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Journal of Integrative Plant Biology 2019年第9期61卷 974-980页

作者： Soohong Kim Yunjin Choi chian kwon Hye Sup Yun Department of Molecular Biology Dankook UniversityCheonan 31116Korea Department of Biological Sciences Konkuk UniversitySeoul 05029Korea

Excessive demand for translation and protein folding in the endoplasmic reticulum(ER) can cause ER stress in plants. Here, we show that CALRETICULIN 1(CRT1) and CRT2 are critical components in the accumulation of VESICLE-ASSOCIATED MEMBRANE PROTEIN 721(VAMP721) and VAMP722 during ER stress responses. We show that CRT2 interacts with VAMP722 and that CRT1/2 post-translationally maintain elevated VAMP721/722 levels under ER *** greater growth inhibition in VAMP721/722-deficient plants, induced by tunicamycin, suggests that plants under ER stress maintain physiological homeostasis, at least in part, by regulating VAMP721/722 levels, as VAMP721/722 are known to participate in various biological processes.

关键词： Endoplasmic reticulum VAMP721/722 in Arabidopsis

Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue

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Molecular Plant 2016年第6期9卷 870-884页

作者： Shin Ae Lee Sejeong Jang Eun Kyung Yoon Jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok Heo chian kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim Department of Systems Biotechnology Konkuk University Seour 05029 Korea Department of Molecular Biotechnology Dong-A University Busan 49201 Korea Department of Molecular Biology Dankook University Yongin 16890 Korea Department of Plant and Environmental New Resources Kyung Hee University Yongin 17104 Korea These authors contributed equally to this article. Present address: The Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Present address: Department of Life Science Research Institute for Natural Sciences Hanyang University Seoul 04763 Korea

In multicellular organisms, controlling the timing and extent of asymmetric cell divisions （ACDs） is crucial for correct patterning. During post-embryonic root development in Arabidopsis thaliana, ground tissue （GT） maturation involves an additional ACD of the endodermis, which generates two different tissues： the endo- dermis （inner） and the middle cortex （outer）. It has been reported that the abscisic acid （ABA） and gibberellin （GA） pathways are involved in middle cortex （MC） formation. However, the molecular mechanisms under- lying the interaction between ABA and GA during GT maturation remain largely unknown. Through transcriptome analyses, we identified a previously uncharacterized C2H2-type zinc finger gene, whose expression is regulated by GA and ABA, thus named GAZ （GA- AND ABA-RESPONSIVE ZINC FINGER）. Seedlings ectopically overexpressing GAZ （GAZ-OX） were sensitive to ABA and GA during MC formation, whereas GAZ-SRDX and RNAi seedlings displayed opposite phenotypes. In addition, our results indicated that GAZ was involved in the transcriptional regulation of ABA and GA homeostasis. In agreement with pre- vious studies that ABA and GA coordinate to control the timing of MC formation, we also confirmed the unique interplay between ABA and GA and identified factors and regulatory networks bridging the two hor- mone pathways during GT maturation of the Arabidopsis root.

关键词： ABA GA GRAS ground tissue root development transcription factor

A Complementary Engineering-Based Building Damage Estimation for Earthquakes in Catastrophe Modeling

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International Journal of Disaster Risk Science 2016年第1期7卷 88-107页

作者： Siau Chen chian Department of Civil and Environmental Engineering National University of Singapore

Catastrophe modeling for earthquakes is conventionally designed as a probabilistic model to estimate the losses based on risk and vulnerability of a portfolio of exposures for a foreseeable set of events. This approach lacks a physical science of building damage that is linked to ground-shaking characteristics. A proposed engineeringbased building damage estimation model based on established theories of seismic wave propagation and structural resonance is presented to address some of these shortcomings. A damage factor is introduced to provide an indication of the relative extent of damage to *** based on the proposed methodology is carried out using data derived from four case studies: the 2011 Tohoku earthquake; the 2007 Bengkulu earthquake; the 2011 Christchurch earthquake; and the 1999 Chi-Chi *** show that the computed damage factors reasonably reflect the extent of actual damage to buildings that was observed in post-earthquake reconnaissance surveys. This indicates that the proposed damage simulation model has a promising future as a complementary assessment tool in building damage estimation in catastrophe modeling.

关键词： Building damage estimation Catastrophe modeling Resonance Seismic engineering Wavelet analysis

Pseudo-static/dynamic solutions of required reinforcement force for steep slopes using discretization-based kinematic analysis

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Journal of Rock Mechanics and Geotechnical Engineering 2019年第2期11卷 289-299页

作者： Changbing Qin Siau Chen chian Department of Civil and Environmental Engineering National University of Singapore

This paper presents a procedure for assessing the reinforcement force of geosynthetics required for maintaining dynamic stability of a steep soil slope. Such a procedure is achieved with the use of the discretization technique and kinematic analysis of plasticity theory, i.e. discretization-based kinematic analysis. The discretization technique allows discretization of the analyzed slope into various components and generation of a kinematically admissible failure mechanism based on an associated flow ***, variations in soil properties including soil cohesion, internal friction angle and unit weight are accounted for with ease, while the conventional kinematic analysis fails to consider the changes in soil properties. The spatialetemporal effects of dynamic accelerations represented by primary and shear seismic waves are considered using the pseudo-dynamic approach. In the presence of geosynthetic reinforcement, tensile failure is discussed providing that the geosynthetics are installed with sufficient length. Equating the total rates of work done by external forces to the internal rates of work yields the upper bound solution of required reinforcement force, below which slopes fail. The reinforcement force is sought by optimizing the objective function with regard to independent variables, and presented in a normalized form. Pseudo-static analysis is a special case and hence readily transformed from pseudodynamic analysis. Comparisons of the pseudo-static/dynamic solutions calculated in this study are highlighted. Although the pseudo-static approach yields a conservative solution, its ability to give a reasonable result is substantiated for steep slopes. In order to provide a more meaningful solution to a stability analysis, the pseudo-dynamic approach is recommended due to considerations of spatial etemporal effect of earthquake input.

关键词： Geosynthetics Pseudo-static/dynamic approach Discretization technique Discretization-based kinematic analysis Reinforced soil Seismic stability

SIMULTANEOUS RECORDING OF FRINGE PATTERNS WITH ONE CAMERA

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Acta Mechanica Sinica 2004年第6期20卷 642-648页

作者：苏飞戴福隆 chian Kerm Sin YI Sung School of MPE Nanyang Technological UniversitySingapore Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China Department of Mechanical Engineering Portland State Univ.OR.USA

A novel method to separate and simultaneously record the Moiréinterferometry fringe patterns of three deformation fields with only one CCD camera is developed;details of its operation principle,key points and error analysis are *** this technique,the deformation in U,V and W fields can be measured simultaneously,so dynamic test with comprehensive information can be *** advantage of this technique over other similar techniques lies in its simplicity,easy implementation and low *** application of this technique is given to show its *** problems that may be caused with this technique are also analyzed.

关键词： moiré interferometry dynamic test fringe pattern polarization optical prism

Integrating sequence and graph information for enhanced drug-target affinity prediction

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Science China(Information Sciences) 2024年第2期67卷 325-326页

作者： Haohuai HE Guanxing CHEN Calvin Yu-chian CHEN Artificial Intelligence Medical Research Center School of Intelligent Systems EngineeringShenzhen Campus of Sun Yat-sen University

Drug discovery is a pivotal discipline involving the identification and development of innovative pharmaceuticals designed to combat a wide array of illnesses. It plays a crucial role in advancing global health outcomes and improving the standard of living for individuals worldwide. However,drug discovery often relies on laborious in vitro experiments,

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Solids flow diagram of a CFB riser using Geldart B-type powders

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Particuology 2012年第1期10卷 51-61页

作者： Shiva Mahmoudi chian Wen Chan Anke Brems Jonathan Seville Jan Baeyens University of Warwick School of Engineering Katholieke Universiteit Leuven Department of Chemical Engineering University of Surrey Faculty of Engineering and Physical Sciences

Riser operating modes are vital to designing a circulating fluidized bed （CFB） reactor for a required process of either a gas-solid or a gas-catalytic nature. Different operating modes provide different solids＇ residence times and mixing behaviors, which define the reactions＇ efficiency and yield. The literature demonstrates distinct operating modes resulting from observed differences in slip factors and the range of particle velocities and their associated residence time distribution. The present research uses positron emission particle tracking （PEPT） in a riser of B-type bed material to determine the different operating modes by measuring （i） particle velocities and residence time distribution, （ii） population densities of these particles in the cross-sectional area of the riser, and （iii） solids flow pattern at the bottom of the riser, Data treatment defines four distinct solids hold-up regimes in the riser and proposes a ＂phase diagram＂ depicting the existence of the different operating modes （dilute, dense, core-annulus and combined） as a function of the superficial gas velocity and solids circulation flux in the riser. The delineated regimes have good agreement with available literature data and known industrial operations. Comparison with literature data for risers using A-type powders is also fair. The diagram enables CFB designers to better delineate operating characteristics.

关键词： Phase diagramDilute riser flowTurbulent fluidized bottom bedCore-annulus flowDense riser up-flow

Modelling smear effect of vertical drains using a diameter reduction method

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 279-290页

作者： Zhichao Shen Siau Chen chian Siew Ann Tan Chun Fai Leung School of Marine Science and Engineering South China University of TechnologyGuangzhouChina Department of Civil and Environmental Engineering National University of SingaporeSingapore

Vertical drains are used to accelerate consolidation of clays in ground improvement *** zones exist around these drains,where permeability is reduced due to soil disturbance caused by the installation *** solution is widely used in practice to consider the effects of drain discharge capacity and smear on the consolidation *** this study,a computationally efficient diameter reduction method(DRM)obtained from the Hansbo solution is proposed to consider the smear effect without the need to model the smear zone *** by analytical and numerical results,a diameter reduction factor is analytically derived to reduce the diameter of the drain,while achieving similar solutions of pore pressure dissipation profile as the classical full model of the smear zone and *** the DRM,the excess pore pressure u obtained from the reduced drain in the original un-disturbed soil zone is accurate enough for practical applications in numerical *** performance of DRM is independent of soil material *** also show equally accurate performance of DRM under conditions of multi-layered soils and coupled radial-vertical groundwater flow.

关键词： Consolidation Vertical drain Smear effect Pore pressure Soil improvement

Hybrid Method to Identify Second-trip Echoes Using Phase Modulation and Polarimetric Technology

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Advances in Atmospheric Sciences 2021年第3期38卷 480-492页

作者： Shuai ZHANG Jinzhong MIN chian ZHANG Xingyou HUANG Jun LIU Kaihua WEI Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science and TechnologyNanjing 210044China Beijing Metstar Radar Co.Ltd. Beijing 100094China Taizhou Meteorological Administration Taizhou 225400China Guangdong Meteorological Observatory Guangzhou 510080China

For pulse Doppler radars,the widely used method for identifying second-trip echoes(STs)in the signal processing level yields significant misidentification in regions of high turbulence and severe wind *** the data processing level,although the novel algorithm for ST identification does not yield significant misidentification in specific regions,its overall identification performance is not ***,this paper proposes a hybrid method for the identification of STs using phase modulation(signal processing)and polarimetric technology(data processing).Through this approach,most of the STs are removed,whereas most of the first-trip echoes(FTs)remain *** with the existing method using a signal quality index filter with an optimized threshold,the hybrid method exhibits superior performance(Heidke skill scores of 0.98 versus 0.88)on independent test datasets,especially in high-turbulence and severe-wind-shear regions,for which misidentification is significantly reduced.

关键词： second-trip echo phase modulation polarimetric radar wind shear

The Recent Progress of Hot Metal Desulfurization in CSC and DSC

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Journal of Iron and Steel Research International 2011年第S2期18卷 64-68页

作者： LIN Yan-chian CHENG Hsien-hua WANG Muh-shun Iron and Steel R&D Dept. Steelmaking Dept. CSC Kaohsiung 81233 Taiwan China

There are two kinds of existing processes for hot metal desulfurization in CSC. One is the injection process in torpedo car, the other is the impelling process in transfer ladle. Lime-based fluxes have been used for both processes. The former was introduced to CSC in 1982. The latter was adopted by CSC and DSC respectively in 2004 and 2010. This paper comprises a theoretical analysis on lime-based flux as desulfurizing agent and an experimental evaluation on impelling process of Kambara (or Kikai) Reactor with a water model and a hot model established in 2001. The comparison of recent mass-production performance for both processes in steelmaking shop has also been included.

关键词： hot metal desulfurization injection process impelling process