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Pleiotropic attenuating effect of Ginkgo biloba against isoprenalineinduced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na^(+) , K^(+) -ATPase activities

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Chinese Herbal Medicines 2024年第2期16卷 282-292页

作者： Jerome Ndudi Asiwe Abodunrin Adebayo Ojetola Nwoke Enekabokom Ekene Esthinsheen Osirim Anthony chibuzor Nnamudi Benjamin Oritsemuelebi Jackson Erozueme Onuelu Nicholas Asiwe Harrison Ogheneochuko Eruotor Saviour Inegbenehi Department of Physiology Delta State UniversityAbraka 1Nigeria Department of Physiology University of IbadanIbadan 3017Nigeria Department of Physiology Adeleke UniversityEde 250Nigeria Department of Pharmacology Rivers State UniversityNkpolu-Oroworukwo 5080Nigeria Department of Physiology Redeemer’s UniversityEde 230Nigeria Department of Biochemistry PAMO University of Medical SciencesPort Harcourt 500211Nigeria Department of Pharmacology Delta State UniversityAbraka 1Nigeria Department of Anatomy University of Port HarcourtChoba 5323Nigeria Department of Medical Laboratory Sciences University of Port HarcourtChoba 5323Nigeria

Objective:Myocardial infarction(MI)is linked to an imbalance in the supply and demand of blood oxygen in the heart ***-blockers and calcium antagonists are just two of the common medications used to treat ***,these have reportedly been shown to be either ineffective or to have undesirable side *** of Ginkgo biloba leaves(GBE),a Chinese herbal product offers special compatibility benefits in therapeutic settings relating to inflammatory diseases and oxidative *** order to better understand how GBE affects MI in rats insulted by isoprenaline(ISO),the current study was ***:The heart weight index,serum lipid profile,cardiac marker enzymes,endogenous antioxidants[catalase(CAT),superoxide dismutase(SOD),glutathione(GSH),nitrites and malondialdehyde(MDA)],inflammatory mediators[tumour necrosis factor alpha(TNF-a)and interleukin-6(IL-6)],immunohistochemical expressions of B-cell lymphoma factor-2(Bcl-2),extracellular signal-regulated kinase(ERK1/2),and mammalian target of rapamycin(mTOR)and histopathological analysis were used to assess the cardioprotective properties of ***:The findings showed that GBE effectively attenuated myocardial infarction by boosting the body’s natural antioxidant defense system and reducing the release of inflammatory cytokines as well as heart injury marker *** expression of Bcl-2,ERK1/2 and mTOR was increased while the histomorphological alterations were ***:The cardioprotective effects of GBE may be due to a mechanism involving increased Bcl-2/mTOR/ERK1/2/Na^(+),K^(+)-ATPase activity.

关键词： antioxidants extracellular signal-regulated kinase Ginkgo biloba extract isoprenaline mammalian target of rapamycin myocardial infarction Na^(+),K^(+)-ATPase

A Systematic Review on Antituberculosis Drug Discovery and Antimycobacterial Potential of Biologically Synthesized Silver Nanoparticles:Overview and Future Perspectives

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Infectious Microbes & Diseases 2022年第4期4卷 139-148页

作者： Christian K.Ezeh chibuzor N.Eze Uju M.E.Dibua stephen C.Emencheta Department of Microbiology University of NigeriaNsukkaEnugu StateNigeria Department of Pharmaceutical Microbiology University of NigeriaNsukkaEnugu StateNigeria

Rapid emergence and quick evolution of drug-resistant and aggressive mycobacterial strains have resulted in the present antimycobacterial drug crisis and the persistence of tuberculosis as a major public health ***/biological nanotechnologies constitute an interesting area of research for discovering antimycobacterial *** review focused on the biological(green)synthesis of silver nanoparticles(AgNPs)as an alternative source of antimycobacterial *** for this study were searched and screened from three electronic databases(Google Scholar,PubMed and ScienceDirect)following the Preferred Reporting Items for Systematic Reviews and Meta-analyses *** from in total 17 eligible studieswere reported in this systematic *** of the 17 studies used plants to fabricate AgNPs,whereas the remaining five studies used microorganisms(bacteria and/or fungi).Silver as part of silver nitrate(AgNO3)was themetal precursor reported for the synthesis of AgNPs in these *** nanoparticles were mostly spherical,with sizes ranging from12 *** minimum inhibitory concentrations varied between studies and were divided into three groups:(i)those more effective than the antibiotic(controls),(ii)those more effective than plant extracts,and(iii)those less effective than the antibiotic *** addition,little or no cytotoxicity effects were *** nanoparticles were also shown to be highly specific or selective toward mycobacterial *** systematic review highlights the antimycobacterial potential of biologically synthesized AgNPs,underscoring the possibility of discovering/developing new antimycobacterial agents using biological synthesis approaches with less toxicity and high selectivity.

关键词： antimycobacterial activity silver nanoparticles cytotoxicity biological synthesis tuberculosis mycobacterial

Profitability Analysis of Selected Steam Methane Reforming Methods for Hydrogen Production

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Journal of Power and Energy Engineering 2022年第8期10卷 45-53页

作者： chibuzor Chinweoke Okechukwu Sunday Boladale Alabi Department of Chemical and Petroleum Engineering University of Uyo Uyo Nigeria

One of the matured methods for producing hydrogen in bulk is steam methane reforming (SMR). The two commercial aspects of producing hydrogen from SMR are SMR with shift reactor (SR) and SMR with dry methane reforming (DRM). Although SMR with SR produces high hydrogen yield, it emits a large quantity of carbon dioxide (CO2). On the contrary, SMR and DRM produce low hydrogen yield but favorably emit a low quantity of CO2. However, it is not obvious which of these methods is more favourable economically. Consequently, using UNISIM Software Package, this study investigates three SMR methods namely SMR with SR, SMR with DRM and SMR with the combination of DRM and SR for the purpose of determining the most favourable route for producing hydrogen. This was done on the basis of feedstock rate of 100 kmol/hr of methane which reacted with 250 kmol/hr of steam for 8000 hrs annually using the rate of CO2 and CO emissions (COx) and the plant net profit percentage as performance indices. The profitability analysis shows that SMR/SR process is the most profitable process with a net profit percentage of 41.3%. Moreover, SMR/SR process has the highest yield and interestingly lowest COx emission rate. It is therefore concluded that the most favourable process route, technically and economically, is SMR/SR for the production of hydrogen using methane as feedstock.

关键词： Hydrogen Steam Methane Reforming Dry methane Reforming Carbon Oxides

Formulation of Domperidone Microspheres Using a Combination of Locally Extracted Chitosan and Hpmc as Polymers

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Journal of Chemistry and Chemical Engineering 2017年第2期11卷 65-74页

作者： stephen Olaribigbe Majekodunmi Cynthia chibuzor Uzoaganobi Department of Pharmaceutics and Pharmaceutical Technology Faculty of Pharmacy University of Uyo P.M.B 1017 UyoAkwa-Ibom State Nigeria

Modeling and optimization of Terminalia catappa *** oil extraction using response surface methodology and artificial neural network

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Artificial Intelligence in Agriculture 2020年第1期4卷 1-11页

作者： Chinedu Matthew Agu Matthew Chukwudi Menkiti Ekwe Bassey Ekwe Albert chibuzor Agulanna Chemical Engineering Department Nnamdi Azikiwe UniversityAwkaNigeria Mechanical Engineering Department Gregory UniversityUturuNigeria Materials and Energy Technology Department Projects Development Institute(PRODA)Emene Industrial AreaEnuguNigeria

In this study,response surface methodology(RSM)and artificial neural network(ANN)were used to optimize Terminalia catappa *** oil(TCKO)*** extraction method was used for the oil extraction,with n-hexane as the extracting *** highest oil yield was obtained at 55℃,150 min,and 0.5 *** physicochemical properties of the TCKO were determined using standard *** chromatographic(GC)analysis and Fourier Transform Infrared(FTIR)were respectively,used to determine the fatty acid composition and prevalent functional groups in *** optimum conditions of temperature,particle size and extraction time,the RSM predicted oil yield was 62.92%,which was validated as 60.34%,whereas ANN predicted yield was 60.39%,which was validated as 60.40%.The results of the physicochemical characterization of TCKO showed that the dielectric strength(DS),viscosity,flash and pour points values were 30.61 KV,20.29 mm^2 s^−1,260°C,and 3℃,*** characterization and FTIR results of TCKOindicated its potential industrial application,especially as transformer *** acids compositions result indicated that the oil was highly unsaturated;while XRD results of Terminalia catappa ***(TCK)samples obtained,both before and after extraction,showed difference in their peaks and corresponding intensities,due to the damage effect of ***,the obtained optimization results indicated that ANN was a better and more effective tool than RSM,due to its higher R^2 and lower RMS values.

关键词： Response surface methodology Artificial neural network Optimization Terminalia catappa L.kernel

Previable Premature Rupture of Membranes in Dichorionic Diamniotic Twin Gestation, Loss of Leading Twin, Emergency Cervical Cerclage and Ceaserean Delivery at Term

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Case Reports in Clinical Medicine 2023年第1期12卷 14-21页

作者： Darlington-Peter chibuzor Ugoji Ugochukwu Sunday Julius Ezenyirioha Ifeanyichukwu Jude Ofor Chukwuemeka Joseph Nwoye God’s Miracle David Banso Sunday Emmanuel Ucha Ugochi Chimerem Ugoji Julius Ezenyirioha Memorial Hospital and Maternity Abakpa Nike Enugu State Nigeria Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State Nigeria Department of Obstetrics and Gynaecology Enugu State University College of Medicine Parklane Enugu State Nigeria School of Nursing Alex Ekwueme Federal University Teaching Hospital Abakaliki Ebonyi State Nigeria

Introduction: Multiple pregnancies have a higher risk of premature delivery and a weakened cervix has been associated with it. In most cases, emergency cerclage has proved to be beneficial as the birth of the first twin is usually followed by the unavoidable delivery of the second twin and most fetus dies shortly after delivery. Studies have noted that delayed delivery of the second fetus in a twin pregnancy is an effective management choice and the use of cervical cerclage after the first delivery is associated with a longer inter-delivery interval. We present a case of previable premature rupture of membrane of a dichorionic diamniotic twin gestation leading to the loss of the leading twin and subsequently having emergency cervical cerclage for the second twin and caesarean delivery at term. Case Presentation: She was a case of a 29 years old, G6P1+4 with 1 living child at a gestational age of 17 weeks plus 5 days who initially was diagnosed with dichorionic diamniotic twin gestation following an early ultrasound but presented with a history of bleeding and passage of liquor per vaginam. Ultrasound done on admission showed cervical funneling and a stable state of the second twin. She subsequently had emergency cervical cerclage after stabilization on account of previable premature rupture of membrane of a dichorionic diamniotic twin gestation with the loss of the leading twin. A repeat ultrasound done prior to discharge showed closed cervical os and a good state of the fetus. She then had elective caesarean delivery at term with a good feto-maternal outcome. Conclusion: Emergency cervical cerclage should be part of the options of management after stabilization in cases of previable premature rupture of membrane in a dichorionic or multichoronic gestation so as to save the viable once.

关键词： Previable Premature Rupture of Membrane Cervical Cerclage Twin Gestation Multiple Gestation Multiple Pregnancy Twin Preterm Delivery Cervical Incompetence Cerclage Interval Delivery

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尼日利亚汉语教学现状的调查分析

尼日利亚汉语教学现状的调查分析

作者： OZIOKO EMMANUEL chibuzor（张弘毅）河北师范大学

学位级别：硕士

本论文通过对尼日利亚汉语教学现状的调查与分析,发现其中存在的问题,探求形成的原因,并提出相应的解决对策与方法。论文的基本框架如下。导言部分,包含选题意义、研究基础、研究方法和研究内容。第一章尼日利亚汉语教学的背景,介绍尼... 详细信息

本论文通过对尼日利亚汉语教学现状的调查与分析,发现其中存在的问题,探求形成的原因,并提出相应的解决对策与方法。论文的基本框架如下。导言部分,包含选题意义、研究基础、研究方法和研究内容。第一章尼日利亚汉语教学的背景,介绍尼日利亚汉语教学的发展概况,归纳出尼日利亚人对汉语教学的基本认识。第二章尼日利亚汉语教学的学校和机构,重点介绍尼日利亚仅有的两所孔子学院。第三章关于尼日利亚汉语教学现状问卷调查及分析是对尼日利亚汉语教学的问卷调查以及分析。第四章尼日利亚汉语教学存在的主要问题,从社会与教学两方面进行分析了尼日利亚汉语教学存在的主要问题。结语部分,笔者从中、尼两方面,提出改进问题的策略和建议。目前,无论是在尼日利亚,还是在中国,对尼日利亚汉语现状调查研究还很少。因此,笔者希望自己的努力可以为以后的相关研究提供一些有益的借鉴和帮助,可以帮助中国的对外汉语工作者了解尼日利亚汉语教学的现状,可以给尼日利亚,中国政府和教育部门提供决策依据,从而更好地在尼日利亚宣传推广中国语言文化。

关键词：尼日利亚汉语教学现状调查分析建议

Tranexamic Acid versus Placebo for Prevention of Primary Postpartum Haemorrhage among High Risk Women Undergoing Caesarean Section in Abakaliki: A Randomized Controlled Trial

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Open Journal of Obstetrics and Gynecology 2019年第6期9卷 914-922页

作者： Nwafor Johnbosco Ifunanya Ibo Chukwunenye Chukwu Obi Chuka Nobert Onwe Blessing Ugoji Darlington-Peter chibuzor Onuchukwu Victor Uchenna Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital Abakaliki Nigeria

Objective: To evaluate the efficacy of tranexamic acid for prevention of postpartum haemorrhage among women undergoing cesarean section who were at high risk of postpartum hemorrhage. Materials and Method: This was a double blind randomized controlled trial conducted at the Alex Ekwueme Federal University Teaching Hospital Abakaliki from January 2016 to December 2017. One hundred and sixty-eight parturients at high risk of postpartum haemorrhage who underwent caesarean section were randomly assigned to receive either tranexamic acid or placebo prior to skin incision. Results: The result of the study showed that the need for additional uterotonic was higher in women in the placebo arm when compared with women in the tranexamic arm of the study (7.4% versus 33.3%, respectively). The incidence of primary post-partum hemorrhage (blood loss > 1000 ml) was significantly lower in the tranexamic acid group compared to placebo group (11.9% versus 50%, respectively, P-value Conclusion: Intravenous tranexamic acid given prior to skin incision at caesarean section reduced the need for additional uterotonics and incidence of primary postpartum among high risk women.

关键词： Tranexamic Acid Maternal Mortality Postpartum Haemorrhage

Gestational Trophoblastic Diseases: A Review of the Clinical Presentation and Management at the Alex Ekwueme Federal University Teaching Hospital Abakaliki

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Case Reports in Clinical Medicine 2019年第6期8卷 164-171页

作者： Nwafor Johnbosco Ifunanya Obi Vitus Okwuchukwu Ibo Chukwunenye Chukwu Obi Chuka Nobert Onwe Blessing Ugoji Darlington-Peter chibuzor Onuchukwu Victor Uchenna Department of Obstetrics and Gynaecology Alex Ekwueme Federal University Teaching Hospital Abakaliki South-East Nigeria Nigeria

Background: Gestational trophoblastic diseases (GTD) are potentially curable with retention of reproductive function once the correct diagnosis is made and treatment is commenced early with adequate follow up. Objective: The objective of this study was to determine the incidence, clinical presentation, management and treatment outcomes of gestational trophoblastic diseases in a tertiary hospital in Abakaliki, South-east Nigeria. Materials and Methods: This was a retrospective descriptive study of gestational trophoblastic diseases managed at Alex Ekwueme Federal University Teaching Hospital, Abakaliki (AEFUTHA) over a 6-year period. The statistical analysis was done using SPSS version 22. Results: The incidence of GTD was 4.6 per 1000 deliveries. Women who were less than 20 years and more than 40 years of age accounted for 5.9% and 23.5% of cases of GTD respectively. Women who were para 5 and above accounted for 76.5% of those who presented with GTD. All the patients presented with vaginal bleeding. Suction evacuation (76.5%) was the commonest form of treatment offered to women with GTD. The commonest complication was anaemia (94.1%). Maternal death due to GTD was 8.8%. Most (58.8%) of the patients did not turn up for follow-up. Conclusion: Gestational trophoblastic diseases has remained an important cause of maternal morbidity and mortality in our hospital due to poor compliance with follow-up. Call and recall system should be introduced in the management of patients with GTD to improve compliance to management standard.

关键词： Gestational Maternal Mortality Chemotherapy Follow-Up