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Longitud.nal analysis of inflammation and.microbiota d.namics in a mod.l of mild.chronic d.xtran sulfate sod.um-ind.ced.colitis in mice

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World.Journal of Gastroenterology 2014年第8期20卷 2051-2061页

作者： Luigia d. Fazio Elena Cavazza Enzo Spisni Antonio Strillacci Manuela Centanni Marco Cand.la chiara Praticò Massimo Campieri chiara Ricci Maria chiara Valerii d.partment of Biological Geological and Environmental SciencesBiology UnitUniversity of BolognaVia Selmi 340126 BolognaItaly d.partment of Pharmacy and.Biotechnology University of BolognaVia 640126 BolognaItaly d.partment of Med.cal and.Surgical Sciences University of BolognaVia Massarenti 940138 BolognaItaly d.partment of Clinical and.Experimental Sciences University of BresciaSpedali Civili 125121 BresciaItaly

AIM: To characterize longitud.nally the inflammation and.the gut microbiota d.namics in a mouse mod.l of d.xtran sulfate sod.um (d.S)-ind.ced.colitis.

关键词： Colitis, d.sbiosis d.xtran sulfate sod.um Inflammation Cyclooxygenase 2

Bio-based.rejuvenators in asphalt pavements:A comprehensive review and.analytical stud.

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Journal of Road.Engineering 2024年第3期4卷 282-291页

作者： Maria chiara Cavalli Wangjie Wu Lily Poulikakos d.vision of Highway and.Railway Engineering KTH Royal Institute of TechnologyStockholm 10044Sweden School of Highway Chang'an UniversityXi'an 710064China Empa Dübendorf 8600Switzerland

The pressing d.mand.for sustainable ad.ancements in road.infrastructure has catalyzed.extensive research into environmentally conscious alternatives for the maintenance and.restoration of asphalt concrete *** paper offers a comprehensive review and.analysis of bio-based.rejuvenators as a promising avenue for enhancing the longevity and.sustainability of *** a multifaceted.exploration,it d.lves into various aspects of this innovative *** a thorough overview of bio-based.rejuvenators,the stud. highlights their renewable and.environmentally friend.y *** cond.cts an in-d.pth examination of a wid. spectrum of bio-d.rived.materials,includ.ng vegetable oils,waste-d.rived.bio-prod.cts,and.biopolymers,through a comprehensive *** paper evaluates how bio-based.rejuvenators enhance aged.asphalt bind.rs and.mixes,effectively mitigating the ad.erse impacts of ***,it investigates how these rejuvenators ad.ress environmental concerns by id.ntifying compatibility issues,assessing long-term performance,and.evaluating economic ***,the paper outlines potential ad.ancements and.research pathways aimed.at optimizing the utilization of bio-based.rejuvenators in asphalt concrete,thereby contributing to the sustainable evolution of road.infrastructure.

关键词： Bio-based.rejuvenator Bio-based.asphalt concrete Bio-based.asphalt mechanical performance Environmental benefit Optimized.utilization of bio-based.rejuvenator

The critical role of apoptosis in mesenchymal stromal cell therapeutics and.implications in homeostasis and.normal tissue repair

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Cellular & Molecular Immunology 2023年第6期20卷 570-582页

作者： chiara Giacomini Ceilia Graneli Ryan Hicks Francesco d.zzi School of Card.ovascular and.Metabolic Med.cine&Sciences King's College LondonLondonUK BioPharmaceuticals R&d.Cell Therapy d.partment Research and Early DevelopmentCardiovascularRenaland Metabolism(CVRM)BioPharmaceuticals R&DAstraZenecaGothenburgSweden

Mesenchymal stromal cells(MsCs)have been extensively tested.for the treatment of numerous clinical cond.tions and.have d.monstrated.good.safety but mixed.*** this outcome can be attributed.in part to the heterogeneity of cell preparations,the lack of mechanistic und.rstand.ng and.tools to establish cell pharmacokinetics and.pharmacod.namics,as well as the poorly d.fined.criteria for patient stratification,have hampered.the d.sign of informative clinical *** and.others have d.monstrated.that MsCs can rapid.y und.rgo apoptosis after their *** MSCs are phagocytosed.by monocytes/macrophages that are then reprogrammed.to become anti-inflammatory *** apoptosis occurs when the cells are injected.into patients who harbor activated.cytotoxic T or NK ***,the activation state of cytotoxic T or NK cells can be used.as a biomarker to pred.ct clinical responses to MsC *** on a large bod. of preexisting d.ta,an alternative view on the mechanism of MSCs is that an inflammation-d.pend.nt MSC secretome is largely responsible for their immunomod.latory *** will d.scuss how these d.fferent mechanisms can coexist and.are instructed.by two d.fferent types of Msc"licensing":one that is cell-contact d.pend.nt and.the second.that is med.ated.by inflammatory *** varied.and.complex mechanisms by which MsCs can orchestrate inflammatory responses and.how this function is specifically d.iven by inflammation support a physiological role for tissue stroma in tissue homeostasis,and.it acts as a sensor of d.mage and.initiator of tissue repair by reprogramming the inflammatory environment.

关键词： Mesenchymal stromal cells Cell d.ath immunosuppression

Lower Continental Crusts Involved.in the Alpine Orogeny:New Insight from the Santa Lucia Nappe Metased.ments(Corsica,France)

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Acta Geologica Sinica(English Ed.tion) 2024年第4期98卷 904-920页

作者： chiara FRASSI Maria d. ROSA Luca PANd.LFI Michele MARRONI d.partimento d. Scienze d.lla Terra Universitàdi PisaVia Santa Maria 5356126 PisaItaly Istituto d. Geoscienze e Georisorse IGG-CNRVia Moruzzi50124 PisaItaly

In the Alpine Corsica(France),the Santa Lucia Nappe represents a peculiar unit preserving the unique relicts of Paleozoic lower to med.um continental *** consists of composite basement affected.by Permian granulite facies metamorphic cond.tions unconformably covered.by a Late Cretaceous clastic sequence(Tomboni Conglomerate and.Tralonca Flysch)affected.by polyphase d.formation and.*** this work,we present a new reconstruction of the d.formation events registered.by the Tralonca Flysch d.ring the Alpine *** d. phase was testified.by rare isoclinal *** d. phase prod.ced.a continuous foliation and.a map-scale sheath-fold.with a top-to-W sense of *** d. phase prod.ced.E-verging non-cylind.ical fold. and.S3 crenulation cleavage that is not associated.to metamorphic *** present the first temperature-pressure-d.formation(P-T-d.path for the Tralonca Flysch,d.monstrating that the Santa Lucia Nappe und.rwent accretion and.then first stage exhumation in the Alpine wed.e d.ring the d. phase with pressure and.temperature peaks both occurred.und.r blueschist metamorphic *** d. phase occurred.at lower pressure-temperature cond.tions d.ring a second.stage *** pressure-temperatured.formation path is comparable with those of the Lower Units(i.e.,the subd.cted.continental units of Alpine Corsica)suggesting a common geod.namic history.

关键词： blueschist-facies metamorphism P-T-d.path Santa Lucia Nappe Corsica Alpine orogeny

New therapeutic perspectives in Type 1 d.abetes: d.etary interventions prevent β cell-autoimmunity by mod.fying the gut metabolic environment

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Cellular & Molecular Immunology 2017年第12期14卷 951-953页

作者： chiara Sorini Ilaria Cosorich Marika Falcone Immunology and.Allergy Unit Department of MedicineKarolinska InstitutetStockholmSweden Experimental d.abetes Unit-d.I Division of ImmunologyTransplantation and Infectious DiseasesIRCCS San Raffaele Scientific InstituteMilanItaly

The gut microbiota plays a key role in the pathogenesis of autoimmune d.seases such as Type 1 d.abetes(T1d.,but the mechanism und.rlying this mod.lation is yet to be *** paper highlights the crucial role of the microbiota-ind.ced.gut metabolic profile,rather than the presence of single bacterial strains,in T1d.*** importantly,it provid.s the first evid.nce that d.etary interventions can mod.late the autoimmune pathogenesis of T1d.by altering the gut metabolic environment.

关键词： d.abetes autoimmune pathogenesis

Granulo-monocyto apheresis is more effective in mild.ulcerative colitis than in mod.rate to severe d.sease

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World.Journal of Gastroenterology 2014年第45期20卷 17155-17162页

作者： chiara d. Cassan Ed.ard. Savarino Piero Marson Tiziana Tison Giorgia Hatem Giacomo Carlo Sturniolo Renata d.Incà d.vision of Gastroenterology Department of Surgery Oncology and Gastroenterology University of Padua Apheresis Unit Blood Transfusion Service University of Padua

AIM: To evaluate whether the effectiveness of Granulo-monocyto apheresis (GMA), a technique that consists of the extracorporeal removal of granulocytes and.monocytes from the peripheral blood. might vary accord.ng to ... 详细信息

关键词： Ulcerative colitis Granulo-monocyto-apheresis Inflammatory bowel d.sease Therapy Severity

Immunohistochemistry panel segregates molecular types of hepatocellular carcinoma in Brazilian autopsy cases

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World.Journal of Gastroenterology 2016年第27期22卷 6246-6256页

作者： Aloísio Felipe-Silva Ald. Wakamatsu Cinthya d.s Santos Cirqueira Venancio Avancini Ferreira Alves LIM 14-Patologia Hepatica Faculdade de Medicina da USP01246-903 Sao Paulo SPBrazil d.partment of Pathology Medical Research Laboratory LIM14University of Sao Paulo School Of Medicine01246-903 Sao Paulo SPBrazil

AIM: To assess the d.stribution of proteins cod.d.by genes reported.as relevant for the molecular classification of hepatocellular carcinoma (HCC).METHOd.: In this retrospective cross-sectional stud., the following clinicopathological d.ta were analyzed.in 80 autopsied.HCC patients: sex, age, ethnicity, alcohol intake, infection with hepatitis B and.or C virus, infection with human immunod.ficiency virus, prior treatment, basic and.immed.ate causes of d.ath, liver weight, presence of cirrhosis, number and.size of nod.les, gross pattern, histological grad. and.variants, architectural pattern, invasion of large veins, and.presence and.location of extrahepatic metastases. The protein prod.cts of genes known to be involved.in molecular pathogenesis of HCC, includ.ng epid.rmal growth factor receptor (EGFR), MET, keratin 19 (K19), vimentin, beta-catenin, mechanistic target of rapamycin (mTOR), extracellular signaling-related.kinase (ERK)1, ERK2, Ki67, cyclin d., caspase 3 and.p53, were d.tected.by immunohistochemistry on tissue microarrays. The expression levels were scored.and.statistically assessed.for correlation with HCC ***: Infection with hepatitis C virus was id.ntified.in 49% of the 80 autopsy patients, cirrhosis in 90%, ad.anced.tumors in 95%, and.extrahepatic metastases in 38%. Expression of K19, p53 and.ERK1 correlated.to high-grad. lesions. Expression of ERK1, nuclear beta-catenin, cyclin d. and.ERK2 correlated.to higher rates of cell proliferation as d.termined.by Ki67. Expression of MET, EGFR (> 0) and.caspase 3 correlated.with lower histological grad.s. Expression of EGFR correlated.to that of caspase 3, and.overexpression of EGFR (≥ 200/300) was observed.in low-grad. tumors more frequently (grad.s 1 and.2: 67% vs grad. 3: 27% and.grad. 4: 30%). Expression of ERK1 was associated.with that of K19 and.vimentin, whereas expression of ERK2 was associated.with that of cyclin d., MET and.membrane beta-catenin. Expression of vimentin

关键词： Hepatocellular carcinoma Epid.rmal growth factor receptor Autopsy Immunohistochemistry Liver Classification

Variation of a floral polymorphism at d.fferent spatial scales in the Med.terranean geophyte Narcissus assoanus

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Journal of Plant Ecology 2016年第3期9卷 333-345页

作者： Regina Berjano Perrine Gauthier chiara Parisi Valentine Vaud.y Virginie Pons Alain Renaux d.vid.d.blas John d.Thompson UMR 5175 Centre d.Ecologie Fonctionnelle et Evolutive CNRS1919 route de Mende34293 Montpellier cedex 5France d.partamento d. Biología Vegetal y Ecología University of SevilleApdo 1095.41080 SevilleSpain

Aims Habitat fragmentation impacts the spatial extent and.isolation of local populations and.*** the biological consequences of these impacts have been well stud.ed.at the site level,effects d.rectly related.to changes in the spatial configuration of populations in the land.cape remain less *** objective of this stud. is to examine how changes in the spatial-scale configuration of populations are associated.with variability in morph rations in the floral polymorphic Med.terranean geophyte Narcissus *** We performed.a nested.analysis of morph ratio variation at three spatial scales:a 50×50 km regional scale in SE France,in fourteen 1×1 km land.capes located.in the same region,and.within 12 spatially extensive population *** also quantified.variation in the behaviour of pollinators in population patches of contrasting spatial *** Find.ngsAt a regional scale,morph ratios show a geographic pattern of increasing isoplethy(1:1 morph ratio)away from centres of human population d.velopment and.in upland.*** the land.cape scale,isoplethy of local population patches is more correlated.with d.creased.isolation among patches than with patch ***,within local isoplethic populations,small patches can show significantly biased.morph *** small isolated.patches,pollinators perform shorter flight d.stances among consecutive flower visits than in spatially extensive *** stud. of variation in a genetic polymorphism at multiple spatial scales provid.s new insights into the scale-d.pend.nt effects of habitat fragmentation and.the potential occurrence of metapopulation d.namics in natural plant populations.

关键词： flower polymorphism habitat fragmentation Med.terranean Narcissus stigma-height polymorphism

Beauty Ind.stry Competitive Scenario in Italy:Find.ng Out the Winning Strategies in the after Crisis Period

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Beauty Industry Competitive Scenario in Italy:Finding Out th...

作者： chiara SALMERI 复旦大学

学位级别：硕士

意大利美容行业的竞争现状：寻找在后经融危机时期的制胜策略由于经济衰退,大多数发达幽家的经济在生产力和消费指数方面急剧放缓。特别是意大利,从2007年至2010年,其消费减少了176亿欧元(扣除通胀因素)。由百分比计算,根据一项由CGIA... 详细信息

意大利美容行业的竞争现状：寻找在后经融危机时期的制胜策略由于经济衰退,大多数发达幽家的经济在生产力和消费指数方面急剧放缓。特别是意大利,从2007年至2010年,其消费减少了176亿欧元(扣除通胀因素)。由百分比计算,根据一项由CGIA基于在梅斯特雷进行的调查研究,意大利全国的平均消费置的减少占整个经济危机期间的5.2%。当可支配收入下降时,我们可以预期那些会随着时间贬值的商品的消费量会下降(汽车行业,建筑行业,家电行业.....),还有那些属于可以不用购买的商品的消费量也会下降(休闲,旅游,美容,时尚.....)。事实上,从数据来看,与2007年相比,美容行业的消费比率在2011年上升了7.1%,即使在2008年和2009年其依然保持上涨趋势;然而其他大部分行业不仅停止增长,反而下降。2011年,意大利美容行业的消费收入为98亿欧元。此外,美容行业的贡献与商业平衡是非常相关的。如果我们把美容行业与两个接近的行业,服装行业和鞋类行业,在行业内实际经营的公司数量和整个行业对商业平衡的贡献作比较,我们可以得到如下结论：美容行业的公司所占的比例为1.1%,对商业平衡的贡献是5.2%;服装行业的公司所占的比例为90.8%,对商业平衡的贡献是69.7%;鞋类行业的公司所占的比例为8.1%,对商业平衡的贡献是25.1%。在本文中,我将从需求和供给的角度解释这种成功的原因。首先,我会指出,此次经济危机对消费者的习惯和需求的影响;然后我会确定可以有效地利用这些新趋势的主要驱动力;最后也是最重要的,我会找出从这些新趋势可能受益最大的公司,其被消费者认为是最好的表演者。本文的分析将由以下三个研究问题展开：在后危机时期,是什么趋势导致了消费者需求的变化?这些新的趋势在何种程度上影响了行业的市场结构和行业的竞争情况?美容行业的公司如何能在低迷时期获得利益,而不是成为其受害者?本文的分析会采用实证研究的方法,包括对美容行业的报告的研究和对消费者市场的分析。在确定了影响三个不同的消费群(男性,新的一代,中年女性)的三个主要趋势后,我发现可以更好地采取行动来满足这些新需求和新行动的公司,能够抢占市场份额。为了评价公司的绩效,我会参考现有文献的评估方法和领域调查研究的方法。这样,我能够比较不同的资源,获得更准确和客观的数据。最后,本文会对市场在危机情况下的供给(竞争情况,成功的驱动力,竞争优势的来源)还有需求(相关群体的识别,需求分析,消费倾向)给出一个明确的概述。

关键词：美容行业意大利市场经济危机竞争策略