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The role of cochlear implantation in alleviating Tumarkin drop attacks of Meniere's disease;a case report

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Journal of Otology 2023年第3期18卷 168-172页

作者： chiara Filippi Edoardo Covelli Haitham H.Elfarargy Simonetta Monini Maurizio Barbara Department of Neuroscience Mental Healthand Sense Organs(NEMOS)Sant’Andrea University HospitalSapienza UniversityRomeItaly Otorhinolaryngology Department Kafrelsheikh UniversityKafrelsheikhEgypt

Ménière’s disease(MD)patients may suffer episodes of sudden falls,named Tu markin drop attacks(DAs).This fall occurs abruptly and without warning or loss of consciousness.DAs usually aggravate the clinical picture of MD and are challenging to manage.The present report describes a case treated by cochlear implantation(CI)due to concomitant deafness and offers some clinical considerations for this condition.A male patient aged 48 years with a 10-year history of definite bilateral MD had profound SNHL on the right and severe SNHL on the left side.He suffered from intermittent attacks of vertigo,ear fullness,and tinnitus and,in the last year,had developed DAs and experienced 14 episodes in the previous six months.The preoperative category of acoustic performance was 3.The Dizziness Handicap Inventory(DHI)questionnaire showed a total score of 46,which indicated a moderate degree of disability.A CI was planned for the right side.The patient did not report any further DAs episode for two years since then.The postoperative category of acoustic performance became 11,and the postoperative DHI questionnaire showed a decrease in the total score(from 46 to 19),which indicated a mild disability.Unilateral CI effectively alleviated the DAs associated with bilateral MD.Our report proposes a new modality for managing vertiginous symptoms in cases of MD with hearing loss without the need for more aggressive surgical interventions with the need for clinical trials to confirm our results.

关键词： Meniere's disease Tumarkin drop attacks Hearing loss Cochlear implant

Same place, different time, head up: Multiple antipredator responses to a recolonizing apex predator

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Current Zoology 2023年第6期69卷 703-717页

作者： Bruno Esattore Agnese Carlotta Rossi Francesco Bazzoni chiara Riggio Raquel Oliveira Ivan Leggiero Francesco Ferretti Department of Ethology Institute of Animal SciencePratelstvi 81510400UhrinevesPragueCzech Republic Department of Ethology and Companion Animal Science Faculty of AgrobiologyFood and Natural ResourcesCzech University of Life SciencesKamycka 12916500SuchdolPragueCzech Republic Department of Life Sciences Research Unit of Behavioral EcologyEthology and Wildlife ManagementUniversity of SienaVia Pier Andrea Mattioli 453100SienaItaly NBFC National Biodiversity Future CenterPalermo 90133Italy

Prey adjust their antipredator behavioral tactics to minimize the risk of an encounter with predators.Spatiotemporal responses of prey to pred-ators have been reported,but the nature of antipredator response is not ubiquitous and it is the object of increasing interest,especially consid-ering the recent recovery of large carnivores in Europe,and the potential for behavioral antipredator responses to elicit consequences at the ecosystem level.We have tested multiple antipredator responses by fallow deer Dama dama to wolf Canis lupus in a Mediterranean protected area recently recolonized by this apex predator.Through intensive camera trapping,we tested for temporal and spatial association between predator and prey,and we have also studied deer vigilance in forest habitats where focal observations are usually impossible.Wolf detection rates were spatially associated with those of fallow deer.Accordingly,no evidence was found for fallow deer avoiding sites with higher predator detection rates.Temporal activity patterns were significantly different between the 2 species,with the wolf being mainly nocturnal whereas fallow deer was active especially during daylight.A comparison with a preliminary study strongly suggests an increase in the diurnal activity of fallow deer along with the stabilization of wolf presence in the area.Both the rate and the duration of vigilance of female fallow deer increased with the local frequency of wolf activity.We suggest an antipredator response based on temporalrather than spatialavoidance,as well as increasedvigilance.

关键词： antipredator responses deer interspecific interactions temporal patterns vigilance

Long-term implications of fetal growth restriction

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World Journal of Clinical Cases 2023年第13期11卷 2855-2863页

作者： Martina D'Agostin chiara Di Sipio Morgia Giovanni Vento Stefano Nobile Department of Pediatrics University of TriesteTrieste 34100Italy Department of Woman and Child Health and Public Health UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Woman and Child Health and Public Health Fondazione Policlinico Universitario A.Gemelli IRCCS-UniversitàCattolica del Sacro CuoreRome 000168Italy

Fetal growth restriction(FGR),or intrauterine growth restriction(IUGR),is a complication of pregnancy where the fetus does not achieve its genetic growth potential.FGR is characterized by a pathological retardation of intrauterine growth velocity in the curve of intrauterine growth.However,the FGR definition is still debated,and there is a lack of a uniform definition in the literature.True IUGR,compared to constitutional smallness,is a pathological condition in which the placenta fails to deliver an adequate supply of oxygen and nutrients to the developing fetus.Infants with IUGR,compared to appropriately grown gestational age infants,have a significantly higher risk of mortality and neonatal complications with long-term consequences.Several studies have demonstrated how suboptimal fetal growth leads to long-lasting physiological alterations for the developing fetus as well as for the newborn and adult in the future.The long-term effects of fetal growth retardation may be adaptations to poor oxygen and nutrient supply that are effective in the fetal period but deleterious in the long term through structural or functional alterations.Epidemiologic studies showed that FGR could be a contributing factor for adult chronic diseases including cardiovascular disease,metabolic syndrome,diabetes,respiratory diseases and impaired lung function,and chronic kidney disease.In this review we discussed pathophysiologic mechanisms of FGR-related complications and potential preventive measures for FGR.

关键词： Fetal growth restriction Intrauterine chronic hypoxia Long-lasting physiological alterations Cardiovascular disease Metabolic syndrome Obstructive pulmonary disease

Endoscopic ultrasound radiofrequency ablation of pancreatic insulinoma in elderly patients:Three case reports

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World Journal of Clinical Cases 2022年第19期10卷 6514-6519页

作者： Gemma Rossi Maria chiara Petrone Gabriele Capurso Stefano Partelli Massimo Falconi Paolo Giorgio Arcidiacono Division of Pancreato-Biliary Endoscopy and Endosonography Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSVita-Salute San Raffaele UniversityMilano 20132Italy Department of Pancreatic Surgery Pancreas Translational and Clinical Research CenterSan Raffaele Scientific Institute IRCCSVita-Salute San Raffaele UniversityMilano 20132Italy

BACKGROUND Endoscopic ultrasound(EUS)-guided radiofrequency ablation(RFA)has recently been proposed as a local treatment for functional pancreatic neuroendocrine neoplasms in patients unfit for surgery,in order to obtain clinical syndrome regression.Data on the safety and long-term effectiveness of this approach are scarce,and EUS-RFA procedures are not standardized.CASE SUMMARY The present case series reports 3 elderly patients with a pancreatic insulinoma and comorbidities,locally treated by EUS-guided RFA with clinical success in terms of hypoglycemic symptoms.RFA procedures were performed during deep sedation,under EUS control with a 19 G needle,an electrode 5-mm in size at a power of 30 W and multiple RFA applications during the same session in order to treat the whole area of the lesions.Immediate relief of symptoms was evident in 2 patients after the first EUS-RFA,while in the third patient a second endoscopic treatment was needed.All 3 patients are symptom-free without need of medications after 24 mo of follow-up with imaging follow-up showing no disease recurrence.A single adverse event of intraprocedural bleeding occurred,which was successfully treated endoscopically.CONCLUSION EUS-RFA represents an effective and safe alternative to surgery for the treatment of insulinomas in elderly patients at high surgical risk.However,larger multicenter studies withlonger follow-up are needed in order to better assess its safety and clinical success.

关键词： Endoscopic ultrasound Radiofrequency ablation Insulinomas Neuroendocrine neoplasms Ablative therapies Case report

Druggable monogenic immune defects hidden in diverse medical specialties:Focus on overlap syndromes

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World Journal of Clinical Pediatrics 2022年第2期11卷 136-150页

作者： Valentina Boz chiara Zanchi Laura Levantino Guglielmo Riccio Alberto Tommasini Department of Medical Surgical and Health SciencesUniversity of TriesteTrieste 34137Italy Department of Pediatrics Institute for Maternal and Child HealthIRCCS Burlo GarofoloTrieste 34137Italy

In the last two decades two new paradigms changed our way of perceiving primary immunodeficiencies:An increasing number of immune defects are more associated with inflammatory or autoimmune features rather than with infections.Some primary immune defects are due to hyperactive pathways that can be targeted by specific inhibitors,providing innovative precision treatments that can change the natural history of diseases.In this article we review some of these“druggable”inborn errors of immunity and describe how they can be suspected and diagnosed in diverse pediatric and adult medicine specialties.Since the availability of precision treatments can dramatically impact the course of these diseases,preventing the development of organ damage,it is crucial to widen the awareness of these conditions and to provide practical hints for a prompt detection and cure.

关键词： Inborn errors of immunity Primary immunodeficiency diseases Precision treatments Immunodysregulation Autoimmunity Overlap syndromes

Hepatopancreatoduodenectomy for the treatment of extrahepatic cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 430-433页

作者： Alberto Porcu Giulia Deiana Claudio F Feo chiara Ninniri Davide Turilli Lorena Tanda Alessandro Fancellu Department of Clinical Surgical and Experimental SciencesUnit of General Surgery 2–Clinica ChirurgicaUniversity of SassariSassariItaly Unit of Radiological Sciences AOU SassariSassariItaly Faculty of Medicine and Surgery University of SassariSassariItaly

To the Editor:Extrahepatic cholangiocarcinoma(ECC)is an uncommon neoplasm associated with a poor prognosis[1-3].Surgical resection represents the only curative approach,since systemic treatments have scarce efficacy in achieving disease control.However,only 10%-40%of patients with ECC are resectable at diagnosis[1].Ma-jor hepatectomy and portal lymphadenectomy are usually required for hilar ECC,while pancreatoduodenectomy is the standard operation for distal ECC[3-5].However,ECC may spread horizon-tally along the biliary tree,causing tumor involvement of the entire extrahepatic biliary system.In these circumstances,hep-atopancreatoduodenectomy(HPD)has been proposed as a pro-cedure with curative intent[2,6,7].

关键词： pancreatoduodenectomy extrahepatic involvement

利用强子探针研究奇特原子核的点质子分布半径及强子探针效应

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Science Bulletin 2024年第11期69卷 1647-1652页

作者：张寂潮孙保华 Isao Tanihata Rituparna Kanungo Christoph Scheidenberger Satoru Terashima 王枫 Frederic Ameil Joel Atkinson Yassid Ayyad Soumya Bagchi Dolores Cortina-Gil Iris Dillmann Alfredo Estradé Alexey Evdokimov Fabio Farinon Hans Geissel Giulia Guastalla Rudolf Janik Satbir Kaur Ronja Knöbel Jan Kurcewicz Yury Litvinov Michele Marta Magdalena Mostazo Ivan Mukha chiara Nociforo Hooi Jin Ong Stephane Pietri Andrej Prochazka Branislav Sitar Peter Strmen Maya Takechi Junki Tanaka Jossitt Vargas Helmut Weick John Stuart Winfield School of Physics Beihang UniversityBeijing 100191China Research Center for Nuclear Physics(RCNP) Osaka UniversityOsaka 567-0047Japan Astronomy and Physics Department Saint Mary’s UniversityHalifax B3H 3C3Canada TRIUMF Vancouver V6T 4A3Canada GSI Helmholtzzentrum für Schwerionenforschung Darmstadt D-64291Germany Justus-Liebig University Gießn 35392Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion ResearchGießn 35392Germany Universidad de Santiago de Compostela Santiago de Compostella E-15706Spain Department of Physics Indian Institute of Technology(Indian School of Mines)Dhanbad 826004India Faculty of Mathematics and Physics Comenius UniversityBratislava 84215Slovakia Department of Physics and Atmospheric Science Dalhousie UniversityHalifax B3H 4R2Canada

We report the charge-changing cross sections(σ_(cc))of 24 p-shell nuclides on both hydrogen and carbon at about 900A MeV,of which^(8,9)Li,^(10–12)Be,^(10,14,15)B,^(14,15,17–22)N and^(16)O on hydrogen and^(8,9)Li on carbon are for the first time.Benefiting from the data set,we found a new and robust relationship between the scaling factor of the Glauber model calculations and the separation energies of the nuclei of interest on both targets.This allows us to deduce proton radii(R_p)for the first time from the cross sections on hydrogen.Nearly identical R_p values are deduced from both target data for the neutron-rich carbon isotopes;however,the R_p from the hydrogen target is systematically smaller in the neutron-rich nitrogen isotopes.This calls for further experimental and theoretical investigations.

关键词： Exotic nuclei Nuclear size Reaction cross section Glauber model Radioactive ion beam

This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic pain.Although the term cystitis suggests an inflammatory or infectious origin,no definite cause has been identified.It occurs in both sexes,but women are twice as much affected.AIM To systematically review evidence of psychiatric/psychological changes in persons with IC/BPS.METHODS Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search 36.Search on ClinicalTrials.gov produced 14 studies,of which none had available data.Eligible were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October 2023.These studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to catastrophizing.CONCLUSION Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/BPS.Such concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

Glacial biodiversity of the southernmost glaciers of the European Alps(Clapier and Peirabroc,Italy)

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Journal of Mountain Science 2022年第8期19卷 2139-2159页

作者： Barbara VALLE Mauro GOBBI Marta TOGNETTI Marina Serena BORGATTI chiara COMPOSTELLA Paolo PANTINI Marco CACCIANIGA Universitàdegli Studi di Milano Department of BiosciencesVia Celoria 2620133 MilanoItaly MUSE-Science Museum of Trento Research and Museum Collections OfficeClimate and Ecology UnitCorso del Lavoro e della Scienza338122 TrentoItaly Universitàdegli Studi di Milano Dipartimento di Scienze della Terra"A.Desio"Via Mangiagalli 3420133 MilanoItaly Museo Civico di Scienze Naturali"E.Caffi" Piazza della Cittadella1024129 BergamoItaly

We applied a multi-taxa approach integrating the co-occurrence of plants,ground beetles,spiders and springtails with soil parameters(temperatures and chemical characteristics)in order to describe the primary succession along two glacier forelands in the Maritime Alps(Italy),a hotspot of Mediterranean biodiversity.We compared these successions to those from Central Alps:Maritime glacier forelands markedly differ for their higher values of species richness and species turnover.Contrary to our expectation,Maritime glacier forelands follow a‘replacement change model’,like continental succession of Inner Alps and differently from other peripheral successions.We propose that the temperatures along these Mediterranean glacier forelands are warmer than those along other Alpine glacier forelands,which promote the faster species turnover.Furthermore,we found that early and mid successional stages of the investigated glaciers are richer in cold-adapted and endemic species than the later ones:we confirmed that the‘replacement change’model disadvantages pioneer,cold-adapted species.Given the overall correspondence among coldadapted and endemic species,the most threatened in this climate phase,our results raise new concerns about the extinction risk of these species.We also describe supraglacial habitat of Maritime glaciers demonstrating that supraglacial debris represents an environment decoupled from the regional climate and may have an important role as refugium for coldadapted and hygrophilous plant and animal species,whose survival can be threatened by climate change and by a rapid ecological succession in the adjacent forelands.

关键词： Arthropod communities Cold-adapted species Glacier forelands Plant communities Primary succession