei Zhang Junxiao Ye Ergang Liu Lu Sun Jiacheng Zhang Seung Jin lee Junbo Gong Huining He Victor C. Yang . State Key Laboratory of Chemical Engineering School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China.. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostic) Tianjin Medical University Tianjin 300072 China.. Department of Pharmacy Ewha Womans University Seoul 120-750 Korea.. Department of Pharmaceutical Sciences College of Pharmacy University of Michigan MI 48109-1065 USA

An anticancer drug delivery system consisting of DNA nanoparticles synthesized by rolling circle amplification （RCA） was developed for prostate cancer membrane antigen （PSMA） targeted cancer therapy. The template of RCA was a DNA oligodeoxynucleotide coded with PSMA-targeted aptamer, drug-loading domain, primer binding site and pH-sensitive spacer. Anticancer drug doxorubicin, as the model drug, was loaded into the drug-loading domain （multiple GC-pair sequences） of the DNA nanoparticles by intercalation. Due to the integrated pH-sensitive spacers in the nanoparticles, in an acidic environment, the cumulative release of doxorubicin was far more than the cumulative release of the drug in the normal physiological environment. In cell uptake experi- ments, treated with doxorubicin loaded DNA nanoparti- cles, PSMA-positive C4-2 cells could take up more doxorubicin than PSMA-null PC-3 cells. The prepared DNA nanoparticles showed the potential as drug delivery system for PSMA targeting prostate cancer therapy.

关键词： aptamer DNA nanoparticles rolling circleamplification doxorubicin drug delivery pH sensitive

Analysis of Autopilot Disengagements Occurring During Autonomous Vehicle Testing

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 58-68页

作者： Chen Lv Dongpu Cao Yifan Zhao Daniel J. Auger Mark Sullman Huaji Wang Laura Millen Dutka lee Skrypchuk Alexandros Mouzakitis School of Aerospace Transport and Manufacturing Cranfield University Cranfield Bedford MK430AL UK Jaguar Land Rover Coventry CV3 4LF UK IEEE

In present-day highly-automated vehicles, there are occasions when the driving system disengages and the human driver is required to take-over. This is of great importance to a vehicle's safety and ride comfort. In the U.S state of California, the Autonomous Vehicle Testing Regulations require every manufacturer testing autonomous vehicles on public roads to submit an annual report summarizing the disengagements of the technology experienced during testing. On 1 January 2016,seven manufacturers submitted their first disengagement reports:Bosch, Delphi, Google, Nissan, Mercedes-Benz, Volkswagen, and Tesla Motors. This work analyses the data from these disengagement reports with the aim of gaining abetter understanding of the situations in which a driver is required to takeover, as this is potentially useful in improving the Society of Automotive Engineers(SAE) Level 2 and Level 3 automation *** events from testing are classified into different groups based on attributes and the causes of disengagement are investigated and compared in detail. The mechanisms and time taken for take-over transition occurred in disengagements are studied. Finally, recommendations for OEMs, manufacturers, and government organizations are also discussed.

关键词： Automated vehicle Disengagement humanvehicle interactions take-over operation vehicle testing

Growth of single crystals in the (Na_(1/2)Bi_(1/2))TiO_(3)-(Sr_(1-x)Ca_(x))TiO_(3) system by solid state crystal growth

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Journal of Advanced Ceramics 2021年第5期10卷 973-990页

作者： Phan Gia LE Huyen Tran TRAN Jong-Sook lee John G.FISHER Hwang-Pill KIM Wook JO Won-Jin MOONC School of Materials Science and Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology50 UNIST-gilEonyang-eupUlju-gunUlsan 44919Republic of Korea Korea Basic Science Institute Gwangju Center77 Yongbong-roBuk-guGwangju 61186Republic of Korea

Ceramics based on(Na_(1/2)B_(1/2))TiO_(3) are promising candidates for actuator applications because of large strains generated by an electric field-induced phase *** example,the(1-x)(Na_(1/2)Bi_(1/2))TiO_(3)-xSrTiO_(3) system exhibits a morphotropic phase boundary at x=0.2-0.3,leading to high values of inverse piezoelectric constant d_(33),which can be further improved by the use of single *** our previous work,single crystals of (Na_(1/2)B_(1/2))TiO_(3)-SrTiO_(3) and (Na_(1/2)Bi_(1/2))TiO_(3)-TiO_(3) were grown by the solid state crystal growth *** in the(Nai/2Bi/2)TiO3-SrTiO3 system was sluggish whereas the (Na_(1/2)B_(1/2))TiO_(3)-CaTiO_(3) single crystals grew *** the present work,0.8(Na_(1/2)Bi_(1/2))Ti0_(3)-0.2(Sr_(1-x)Ca_(x))Ti0_(3) single crystals(with x=0.0,0.1,0.2,0.3,0.4)were produced by the solid state crystal growth technique in an attempt to improve crystal growth *** dependence of mean matrix grain size,single crystal growth distance,and electrical properties on the Ca concentration was investigated in *** investigations indicated that at x=0.3 the matrix grain growth was suppressed and the driving force for single crystal growth was *** Sr with Ca increased the shoulder temperature T_(s) and temperature of maximum relative permittivity T_(max),causing a decrease in inverse piezoelectric properties and a change from normal to incipient ferroelectric behavior.

关键词： (Na_(1/2)Bi_(1/2))TiO_(3) lead-free piezoelectric single crystal microstructure electrical properties

Do people with low back pain walk differently? A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第4期11卷 450-465页

作者： Jo Armour Smith Heidi Stabbert Jennifer J.Bagwell Hsiang-Ling Teng Vernie Wade Szu-Ping lee Department of Physical Therapy Chapman UniversityIrvineCA 92618USA Department of Physical Therapy California State UniversityLong BeachCA 90840USA Department of Physical Therapy University of NevadaLas VegasNV 89154USA

Background:The biomechanics of the trunk and lower limbs during walking and running gait are frequently assessed in individuals with low back pain(LBP).Despite substantial research,it is still unclear whether consistent and generalizable changes in walking or running gait occur in association with *** purpose of this systematic review was to identify whether there are differences in biomechanics during walking and running gait in individuals with acute and persistent LBP compared with back-healthy ***:A search was conducted in PubMed,CINAHL,SPORTDiscus,and PsycINFO in June 2019 and was repeated in December *** were included if they reported biomechanical characteristics of individuals with and without LBP during steady-state or perturbed walking and *** data included spatiotemporal,kinematic,kinetic,and electromyography *** reporting quality and potential for bias of each study was *** were pooled where possible to compare the standardized mean differences(SMD)between back pain and back-healthy control ***:Ninety-seven studies were included and *** studies investigated acute pain and the rest investigated persistent *** studies investigated running *** the studies,20%had high reporting quality/low risk of *** comparison with back-healthy controls,individuals with persistent LBP walked slower(SMD=-0.59,95%confidence interval(95%CI):-0.77 to-0.42)and with shorter stride length(SMD=-0.38,95%CI:-0.60 to-0.16).There were no differences in the amplitude of motion in the thoracic or lumbar spine,pelvis,or hips in individuals with *** walking,coordination of motion between the thorax and the lumbar spine/pelvis was significantly more in-phase in the persistent LBP groups(SMD=-0.60,95%CI:-0.90 to-0.30),and individuals with persistent LBP exhibited greater amplitude of activation in the paraspinal muscles(SMD=0.52,95%CI:0.23-0.80).There were no consistent differences in ru

关键词： Biomechanics Low back pain Running Walking