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Correction of hypovitaminosis D improved global longitudinal strain earlier than left ventricular ejection fraction in cardiovascular older adults after orthopaedic surgery

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Journal of Geriatric Cardiology 2018年第8期15卷 519-522页

作者： Matteo Briguglio Luigi Gianturco Daniele Stellat chiara colombo Marika Bonadies Oscar Salat Mauro Anselmi Giuseppe Banff Maurizio Turiel Cardiology Unit IRCCS Orthopaedic Institute Galeazzi Milan Italy Scientific Direction IRCCS Orthopaedic Institute Galeazzi Milan Italy University Vitae Salute San Raffaele Milan Italy

Background Cardiovascular diseases and insufficient levels of vitamin D are risk factors for adverse surgical outcomes, and they are both commonly present among older adults undergoing orthopaedic surgery. Giving the cardiovascular effects of vitamin D, pre-operative diagnosis of hypovitaminosis D would be a valuable step for the implementation of supplementation protocols. We investigated if the nor- malization of serum 25 [OH] D could ameliorate cardiac performance of older adults suffering from cardiovascular diseases. Methods We enrolled 47 older adults scheduled for major orthopaedic surgery and suffering from hypovitaminosis D. Patients underwent 6-months cal- cifediol supplementation with a starting dose at first post-operative day of 50 ~tg/die in liquid preparation. Down-titration to 20 Ixg/die at 3-months assessment was planned. Cardiac performance was evaluated by measuring left ventricular ejection fraction （LVEF） and global longitudinal strain （GLS） during pre-operative assessments and at 1-month, 3-months, 6-months follow-ups. Results Six months of cal- cifediol supplementation were associated with a significant improvement of both LVEF （＋ 3.94%; 95% CI： -4.0789 to -0.8232; P 〈 0.01） and GLS （＋ 18.56%; Z = -5.895; P 〈 0.0001）. Conclusions Calcifediol supplementation normalized serum 25 [OH] D concentration after 1-month treatment. GLS offered better insights into myocardial contractile amelioration than LVEF, thus being useful for detecting earlier subclinical changes that may anticipate hemodynamic modifications.

关键词： Global longitudinal strain Left ventricular ejection fraction Orthopedic surgery Transthoracic echocardiography Vitamin D

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Therapeutic targeting of cellular prion protein: toward the development of dual mechanism anti-prion compounds

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Neural Regeneration Research 2025年第4期20卷 1009-1014页

作者： Antonio Masone chiara Zucchelli Enrico Caruso Giovanna Musco Roberto Chiesa Laboratory of Prion Neurobiology Department of NeuroscienceIstituto di Ricerche Farmacologiche Mario Negri IRCCSMilanItaly Biomolecular NMR Unit Division of Genetics and Cell BiologyIRCCS Ospedale San RaffaeleMilanItaly Department of Biotechnology and Life Sciences University of InsubriaVareseItaly

PrPSc,a misfolded,aggregation-prone isoform of the cellular prion protein(PrPC),is the infectious prion agent responsible for fatal neurodegenerative diseases of humans and other *** adopt different pathogenic conformations(prion strains),which can be resistant to potential drugs,or acquire drug resistance,posing challenges for the development of effective *** PrPCis the obligate precursor of any prion strain and serves as the mediator of prion neurotoxicity,it represents an attractive therapeutic target fo r prion *** this minireview,we briefly outline the approaches to target PrPCand discuss our recent identification of Zn(Ⅱ)-Bn PyP,a PrPC-targeting porphyrin with an unprecedented bimodal mechanism of *** argue that in-depth understanding of the molecular mechanism by which Zn(Ⅱ)-Bn PyP targets PrPCmay lead toward the development of a new class of dual mechanism anti-prion compounds.

关键词： anti-prion drug anti-PrPC antibody antisense oligonucleotide neurodegeneration pharmacological chaperone porphyrin prion disease PrPC degrader PrPC shedding zinc finger repressor

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Peptide aptamers:The versatile role of specific protein function inhibitors in plant biotechnology

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Journal of Integrative Plant Biology 2015年第11期57卷 892-901页

作者： Monica colombo chiara Mizzotti Simona Masiero Martin M.Kater Paolo Pesaresi Research and Innovation Centre Fondazione Edmund MachSan Michele all'Adige(Trento) Department of Biosciences University of Milan

In recent years, peptide aptamers have emerged as novel molecular tools that have attracted the attention of researchers in various fields of basic and applied science, ranging from medicine to analytical chemistry. These artificial short peptides are able to specifically bind, track, and inhibit a given target molecule with high affinity, even molecules with poor immunogenicity or high toxicity, and represent a remarkable alternative to antibodies in many different applications. Their use is on the rise, driven mainly by the medical and pharmaceutical sector. Here we discuss the enormous potential of peptide aptamers in both basic and applied aspects of plant biotechnology and food safety. The different peptide aptamer selection methods available both in vivo and in vitro are introduced, and the most important possible applications in plant biotechnology are illustrated. In particular, we discuss the generation of broad- based virus resistance in crops, ＂reverse genetics＂ and aptasensors in bioassays for detecting contaminations in food and feed. Furthermore, we suggest an alternative to the transfer of peptide aptamers into plant cells via genetic transformation, based on the use of cell-penetrating peptides that overcome the limits imposed by both crop transformation and Genetically Modified Organism commercialization.

关键词： Biosensors functional genomics peptide aptamers resistance

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Characterization of color,phenolic profile,and antioxidant activity of Italian pigmented rice varieties after different technological treatments

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Food Bioscience 2023年第3期53卷 1657-1664页

作者： Francesca colombo Carola Cappa Corinne Bani Marco Magni Simone Biella Patrizia Restani chiara Di Lorenzo Department of Pharmacological and Biomolecular Sciences(DiSFeB) Universitàdegli Studi di Milano20133MilanItaly Department of Food Environmental and Nutritional Sciences(DeFENS) Università degli Studi di Milano20133MilanItaly Centro di Ricerca Coordinata(CRC)“Innovation for Well-Being and Environment” Università degli Studi di MilanoMilanItaly

Pigmented rice varieties are rich in antioxidant and anti-inflammatory compounds(*** and proanthocyanidins).Therefore,their consumption could exert beneficial effects,particularly in people suffering from chronic diseases(e.g.,celiac disease).Pigmented rice is commonly consumed as brown rice,but technological treatments could be applied to reduce its cooking time and improve its nutritional value(vitamins and minerals).In this study,two relatively new pigmented varieties(Violet and Orange)were characterized in terms of phenolic content and antioxidant capacity and the impact of two technological treatments(e.g.,milling and parboiling)on their phytochemical composition was *** pigmented and one non-pigmented Italian varieties were included for *** technological processes affected the concentration of phenolic compounds and their relative antioxidant *** milling mainly reduced the phenolic content and the antioxidant activity,anthocyanins seem to be more affected by parboiling(reduction of 91.5%).Despite the effects of technological treatments on active compounds,pigmented varieties still represent an interesting antioxidant source when compared to the non-pigmented ones.

关键词： Pigmented rice Technological treatments Polyphenols Antioxidant capacity

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Cytoskeleton reorganization and ultrastructural damage induced by gliadin in a three-dimensional in vitro model

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World Journal of Gastroenterology 2005年第48期11卷 7597-7601页

作者： Ersilia Dolfini Leda Roncoroni Luca Elli chiara Fumagalli Roberto colombo Simona Ramponi Fabio Forlani Maria Teresa Bardella Department of Biology and Genetics for Health Sciences Department of Digestive Diseases and Endocrinology Department of Biology Milan Research Imaging Centre Department of Agrifood Molecular Sciences

AIM： To evaluate the interplay between gliadin and LoVo cells and the direct effect of gliadin on cytoskeletal patterns.METHODS： We treated LoVo multicellular spheroids with digested bread wheat gliadin in order to investigate their morphology and ultrastructure （by means of light microscopy and scanning electron microscopy）, and the effect of gliadin on actin （phalloidin fluorescence） and the tight-junction protein occludin and zonula occluden-1.RESULTS： The treated spheroids had deep holes and surface blebs, whereas the controls were smoothly surfaced ovoids. The incubation of LoVo spheroids with gUadin decreased the number of intracellular actin filaments, impaired and disassembled the integrity of the tight-junction system.CONCLUSION： Our data obtained from an ＂in vivolike＂ polarized culture system confirm the direct noxious effect of gliadin on the cytoskeleton and tight junctions of epithelial cells. Unlike two-dimensional cell culture systems, the use of multicellular spheroids seems to provide a suitable model for studying cell-cell interactions.

关键词： Celiac disease Gliadin Cytoskeleton Multicellular spheroids

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Cardiovascular injuries and SARS-COV-2 infection:focus on elderly people

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Journal of Geriatric Cardiology 2021年第7期18卷 534-548页

作者： Claudia colombo Laura Garatti Giulia Ferrante Francesca Casadei Claudio Montalto Gabriele Crimi chiara Cogliati Enrico Ammirati Stefano Savonitto Nuccia Morici Department of Cardiology De Gasperis Cardio Center ASST Grande Ospedale Metropolitano NiguardaMilanItaly School of Medicine and Surgery University of Milano BicoccaItaly Division of Cardiology Heart and Lung DepartmentSan Paolo HospitalASST Santi Paolo and CarloUniversity of MilanItaly Division of Cardiology University of PaviaPaviaLombardiaItaly Interventional Cardiology Unit Cardio Thoraco Vascular Department(DICATOV)IR-CCS Policlinico San MartinoGenovaItaly Internal Medicine Department of Medicine and RiabilitationASST Fatebenefratelli-SaccoLuigi Sacco HospitalMilanItaly De Gasperis Cardio Center and Transplant Center Niguarda HospitalMilanItaly Division of Cardiology Ospedale ManzoniLeccoItaly

The novel coronavirus disease(COVID-19)has hit the healthcare system *** risk of severe infection and mortality increases with advancing age,especially in subjects with comorbidities such as cardiovascular disease,hypertension,diabetes,obesity and ***,cardiovascular complications such as myocardial injury,heart failure and thromboembolism are frequently observed in COVID-19 cases,and several biomarkers(troponin,NTpro BNP and D-Dimer)have been identified as prognostic indicators of disease severity and worst ***,there is no specific therapy against SARS-Co V-2,although many medications are under *** aim of this review will be to explore the intertwined relationship between COVID-19 disease and the cardiovascular system,focusing on elderly *** available supportive treatments along with the related concerns in elderly patients,due to their comorbidities and polypharmacotherapy,will be explored.

关键词： injuries cardiovascular infection

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Seismic response of continuous span bridges through fiber-based finite element analysis

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Earthquake Engineering and Engineering Vibration 2006年第1期5卷 119-131页

作者： chiara Casarotti Rui Pinho University of Pavia Structural Mechanics Dept. Via Ferrata 1 27100 Pavia Italy

It is widely recognized that nonlinear time-history analysis constitutes the most accurate way to simulate the response of structures subjected to strong levels of seismic excitation. This analytical method is based on sound underlying principles and has the capability to reproduce the intrinsic inelastic dynamic behavior of structures. Nonetheless, comparisons with experimental results from large-scale testing of structures are still needed, in order to ensure adequate levels of confidence in this numerical methodology. The fiber modelling approach employed in the current endeavor inherently accounts for geometric nonlinearities and material inelasticity, without a need for calibration of plastic hinges mechanisms, typical in concentrated plasticity models. The resulting combination of analysis accuracy and modelling simplicity, allows thus to overcome the perhaps not fully justifiable sense of complexity associated to nonlinear dynamic analysis. The fiber-based modelling approach is employed in the framework of a finite element program downloaded from the Intemet for seismic response analysis of framed structures. The reliability and accuracy of the program are demonstrated by numerically reproducing pseudo-dynamic tests on a four span continuous deck concrete bridge. Modelling assumptions are discussed, together with their implications on numerical results of the nonlinear time-history analyses, which were found to be in good agreement with experimental results.

关键词： bridges seismic response pseudo-dynamic testing nonlinear dynamic analysis fiber modelling

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Quantifying Environmental Impacts of Temporary Housing at the Urban Scale: Intersection of Vulnerability and PostHurricane Relief in New Orleans

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International Journal of Disaster Risk Science 2019年第4期10卷 478-492页

作者： Claire McConnell chiara Bertolin Department of Architecture and Technology Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway Department of Mechanical and Industrial Engineering Norwegian University of Science and Technology(NTNU)7491 TrondheimNorway

The increasing risk and exposure of people and assets to natural hazards and disasters suggests an increasing need for temporary housing following *** to natural hazards is dependent on the resources available to families or communities to prepare for and mitigate risk,influenced by social *** study seeks to quantify the total environmental impact of temporary housing deployment in New Orleans,using the catastrophic impact of Hurricane Katrina in southern Louisiana in August 2005 as a case *** employ a novel approach to estimate displacement period and take into account social vulnerability across New Orleans neighborhoods to better understand the scale of post-disaster relief and its global warming *** methodology implemented in this study comprises three steps:a risk assessment,a life cycle assessment,and a resulting total impact *** demonstrate the considerable risk of greenhouse gas emissions and energy impacts from temporary housing deployment linked to hurricane ***,we show that environmental impact is highly sensitive to displacement period and find the current methodology of anticipating temporary housing use by hazard alone to be ***,the approach presented in this article provides tools to politicians and disaster risk professionals that allow for resource investment planning to decrease social vulnerability,thus enhancing resilience and adaptive capacity in a more homogeneous way at the urban scale.

关键词： Disaster risk Global warming potential Hurricane Katrina Life cycle assessment New Orleans Social vulnerability Temporary housing

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Focus on cardiac troponin complex:From gene expression to cardiomyopathy

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Genes & Diseases 2024年第6期11卷 115-134页

作者： Rosetta Ragusa chiara Caselli Institute of Clinical Physiology CNRvia Moruzzi 1Pisa 56124Italy Fondazione Toscana Gabriele Monasterio via Moruzzi 1Pisa 56124Italy

The cardiac troponin complex(cTn)is a regulatory component of *** consists of three subunits:cardiac troponin C(cTnC),which confers Ca2+sensitivity to muscle;cTnl,which inhibits the interaction of cross-bridge of myosin with thin filament during dias-tole;and cTnT,which has multiple roles in sarcomere,such as promoting the link between the cTnl-cTnC complex and tropomyosin within the thin filament and influencing Ca2+sensi-tivity of cTn and force development during *** that interfere with inter-actions within cTn and/or other thin filament proteins can be key factors in the regulation of cardiac *** conditions include alterations in myoflament Caz+sensitivity,direct changes in cTn function,and triggering downstream events that lead to adverse cardiac remodeling and impairment of heart *** review describes gene expression and post-translational modifications of cTn as well as the conditions that can adversely affect the deli-cate balance among the components of cTn,thereby promoting contractile dysfunction.

关键词： Cardiac troponin Cardiomyopathy Genemutation Post-translational modification Therapy

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Comparison of laboratory and field electrical resistivity measurements of a gypsum rock for mining prospection applications

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International Journal of Mining Science and Technology 2019年第6期29卷 841-849页

作者： chiara Caselle Sabrina Bonetto Cesare Comina Department of Earth Science (DST) Torino University

Geophysical surveys are frequently applied in mining prospection to detect the presence and volume of ore bodies of different ***,in gypsum ore bodies exploitation,electrical resistivity measurements are usually the most used ***,it has been observed that different electrical resistivity values can be obtained depending on geometrical features and composition of ***,electrical resistivity of gypsum rocks depends on several parameters,such as gypsum purity,nature of secondary minerals,porosity,saturation and interstitial fluid *** and hydrogeological setting,in particular,were recognized as the most influencing *** conditions of gypsum rock masses are also very relevant for exploitability,safety conditions and economic feasibility and should be accurately known during the prospection and planning phases of the *** this work,a relationship between electrical resistivity and saturation degree of gypsum is *** possibility to estimate gypsum porosity with the use of this relationship is also *** reliability of laboratory measurements is finally verified in comparison with field and modelled resistivity *** reported results underline the potentiality of the proposed approach to obtain a reliable characterization of the studied ore body.

关键词： Gypsum rock Electrical resistivity Saturation Porosity Archie ERT Quarry

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