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Histopathology and immunophenotyping of late onset cutaneous manifestations of COVID-19 in elderly patients: Three case reports

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World Journal of Clinical Cases 2021年第20期9卷 5744-5751页

作者： Maria Mazzitelli Stefano Dastoli chiara Mignogna Luigi Bennardo Elena Lio Maria chiara Pelle Enrico Maria Trecarichi Branca Isabel Pereira Steven Paul Nisticò Carlo Torti Department of Medical and Surgical Sciences Infectious and Tropical Disease UnitMagna Graecia UniversityCatanzaro 88100Italy Department of Health Sciences Magna Graecia Universitàof CatanzaroCatanzaro 88100Italy Interdipartimental Service Center Pathology UnitPugliese Ciaccio HospitalCatanzaro 88100Italy Department of Health Sciences Magna Graecia UniversityCatanzaro 88100Italy Department of Medical and Surgical Sciences Magna Graecia Universitàof CatanzaroCatanzaro 88100Italy HIV/GUM Directorate Chelsea and Westminster Hospital Foundation TrustLondon SW109NHUnited Kingdom

BACKGROUND Several cutaneous manifestations such as urticarial rash,erythematous patches and chilblain-like lesions have been described in young adults with coronavirus disease 2019(COVID-19)and are present in up to 20%patients,but few reports exist describing histopathological and immunophenotypic characteristics of dermatological lesions in older *** aim was to characterize skin lesions in elderly patients during late stages of COVID-19 from clinical,histological and immunophenotypic *** SUMMARY Three patients,admitted for COVID-19,and who developed cutaneous manifestations underwent skin *** analysis for CD20,CD3,CD4 and CD8 was performed on skin biopsies to assess immune cell ***1a was used as a marker of Langerhans cells,and CD31 as a marker of endothelial *** the three study patients,cutaneous manifestations were evident in the late-stage of COVID-19(mean time from the first positive severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)swab to rash onset was 35 d).Skin biopsies showed a similar pattern of T lymphocyte infiltration in all ***,a chronic dermatitis with perivascular lymphocytic infiltrate was observed with predominance of CD3+T-cell(CD3+).CONCLUSION Our study confirms previous *** and immunophenotypic patterns in our patients confirm results described in the two previous reported *** pattern is similar to what is found in some lympho-proliferative ***,since these findings are non-specific,SARS-CoV-2 infection should be suspected.

关键词： COVID-19 SARS-CoV-2 Rash T-helper infiltrates Cutaneous manifestation Case report

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Upper aerodigestive tract disorders and gastro-oesophageal reflux disease

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World Journal of Clinical Cases 2015年第2期3卷 102-111页

作者： Andrea Ciorba chiara Bianchini Michele Zuolo Carlo Vittorio Feo ENT Department University of Ferrara S.Anna University Hospital Department of Surgery University of Ferrara

A wide variety of symptoms and diseases of the upper aerodigestive tract are associated to gastro-oesophageal reflux disease(GORD). These disorders comprise a large variety of conditions such as asthma, chronic otitis media and sinusitis, chronic cough, and laryngeal disorders including paroxysmal laryngospasm. Laryngopharyngeal reflux disease is an extraoesophageal variant of GORD that can affect the larynx and pharynx. Despite numerous research efforts, the diagnosis of laryngopharyngeal reflux often remains elusive,unproven and controversial, and its treatment is then still empiric. Aim of this paper is to review the current literature on upper aerodigestive tract disorders in relation to pathologic gastro-oesophageal reflux, focusing in particular on the pathophysiology base and results of the surgical treatment of GORD.

关键词： Clinical management Gastro-oesophageal reflux Extraoesophageal disease Upper aerodigestive tract disorders Etiopathogenesis Therapy

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Liquid biopsy in endometrial cancer

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 399-416页

作者： Francesca Malentacchi chiara Sgromo Lorenzo Antonuzzo Serena Pillozzi Department of Clinical Experimental and Biomedical Sciences University of FlorenceFlorence 50134Italy Clinical Oncology Unit Careggi University HospitalFlorence 50134Italy

Liquid biopsy(LB)is an emerging tool for the evaluation of relapse in several cancers and nowadays is used in lung cancer for primary detection and molecular characterization when tumoral tissue is not *** can represent an innovative biospecimen for the screening,diagnosis,and monitoring of all types of cancer and for monitoring of therapeutic *** includes several biofluids such as blood,urine,peritoneal fluid/lavage,and analytes(circulating tumor cells,circulating tumor DNA,long noncoding RNA,microRNA,vesicles,mRNA,and protein)that can play different roles in diagnosis,prognosis,and patient management as well as in the improvement of the knowledge of cancer *** cancer(EC)is a tumor usually detected at low stage with a good prognosis,but few low risk cases,unexpectedly,can evolve to bad *** to now,no molecular target exists to treat advanced stage or to define the evolution of low stage *** review focuses on how the LB may help in the management and characterization of patients affected by EC.

关键词： Endometrial cancer liquid biopsy long noncoding RNA circular RNA circulating tumor DNA circulating tumor cell extracellular vesicle peritoneal lavage

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Trends in tropospheric ozone concentrations and forest impact metrics in Europe over the time period 2000–2014

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Journal of Forestry Research 2021年第2期32卷 543-551页

作者： chiara Proietti Maria Francesca Fornasier Pierre Sicard Alessandro Anav Elena Paoletti Alessandra De Marco Italian Institute for Environmental Protection and Research(ISPRA) via Brancati 4800144 RomeItaly ARGANS 260 route du Pin Montard06410 BiotFrance Italian National Agency for New Technologies Energy and the EnvironmentC.R.Casaccia00123 RomeItaly IRET-CNR Via Madonna del Piano 10Florence50019 Sesto FiorentinoItaly

In Europe,tropospheric ozone pollution appears as a major air quality issue,and ozone concentrations remain potentially harmful to *** this study we compared the trends of two ozone metrics widely used for forests protection in Europe,the AOT40(Accumulated Ozone over Threshold of 40 ppb)which only depends on surface air ozone concentrations,and the Phytotoxic Ozone Dose which is the accumulated ozone uptake through stomata over the growing season,and above a threshold Y of uptake(PODY).By using a chemistry transport model,we found that European-averaged ground-level ozone concentrations(−2%)and AOT40 metric(−26.5%)significantly declined from 2000 to 2014,due to successful control strategies to reduce the emission of ozone precursors in Europe since the early *** contrast,the stomatal ozone uptake by forests increased from 17.5 to 26.6 mmol O3 m^(−2)despite the reduction in ozone concentrations,leading to an increase of potential ozone damage on plants in *** a climate change context,a biologically-sound stomatal flux-based standard(PODY)as new European legislative standard is needed.

关键词： Tropospheric ozone AOT40 POD Trendm Mann-Kendall test

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An integrated approach to investigate climate-driven rockfall occurrence in high alpine slopes: the Bessanese glacial basin, Western Italian Alps

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Journal of Mountain Science 2020年第11期17卷 2591-2610页

作者： VIANI Cristina CHIARLE Marta PARANUNZIO Roberta MERLONE Andrea MUSACCHIO chiara COPPA Graziano NIGRELLI Guido Department of Earth Sciences University of Torino10125 TorinoItaly Research Institute for Geo-Hydrological Protection Italian National Research Council10135 TorinoItaly Institute of Atmospheric Sciences and Climate Italian National Research Council10133 TorinoItaly National Institute of Metrological Research 10135 TorinoItaly

Rockfalls are one of the most common instability processes in high *** represent a relevant issue,both for the risks they represent for(infra)structures and frequentation,and for their potential role as terrestrial indicators of climate *** study aims to contribute to the growing topic of the relationship between climate change and slope instability at the basin *** selected study area is the Bessanese glacial basin(Western Italian Alps)which,since 2016,has been specifically equipped,monitored and investigated for this *** order to provide a broader context for the interpretation of the recent rockfall events and associated climate conditions,a cross-temporal and integrated approach has been *** this purpose,geomorphological investigations(last 100 years),local climate(last 30 years)and near-surface rock/air temperatures analyses,have been carried *** research outcomes show that rockfalls occurred in two different geomorphological positions:on rock slopes in permafrost condition,facing from NW to NE and/or along the glacier margins,on rock slopes uncovered by the ice in the last *** thaw of the active layer and/or glacier debutressing can be deemed responsible for slope failure *** regard to timing,almost all dated rock falls occurred in *** the July events,initiation may have been caused by a combination of rapid snow melt and enhanced seasonal thaw of the active layer due to anomalous high temperatures,and *** events are,instead,associated with a significant positive temperature anomaly on the quarterly scale,and they can be ascribed to the rapid and/or in depth thaw of the permafrost active *** to our findings,we can expect that in the Bessanese glacierized basin,as in similar high mountain areas,climate change will cause an increase of slope instability in the *** fasten knowledge deepening,we highlight the need for a growth of a network of high elevation

关键词： Rockfalls Climate change Air and rock temperature Periglacial environment Western Italian Alps

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Feeding broiler chickens with arginine above recommended levels:effects on growth performance,metabolism,and intestinal microbiota

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1528-1541页

作者： Giorgio Brugaletta Marco Zampiga Luca Laghi Valentina Indio chiara Oliveri Alessandra De Cesare Federico Sirri Department of Agricultural and Food Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Veterinary Medical Sciences Alma Mater Studiorum-University of BolognaOzzano Dell’Emilia40064 BolognaItaly Department of Physics and Astronomy Alma Mater Studiorum-University of Bologna40127 BolognaItaly

Background Arginine is an essential amino acid for chickens and feeding diets with arginine beyond the recommended levels has been shown to influence the growth performance of broiler chickens in a positive ***,further research is required to understand how arginine supplementation above the widely adopted dosages affects metabolism and intestinal health of ***,this study was designed to assess the effects of arginine supplementation(i.e.,total arginine to total lysine ratio of 1.20 instead of 1.06-1.08 recommended by the breeding company) on growth performance of broiler chickens and to explore its impacts on the hepatic and blood metabolic profiles,as well as on the intestinal *** this purpose,630 one-day-old male Ross 308 broiler chicks were assigned to 2 treatments(7 replicates each) fed a control diet or a crystalline L-arginine-supplemented diet for 49 *** Compared to control birds,those supplemented with arginine performed significantly better exhibiting greater final body weight at D49(3778 vs.3937 g;P < 0.001),higher growth rate(76.15 vs.79.46 g of body weight gained daily;P < 0.001),and lower cumulative feed conversion ratio(1.808 vs.1.732;P < 0.05).Plasma concentrations of arginine,betaine,histidine,and creatine were greater in supplemented birds than in their control counterparts,as were those of creatine,leucine and other essential amino acids at the hepatic *** contrast,leucine concentration was lower in the caecal content of supplemented *** alpha diversity and relative abundance of Firmicutes and Proteobacteria(specifically Escherichia coli),as well as increased abundance of Bacteroidetes and Lactobacillus salivarius were found in the caecal content of supplemented *** The improvement in growth performance corroborates the advantages of supplementing arginine in broiler *** can be hypothesized that the performance enhancement found in this study is associated with the i

关键词： Arginine Broiler chicken Growth performance Metabolism Microbiota

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Evaluation of dietary addition of 2 essential oils from Achillea moschata,or their components (bornyl acetate,camphor,and eucalyptol) on in vitro ruminal fermentation and microbial community composition

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Animal Nutrition 2021年第1期7卷 224-231页

作者： Stefania Colombini Andrea Rota Graziosi Pietro Parma Marcello Iriti Sara Vitalini chiara Sarnataro Mauro Spanghero Dipartimento di Scienze Agrarie e Ambientali—Produzione TerritorioAgroenergiaUniversitàDegli Studi di MilanoVia Celoria 220133 MilanoItaly Dipartimento di Scienze Agroalimentari Ambientali e AnimaliUniversitàDegli Studi di Udine33100 UdineItaly

This study investigated the effects of 2 Achillea moschata essential oils extracted from plants collected in 2 different valleys of the Italian Alps and 3 pure compounds of oils—bornyl acetate(BOR),camphor(CAM),and eucalyptol(EUCA)—on in vitro ruminal fermentation and *** in vitro batch fermentation experiment(Exp.1)tested the addition of all of the substances(2 essential oils and 3 compounds)in fermentation bottles(120 mL)at 48 h of incubation,whereas a subsequent in vitro continuous culture experiment(Exp.2)evaluated the pure compounds added to the fermenters(2 L)for a longer incubation period(9 d).In both experiments,total mixed rations were incubated with the additives,and samples without additives were included as the control(CTR).Each treatment was tested in duplicate and was repeated in 3 and 2 fermentation runs in Exp.1 and 2,*** production(GP)in Exp.1 was similar for all of the treatments,and short chain volatile fatty acid(SCFA)production was similar in both experiments except for a decrease of SCFA produced(P=0.029)due to EUCA addition in *** to CTR,BOR and CAM reduced the valerate proportion(P=0.04)in Exp.1,and increased(P<0.01)the acetate proportion in *** treatments increased(P<0.01)total protozoa counts(+36.7%and+48.4%compared to CTR on average for Exp.1 and 2,respectively).In Exp.1,all of the treatments lowered the Bacteroidetes and Firmicutes and increased the Proteobacteria relative abundances(P<0.05),whereas in Exp.2,the EUCA addition increased(P=0.012)the *** Exp.1,methane(CH4)as a proportion of the GP was lowered(P=0.004)by the addition of CAM and EUCA compared to CTR,whereas in Exp.2,EUCA reduced the amount of stoichiometrically calculated CH4 compared to ***,essential oils extracted from *** and the pure compounds did not depress in vitro rumen fermentation,except for EUCA in *** both experiments,an increase of the protozoal population occurred for all the additives.

关键词： Methane Rumen fermentation Achillea moschata Protozoa Microbiome

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Thyroid carcinoma showing thymus-like differentiation: Case presentation of a young man

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World Journal of Clinical Oncology 2014年第5期5卷 1117-1120页

作者： chiara Abeni chiara Ogliosi Luigina Rota Paola Bertocchi Alessandra Huscher Giordano Savelli Mariano Lombardi Alberto Zaniboni Department of Medical Oncology Fondazione Poliambulanza 25124 Brescia Italy Department of Radiotherapy Fondazione Poliambulanza 25124 Brescia Italy Department of Nuclear Medicine Fondazione Poliambulanza 25124 Brescia Italy Department of Pathology Fondazione Poliambulanza 25124 Brescia Italy

Ectopic thymic tissue can be present in the thyroid gland and a carcinoma showing thymus-like differentiation(CASTLE) may arise from such tissue. We are reported the case of a 26-year-old man with CASTLE, with cervical subcutaneous nodules relapse, who showed a good response to treatment with surgery, chemotherapy and radiotherapy. The problematic aspect of this case was the diagnosis; only on review were we able to make a final diagnosis. CASTLE is a very rare neoplasm. It is important to differentiate this cancer from others tumors such as primary or metastatic squamous cell carcinoma of the head and neck or squamous cell thyroid carcinoma, because the therapy and prognosis are *** is complicated and requires careful histological analysis(CD5- and P63-positive with presence of Hassall's corpuscles); unfortunately there is no gold standard treatment so, in this case, we administered a sandwich of chemotherapy and radiotherapy.

关键词： Carcinoma showing thymus-like differentiation thymic CD5 Hassall’s corpuscles Thyroidectomy Chemotherapy Radiotherapy

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Thermal energy storage as a way to improve transcritical CO_(2) heat pump performance by means of heat recovery cycles

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Energy Storage and Saving 2023年第3期2卷 532-539页

作者： chiara Mancinelli Michele Manno Marco Salvatori Alessandro Zaccagnini Department of Industrial Engineering University of Rome“Tor Vergata”RomeIT00133Italy

Electrification of the heating sector is a major target of energy transition towards a more sustainable,efficient,and less polluted *** pumps are considered more suitable than electrical heaters or fossil-fueled boilers;however,common refrigerants cause ozone layer depletion,which exacerbates the greenhouse *** refrigerants,such as CO_(2),perform comparably and even better than hydrofluorocarbons while minimizing the negative *** study presents a model of a water-heater CO_(2) transcritical heat pump in a configuration that increases the overall coefficient of performance(COP)by introducing thermal energy storage(TES).The thermodynamic cycle was divided into two separate *** heating the TES(charging),warm water was used as the heating fluid in the evaporator to increase the evaporation temperature and pressure of CO_(2),which reduced the work of the *** the water temperature decreased progressively,the discharge cycles improved the total *** case study focuses on dairy processes and suggests a more straightforward and cheaper method to improve cycle efficiency than the current processes,such as ejector-expansion systems or double compression.

关键词： Energy efficiency Natural refrigerants CO_(2)heat pump Thermal energy storage Dairy industry

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从热力学计算到定形体系的实验表征设计全金属复合相变材料

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Transactions of Nonferrous Metals Society of China 2024年第5期34卷 1393-1412页

作者： chiara CONFALONIERI Alessandra CAMNAGHI Elisabetta GARIBOLDI Politecnico di Milano Department of Mechanical EngineeringVia La Masa 120156 MilanItaly

用于热能管理的复合相变材料(C-PCMs)利用其一个或多个低熔点活性相的可逆相变(如熔化—凝固)存储和释放热能作为潜热。同时,高熔点的惰性相可以提供额外的性能,如定形性和改善的导热性。从难混溶合金中可获得具有这些特征的全金属复合... 详细信息

用于热能管理的复合相变材料(C-PCMs)利用其一个或多个低熔点活性相的可逆相变(如熔化—凝固)存储和释放热能作为潜热。同时,高熔点的惰性相可以提供额外的性能,如定形性和改善的导热性。从难混溶合金中可获得具有这些特征的全金属复合材料体系。本文将热力学计算和实验测试相结合,探讨二元(Al-In,Al-Sn,Al-Bi和Cu-Bi)和三元(Al-In-Sn和Al-Bi-Sn)难混溶合金在100~300℃的温度范围内用作C-PCMs的潜力。结果表明,将这两种方法相结合对于全面理解复合体系和找到满足设计需求的最佳解决方案十分必要,它克服了“试错”法浪费时间的弊端,并为模拟提供了高质量的数据。

关键词：复合相变材料合金设计热力学性能定形性储热

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