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Clinical considerations for critically ill COVID-19 cancer patients:A systematic review

World Journal of Clinical Cases 2021年第28期9卷 8441-8452页

作者： chidambaram ramasamy Ajay Kumar Mishra Kevin John John Amos Lal Department of Internal Medicine Saint Vincent HospitalWorcesterMA 01608United States Department of Medicine Bangalore Baptist HospitalBangalore 578954India Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55902United States

BACKGROUND The World Health Organization(WHO)on March 11,2020,had declared the novel coronavirus disease 2019(COVID-19)outbreak a global *** COVID-19 infection continues to be a pandemic and is currently causing overwhelming challenges to healthcare across the *** patients represent a unique population vulnerable to COVID-19 infection due to their advanced age,intrinsic frailty,medical comorbidities,immunosuppression,and frequent health care visits for their underlying *** analysis of COVID-19 infection among cancer patients is crucial to aid in the optimal management of these *** To identify contributors of worse outcomes in patients with malignancy and COVID-19 and to describe the role of critical *** In this review,we summarized the information from seminal articles on the presentation and management of patients with COVID-19 and malignancy that were published before December 10,*** searched the Pub Med and Medline database for“COVID-19”and“Cancer”,“Malignancy”.Studies published in English,including adults with malignancy and COVID-19 infection,were eligible to be included in this *** on patients that provided details on malignancy,clinical presentation,management,and outcome were *** details of malignancy that were included are the site of cancer,histopathological type,stage,chemotherapy,and *** of COVID-19 infection that were obtained are clinical presentation,the modality of testing,imaging,management,and *** care details that were obtained were the type of the organ dysfunction and the requirement of organ support measures,requirement of noninvasive,invasive ventilation,management of vasopressor support,and *** that did not have patient details,opinions,letters,and articles not published in English were *** articles were reviewed by 2 independent *** were screened for the above terminologies by independent clinician

关键词： COVID-19 Cancer Critical care Mortality Pandemic

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Heart failure in COVID-19 patients:Critical care experience

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World Journal of Virology 2022年第1期11卷 1-19页

作者： Kevin John John Ajay K Mishra chidambaram ramasamy Anu A George Vijairam Selvaraj Amos Lal Department of Critical Care Believers Church Medical College HospitalThiruvalla 689103India Department of Internal Medicine Division of Cardiovascular MedicineSaint Vincent HospitalWorcesterMA 01608United States Division of Medicine The Miriam Hospital and Warren Alpert Medical School of Brown UniversityProvidenceRI 02906United States Department of Medicine Division of Pulmonary and Critical Care medicineMayo ClinicRochesterMN 55902United States

Patients with heart failure(HF)may be at a higher risk of coronavirus disease 2019(COVID-19)infection and may have a worse outcome due to their comorbid conditions and advanced *** this narrative review,we aim to study the interaction between COVID-19 and HF from a critical care *** performed a systematic search for studies that reported HF and critical carerelated outcomes in COVID-19 patients in the PubMed and Medline *** a total of 1050 papers,we identified 26 that satisfied the eligibility criteria for our *** such as patient demographics,HF,intensive care unit(ICU)admission,management,and outcome were extracted from these studies and *** reported outcomes in heart-transplant patients with COVID-19 *** hospitalized patients with COVID-19,the prevalence of HF varied between 4%and 21%.The requirement for ICU admission was between 8%and 33%.HF patients with COVID-19 had an overall mortality rate between 20%and 40%.We identified that HF is an independent predictor of mortality in hospitalized COVID-19 patients,and patients with HF were more likely to require ventilation,ICU admission and develop *** with HF with reduced ejection fraction did worse than those with HF with midrange ejection fraction,and HF with preserved ejection ***-19 patients with HF should be identified early and managed aggressively in an attempt to improve outcomes in this cohort of patients.

关键词： Heart failure COVID-19 Critical care Intensive care Mortality

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Antiviral efficacy of Andrographis paniculata and andrographolides:A narrative review

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Asian Pacific Journal of Tropical Biomedicine 2024年第11期14卷 461-476页

作者： Kumarappan chidambaram Department of Pharmacology College of PharmacyKing Khalid UniversityAbha 61421Saudi Arabia

The rise of emerging infectious diseases has become notably prominent due to ecological changes and mutations in *** respiratory illness outbreak caused by the COVID-19 pandemic has spread *** products contain numerous structures and biological activities,offering ample options for discovering new antiviral drugs with unique targets and *** paniculata has been utilized in Indian Ayurvedic,Swedish,Traditional Thai,and Chinese medicine to alleviate coughs,colds,and influenza ***-stage laboratory studies indicate that this herbal extract may reduce inflammation and fever,and boost the body's natural defenses against viruses,potentially leading to symptom *** review aims to systematically present clinical trial data about antiviral herbal formulations derived from Andrographis paniculata,delineating the antiviral effects of both natural and synthetic derivatives,along with in silico analyses.

关键词： Ayurveda Andrographis paniculata Antiviral formulations Andrographolides COVID-19

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A review on the development of electrolytes for lithiumbased batteries for low temperature applications

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Frontiers in Energy 2023年第1期17卷 43-71页

作者： Jason A.MENNEL Dev chidambaram Department of Chemical and Materials Engineering University of Nevada−RenoRenoNV 89557USA Department of Chemical and Materials Engineering Nevada Institute for Sustainability University of Nevada−RenoRenoNV 89557USA

The aerospace industry relies heavily on lithium-ion batteries in instrumentation such as satellites and land *** equipment is exposed to extremely low temperatures in space or on the Martian *** extremely low temperatures affect the discharge characteristics of the battery and decrease its available working *** solvents,cosolvents,additives,and salts have been researched to fine tune the conductivity,solvation,and solid-electrolyte interface forming properties of the *** different resistive phenomena have been investigated to precisely determine the most limiting steps during charge and discharge at low *** mission lifespans as well as self-reliance on the chemistry are now highly desirable to allow low temperature performance rather than rely on external heating *** Martian rovers are equipped with greater instrumentation and demands for greater energy storage rise,new materials also need to be adopted involving next generation lithiumion chemistry to increase available *** these objectives in mind,tailoring of the electrolyte with highercapacity materials such as lithium metal and silicon anodes at low temperatures is of high *** review paper highlights the progression of electrolyte research for low temperature performance of lithium-ion batteries over the previous several decades.

关键词： electrolyte lithium-ion low temperature aerospace solid-electrolyte interface

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A simple method of tuning series cascade controllers for unstable systems

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控制理论与应用（英文版） 2013年第4期11卷 661-667页

作者： Simi SANTOSH M.chidambaram Department of Chemical Engineering Indian Institute of Technology Madras

A simple method is proposed to design P/PI controllers for a series cascade control system for unstable first order plus time-delay （FOPTD） systems. In this paper, the controller design for unstable FOPTD systems cascaded in series with stable/unstable FOPTD systems is considered. The proposed method is based on equating the coefficients of corresponding powers of s and s2 in the numerator to α1 and α2 times those of the denominator of the closed-loop transfer function for a servo problem. The open loop system consists of an unstable FOPTD system cascaded in series with a stable/unstable FOPTD system. Only two tuning parameters （α1 and α2） are required for the design of controllers. The closed-loop performances are evaluated for both the servo and regulatory problems and the performances are found to be better than that of the well established synthesis method. The robustness for uncertainty in the model parameters is studied and compared with that of the controllers designed by the synthesis method.

关键词： Cascade control Time-delay process PI controller P controller FOPTD model Tuning

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Theoretical and Computational Analyses of LNG Evaporator

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Journal of Thermal Science 2017年第2期26卷 132-137页

作者： Palani Kumar chidambaram Yang Myung Jo Heuy Dong Kim FMTRC Daejoo Machinery Co Ltd Department Mechanical Engineering Andong National University

Theoretical and numerical analysis on the fluid flow and heat transfer inside a LNG evaporator is conducted in this work. Methane is used instead of LNG as the operating fluid. This is because; methane constitutes over 80% of natural gas. The analytical calculations are performed using simple mass and energy balance equations. The analytical calculations are made to assess the pressure and temperature variations in the steam tube. Multiphase numerical simulations are performed by solving the governing equations(basic flow equations of continuity, momentum and energy equations) in a portion of the evaporator domain consisting of a single steam pipe. The flow equations are solved along with equations of species transport. Multiphase modeling is incorporated using VOF method. Liquid methane is the primary phase. It vaporizes into the secondary phase gaseous methane. Steam is another secondary phase which flows through the heating coils. Turbulence is modeled by a two equation turbulence model. Both the theoretical and numerical predictions are seen to match well with each other. Further parametric studies are planned based on the current research.

关键词： LNG Evaporator Analytical Calculation Numerical Simulation

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Complex regional pain syndrome: a recent update

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Burns & Trauma 2017年第1期5卷 24-34页

作者： En Lin Goh Swathikan chidambaram Daqing Ma Anaesthetics Pain Medicine and Intensive CareDepartment of Surgery and CancerFaculty of MedicineImperial College LondonChelsea and Westminster Hospital369 Fulham RoadLondon SW10 9NHUK

Complex regional pain syndrome (CRPS) is a debilitating condition affecting the limbs that can be induced by surgery or trauma. This condition can complicate recovery and impair one’s functional and psychological well-being. The wide variety of terminology loosely used to describe CRPS in the past has led to misdiagnosis of this condition, resulting in poor evidence-base regarding the treatment modalities available and their impact. The aim of this review is to report on the recent progress in the understanding of the epidemiology, pathophysiology and treatment of CRPS and to discuss novel approaches in treating this condition.

关键词： CRPS Epidemiology Pathophysiology Treatment Future therapy

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Antihaemolytic and snake venom neutralizing effect of some Indian medicinal plants

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Asian Pacific Journal of Tropical Medicine 2011年第9期4卷 743-747页

作者： chidambaram Kumarapppan Albert Iaswanth Karpagam Kumarasunderi Department of Life Sciences.International Medical University Kuala LumpurMalaysia Department of Pharmacology Periyar College of Pharmaceutical Sciences.Tamilnadn.India

Objective:To validate traditional claims of usefulness of the Indian plants in management of poisonous snakebite and evaluate the antivenom properties displayed bv the alcoholic extracts of Andrographis paniculata（***）,Crutera magna（***）.Gloriosa superba （***） and Hydrocotyle javanica（***）.Methods:These plants were collected, identified and the extracts were prepared bv using conventional Soxhlet ethanol extraction *** venom neutralization activity was accessed in mice（20-25g） and number of mortalities was observed against clinically important snake（Naja nigricollis） *** study also deals with in vitro membrane stabilizing activity of these plants against hyposaline induced human red blood corpuscles（HRBC）.Results:Extracts of *** and *** gave 80%and 90%protection to mice treated with minimum lethal dose of venom(LD99).These two plants showed significant neutralization effect against the venoms of Naja nigricollis venom.H. javanica and ***（25-100 mg/ml.） produced significant changes of membrane stabilization of human red blood cells（HRBC） exposed to hyposaline-induced ***:We conclude that probably due to presence of various phytochemicals plays an important role in the anti-venom potential of these Indian medicinal plants against Naja nigricollis *** above observations confirmed ***,G,*** and *** plant extracts possess potent snake venom neutralizing capacity and could potentially be used as an adjuvants for antivenin therapy in case of snakebite *** against the local effects of cobra venoms.

关键词： Antivenom activity Naja nigricollis hemolysis neutralization Indian medicinal plants

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Effect of heat treatment conditions on the passivation behavior of WE43CMg-Y-Nd alloy in chloride containing alkaline environments

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Journal of Magnesium and Alloys 2017年第2期5卷 147-165页

作者： Jakraphan Ninlachart Zachary Karmiol Dev chidambaram Krishnan SRaja Chemical and Materials Engineering University of IdahoMoscowID 83844-1021USA Chemical and Materials Engineering University of NevadaRenoNV 89557-0388USA

Mg–Y–Nd alloy(WE43C or Elektron 43)is a heat treatable magnesium wrought alloy that can be used up to 250 ℃ for aerospace *** alloy has excellent mechanical properties(UTS:up to 345 MPa at room temperature)and improved corrosion *** passivation studies were conducted on this alloy under different heat treatment conditions in 0.1 M NaOH solution with the addition of chloride from 0 to 1000 *** passive potential range typically extended to more than 1.5 VAg/*** transpassive potential was not dependent on the heat treatment condition of the alloy when the chloride concentration increased up to 500 ***,pitting protection potential varied with the heat treatment condition when the chloride addition was 500 ppm or *** specimen surface was analyzed using scanning electron microscopy(SEM),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and Raman spectroscopy to understand the passivation behavior of this *** passivated surface of the WE43C specimens indicated that the surface layer consisted of MgO,Mg(OH)_(2),and rare earth oxide phases,and the heat treatment conditions did not significantly affect the composition of the surface film.

关键词： Elektron 43 Magnesium alloy Corrosion Passivation Chloride

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Novel degradation products of argatroban: Isolation, synthesis and extensive characterization using NMR and LC-PDA-MS/Q-TOF

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Journal of Pharmaceutical Analysis 2018年第2期8卷 86-95页

作者： Vinodh Guvvala Venkatesan chidambaram Subramanian Jaya Shree Anireddy Mahesh Konda Centre for Chemical Science&Technology Institute of Science& Technology JNTUH Gland Pharma Ltd. Research and Development D.P.Pally

Forced degradation study of argatroban under conditions of hydrolysis(neutral, acidic and alkaline), oxidation,photolysis and thermal stress, as suggested in the ICH Q1 A(R2), was accomplished. The drug showed significant degradation under hydrolysis(acidic, alkaline) and oxidation(peroxide stress) conditions. The drug remained stable under thermal and photolytic stress conditions. In total, seven novel degradation products(DP-1 to DP-7) were found under diverse conditions, which were not reported earlier. The chemical structures of these degradation products were characterized by ~1H NMR,^(13)C NMR, 2 D NMR, Q-TOF-MSnand IR spectral analysis and the proposed degradation products structures were further confirmed by the individual synthesis.

关键词： Argatroban Forced degradation NMR LC-PDA LC-MS/Q-TOF-MSn

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