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World Journal of Gastroenterology 2014年第29期20卷 9732-9743页

作者： Alfonso De Stefano chiara Carlomagno Department of Clinical Medicine and Surgery University of Naples Federico Ⅱ

Systematic analysis of the epidermal growth factor receptor(EGFR)pathway revealed that biomarkers could be used to predict the response to and outcome of antiEGFR therapies in patients affected by metastatic colorectal *** have conducted a review on the most recent findings and advances on this *** this aim,we searched the PubMed database for articles devoted to predictive and prognostic biomarkers for patients administered cetuximab-and panitumumab-based *** we review the state of the art and the controversies about the molecular factors known to be predictors of the efficacy of anti-EGFR therapy,namely,KRAS,BRAF,NRAS,PI3KCA and PTEN,and we discuss their prognostic value in colorectal cancer patients.

关键词： KRAS Anti-epidermal growth factor receptor Metastatic colorectal cancer Biomarkers

Integration of multi-stage membrane carbon capture processes to coal-fired power plants using highly permeable polymers

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Green Energy & Environment 2016年第3期1卷 211-221页

作者： Maria-chiara Ferrari Davide Bocciardo Stefano Brandani School of Engineering University of Edinburgh

Membrane separation systems could be a feasible option as post combustion carbon capture technologies in coal-fired power *** advancement on membrane materials based on microporous super glassy polymers could improve significantly the capture process but the properties of the materials have to guide the design of the separation stage. In this study an advanced hybrid two-stage membrane process employing one of the most permeable polymer known(PIM-1) is retrofitted to a coal fired power plant and the process is analysed in terms of energy requirement and cost performance. The results are based on the use of an in-house detailed membrane module model implemented in UniSim Design~?, the Honeywell process flowsheet simulator. The study indicates the need for advanced configuration in order for highly permeable membranes to be competitive with more mature technologies in terms of capture cost. The effect of ageing and impurities on the material is also investigated in order to predict the decline in process performance over time and suggest a timeproof design.

关键词： Membranes PIMs Post-combustion LCOE

Dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 101-109页

作者： Mariarosaria D'Amato Gennaro Iengo Nicola Massa chiara Carlomagno Department of Oncology Ospedale San Rocco ASL CasertaSessa Aurunca 81037CampaniaItaly Department of Clinical Medicine and Surgery University of Naples Federico IINaples 80131CampaniaItaly

BACKGROUND Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(DPD),encoded by the DPYD *** 7%of the European population is a carrier of DPYD gene polymorphisms associated with reduced DPD enzyme *** To assess the prevalence of DPYD polymorphisms and their impact on fluoropyrimidine tolerability in Italian patients with gastrointestinal *** A total of 300 consecutive patients with a diagnosis of gastrointestinal malignancy and treated with a fluoropyrimidine-based regimen were included in the analysis and divided into two cohorts:(1)149 patients who started fluoropyrimidines after DPYD testing;and(2)151 patients treated without DPYD *** the patients in cohort A,15%tested only the DPYD2A polymorphism,19%tested four polymorphisms(DPYD2A,HapB3,c.2846A>T,and DPYD13),and 66%tested five polymorphisms including *** Overall,14.8%of patients were found to be carriers of a DPYD variant,the most common being DPYD6(12.1%).Patients in cohort A reported≥G3 toxicities(P=0.00098),particularly fewer nonhematological toxicities(P=0.0028)compared with cohort B,whereas there was no statistically significant difference between the two cohorts in hematological toxicities(P=0.6944).Significantly fewer chemotherapy dose reductions(P=0.00002)were observed in cohort A compared to cohort B,whereas there was no statistically significant differences in chemotherapy *** Although this study had a limited sample size,it provides additional information on the prevalence of DPYD polymorphisms in the Italian population and highlights the role of pharmacogenetic testing to prevent severe toxicity.

关键词： Dihydropyrimidine dehydrogenase DPYD polymorphisms Fluoropyrimidine Caucasian population Gastrointestinal cancers

Chemical substances present in discharge water generated by laundry industry:Analytical monitoring

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Water Science and Engineering 2023年第4期16卷 324-332页

作者： Dario Lacalamita chiara Mongioví Grégorio Crini Chrono-environnement Laboratory University of Franche-Comté16 Route de GrayBesançon 25000France

To our knowledge,precise data concerning the pollution in terms of qualitative and quantitative fluctuations in discharge water from the laundry sector have seldom been *** study investigated the chemical composition of the discharge water from a laundry *** 160 chemical substances and 15 standard water parameters were *** results showed that the discharge water presented both inorganic and organic polycontamination with a high degree of qualitative and quantitative ***,of all monitored substances,only five metals(Al,Cu,Fe,Sr,and Zn),five minerals(P,Ca,K,Na,and S),and alkylphenols were systematically present and *** a daily average water flow of 129 m^(3),the released metal flux was 356 g/***,such as trichloromethane,brominated diphenyl ether(BDE)47,and fluorides,were occasionally found and *** substances,such as chlorophenols,organo-tins,and pesticides were never *** the samples had quantifiable levels in the chemical oxygen demand(COD),biological oxygen demand(BOD),and *** the concentrations of Zn(8.3 g/d),Cu(21.4 g/d),and BOD(57.4 g/d)were close to or above the regulatory values:74.0 g/d for Zn,9.0 g/d for Cu,and 57.0 kg/d for *** data obtained from this study are useful to the choice of additional treatments for the reduction of pollutant fluxes.

关键词： Laundry Discharge water Chemical analysis Water parameter Chemical substance

The antiaging role of oxytocin

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Neural Regeneration Research 2021年第12期16卷 2413-2414页

作者： Tarek Benameur Maria A.Panaro chiara Porro College of Medicine Department of Biomedical SciencesKing Faisal University Al-AhsaKingdom of Saudi Arabia Department of Biosciences Biotechnologies and BiopharmaceuticsUniversity of BariBariItaly Department of Clinical and Experimental Medicine University of FoggiaFoggiaItaly

The human life expectancy is continuously *** the past two decades,a large number of studies have been extensively exploring the molecular mechanisms which play critical roles in determining *** is a physiological and... 详细信息

关键词： aging continuously physiological

Sampling strategies for estimating forest cover from remote sensing-based two-stage inventories

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Forest Ecosystems 2015年第3期2卷 208-219页

作者： Piermaria Corona Lorenzo Fattorini Maria chiara Pagliarella Consiglio per la ricerca in agricoltura e l’analisi dell’economia agraria-Forestry Research Centre University of Siena-Department of Economic and Statistics University of Molise-Department of Biosciences and Territory

Background: Remote sensing-based inventories are essential in estimating forest cover in tropical and subtropical countries, where ground inventories cannot be performed periodically at a large scale owing to high costs and forest inaccessibility(e.g. REDD projects) and are mandatory for constructing historical records that can be used as forest cover baselines. Given the conditions of such inventories, the survey area is partitioned into a grid of imagery segments of pre-fixed size where the proportion of forest cover can be measured within segments using a combination of unsupervised(automated or semi-automated) classification of satellite imagery and manual(i.e. visual on-screen)enhancements. Because visual on-screen operations are time expensive procedures, manual classification can be performed only for a sample of imagery segments selected at a first stage, while forest cover within each selected segment is estimated at a second stage from a sample of pixels selected within the segment. Because forest cover data arising from unsupervised satellite imagery classification may be freely available(e.g. Landsat imagery)over the entire survey area(wall-to-wall data) and are likely to be good proxies of manually classified cover data(sample data), they can be adopted as suitable auxiliary ***: The question is how to choose the sample areas where manual classification is carried out. We have investigated the efficiency of one-per-stratum stratified sampling for selecting segments and pixels, where to carry out manual classification and to determine the efficiency of the difference estimator for exploiting auxiliary information at the estimation level. The performance of this strategy is compared with simple random sampling without ***: Our results were obtained theoretically from three artificial populations constructed from the Landsat classification(forest/non forest) available at pixel level for a study area located in central Italy,

关键词： Spatially balanced sampling Auxiliary information

Cerebral ultrasound abnormalities in offsprings of women with C677T homozygous mutation in the MTHFR gene:a prospective study

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World Journal of Pediatrics 2015年第2期11卷 134-140页

作者： Laura Pogliani chiara Cerini Francesca Penagini Piergiorgio Duca chiara Mameli Gian Vincenzo Zuccotti Department of Pediatrics L.Sacco HospitalUniversity of Milan74 GB GrassiMilanIT 20157Italy Department of Clinical Sciences L.Sacco HospitalUniversity of Milan74 GB GrassiMilanIT 20157Italy

Background:Perinatal stroke is a common cause of neurologic *** clinically under-recognized,its true incidence is not *** thrombophilia is likely to be a predisposing *** date,a general consensus for evaluation of babies born to mothers with genetic thrombotic predisposition is *** study was undertaken to assess the frequency of cerebral abnormalities in the offspring of women with homozygous C677T mutation in the MTHFR gene,and to seek for association with additional maternal or pregnancy risk ***:Mother-infant pairs were consecutively recruited from October 2006 through February *** underwent a thorough physical examination at birth,and a cerebral ultrasound examination(cUS)was performed within 24 hours of their *** neonates with major cerebral lesions,a thrombophilia panel test was ***-up cUS was performed in babies with major or minor cerebral ***:Ninety-one neonates(47 males)were *** cUS,abnormalities were detected in 18(19.8%)*** neonates were diagnosed with a minor lesion;a major ischemic/hemorrhagic lesion was found in 6 *** were a neat male preponderance and significant associations with a history of suspected miscarriage,maternal coagulation factors gene mutations,and reduced protein S or protein C ***:Our data confirmed a high incidence of cerebral abnormalities in neonates born to women with C677T homozygous mutation in the MTHFR *** at birth proved to be an effective screening tool or a diagnostic test,that should be routinely performed in babies born to mothers with known thrombotic predisposition.

关键词： cerebral ultrasound maternal thrombophilia methylenetetrahydrofolatereductase polymorphism perinatal stroke

Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

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World Journal of Gastroenterology 2014年第8期20卷 2051-2061页

作者： Luigia De Fazio Elena Cavazza Enzo Spisni Antonio Strillacci Manuela Centanni Marco Candela chiara Praticò Massimo Campieri chiara Ricci Maria chiara Valerii Department of Biological Geological and Environmental SciencesBiology UnitUniversity of BolognaVia Selmi 340126 BolognaItaly Department of Pharmacy and Biotechnology University of BolognaVia 640126 BolognaItaly Department of Medical and Surgical Sciences University of BolognaVia Massarenti 940138 BolognaItaly Department of Clinical and Experimental Sciences University of BresciaSpedali Civili 125121 BresciaItaly

AIM: To characterize longitudinally the inflammation and the gut microbiota dynamics in a mouse model of dextran sulfate sodium (DSS)-induced colitis.

关键词： Colitis, Dysbiosis Dextran sulfate sodium Inflammation Cyclooxygenase 2

Physical activity support or weight loss counseling for nonalcoholic fatty liver disease?

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World Journal of Gastroenterology 2014年第29期20卷 10128-10136页

作者： Luca Montesi chiara Caselli Elena Centis chiara Nuccitelli Simona Moscatiello Alessandro Suppini Giulio Marchesini Unit of Metabolic Diseases and Clinical Dietetics "Alma Mater Studiorum" University S. Orsola-Malpighi Hospital

AIM: To determine the clinical effectiveness of intense psychological support to physical activity (PA) in nonalcoholic fatty liver disease (NAFLD), compared with cognitive-behavioral treatment (CBT).

关键词： Nonalcoholic fatty liver disease Behavior treatment Physical activity Physical fitness Weight loss liver fat Liver enzymes

Polymorphisms in the IFNL3/IL28B gene and hepatitis C: From adults to children

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World Journal of Gastroenterology 2014年第28期20卷 9245-9252页

作者： Giuseppe Indolfi chiara Azzari Massimo Resti Paediatric and Liver Unit Meyer Children’s University Hospital of Florence Immunology Unit and Laboratory at Meyer Children’s University Hospital of Florence Department of Health Sciences University of Florence

The purpose of the present review is to summarise the current knowledge on the association between single nucleotide polymorphisms (SNPs) in the interferon L3 (IFNL3) gene and hepatitis C virus (HCV) infection in children. Many studies in adults have demonstrated that genetic variation in IFNL3 is a strong predictor of the virological response in treatment-naive patients with HCV genotype 1 who were treated with Pegylated-IFN-α and ribavirin. Genetic variation in IFNL3 is also associated with the spontaneous clearance of HCV. Thus far, few paediatric studies have explored the association between variations in the IFNL3 gene and either spontaneous or treatment-induced clearance of HCV. The CC genotype of the rs12979860 SNP is associated with the spontaneous clearance of HCV in children independently of HCV genotype. Four paediatric studies have shown that both the CC genotype of the rs12979860 SNP and the TT genotype of the rs8099917 SNP are associated with the treatment-induced (IFN monotherapy and Pegylated-IFN-α and ribavirin association) clearance of HCV, while the rs12980275 SNP did not affect the virological response. The possible role of IFNL3 gene variation as a pre-treatment and on-treatment predictor of virological response in children is highly attractive but still undetermined. Further paediatric studies are needed to evaluate if testing for SNPs in IFNL3, either alone or together with other predictors of response to treatment, could be used to direct treatment strategies, including an avoidance of unnecessary protease inhibitor therapy and the duration of treatment.

关键词： Hepatitis C virus Children Interferon L3 IL28B Interferon-λ Treatment Virological response